Clinical trials: Therapy Strategies
Febrile Neutropenia (FN), Pediatric Cancer
Early Discontinuation of Antibiotics in Paediatric High-risk Febrile Neutropenia
The goal of this clinical trial is to evaluate whether stopping antibiotic treatment early is safe in paediatric patients with cancer who develop high-risk febrile neutropenia but show good clinical evolution and low biomarker…
- Conditions
- Febrile Neutropenia (FN), Pediatric Cancer, Hematologic Malignancies, Solid Tumors
- Trial name
- E-STOP2 (NCT07590648)
- Testing
- Early Discontinuation of Antibiotics, Standard Antibiotic Continuation Strategy
- Where
- 4 sites in Spain
- Volunteers
- 136 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
COVID-19, Immunodeficiency
OPtimisation of Antiviral Therapy in Immunocompromised COVID-19 Patients: a Randomized Factorial Controlled Strategy Trial
The overall purpose of the trial is to evaluate the efficacy and safety of possible combination antiviral therapy DAA (remdesivir + nirmatrelvir/r)∞ versus the reference monotherapy (nirmatrelvir/r alone) and to assess the…
- Trial name
- OPTICOV (NCT05587894)
- Testing
- Paxlovid 5 days, Paxlovid 10 days, Veklury
- Where
- 18 sites in France, Italy and 1 more
- Volunteers
- 256 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Acute Lymphoblastic Leukemia
Mercaptopurine Therapeutic Drug Monitoring to Optimize the Maintenance Phase of Childhood ALL
Acute lymphoblastic leukemia (ALL) is the most common hematological malignancy in children (<18 years). The success of pediatric ALL therapy is remarkable but important challenges still need to be faced, including cure rates in…
- Trial name
- NCT05811845
- Where
- 4 sites in Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS Burlo Garofolo
Pilonidal Sinus, Wound Heal
PILONIDAL SINUS: CONVENTIONAL CARE VERSUS NEGATIVE PRESSURE THERAPY.
Pilonidal Sinus PS is a prevalent disease in young patients. There is currently no consensus on the surgical treatment of choice.
- Trial name
- SINUS-TPN (NCT05474911)
- Testing
- Negative pressure therapy, Conventional wound care
- Where
- Spain
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Sebastiano Biondo
Habitual Patellar Dislocation
Adults Habitual Patellar Dislocation:a Multiple-center Clinical Investigation Regarding Diagnosis and Therapeutic Strategy
Adult habitual dislocation of the patella is a common dislocation of the patella. The range of lesions is wide and the severity is high. Clinical diagnosis and treatment are difficult.
- Trial name
- NCT04556812
- Testing
- Four-in-one procedure, soft-tissue surgery
- Volunteers
- 120 people
- Sponsor
- Hui Zhang
Anorexia Nervosa, Mental Health Issue
Norwegian Microbiota Study in Anorexia Nervosa
Anorexia nervosa (AN) is a serious mental disorder occurring mainly in women. AN is characterized by severely restricted food-intake and subsequent low weight.
- Conditions
- Anorexia Nervosa, Mental Health Issue, Microbiota, Diet
- Trial name
- NORMA (NCT06144905)
- Testing
- standard care treatment program
- Where
- Norway
- Volunteers
- 180 people
- Sponsor
- Norwegian University of Life Sciences
Hodgkin Lymphoma
CCCG-HD-2018 for Children and Adolescents With Newly Diagnosed Hodgkin Lymphoma
The incidence of Hodgkin's lymphoma (HL) in Chinese children and adolescents is only 1 / 10 of that in Europe and the United States, which is a "rare" childhood tumor.
- Trial name
- NCT04726501
- Testing
- Combined chemotherapy with or without involved-field radiotherapy
- Where
- 3 sites in China
- Volunteers
- 200 people
- Sponsor
- Children's Cancer Group, China
Community Acquired Pneumonia (CAP), Community Acquired Pneumonia
Comparing Antibiotic Treatment Strategies for Children With Pneumonia in Outpatient Settings: (STAMPP)
The goal of this clinical trial is to determine if a "watch and wait" antibiotic strategy, called Safety Net Antibiotic Prescribing (SNAP), can safely reduce unnecessary antibiotic use while ensuring that children diagnosed with…
- Trial name
- STAMPP (NCT06986148)
- Testing
- Immediate Antibiotic Prescribing Group Instructions, Safety Net Antibiotic Prescribing (SNAP) Group Instructions
- Where
- 4 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Description of an Effective Surgical Strategy to Treat Cancer Related Lymphedema, a High Incidence Pathology
COMBINATION OF LYMPHATICO-VENULAR ANASTOMOSIS AND LIPOSUCTION IN TREATING LYMPHEDEMA
cooperation of an International team with many years of experience in surgical management of lymphedema description of an effective surgical strategy to treat cancer-related lymphedema, a high incidence pathology the combination…
- Trial name
- NCT04536064
- Testing
- LVA and liposuction
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- University of Siena
Neoplasms, Cancer
Omics of Cancer: OncoGenomics
Background: Cancer is a leading cause of death in the United States. Researchers want to know more about how cancer develops and grows. They want to understand more about cancers that run in families.
- Trial name
- NCT05431439
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Obesity, Atherosclerosis
Observational Study of Early Metabolic and Vascular Changes in Obesity
To work against the increasing burden of obesity, the STYJOBS / EDECTA (STYrian Juvenile OBesity Study / Early DetECtion of Atherosclerosis) project was started at the Medical University of Graz in 2003.
- Conditions
- Obesity, Atherosclerosis, Inflammation, Adiponectin Deficiency
- Trial name
- STYJOBS (NCT00482924)
- Testing
- Lifestyle intervention
- Where
- Austria
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Epilepsy, Ketogenic Dieting
Evaluation Of Strategies For Improving Ketogenic Diet Compliance
In order to increase adherence to ketogenic diet treatment, palatability of meals and diversify the foods offered to patients a ketogenic kitchen will be created.
- Conditions
- Epilepsy, Ketogenic Dieting, Compliance, Treatment
- Trial name
- NCT05112107
- Testing
- Culinary workshops
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo General Hospital
Schistosomiasis
Childhood Schistosomiasis: a Novel Strategy Extending the Benefits/Reach of Antihelminthic Treatment
Objective and Hypotheses: This project has the overall objective of implementing and evaluating new approaches to reducing the current and future burden of urinary schistosomiasis in young children using the antihelminthic drug…
- Trial name
- NCT02495909
- Where
- Zimbabwe
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Diabetes
The Effect of Gastric Emptying on Blood Glucose Profile of Type 1 Diabetes Mellitus and Its Therapeutic Strategies
Establish a cohort study to describe the characteristics of gastric emptying in patients with type 1 diabetes, and adjust the timing of insulin injection during meals to improve blood glucose fluctuations according to the speed…
- Trial name
- NCT06173934
- Testing
- insulin injection 15 minutes before meals, Insulin injection 15 minutes after eating
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
B-cell Acute Lymphoblastic Leukemia
Blinatumomab and Auto-HSCT Sandwich Strategy as Consolidation Therapy for B-ALL
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the main method potentially curing adult B-ALL, but the high treatment-related mortality (NRM) affects overall survival (OS).
- Trial name
- NCT06507514
- Testing
- blinatumomab and auto-HSCT "sandwich " strategy
- Where
- China
- Volunteers
- 4 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Helicobacter Infections, Gastritis
Tailored Treatment of H. Pylori Infection Based Polymorphisms of CYP2C19 and 23S rRNA of H. Pylori
The eradication rate of the standard H. pylori eradication therapy (such as the triple therapy with a proton pump inhibitor [PPI], amoxicillin and clarithromycin) depends on bacterial susceptibility to clarithromycin and…
- Conditions
- Helicobacter Infections, Gastritis, Gastric Ulcer, Duodenal Ulcer
- Trial name
- NCT00149084
- Testing
- Lansoprazole, clarithromycin, amoxicillin
- Where
- Japan
- Volunteers
- 296 people
- Sponsor
- Hamamatsu University