Clinical trials: sponsored by Rennes University Hospital
Splenomegaly, Splenectomy
Study of the Prevalence of Acid Sphingomyelinase Deficiency/Niemann Pick AB and B Disease in Patients With Diffuse Interstitial Lung Disease
The goal of this clinical trial is to optimise and facilitate screening for Acid SphingoMyelinase Deficiency (ASMD) disease, by evaluating acid sphingomyelinase activity and, where appropriate, LysoSM levels in a cohort of 200…
- Conditions
- Splenomegaly, Splenectomy, Thrombopenia, Interstitial Lung Disease (ILD)
- Trial name
- Niemann-PID (NCT06869499)
- Testing
- Blood sampling for dosage
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Wladimir MAUHIN, Dr
Diabetic Foot Ulcer
Pathogenicity Factors of Staphylococcus Pettenkoferi in Foot Wounds and Osteitis in Diabetic Patients
Gram-positive cocci, particularly Staphylococcus aureus and coagulase-negative staphylococci (SCoN), are the bacteria most frequently isolated from diabetic foot ulcers. Although studies have been carried out on the role of S.
- Trial name
- PETTENK-OS (NCT06688084)
- Testing
- Molecular epidemiology of the collection, Study of the resistome of the S. pettenkoferi population, Study of the virulome of the S. pettenkoferi population
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Cerebral Palsy, Hemiparesis; Poststroke/CVA
Characterization of Muscle Activity During a Surface EMG-controlled Rehabilitation Game
The aim of this pilot study is to evaluate muscular activity during a single session of surface electromyography controlled exergame (muscle activation, number of contraction…) in cerebral palsy kids, hemiparetic adults and…
- Conditions
- Cerebral Palsy, Hemiparesis; Poststroke/CVA, Healthy (Controls)
- Trial name
- CONTRACTIV-1S (NCT07838688)
- Testing
- Surface electromyography (sEMG)-controlled rehabilitation game
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Amputation of Lower Extremity, All Causes
Gait and Energy Expenditure in Children With Lower Limb Amputation (MAPEDE)
In lower limb amputation, prosthetic gait has been shown to be particularly energy-intensive. While energy expenditure has been the focus of many studies in adult amputees, this area of research is less developed for paediatric…
- Trial name
- MAPEDE (NCT07076602)
- Testing
- Gait and energy expenditure
- Where
- 8 sites in France
- Volunteers
- 48 people
- Sponsor
- Rennes University Hospital
Concussion, Brain, Sports-related Concussion
Ecological Test Standardization for Concussion Assessment in Football Players
Concussion is a major concern in the sports world. It represents an immediate and transient alteration of neurological functions due to a direct or indirect trauma, with or without loss of consciousness.
- Conditions
- Concussion, Brain, Sports-related Concussion, Football Players, Traumatic Brain Injury, Mild
- Trial name
- COMOFOOT (NCT07431320)
- Testing
- Ecological Dual-Task Cognitive Assessment, Visuospatial Working Memory Ecological Test
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de Kerpape
Sudden Cardiac Arrest, Sudden Cardiac Death
Sudden Cardiac Arrest Related to Sport in Young and Value of the Genetic Assessment: a French Prospective Register
The increased risk of sudden cardiac arrest (SCA) or sudden cardiac death (SCD) related to vigorous physical activity is well-documented.
- Trial name
- RESOUDRE (NCT06642168)
- Testing
- Whole exome sequencing to detect myocardial genetic mutations (SCA group only)
- Where
- 26 sites in France
- Volunteers
- 80 people
- Sponsor
- Rennes University Hospital
Interprofessional Education
Impact of IPE in Multidisciplinary Primary Care Centres on Collaborative Competency of Healthcare Students (FLIRT-MSP)
The aim of our study is to evaluate the impact of interprofessional education program (IPEP) for healthcare students in clinical placement in MPCC on interprofessional collaboration (IPC), comparing the acquisition of…
- Trial name
- FLIRT-MSP (NCT06789939)
- Testing
- Train the trainer program for MPCC professionals
- Where
- 26 sites in France
- Volunteers
- 96 people
- Sponsor
- Rennes University Hospital
Self-management
Self-management Education in Multi-professional Health Centres
The goal of this observational study is to learn about the best educative and organizational dimensions favouring the development of self-management education in multiprofessional health centres.
- Trial name
- ETHOPEE (NCT05950451)
- Testing
- No intervention
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Rennes University Hospital
Infant, Premature
Preliminary Study to the Conception of a Non-invasive Neonatal Monitoring System With Development of a Database
Each year, 300 000 new borns are hospitalised in neonatology units in Europe. This period is very sensitive as newborns are exposed to a high risk of morbidity and mortality, with severe impact on neuro-developmental prognostic.
- Trial name
- Digi-NewB (NCT02863978)
- Testing
- Multimodal signal acquisitions
- Where
- 6 sites in France
- Volunteers
- 746 people
- Sponsor
- Rennes University Hospital
Infertility, Intellectual Disability
Prospective Study to Assess Medical Performance of Optical Mapping and Long Read Sequencing in Detecting Numerical and Structural Chromosome Abnormalities
Chromosomal aberrations are major causes of developmental disorders (Intellectual disability (ID), multiple congenital anomalies (MCA), autism spectrum disorders (ASD)) as well as reproductive disorders (RD) in particular…
- Conditions
- Infertility, Intellectual Disability, Malformation, Miscarriage
- Trial name
- CHROMAPS (NCT05290051)
- Testing
- Optical Genome Mapping (Bionano®), Longread sequencing (Nanopore®)
- Where
- France
- Volunteers
- 350 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Orthodontic Appliance
Comparison of the Effectiveness of Three Teaching Methods in Oral Hygiene in Adolescent Orthodontic Patients
Orthodontic appliances have been shown to interfere with oral hygiene maneuvers by providing many additional sites for formation and retention of biofilm.
- Trial name
- MAHO (NCT04444154)
- Testing
- Control group, Group with active participation, Group with video and quizz
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Rennes University Hospital
Malnutrition, Child
The "Self Evaluation of Food Intake" (SEFI) as a Screening Test for Hospital Malnutrition in Children Over 10 Years
The goal is to find a simple tool that can be used by medical and paramedical staff and that is reliable to identify children at risk for malnutrition.
- Trial name
- SEFI (NCT04536974)
- Testing
- SEFI tool
- Where
- 6 sites in France
- Volunteers
- 368 people
- Sponsor
- Rennes University Hospital
ARDS Related to Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 2, Acute Refractory Heart Failure Related to SARS-CoV 2
Extracorporeal Membrane Oxygenation (ECMO) and Coronavirus Disease (COVID) 19
The role of ECMO in the treatment of patients with severe COVID-19 (Acute Respiratory Distress Syndrome (ARDS) and/or acute refractory heart failure) is not yet known.
- Trial name
- ECMO-SARS (NCT04397588)
- Where
- 44 sites in France
- Volunteers
- 761 people
- Sponsor
- Rennes University Hospital
Intensive Care Unit Syndrome
PREMAPIV : Intravesical Pressure Variation at Different Bladder Instillation Volumes in Newborn Children
Abdominal Compartment Syndrome (ASC) is defined by an Intra Abdominal Hypertension (IAH) associated with a new organ failure. The occurrence of this syndrome is not well known in infants.
- Trial name
- NCT01296724
- Testing
- Measure of intravesical pressure
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Rennes University Hospital
Premature
Gut Bacteria and Brain of the Baby
The project is a prospective French population based cohort. A hundred moderate preterms born at GA30-326/7 will be enrolled for a longitudinal follow-up up to 2 years of corrected age.
- Trial name
- BaBBa (NCT04432636)
- Testing
- Data collection of environmental factors, Collection of maternal feces, Collection of infant feces
- Where
- France
- Volunteers
- 94 people
- Sponsor
- Rennes University Hospital
Emergencies
Population Pharmacokinetics of Metronidazole in Neonates
The objective of NEOPOPI is to conduct a population pharmacokinetic study of metronidazole in neonates, in order to evaluate and optimize neonatal dose regimen.
- Trial name
- METROPOP (NCT04031183)
- Where
- 7 sites in France
- Volunteers
- 171 people
- Sponsor
- Rennes University Hospital
Hepatoblastoma, Carcinoma, Hepatocellular
Paediatric Hepatic International Tumour Trial
The PHITT trial is an over-arching study for patients with Hepatoblastoma (HB) and Hepatocellular Carcinoma (HCC). This trial will use a risk-adapted approach to the treatment of children diagnosed with HB.
- Trial name
- PHITT (NCT03017326)
- Testing
- Cisplatin, Doxorubicin, Carboplatin
- Where
- 32 sites in Austria, Belgium and 12 more
- Volunteers
- 450 people
- Sponsor
- University of Birmingham
Acute Lymphoid Leukemia Relapse, Acute Lymphoid Leukemia Relapse After Bone Marrow Transplant
Safety of Clofarabine With Multiagent Chemotherapy in Childhood Acute Lymphoblastic Leukemia
The purpose of this study is to determine Maximum Tolerated Dosage (MTD), Dosage Limited Toxicities (DLT), and the Rate Phase 2 Dosage of clofarabine when used in combination with etoposide, asparaginase, mitoxantrone and…
- Trial name
- Vandevol (NCT01279096)
- Testing
- Clofarabine
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Lille
Cerebral Palsy
Association of a HABIT-ILE Course and a Home Programme on the Bimanual Performance of Children With Cerebral Palsy
This non-inferiority, mixed-methods, multicentre randomised controlled trial will compare the effects of functional changes and families' resources at 3 months of the PARTNER programme (35h HABIT-ILE + 15h home programme) with…
- Trial name
- PARTNERSHIP (NCT06963151)
- Testing
- Behavioral: Hand-Arm Bimanual Intensive Therapy Including Lower Extremities
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Fondation Ildys
Apnea of Prematurity
Apnea Treatment in Premature Infants Using an Automatic Vibro-tactile Stimulator Triggered by the Detection of Apnea-bradycardia.
The goal of the SENSITACT system is to activate an adaptive kinesthetic stimulation to treat apnea-bradycardia events on preterm infants, while minimizing deleterious effects, in particular arousals that can be due either to…
- Trial name
- SENSITACT (NCT03651648)
- Testing
- SENSITACT System
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Rennes University Hospital