Clinical trials: Validity
Rejection Acute Renal, Rejection Chronic Renal
Extended Validation of Donor-derived Cell-free DNA in Kidney Transplant Recipients
This is a multinational, multi-center, observational cohort study. Kidney allograft rejection is poorly detected by standard-of-care biomarkers.
- Conditions
- Rejection Acute Renal, Rejection Chronic Renal, Transplantation, Kidney Rejection Transplant
- Trial name
- VALiDATE (NCT07805343)
- Testing
- Donor-derived cell-free DNA
- Where
- 25 sites in United States, Belgium and 6 more
- Volunteers
- 5,000 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Low Anterior Resection Syndrome, Radiotherapy
Development and Validation of The Post-RT LARS Prediction Model (PORTLARS)
Bowel dysfunction is common after a restorative rectal cancer resection. Neoadjuvant radiotherapy is an influential factor that impairs bowel function and quality of life.
- Conditions
- Low Anterior Resection Syndrome, Radiotherapy, Rectal Cancer
- Trial name
- PORTLARS (NCT05129215)
- Testing
- Questionnaire
- Where
- China
- Volunteers
- 901 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Nutritional Assessment
Validity of the PortionSize App to Measure Children's Food Intake
The purpose of this study is to assess the validity of the PortionSize™ app to quantify children's own dietary intake and children's intake by parents or caregivers.
- Trial name
- NCT05587816
- Testing
- Validation of the PortionSize app
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Sedation
Assessment of Sedation During Endoscopy
Use of sedation is often required in endoscopic procedures such as ERCP (endoscopic retrograde cholangiopancreatography). However, assessment of the level of sedation during these procedures is not investigated in detail.
- Trial name
- NCT01747733
- Testing
- Bispectral Index
- Where
- Finland
- Volunteers
- 200 people
- Sponsor
- Helsinki University Central Hospital
Human Factors, Acceptability
Human Factors Validation and Acceptability Testing of a Stimulation Device
Our team have developed a mattress topper, consisting of rubber tubes attached side to side that are deflated and inflated, mimicking dynamic touch and optimal CT stimulation (3cm/s).
- Conditions
- Human Factors, Acceptability, Tolerance
- Trial name
- NICU-TAC (NCT06659978)
- Testing
- Device tolerance, Acceptability questionnaire
- Where
- 3 sites in United Kingdom
- Volunteers
- 34 people
- Sponsor
- University of Liverpool
Otic Barotrauma, Pressure Injury
Diagnostic Precision and Accuracy Using the Teed Scoring System Versus the O'Neill Grading System
This validation study investigates the diagnostic precision and accuracy when grading otic barotrauma using two alternative gradings systems including the TEED and the OGS grading systems.
- Conditions
- Otic Barotrauma, Pressure Injury, Ear Injury, Barotitis
- Trial name
- OGS (NCT04726306)
- Testing
- Otic Barotrauma Grading System
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Pathologic Processes
Pivotal Study for Validation of Philips Dx (PDx)
The primary objective of this study is to show safety and effectiveness of the PDx for In Vitro Diagnostic (IVD) use as an aid to the pathologist to view, review and diagnose digital images of surgical pathology slides.
- Trial name
- NCT02529137
- Where
- 4 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Philips Digital & Computational Pathology
Acute Kidney Injury, Mechanical Ventilation
Biomarker and Renal Angina Validation to Assess Heart-Kidney Outcomes After Amino Acid Therapy
The goal of the BRAVE-HEART study is to learn if an amino acid infusion can reduce the risk of developing acute kidney injury after cardiac surgery in children. The main questions it aims to answer are: 1.
- Trial name
- BRAVE-HEART (NCT07212595)
- Testing
- Amino Acid infusion, Lactated ringers solution
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Dana Fuhrman
Cerebral Palsy (CP)
Feasibility of the Trunk and Upper Extremity Assessments for Teleassessment in Children Cerebral Palsy
This study was conducted to investigate the suitability of trunk and upper extremity assessments used within the scope of the ICF for tele-assessment in children with hemiplegic cerebral palsy (CP).
- Trial name
- NCT06707831
- Testing
- Teleassessment
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Hacettepe University
Scapular Muscle Endurance, Adolescent
Validity and Reliability of the Scapular Muscular Endurance Test
The scapula plays a crucial role in proper shoulder function, contributing to synchronized scapular rotation during humeral motion, serving as a stable base for rotator cuff activation, and acting as a key link in the kinetic…
- Trial name
- NCT06846242
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people
- Sponsor
- Istinye University
HIV
Validation of a Community Survey Methodology for Measuring PMTCT Program Impact
Validate a promising community survey methodology for evaluating the Prevention of Mother to Child Transmission (PMTCT) program effectiveness against a "gold standard" cohort design and to identify individual- and facility-level…
- Trial name
- NCT01951794
- Where
- Zambia
- Volunteers
- 827 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
ELECTROENCEPHALOGRAPHIC VARIANT PATTERN 1 (Disorder)
Self Abrading Rapidly Applied Electrode Validation
The SARA (Self Abrading Rapidly Applied) electrode will speed EEG patient hookup by combining multiple steps that burden conventional EEG procedures into one.
- Trial name
- SARA (NCT02200523)
- Testing
- SARA electrode, Gold cup
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cleveland Medical Devices Inc
Dietary Assessment
Dietary Intake of Folic Acid and Vitamin B12 Among Teenage Girls - Validation of Food Frequency Questionnaire
Folate and vitamin B12 deficiencies are associated with various health issues, including anemia, cardiovascular disease, depression, and birth defects.
- Trial name
- NCT06094023
- Testing
- Food Frequency Questionnaire, 24 Hour food recall
- Where
- Ethiopia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Ghent
Child Development, Child Development Disorder
The Indonesian Version of Ages and Stages Questionnaire III Accuracy Compared to Bayley Scales of Infant Development III
This study aimed to evaluate the concurrent validity information of the 24-, 30-, and 36-month Indonesian ASQ-3 with the Bayley Scales of Infant and Toddler Development 3rd Edition (BSID-III) in Indonesian children.
- Conditions
- Child Development, Child Development Disorder, Development Delay, Developmental Delay
- Trial name
- NCT05408351
- Where
- Indonesia
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Malaria Diagnosis
Validation of RealAmp Method for the Diagnosis of Malaria in Endemic Areas of Brazil
Worldwide, approximately 2 billion people live in areas at risk for malaria with morbidity surpassing 250 million cases, with approximately 800,000 deaths, per year.
- Trial name
- NCT02371395
- Testing
- Realtime amplification (RealAmp)
- Where
- Brazil
- Volunteers
- 1,000 people
- Sponsor
- Centers for Disease Control and Prevention
Ophthalmological Disorder
Development and Validation of a Deep Learning System for Multiple Ocular Fundus Diseases Using Retinal Images
Retinal images can reflect both fundus and systemic conditions (diabetes and cardiovascular disease) and firstly to be used for medical artificial intelligence (AI) algorithm training due to its advantages of clinical…
- Trial name
- NCT04213430
- Testing
- diagnostic
- Where
- China
- Volunteers
- 300,000 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Amyotrophic Lateral Sclerosis
Validation of Czech Language Versions of Questionnaires for ALS Patients' Functional Status and Biomarker Long-term Follow-up
Questionnaires and scales used to assess the clinical status and quality of life of patients with amyotrophic lateral sclerosis (ALS) are an important tool to monitor the disease progression and current needs of patients.
- Trial name
- NCT06426030
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Masaryk University
Alarm Fatigue
Design and Validation of a German Language Questionnaire for Measuring Alarm Fatigue in Intensive Care Units
False-positive and non-actionable alarms can lead to staff desensitization ("alarm fatigue") and thus patient endangerment. With this study the investigators create a basic tool to survey alarm fatigue of intensive care staff…
- Trial name
- alarmZen1 (NCT04994600)
- Testing
- Reduces number of question items
- Where
- Germany
- Volunteers
- 700 people
- Sponsor
- Charite University, Berlin, Germany
Arrhythmias, Cardiac
Validation of ECG Waveform and Arrhythmia Diagnosis Concordance for Pediatric Patients Using ECG Monitoring Patch
This study will verify the 1-channel patch-type ECG's arrhythmia diagnostic concordance rate and electrocardiogram measurement performance in pediatric patients by collecting ECG signals from patch-type ECG and Holter device…
- Trial name
- NCT05756309
- Testing
- Electrocardiogram measurements by holter device and patch-type electrocardiographic at the same time
- Where
- South Korea
- Volunteers
- 105 people
- Sponsor
- Mezoo Co., Ltd.
Oncology
Validation of the GMFM-88 Scale and of the FAAP-O Scale in Pediatric Patients Affected by Cancer
The primary objective of this study is to validate the Gross Motor Function Measure Scale-88 (GMFM-88) on the Italian pediatric cancer population.
- Trial name
- FAAP-O (NCT04862130)
- Where
- 10 sites in Italy
- Volunteers
- 217 people
- Sponsor
- Associazione Italiana Ematologia Oncologia Pediatrica
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