Clinical trials: Translational Research
Specimens Are to be Collected From Subjects Who Are Having or Have Had a Fluid or Tissue Removed, a Biopsy or a Blood or Bone Marrow Draw
B2RAD Translational Medicine Study
Recent advances in understanding the molecular and cellular pathology of many diseases have resulted in direct benefit to today's patients.
- Trial name
- B2RAD (NCT05292430)
- Testing
- Specimen Collection
- Where
- 2 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sohail Rao
Undiagnosed Diseases, Cardiovascular Disease
Human Biospecimen Procurement Protocol: Biorepository to Support Translational Research to Identify Disease Mechanism(s)
Background: Studies show that rare genetic variants might lead to diseases. Researchers want to collect blood and tissue samples so they can study them and better understand diseases.
- Trial name
- NCT02543996
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Exposure, Health Behavior
Advancing Tools for Human Early Lifecourse Exposome Research and Translation- Adolescence Follow-up of the HELIX Subcohort
ATHLETE will set up a prospective Europe-wide exposome cohort covering the first 2 decades of the life course, which will integrate data on the external, chemical, physical,behavioral, and social domains of the exposome, as well…
- Conditions
- Exposure, Health Behavior, Environment
- Trial name
- ATHLETE (NCT05158010)
- Testing
- HELIX's follow-up
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Healthy Volunteers
Collection and Analysis of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers
The Hematology Branch of the National Heart, Lung, and Blood Institute is doing a variety of laboratory research experiments that require blood and tissue samples from healthy volunteers.
- Trial name
- NCT00442195
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Metabolic Syndrome X
Study of Chronic Degenerative Diseases
The prevalence of obesity and type 2 diabetes mellitus (DM) in children have been increasing in parallel at an alarming rate. In particular, the increasing prevalence of type 2 DM is attributable to genetic factors, clinical…
- Trial name
- NCT02495961
- Where
- Mexico
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Asociación Científica Latina A.C.
Posttraumatic Stress Disorder
Resilient Roots: Supporting Youth and Families
Resilient Roots is integrated into the TRANSFORM Center to promote translation of research findings into clinical interventions, to inform the next generation of research on child abuse and neglect (CAN), and to facilitate…
- Trial name
- NCT06535516
- Testing
- Trauma-Focused Cognitive Behavioral Therapy (TF-CBT), Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) augmented with Socialization (S)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Critical Care, Fluid Resuscitation
The Fluid Translation of Research Into Practice Study
Translating reliable evidence on fluid resuscitation of intensive care patients into clinical practice - Improving patient outcomes and containing public health costs
- Trial name
- Fluid-TRIPS (NCT02002013)
- Where
- Australia
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- The George Institute for Global Health, Australia
School-based Intervention, Sleep
Educational Intervention for Sleep Hygiene Nursing in Adolescents
There is an urgent need to influence the knowledge and beliefs associated with sleep (TV viewing, use of electronic devices, sedentary activity...) of school children through holistic interventions involving students, parents…
- Trial name
- ENISHA-ST (NCT06805708)
- Testing
- Sleep hygiene training programme
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Obesity
Translational Obesity Research
The proposed project takes an innovative approach to childhood obesity prevention, for which there currently no evidence-based programs, and for which results of current trials have produced mainly short-term or disappointing…
- Trial name
- Pathways (NCT00787709)
- Testing
- Pathways
- Where
- United States
- Volunteers
- 1,005 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Insulin Sensitivity, Flow-mediated Dilation
Vitamin D, Insulin Sensitivity, and Vascular Associations in Adolescents
The overall objectives of this study are to examine the relationships between circulating vitamin D, insulin sensitivity, and multiple indices of vascular function and to examine whether vitamin D deficiency in AA is responsible…
- Conditions
- Insulin Sensitivity, Flow-mediated Dilation, Arterial Stiffness
- Trial name
- DIVA (NCT01041365)
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Genetic Disease, Nervous System Diseases
Prospective Cohort Study of Neurogenetic Diseases
Neurogenetic diseases (NGD) represent rare and hereditary forms of neurological diseases. The goal of CNGD is to create a one-window approach for NGDs, to facilitate and accelerate participation in research projects through deep…
- Trial name
- CNGD (NCT06048523)
- Testing
- Patient cohort, Control cohort
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
PANS, Pediatric Acute-Onset Neuropsychiatric Syndrome
Biomarkers for Diagnosis and Treatment Response in Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)
Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is a complex neuropsychiatric disorder characterized by the abrupt onset of symptoms and currently diagnosed mainly on clinical criteria, as reliable diagnostic biomarkers…
- Trial name
- BIOMA-PANS (NCT07718958)
- Testing
- Psycodiagnostic evaluation, Polysomnography, 1H-NMR analysis
- Where
- 5 sites in Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Cancer, Surgery
A Platform Study for solId orgaN CancERs
Generating bespoke biosampling protocols for individual tumour specific translational projects is onerous, cumbersome and inefficient.
- Trial name
- PINCER (NCT05650125)
- Testing
- Biosampling
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Childhood Leukemia
Advanced Translational Research on Childhood Leukemia
Prognosis of children with leukemia, the most common pediatric cancer, has improved markedly. Yet, relapse still occurs in 15-40% of patients with a probability of survival of <50%, which is unlikely to be boosted by…
- Trial name
- NCT04478006
- Testing
- RNA-seq, whole exon sequencing, Cytogenetics test
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Overweight, Memory Disorder
Translation of Obesity and Cognitive Program by Lay Health Educators
Obesity is a major public health problem among older adults, with 31% of non-institutionalized older persons (60 years+) in the US obese and projections indicating that this will rise to 40% by 2010.
- Trial name
- Coaches (NCT01377506)
- Testing
- lifestyle counseling, Cognitive Training
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Use of Research Evidence
Effects of an Evidence Service on Health System Policymakers' Use of Research Evidence
The investigators have developed an online database called 'Health Systems Evidence,' which contains synthesized research evidence and additional details about this evidence that can make it easier for health system policymakers…
- Trial name
- NCT01307228
- Testing
- Health Systems Evidence
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Use of Research Evidence
Effects of an Evidence Service on Community-based AIDS Service Organizations' Use of Research Evidence
The investigators have developed an online database called 'Synthesized HIV/AIDS Research Evidence' (SHARE), which is designed to support the use of research evidence by those working in the HIV/AIDS sector.
- Trial name
- NCT01257724
- Testing
- SHARE (Synthesized HIV/AIDS Research Evidence)
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ontario HIV Treatment Network
Aggression, Conduct Disorder
Real-time fMRI for the Treatment of Aggressive Behavior in Adolescents
The purpose of this study is to determine whether real-time fMRI feedback is effective in the treatment of aggressive behavior problems in adolescents with high callous unemotional traits when compared to treatment as usual.
- Trial name
- NCT02563145
- Testing
- Real-time fMRI feedback, Treatment as usual
- Where
- Germany
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Substance Abuse, Substance Use Disorders
Testing Strategies to Improve Substance Misuse Prevention Research Use in State Policy Contexts
If science is to inform effective substance misuse prevention policy and ultimately improve public health, the field needs an effective strategy for directly supporting policymakers' use of research evidence, yet our field lacks…
- Conditions
- Substance Abuse, Substance Use Disorders, Prevention, Legislation
- Trial name
- NCT06856148
- Testing
- Intervention: RPC Group, Active Comparator: Control Group
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Penn State University