Clinical trials: ACL Injuries
Anterior Cruciate Ligament Injuries, Quadriceps Muscle Atrophy
Vitamin D to Improve Quadricep Muscle Strength
Quadriceps muscle strength is one of the key determinants for patients to fulfill the Return-to-Play (RTP) criteria after an anterior cruciate ligament reconstruction (ACLR), in which the muscle size is directly linked to muscle…
- Conditions
- Anterior Cruciate Ligament Injuries, Quadriceps Muscle Atrophy, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
- Trial name
- NCT05174611
- Testing
- Vitamin D3
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Exploring Prolonged AMR in ACL Reconstructed Patients
The goal of this observational study is to explore the significance of subject-reported outcomes and clinical parameters in relation to the occurence of prolonged presence of arthrogenic muscle responses (AMR) in anterior…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear, ACL
- Trial name
- NCT06430775
- Where
- Belgium
- Volunteers
- 190 people
- Sponsor
- University Ghent
ACL - Anterior Cruciate Ligament Rupture
Intraoperative Analysis of Knee Kinematics During ACL Reconstruction - an Exploratory Study
Reconstruction of anterior cruciate ligament (ACL) is a common procedure in orthopaedic surgery, aimed at restoring stability to your knee.
- Trial name
- CINEGEN (NCT07655726)
- Testing
- Knee Cinematics
- Where
- France
- Volunteers
- 30 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Anterior Cruciate Ligament Injuries, Exercise
Preventing Posttraumatic Osteoarthritis With Physical Activity Promotion
Osteoarthritis (OA) is a leading cause of disability worldwide that affects millions of Americans each year. Posttraumatic OA (PTOA) significantly impacts patients after anterior cruciate ligament (ACL) injury and ACL…
- Conditions
- Anterior Cruciate Ligament Injuries, Exercise, Cartilage, Articular, Knee Injuries
- Trial name
- NCT04906499
- Testing
- Physical Activity Promotion
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of North Carolina, Chapel Hill
Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Tear
Bridge-Enhanced ACL Repair-Safety Study (BEAR Trial)
This study will assess the safety and early efficacy of a newly developed device, bridge-enhanced scaffold (MIACH™,) used to repair a torn anterior cruciate ligament (ACL.) Ten participants will undergo surgery with the new…
- Trial name
- BEAR (NCT02292004)
- Testing
- ACL Repair with MIACH Scaffold, Standard ACL Reconstruction
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Miach Orthopaedics
Anterior Cruciate Ligament Rupture, Surgery
ALL Ultrasound Predicts the Success of ACL Repair?
This case series evaluates whether patients with an anterior cruciate ligament (ACL) repair have better outcome if the anterolateral ligament (ALL) was repaired or not considering the ultrasound (US) pre-surgical recommendation.
- Trial name
- ALL_US (NCT04373408)
- Testing
- ACL repair without anterolateral repair, ACL repair with anterolateral repair
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Adrien Schwitzguebel
Patellar Dislocation, ACL Injury
The Faroese Knee Cohort: Etiology and Long-term Implications of Trochlear Dysplasia and Patellar Dislocations.
The investigators intend to establish a national cohort including all persons in the ages from 15-20 years old with patellar instability (PI) or a prior knee injury (ACL-ruptur or meniscus damage) .
- Conditions
- Patellar Dislocation, ACL Injury, Meniscus Lesion, Trochlear Dysplasia
- Trial name
- FKC (NCT04607538)
- Testing
- No intervention is made
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Anterior Cruciate Ligament Rupture
Evaluation After Reconstruction of the Anterior Cruciate Ligament of the Knee Using the Bioresorbable Interference Screw (SMS): Resorbability, Per- and Post-operative Complications and Articular Functional Recovery.
The investigators will evaluate the benefit of a new bioresorbable screw for repair of anterior cruciate ligament over 3 years.
- Trial name
- BIORELICA (NCT03529552)
- Testing
- Anterior Cruciate Ligament Reconstruction
- Where
- 3 sites in France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
ACL, Anterior Cruciate Ligament Injury
Decreasing Knee Injury Risk Factors With Neuromuscular Training
Anterior cruciate ligament (ACL) tears are disabling injuries that place a significant burden on the athlete. Roughly 80% of these injuries are linked to a noncontact mechanism, with more than 70% of them occurring while landing…
- Trial name
- NCT01433718
- Testing
- Neuromuscular and Resistance Training
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ohio University
Anterior Cruciate Ligament Rupture, Knee Instability
Single and Double Bundle ACL Reconstructions, in Term of Cartilage Damage Due to Remaining Instability After Surgery.
The prevalence of ACL (Anterior Cruciate Ligament) ruptures is relatively high, primarily due to sports and military training injuries.
- Conditions
- Anterior Cruciate Ligament Rupture, Knee Instability, Cartilage Damage
- Trial name
- ACL (NCT04626999)
- Testing
- Single Bundle ACL Reconstruction, Double Bundle ACL Reconstruction
- Where
- Indonesia
- Volunteers
- 52 people
- Sponsor
- Universitas Indonesia
Anterior Cruciate Ligament Rupture, Ligament Knee Injury
Combined Intra- and Extra-articular ACL Reconstruction Versus Isolated Intra-articular ACL Reconstruction
Abstract Introduction: Autologous hamstring tendons are the most commonly used grafts in ACL reconstruction worldwide. There are several ways to prepare the graft using these tendons.
- Trial name
- NCT06505525
- Testing
- Extra-articular reconstruction with the Anterolateral Ligament
- Where
- 2 sites in Brazil
- Volunteers
- 146 people
- Sponsor
- Federal University of São Paulo
Anterior Cruciate Ligament Tear
Bone Marrow Aspirate Concentrate for Anterior Cruciate Ligament Tear Treatment.
A single armed multicenter study enrolling 20 patients using autologous bone marrow aspirate concentrate (which is done under local or general anesthesia to aspirate around 1-2 cc/kg body weight then concentration which is done…
- Trial name
- NCT06353503
- Testing
- autologous bone marrow aspirate concentrate
- Where
- Iraq
- Volunteers
- 20 people
- Sponsor
- abdulmajeed hammadi
Anterior Cruciate Ligament Injury, Knee Injuries
Sensory Deficit Following ACL Reconstruction: PRF Pilot Study
Pilot, single-center, non-randomized, parallel-group clinical study designed to assess whether intraoperative application of autologous platelet-rich fibrin (PRF) at the bone-patellar tendon-bone (BPTB) donor site reduces…
- Conditions
- Anterior Cruciate Ligament Injury, Knee Injuries, Sensory Disorders, Bone-Patellar Tendon-Bone Autograft
- Trial name
- PRF-ACL (NCT07257666)
- Testing
- Platelet-rich fibrin (PRF), Standard Closure (Control)
- Where
- Serbia
- Volunteers
- 53 people
- Sponsor
- University of Belgrade
Knee Injuries, Rehabilitation
Biomechanical Determinants of Different Rehabilitation Protocols for ACL Reconstruction
Purpose of the study is to investigate the effects of the criterion rehabilitation protocol versus accelerated rehabilitation protocol on the biomechanical determinants of the quality of performance and risk of reinjury.
- Trial name
- NCT05733936
- Testing
- rehabilitation protocol
- Where
- Egypt
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Delta University for Science and Technology
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Tendon-Bone Versus All-Soft-Tissue for ACL Reconstruction: A Patient-Blinded Randomized Clinical Trial
In primary pediatric Anterior cruciate ligament (ACL) reconstruction, the quadriceps tendon with either tendon and patellar bone or an all-tendon graft is commonly employed.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
- Trial name
- NCT04039971
- Testing
- ACL Reconstruction
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Denver
Anterior Cruciate Ligament Injuries
Rate of Non-copers to Non-surgical ACL Treatment After 3 Months of Rehabilitation
The aim is to determine the sensitivity and specificity of a screening tool to identify patients who undergo ACL reconstruction (non-copers) after 3 months of standard rehabilitation following an anterior Cruciate ligament (ACL)…
- Trial name
- NCT04847258
- Testing
- Standard rehabilitation
- Where
- Denmark
- Volunteers
- 357 people
- Sponsor
- Vejle Hospital
ACL, ACL - Anterior Cruciate Ligament Rupture
Conservative Treatment With Blood Flow Restriction in Patients With Total ACL Rupture. "Randomized Clinical Trial"
The goal of this randomised clinical trial is to evaluate the effects of exercise with blood flow restriction (BFR) in patients with a complete anterior cruciate ligament (ACL) rupture.
- Trial name
- NCT06727344
- Testing
- Blood Flow Restriction, Brace
- Where
- 2 sites in Cyprus
- Volunteers
- 20 people
- Sponsor
- European University Cyprus
Anterior Cruciate Ligament Injury
Differential Biomechanical Effects of an ACL Injury Prevention Program in Women's Basketball and Soccer Players
Anterior cruciate ligament injury programs are less successful in women's basketball than soccer players, yet the reason for this discrepancy is unknown.
- Trial name
- NCT02530333
- Testing
- Neuromuscular Prevention Program
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- High Point University
Anterior Cruciate Ligament Injury, ACL
Mechanical Perturbation Training for ACL Injury Prevention
A prospective trial will be used to evaluate the efficacy of prophylactic mechanical perturbation training program. 24 female athletes who are regular participants in activities that involve cutting, pivoting, jumping, and…
- Trial name
- NCT03080402
- Testing
- Mechanical Perturbation Training
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Sports Injury, Orthopedic Disorder
Training of Falling Techniques on Landing Mechanics
The overall purpose of this study is to quantify the effect and retention of one-week training of falling techniques on landing biomechanics associated with anterior cruciate ligament (ACL) loading compared to soft-landing…
- Conditions
- Sports Injury, Orthopedic Disorder, Knee Injuries, Anterior Cruciate Ligament Injuries
- Trial name
- NCT04768088
- Testing
- Falling Training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Wyoming