Clinical trials: ARTHROPLASTY, REPLACEMENT; ANESTHESIA
Knee Injuries
Evaluation of Patient Reported Outcomes (PRO) After Total Knee Arthroplasty (TKA) Under Spinal Anesthesia
The purpose of this study will be to evaluate and compare patients undergoing total knee arthroplasty (TKA) with sensor guidance versus that of a standard technique.
- Trial name
- NCT03053453
- Testing
- Spinal Surgery, Verasense Knee System device
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- NYU Langone Health
Arthroplasty, Replacement, Knee
Testing Regional Anesthesia Techniques for Up and Early Discharge Following Knee Arthroplasty - A Feasibility Study
To assess feasibility of a a trial investigation postoperative patient-reported quality of recovery after total knee arthroplasty (TKA) with periarticular joint injection (PAI) ± single shot adductor canal block with or without…
- Trial name
- TRUE KnORTH 2 (NCT06054750)
- Testing
- Ropivacaine, Normal saline
- Where
- Canada
- Sponsor
- McMaster University
Postoperative Cognitive Dysfunction, Alzheimer Disease
Tau Pathology in the Brain After Hip or Knee Replacement Surgery
The goal of this observational study is to study whether major surgery is linked to changes in the brain that are typical of Alzheimer's disease.
- Conditions
- Postoperative Cognitive Dysfunction, Alzheimer Disease, Tauopathies, Neuroinflammation
- Trial name
- TAU-PET (NCT07871487)
- Testing
- Hip or Knee Arthroplasty Under Spinal Anesthesia
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Uppsala University Hospital
Total Knee Replacement, Primary Knee Arthroplasty
Postoperative Knee Strength Following Total Knee Replacement: A Double-Blinded Randomized Comparison Study
Major surgery involving the knee is often associated with severe postoperative pain. Postoperative pain control remains a significant contributor to delayed recovery and length of hospital stay.
- Trial name
- NCT01620047
- Testing
- Fentanyl, Ropivacaine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of South Florida
Postoperative Pain Management in Total Knee Arthroplasty
Dexmedetomidine as an Adjunct to Periarticular Ropivacaine in Total Knee Replacement: A Pilot Randomised Controlled Trial
This study aims to evaluate whether adding dexmedetomidine to ropivacaine-based periarticular infiltration (PAI) improves postoperative pain control in patients undergoing total knee replacement (TKR).
- Trial name
- NCT07176065
- Testing
- Ropivacaine + saline solution, Ropivacaine + Dexmedetomidine
- Where
- Malaysia
- Volunteers
- 60 people
- Sponsor
- University of Malaya
Pain, Postoperative; Anesthesia, Regional, Arthroplasty, Replacement, Hip
Analgesic Efficacy of Continuous SESP vs Continuous FICB After Hip Arthroplasty
The primary objective of this prospective, randomized, observer-blinded controlled trial is to compare the postoperative analgesic efficacy of continuous intermediate-approach sacral erector spinae plane (SESP) block versus…
- Trial name
- SESP-HIP (NCT07516795)
- Testing
- Continuous Sacral Erector Spinae Plane Block, Continuous Fascia Iliaca Compartment Block
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Bach Mai Hospital
Knee Osteoarthritis, Postoperative Pain Management
Effect of iPACK and BiFeS Blocks on Quality of Recovery After Total Knee Arthroplasty
This prospective, randomized, double-blind clinical trial aims to compare the effects of two different posterior knee analgesia techniques-iPACK block (Interspace Between the Popliteal Artery and the Capsule of the posterior…
- Conditions
- Knee Osteoarthritis, Postoperative Pain Management, Total Knee Arthroplasty
- Trial name
- BiFeS-TKA (NCT07248072)
- Testing
- Adductor Canal Block (ACB) Only, IPACK block, BiFeS Block
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Ataturk University
Anesthesia Morbidity, Osteoarthritis, Knee
Evaluation of Anesthetic Techniques in Outpatient Total Joint Replacement Surgery in an Integrated Health Care Delivery System
The study is a retrospective cohort study of adult patients undergoing outpatient primary unilateral total knee or total hip replacement surgeries from 2017 to 2019 assessing for difference in anesthetic techniques and outcomes.
- Conditions
- Anesthesia Morbidity, Osteoarthritis, Knee, Osteoarthritis, Hip
- Trial name
- NCT04203732
- Testing
- Anesthesia Type
- Where
- United States
- Volunteers
- 12,466 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Postoperative Pain, Regional Anesthesia
Comparison of Continuous Fascia Iliaca Compartment Block With Continuous PENG Block in Total Hip Replacement Cases
Adequate pain management after total hip arthroplasty (THA) is crucial for early ambulation and patient satisfaction. However, due to the hip joint's innervation complexity, the optimal regional analgesia technique for THA…
- Conditions
- Postoperative Pain, Regional Anesthesia, Pain Management, Total Hip Arthroplasty
- Trial name
- PENG (NCT06806865)
- Testing
- Periarticular nerve group block (PENG), Continuous supra-inguinal fascia iliaca compartment block (SIFICB)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Namik Kemal University
Total Hip Arthroplasty
Spinal Anesthesia in Total Hip Arthroplasty
Spinal anesthesia is commonly used in patients undergoing total hip replacements. The purpose of this study is to compare lidocaine to bupivacaine spinal anesthesia in patients having a total hip arthroplasty (THA).
- Trial name
- NCT02818894
- Testing
- Lidocaine, Bupivacaine
- Where
- 2 sites in United States
- Volunteers
- 135 people
- Sponsor
- Thomas L Bradbury
Anesthesia, Spinal, Arthroplasty, Replacement, Knee
Mepivacaine vs Bupivacaine Spinal Anesthesia for TKA
This study is a prospective, double-blind prospective randomized controlled trial comparing mepivacaine and bupivacaine spinal anesthesia for same-day discharge readiness following a unilateral primary elective TKA procedure.
- Trial name
- NCT06291727
- Testing
- Mepivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Prisma Health-Upstate
MYOCARD INFARCTUS, Non Cardiac Surgery
Myocardial Injury After Noncardiac Surgery (MINS) in Patients Undergoing Knee and Hip Arthroplasty
The aim of this study is to determine the incidence of myocardial injury after noncardiac surgery (MINS) in patients undergoing elective total knee or hip arthroplasty, and to identify the demographic, clinical, laboratory, and…
- Conditions
- MYOCARD INFARCTUS, Non Cardiac Surgery, ARTHROPLASTY, REPLACEMENT; ANESTHESIA
- Trial name
- MINS (NCT07098468)
- Where
- Turkey (Türkiye)
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Arthroplasty, Replacement, Knee, Pain, Postoperative
Adductor Canal Block for Total Knee Arthroplasty
Total knee arthroplasty (TKA) can be associated with a large amount of postoperative pain. This pain can oftentimes be severe enough to limit participation in physical therapy and ultimately delay discharge resulting in increased…
- Trial name
- NCT02453360
- Testing
- Adductor Canal Block
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Wisconsin, Madison
Osteoarthritis, Hip
Systemic Steroids for Peripheral Nerve Blocks
This study will investigate the ability of systemic dexamethasone to prolong the sensory block duration for lumbar plexus nerve blockade.
- Trial name
- NCT02464176
- Testing
- Dexamethasone, Bupivacaine, Epinephrine
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Arthroplasty, Replacement, Knee, Pain, Postoperative
Comparison Of Femoral Block And Middle Adductor Canal Block In Patients With Knee Arthroplasty
Femoral and adductor nerve blocks with ultrasonography(USG) guidance are used effectively and efficiently in post-operative pain management in lower extremity surgical procedures.
- Conditions
- Arthroplasty, Replacement, Knee, Pain, Postoperative, Anesthesia and Analgesia, Anesthesia, Conduction
- Trial name
- NCT04768764
- Testing
- Ultrasound Guided Middle Adductor Canal Block, Ultrasound Guided Femoral Nerve Block., Bupivacain
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Bozyaka Training and Research Hospital
Spinal Anesthesia
The Bupivacaine Dose Sparing Effect of Intrathecal Epinephrine
Intrathecal epinephrine has been known to increase the duration of spinal anesthesia, or increase the quality of anesthesia. However, there is still a controversy, and the mechanism of epinephrine is recently suggested as a…
- Trial name
- NCT01261078
- Testing
- epinephrine 25, Epinephrine 50, epinephrine 100
- Where
- South Korea
- Volunteers
- 75 people
- Sponsor
- Seoul Medical Center
Arthroplasty, Replacement, Knee
Music Therapy Versus Control for Total Knee Arthroplasty
For millennia, people have listened to and enjoyed music for entertainment, as a distraction from daily troubles, and as a means to relax and relieve stress.
- Trial name
- NCT03569397
- Testing
- Music Therapy
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Alabama at Birmingham
Arthroplasty, Knee
Effect of Body-mass Index (BMI) on Median Effective Dose of Intrathecal Hyperbaric Bupivacaine
The effect of Body-mass index (BMI) on requirements of local anesthetics used in spinal anesthesia has not been well established.
- Trial name
- NCT01291186
- Testing
- BPV6NO, BPV7NO, BPV8NO
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Seoul Medical Center
Knee Osteoarthritis
Psoas Sciatic Blockade for Knee Arthroplasty
Objectives: To compare the efficacy of continuous combined psoas sciatic block as a sole anaesthetic technique with conventional combined spinal epidural anesthesia for patients undergoing total knee arthroplasty.
- Trial name
- NCT03088371
- Testing
- Bupivacaine 0.25%, Pajunk Needle, Portex combined spinal epidural kit
- Volunteers
- 80 people
- Sponsor
- Menoufia University
Osteoarthritis of Hip, Regional Anesthesia
Continuous Lumbar Plexus Block With and Without Parasacral Block in Patients Undergoing Total Hip Replacement
The purpose of this research study is to evaluate the analgesic efficacy of adding a single shot parasacral (sciatic) nerve block to a continuous lumbar plexus block in patients undergoing total hip replacement.
- Conditions
- Osteoarthritis of Hip, Regional Anesthesia, Other Acute Postoperative Pain, Total Hip Arthroplasty
- Trial name
- NCT02161484
- Testing
- Continuous Lumbar Plexus Block, Parasacral Nerve Block, Ropivacine 0.2%
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Rita Merman