Clinical trials: ARDS, Human, open to volunteers
Acute Respiratory Distress Syndrome (ARDS)
Clinical Trial With Aprotinin in the Acute Respiratory Distress Syndrome Treatment
This is a multicentre, double-blind, placebo-controlled Phase III randomized clinical trial designed to evaluate the efficacy and safety of inhaled aprotinin in adult patients with moderate or severe acute respiratory distress…
- Trial name
- NCT07317050
- Testing
- Aprotinin (inhaled)
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Fundacion del Hospital Nacional de Paraplejicos para la Investigacion y la Integracion
Fibrinogen, Albumin
Fibrinogen-to-Albumin Ratio as a Predictor of Acute Respiratory Distress Syndrome in Traumatic Brain Injury
this study aims to assess the ability of fibrinogen-to-albumin ratio to predict the development of Acute respiratory distress syndrome in traumatic brain injury patients.
- Conditions
- Fibrinogen, Albumin, ARDS, TBI (Traumatic Brain Injury)
- Trial name
- FARDS (NCT07664358)
- Testing
- Fibrinogen-to-albumin ratio
- Where
- Egypt
- Volunteers
- 350 people
- Sponsor
- Tanta University
Acute Respiratory Distress Syndrome
A Clinical Trial of Human Umbilical Cord Mesenchymal Stem Cell Injection for the Treatment of Severe Acute Respiratory Distress Syndrome
Primary Objective: To evaluate the safety and tolerability of human umbilical cord mesenchymal stem cell injection in the treatment of moderate/severe acute respiratory distress syndrome.Secondary Objectives: To explore the…
- Trial name
- ARDS (NCT07413978)
- Testing
- 1 vial containing a total of 5×10^7 cells, 2 vial containing a total of 1×10^8 cells, 3 vial containing a total of 1.5×10^8 cells
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Changchun Tuohua Pharmaceutical Co., Ltd.
Acute Hypoxemic Respiratory Failure, Mechanical Ventilation
Safety and Efficacy of Low-Flow ECMO in a Multi-modal Cohort of Adults in Respiratory Failure
The current standard of care (SOC) for treatment of patients with acute respiratory distress syndrome (ARDS), inhalation injury, volume overload, and/or pulmonary dysfunction is mechanical ventilation (MV).
- Conditions
- Acute Hypoxemic Respiratory Failure, Mechanical Ventilation, Acute Respiratory Distress Syndrome (ARDS)
- Trial name
- NCT06938217
- Testing
- Low-flow ECMO
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Institute for Extracorporeal Life Support
Exacerbation Copd, Acute Respiratory Distress
High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease
Chronic obstructive lung disease is a disabling disease that affects people usually after several years of smoke tobacco exposure and affects millions of patients worldwide.
- Conditions
- Exacerbation Copd, Acute Respiratory Distress, Acute Hypercapnic Respiratory Failure
- Trial name
- HiFOLD (NCT03033251)
- Testing
- Non Invasive Ventilation, High Flow Oxygen Cannula 50, High Flow Oxygen Cannula 30
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Focal Acute Respiratory Distress Syndrome
Ventilatory Strategy Based on Ultrasound Lung Morphology in Patients With Focal ARDS
ARDS is characterized by a diffuse, bilateral, extensive alveolar-interstitial infiltrate related to damage to the alveolar membrane. Studies of lung morphology assessed by CT scan have shown 2 types of ARDS.
- Trial name
- LUVS (NCT04966624)
- Testing
- LUVS" ventilatory strategy composed of a bundle of measures, Ventilatory management according to international recommendations (Société de Réanimation de la Langue Française)
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Acute Respiratory Distress Syndrome, Infections
Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)
BTI-203 is a randomized, double-blind, placebo-controlled, multicenter, Phase 2 proof-of-concept (POC) study to evaluate the efficacy and safety of rhu-pGSN plus standard of care (SOC) in subjects with moderate-to-severe ARDS…
- Trial name
- NCT05947955
- Testing
- Rhu-pGSN, normal saline
- Where
- 65 sites in United States, Belgium and 11 more
- Volunteers
- 600 people
- Sponsor
- BioAegis Therapeutics Inc.
Acute Respiratory Distress Syndrome (ARDS)
RecruitmEnt Assessed by eleCtRical Impedance Tomography
The RECRUIT study is a multinational, multicenter physiological observational study conducted by the PLUG working group. It is a single-day study (1.5-2 hours) associated with specific lung (de)recruitment maneuvers to verify the…
- Trial name
- RECRUIT (NCT04460859)
- Testing
- Specific lung recruitment maneuvers
- Where
- 4 sites in Brazil, Canada and 2 more
- Volunteers
- 171 people
- Sponsor
- Unity Health Toronto
Acute Respiratory Distress Syndrome (ARDS), Ventilator-induced Lung Injury
Electrical Impedance Tomography-Based Prognostic Model for ARDS
This multicenter, prospective, observational study aims to develop and validate an EIT-based prognostic model for ARDS. By focusing on the pathophysiological characteristics of ARDS and the causes of ventilator-induced lung…
- Trial name
- NCT06967207
- Testing
- Not applicable- observational study
- Where
- 4 sites in China
- Volunteers
- 625 people
- Sponsor
- XiaoJing Zou,MD
Acute Respiratory Distress Syndrome
Effect of Spontaneous Breathing in APRV Mode on Respiratory Physiology of ARDS Patients
This is a single-center, prospective, randomized, three-period crossover physiological study in adult patients with moderate-to-severe acute respiratory distress syndrome (ARDS, PaO₂/FiO₂ ≤150 mmHg).
- Trial name
- SBA-APRV (NCT07798154)
- Testing
- APRV ventilation with low-level spontaneous breathing, APRV ventilation with high-level spontaneous breathing, APRV ventilation with fully suppressed spontaneous breathing
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
ARDS (Acute Respiratory Distress Syndrome)
EXTEND ARDS-J Esophageal Pressure Study
Background: Acute respiratory distress syndrome (ARDS) patients require careful assessment before extubation to prevent failure, which is associated with poor outcomes.
- Trial name
- NCT06734988
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Sapporo Medical University
ARDS, Human
Extracorporeal Carbon Dioxide Removal Using PrismaLung in Reducing Ventilator Induced Lung Injury
Lung protective ventilation with low tidal volumes and low driving pressure are known to reduce mortality in mechanically ventilated patients with acute respiratory failure.
- Trial name
- NCT06321497
- Testing
- Extracorporeal carbon dioxide removal
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- Peninsula Health
ARDS (Acute Respiratory Distress Syndrome)
Comparative Analysis of Salivary and Bronchoalveolar Lavage IL-6 and TNF-α as Biomarkers in Pediatric Acute Respiratory Distress Syndrome
The aim of this study is to determine the degree of agreement in cytokines level measured through BAL and those measured through salivary glands excretion.
- Trial name
- NCT07380373
- Testing
- Bronchoscopy
- Where
- Egypt
- Volunteers
- 37 people
- Sponsor
- Ain Shams University
Acute Respiratory Distress Syndrome
Development and Multicenter Validation of an Explainable System for Neonatal ARDS-Compatible Phenotyping
Neonatal acute respiratory distress syndrome (NARDS) can be difficult to identify consistently because relevant information is distributed across clinical notes, imaging reports, and respiratory support records.
- Trial name
- NCT07920718
- Volunteers
- 1,600 people
- Sponsor
- Guangzhou Women and Children's Medical Center
ARDS (Acute Respiratory Distress Syndrome)
Titration of Positive End-expiratory Pressure: Comparison Between Manual Thoracic or Abdominal Compression and Electrical Impedance Tomography
Patients with acute respiratory distress syndrome are placed on mechanical ventilation, and the adjustment of ventilator parameters is an important step in their care, in particular positive expiratory pressure, applied at the…
- Trial name
- TICTAC (NCT07623590)
- Testing
- PEEP titrations
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Saint Joseph Saint Luc de Lyon
Acute Respiratory Distress Syndrome (ARDS), Acute Hypoxemic Respiratory Failure
Spontaneous vs Controlled Mechanical Ventilation in Acute Hypoxemic Respiratory Failure
Acute hypoxemic respiratory failure may progress to acute respiratory distress syndrome, a life-threatening condition that often requires mechanical ventilation.
- Trial name
- SVALBARD (NCT07463885)
- Testing
- Spontaneous Ventilation Strategy, Controlled Ventilation Strategy
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Oslo University Hospital
Acute Respiratory Distress Syndrome, Sepsis
Effect of Albumin Therapy in Mechanically Ventilated Patients With Sepsis-Associated ARDS
Sepsis-associated acute respiratory distress syndrome (ARDS) is a severe condition where severe infection causes fluid accumulation in the lungs, often requiring invasive mechanical ventilation.
- Conditions
- Acute Respiratory Distress Syndrome, Sepsis, Hypoalbuminemia
- Trial name
- ALB-SARDS (NCT07857928)
- Where
- China
- Volunteers
- 260 people
- Sponsor
- The Second Affiliated Hospital of Hainan Medical University
Acute Lung Injury(ALI), Liver Cirrhosis
Digital Early Warning System for Acute Lung Injury in Liver Surgery
This study aims to develop an explainable machine learning model that takes into account the characteristics of cardiopulmonary interactions.
- Conditions
- Acute Lung Injury(ALI), Liver Cirrhosis, ARDS, Human, MASLD
- Trial name
- NCT07070362
- Where
- 4 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Acute Respiratory Distress Syndrome
Effect of Continuous Prolonged Prone Position Versus Intermittent Daily Prone Position in ARDS
Prone position (placing the patient on his abdomen) has been shown to be an effective intervention to decrease mortality in adults connected to mechanical ventilation for moderate to severe Acute Respiratory Distress Syndrome…
- Trial name
- ePRONE (NCT06854627)
- Testing
- Daily prone position sessions, Prolonged prone position sessions
- Where
- 38 sites in Argentina, Chile and 4 more
- Volunteers
- 780 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Lung Cancer Diagnosis
Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening
The PROACT LUNG study is a prospective multi-center observational study to validate a blood-based test for the early detection of lung cancer by collecting blood samples from high-risk participants who will undergo a routine…
- Trial name
- PROACT-LUNG (NCT06122077)
- Testing
- blood draw
- Where
- 36 sites in United States
- Volunteers
- 20,000 people
- Sponsor
- Freenome Holdings Inc.