Clinical trials: AI Chatbot
AI Companionship
How Do Artificially Intelligent Companions Influence Psychological Outcomes?
This randomized longitudinal study examines how interacting with an artificially intelligent (AI) companion affects psychological well-being, social experiences, and interpersonal attitudes and behaviors over time.
- Trial name
- NCT07858279
- Testing
- AI Companion Interaction
- Where
- United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Vaccine Hesitancy, COVID-19
The Impact of a Web-based Psychoeducation Programme with a Motivational AI Chatbot on Covid-19 Vaccine Hesitancy
Vaccine hesitancy is defined as 'delay in acceptance or refusal of vaccines, despite the availability of vaccine service' and was named one of the top ten global health threats by the World Health Organization in 2019.
- Trial name
- NCT05531058
- Testing
- AI-driven Vaccine Communicator, Self-learning of COVID-19 vaccine knowledge
- Where
- Hong Kong
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Healthy
AI Chatbot for HPV Vaccine Literacy Among Caregivers in Japan
The goal of this study is to learn if an innovative digital artificial intelligence (AI)-based communication tool works to enhance health literacy among Japanese caregivers regarding Human Papillomavirus (HPV) vaccination.
- Trial name
- NCT06702423
- Testing
- AI-based chatbot, Leaflet
- Where
- United Kingdom
- Volunteers
- 804 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Oral Cancer, Chatbot
Enhancing Oral Cancer Awareness
To evaluate the impact of AI-powered chatbot interactions versus traditional educational handouts on increasing participants' knowledge of oral cancer and its prevention
- Conditions
- Oral Cancer, Chatbot, Patient Education, Prevention
- Trial name
- NCT06682494
- Testing
- Traditional Education, AI-powered Chatbox
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Autism Spectrum Disorder, Attention Deficit Disorder With Hyperactivity (ADHD)
Pai.ACT: AI-Driven ACT Chatbot for Mental Health Triage and Service Evaluation
Parents of children with special needs in Hong Kong often face limited psychological support, which can negatively impact the child rehabilitation process and the well-being of parent-child relationships.
- Conditions
- Autism Spectrum Disorder, Attention Deficit Disorder With Hyperactivity (ADHD), Neurodevelopmental Disorder (Diagnosis), Dyslexia
- Trial name
- NCT06808555
- Testing
- Pai.ACT Group, Control Group
- Where
- 20 sites in Hong Kong
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
HPV Vaccination Intent
Conversations With AI Chatbots Increase Short-Term Vaccine Intentions But Do Not Outperform Standard Public Health Messaging
The goal of this clinical trial is to test whether short conversations with large language model (LLM) chatbots can persuade vaccine-hesitant parents to vaccinate their children against human papillomavirus (HPV).
- Trial name
- NCT07132125
- Testing
- Default-style LLM chatbot, Conversational-style LLM chatbot, Public health informational materials
- Where
- United States
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Healthy
Chatbot Intervention Effects on Belief Updating in Anhedonia
The main aim of the present study is to investigate the effects of a Motivational Interviewing-based artificial intelligence chatbot on belief updating in college students with elevated levels of depression and anhedonia by…
- Trial name
- NCT07663019
- Testing
- MI Chatbot Interaction, Active Control Chatbot Interaction
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Artificial Intelligence (AI), Clinical Reasoning
AMIE's Clinical Conversational Abilities in an Urgent Care Setting
The purpose of this study is to determine the feasibility of a conversational artificial intelligence (AI) system to have a meaningful clinical conversation with a patient prior to an urgent care visit with their primary care…
- Trial name
- NCT06911398
- Testing
- Articulate Medical Intelligence Explorer (AMIE)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Influenza Vaccines
Vaccine Chatbot for Improving Influenza Vaccination Uptake
This study aims to assess the impact of a vaccine chatbot on improving influenza vaccination uptake among children aged between 6 and 59 months through a cluster randomized trial.
- Trial name
- NCT06657573
- Testing
- An AI-enabled chatbot tailored for influenza vaccine consultation
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Fudan University
Healthy
Chatbot Intervention Effects on Social and Monetary Incentive Processing in Anhedonia
The main aim of the present study is to investigate the effects of a Motivational Interviewing-based artificial intelligence chatbot on social incentive processing in college students with elevated levels of depression and…
- Trial name
- NCT07665242
- Testing
- MI Chatbot Interaction, Active Control Chatbot Interaction
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Peri-Implant Mucositis, Peri-implantitis
Impact of an AI-Based Chatbot on Implant Patient Management: RCT
Background: Dental implant therapy is a well-established and predictable procedure for replacing missing teeth, with high long-term survival rates.
- Conditions
- Peri-Implant Mucositis, Peri-implantitis, Peri-Implant Health, Peri-implant Inflammation
- Trial name
- NCT07300657
- Testing
- AI Chatbot, Standard Oral Hygiene Education
- Where
- Italy
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Catania
Normal Labor
Generative AI-Powered Intrapartum Clinical Decision Support Among Healthcare Providers
Pregnancy and childbirth are uniquely important events in women's lives because they are accompanied by major physical, emotional, and psychological changes.
- Trial name
- NCT07720531
- Testing
- Generative AI-Powered Intrapartum Chatbot
- Where
- Egypt
- Volunteers
- 427 people, healthy volunteers welcome
- Sponsor
- Delta University for Science and Technology
Control Condition, Intervention
Effectiveness of AI Chatbots in Improving Students' General Wellbeing
The goal of this randomised controlled trial is to evaluate the effectiveness of an AI mental health chatbot in promoting emotional wellbeing and perceived empathy among university students in Singapore with mild or subclinical…
- Trial name
- NCT06965439
- Testing
- AI-delivered emotional wellbeing support, Neutral writing tasks
- Where
- Singapore
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Healthy Lifestyle
A Pilot Randomized Controlled Trial of Chatbot Use in Older Adults for Lifestyle Change
The purpose of this study is to evaluate the acceptability and preliminary effectiveness of a smartphone-delivered AI-based chatbot in promoting healthy dietary behavior and physical activity participation among older adults.
- Trial name
- NCT06901037
- Testing
- A chatbot-based intervention
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Osteoporosis, Sarcopenia
Osteoporosis and Sarcopenia Prevention in Middle-Aged Population
This initiative is designed to yield substantial and multi-level benefits for the Hong Kong community by pioneering a transformative model of preventive healthcare.
- Trial name
- FORTIFY (NCT07611097)
- Testing
- Intervention Group, Control Group
- Where
- Hong Kong
- Volunteers
- 8,336 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Reflects the Intervention (AI Chatbot)
The goal of this clinical trial is to investigate the impact of an AI-powered chatbot intervention on improving knowledge, attitudes, and empowerment in breast cancer patients.
- Trial name
- BC-CHAT (NCT06943911)
- Testing
- AI Chatbot for Breast Cancer Patient Education and Empowerment
- Where
- Egypt
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Mostafa Shaban
Healthy
Building Cognitive Resilience to Vaccine Misinformation Using AI: Evidence From a Randomised Trial
This study aims to understand how parents and caregivers in the United Kingdom engage with information about childhood vaccination (routine vaccines for children and adolescents, excluding tetanus or international travel-related…
- Trial name
- NCT07488962
- Testing
- AI-driven chatbot, Social media infographic
- Where
- United Kingdom
- Volunteers
- 1,008 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Healthy
Building Cognitive Resilience to Vaccine Misinformation Using AI in Europe
This multi-country trial evaluates an AI chatbot designed to counter cognitive biases and inoculate parents against vaccine misinformation, embedded within a large survey across five European countries (n=5,000).
- Trial name
- NCT07551986
- Testing
- AI-driven chatbot, Social media infographic
- Where
- United Kingdom
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Hyperglycaemia, Hypertension
Developing an AI Pharmacy Chatbot for the Population of Hong Kong
The primary objective of this study is to is to develop a conversational AI service (chatbot) in Hong Kong to assist patients and caregivers with inquires related to Hospital Authority (HA)-prescribed medications, and to evaluate…
- Conditions
- Hyperglycaemia, Hypertension, Hyperlipidaemia, Artificial Intelligence (AI)
- Trial name
- NCT07037563
- Testing
- An AI pharmacy chatbot offering information related to HA-prescribed medication for hyperglycaemia, hypertension, and hyperlipidaemia
- Where
- 2 sites in Hong Kong
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Pregnancy, Prenatal Care
Comparing AI and Standard Pregnancy Chatbots
Many pregnant women in India use mobile phones to get health information. Nivi runs a free WhatsApp service called askNivi that answers questions about pregnancy and sends reminders about prenatal care visits.
- Conditions
- Pregnancy, Prenatal Care, Maternal Health
- Trial name
- NCT07883993
- Testing
- Scripted maternal health chatbot, MATRI retrieval-augmented maternal health chatbot
- Where
- India
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Nivi, Inc.