Clinical trials: Misoprostol
Uterine Fibroid
The Efficacy and Safety of Preoperative Misoprostol in Blood-loss Reduction During Myomectomy.
Open myomectomy remains the principal treatment for symptomatic fibroids in sub-Saharan countries irrespective of fertility desires.
- Trial name
- MM (NCT03509168)
- Testing
- Misoprostol Pfizer Brand, Non-insertion of Misoprostol Pfizer Brand
- Where
- Uganda
- Volunteers
- 46 people
- Sponsor
- Makerere University
Induced Abortion
Study of Sublingual Versus Oral Misoprostol Administration Following Mifepristone 200 mg for Abortion up to 63 Days Gestation
This open-label, randomized study is being conducted to determine whether a dose of 400 mcg of sublingual misoprostol (i.e., under the tongue) taken 24 hours following administration of mifepristone 200 mg is effective and…
- Trial name
- NCT00286208
- Testing
- Mifepristone, misoprostol
- Where
- 9 sites in Moldova, Tunisia and 1 more
- Volunteers
- 1,443 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Labor, Induced
Sublingual Misoprostol for Induction of Labor
The purpose of this study is to compare effectiveness and safety of a sublingual misoprostol 12,5 mcg with vaginal misoprostol 25 mcg for induction of labour with an alive and term fetus.
- Trial name
- SUBMISO (NCT01406392)
- Testing
- Misoprostol 25mcg, Sublingual Misoprostol
- Where
- Brazil
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Labor Induction
Factors Influencing the Abortion Interval of Second-trimester Termination of Pregnancy Using Misoprostol
This study aims to analyze the factors influencing the abortion interval of second-trimester termination of pregnancy using misoprostol.
- Trial name
- NCT01927822
- Where
- Taiwan
- Volunteers
- 101 people
- Sponsor
- Far Eastern Memorial Hospital
Labour Induction
Oral Misoprostol Versus Vaginal Dinoprostone For Induction Of Labour: A Randomized Controlled Clinical Trial
This study is to compare between oral misoprostol in solution and vaginal dinoprostone in induction of labour in primiparous women with singleton pregnancy as regards efficiency and safety to both mother and fetus.
- Trial name
- NCT02168881
- Testing
- Misoprostol, Dinoprostone
- Where
- Egypt
- Volunteers
- 342 people
- Sponsor
- Ain Shams University
Postpartum Hemorrhage
Buccal Misoprostol During Cesarean Section for Preventing Postpartum Hemorrhage
Objective: to demonstrate that buccal misoprostol administration during cesarean delivery in women with risk factors for uterine atony decreases the need for additional uterotonic medications, uterine atony and postpartum…
- Trial name
- NCT01733329
- Testing
- Misoprostol, Folic Acid
- Where
- Mexico
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Abortion Early, Pregnancy Related
Mail Order Mifepristone Study
This study aims to evaluate the feasibility, acceptability, and effectiveness of dispensing mifepristone via a mail-order pharmacy.
- Trial name
- NCT03913104
- Testing
- Mifepristone
- Where
- 11 sites in United States
- Volunteers
- 536 people, healthy volunteers welcome
- Sponsor
- Daniel Grossman, MD
Cesarean Section Complications
Carbetocin Versus Misoprostol. A Retrospective Comparative Study
Cesarean section is one of the most common surgeries practiced for save delivery of the fetus, however it is not a safe route of delivery its incidence is rising especially in high and middle income countries.
- Trial name
- NCT04313218
- Testing
- Carbetocin
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Port Said University hospital
Post Partum Hemorrhage
Intrauterine Misoprostol Versus Intravenous Oxytocin Infusion During Cesarean Delivery
Bleeding is still the major cause of mortality and morbidity in postpartum period. World health organization has reported 585000 deaths for pregnancy each year. Twenty five percent of cases die from post-partum bleeding.
- Trial name
- NCT03148574
- Testing
- Misoprostol, Oxytocin
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- Assiut University
Postpartum Hemorrhage
Misoprostol as First Aid Measure to Address Excessive Postpartum Bleeding
The overall study purpose is to evaluate the safety, feasibility and acceptability of advance distribution of misoprostol to be used as 'first aid treatment' administered by the woman herself or her family to help treat excessive…
- Trial name
- NCT02853552
- Testing
- Misoprostol
- Volunteers
- 4,330 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Abortion, Therapeutic
A Randomized Study of Cervical Priming With Misoprostol Prior to Elective First Trimester Pregnancy Termination
The purpose of this study is to determine whether misoprostol administered prior to elective first trimester pregnancy has an effect on pain and ease of procedure and complications.
- Trial name
- NCT00310921
- Testing
- Misoprostol
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
To Evaluate the Impact of the Vaginal Ph and Acidification of Vaginal Misoprostol on Its Efficacy in Facilitating Induction of Mid-trimester Abortion.
Study of Effect of Vaginal ph and Acidification of Vaginal Misoprostol on Its Efficacy for Induction of Midtrimester Abortion
To evaluate the impact of the vaginal Ph and acidification of vaginal misoprostol on its efficacy in facilitating induction of midtrimester abortion.
- Trial name
- NCT01241045
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Incomplete Abortion
Sublingual Misoprostol for the Treatment of Incomplete Abortion: Operations Research
This study will investigate the use of misoprostol for first-line treatment of incomplete abortion at tertiary hospitals in Myanmar.
- Trial name
- NCT02707653
- Testing
- Misoprostol
- Where
- 2 sites in Burma
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Pregnancy, Labor, Induced
Labor Induction With Oral Versus Vaginal Misoprostol
This study will compare vaginal and oral misoprostol, to determine whether a vaginal misoprostol regimen achieves a higher vaginal delivery rate in a real-world, high-volume setting, and whether this regimen reduces time and…
- Trial name
- NCT04755218
- Where
- United States
- Volunteers
- 2,546 people
- Sponsor
- University of Texas Southwestern Medical Center
Family Planning
Misoprostol Prior to IUD Insertion in Nullipara
The use of misoprostol at a dose of 400 µg administered vaginally four hours prior to IUD insertion increased the ease of insertion and reduced the incidence of pain during the procedure, although the frequency of cramps…
- Trial name
- NCT03490617
- Testing
- Vaginal misoprostol
- Where
- Brazil
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Induction of Labor
Comparison of Two Protocols of Misoprostol (PGE1) and the Rate of Cesarean Section Due to Failed Induction.
To compare two protocols of misoprostol use for cervical ripening: 3 doses (25 ug vaginal each) or up to six doses, every six hours, until an adequate cervical condititon was achieved (BIshop score > 6).
- Trial name
- NCT03489798
- Testing
- 6 misoprostol, 3 misoprostol
- Where
- Panama
- Volunteers
- 310 people
- Sponsor
- Saint Thomas Hospital, Panama
Pain
Misoprostol Prior to Intrauterine Device (IUD) Insertion in Nulliparous Women
The purpose of this study is to see if using misoprostol makes the intrauterine device insertion easier and less painful in women who have never had a baby.
- Trial name
- NCT01307111
- Testing
- Misoprostol
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Postpartum Hemorrhage (PPH)
Misoprostol for Treatment of Postpartum Haemorrhage (PPH) in Home Births
Misoprostol, a prostaglandin E1 that induces uterine contractions, has been proposed as a low cost, easy-to-use option for prevention and treatment of Postpartum Haemorrhage (PPH), especially in settings where injectable…
- Trial name
- NCT01508429
- Testing
- Misoprostol
- Where
- Afghanistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Complete Abortion
Mifepristone and Misoprostol for the Termination of Pregnancy up to 70 Days' Gestation in Kazakhstan
The study will be conducted in 4 sites and will examine how a simplified outpatient medical abortion procedure using mifepristone and misoprostol, with the option to take mifepristone at a place of woman's choosing, works in…
- Trial name
- NCT02018796
- Testing
- Mifepristone, misoprostol
- Where
- 4 sites in Kazakhstan
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Post Partum Hemorrhage
Sublingual Misoprostol in Reduction of Caesarean Blood Loss
Caesarean delivery is inevitably associated with a higher amount of blood loss vis-à-vis primary postpartum haemorrhage, when compared to vaginal delivery.
- Trial name
- SUMIROCBLOL (NCT05532215)
- Testing
- Misoprostol, Oxytocin
- Where
- Nigeria
- Volunteers
- 152 people
- Sponsor
- OZORI EBIOGBO STANLEY