Clinical trials: Achalasia Cardia
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Achalasia Cardia, Achalasia
Full-thickness Versus Progressive Myotomy in Peroral Endoscopic Esophageal Myotomy in Achalasia: A Randomized Controlled Trial
Peroral endoscopic esophageal myotomy (POEM) has been established as an effective therapy for Achalasia. It is still not known how deep the myotomy should be and if it should include the circular and longitudinal muscles or not.
- Trial name
- NCT07875686
- Testing
- Full thickness myotomy, Progressive thickness myotomy
- Where
- 2 sites in Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Achalasia Cardia, Tumor
Artificial Intelligence-Guided Detection of Blood Vessels to Enhance Safety in Third-Space Endoscopic Procedures
This prospective study aims to evaluate the performance of a novel Artificial Intelligence (AI) clinical decision support tool during third space endoscopic procedures, such as Endoscopic Submucosal Dissection (ESD) and Peroral…
- Trial name
- NCT07399652
- Testing
- AI generated segmentation mask for sub-mucosal blood vessels
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Asian Institute of Gastroenterology, India
Achalasia Cardia, GERD (Gastroesophageal Reflux Disease)
Biological Optimization Versus Standard Care in Post-POEM Achalasia Patients (BIO-POEM)
This study aims to evaluate whether a structured biological optimization program can improve reflux symptoms and overall recovery in patients with achalasia cardia who previously underwent Peroral Endoscopic Myotomy (POEM).
- Trial name
- BIO-POEM 1 (NCT07620899)
- Testing
- Structured Biological Optimization
- Where
- India
- Volunteers
- 166 people
- Sponsor
- Asian Institute of Gastroenterology, India
Achalasia Cardia
Serum Anti-enteric Neuronal Antibodies in Patients With Achalasia and Their Association With Clinical Profiles
Achalasia is a rare esophageal motility disorder characterized by impaired relaxation of the lower esophageal sphincter and progressive esophageal dilation.
- Trial name
- NCT07451301
- Testing
- peroral endoscopic myotomy (POEM)
- Where
- China
- Volunteers
- 195 people
- Sponsor
- Peking Union Medical College Hospital
Achalasia Cardia, GERD-HRQL Scale
Compare the Quality of Life of Patients With Achalasia Cardia (AC) After Laparoscopic and Open Esophagocardiomyotomy.
Study design. A randomized, prospective design study with retrospective data addition was conducted at two medical institutions between December 2017 and July 2025.
- Conditions
- Achalasia Cardia, GERD-HRQL Scale, Eckardt Scale
- Trial name
- GERD-HRQL (NCT07177222)
- Testing
- laparoscopic esophagocardiomyotomy, open surgery
- Where
- Kyrgyzstan
- Volunteers
- 38 people
- Sponsor
- Osh State University
Achalasia Cardia
Comparison of Balloon Dilatation and Per Oral Endoscopic Myotomy in Children With Achalasia Cardia
To compare the efficacy of balloon dilatation (BD) and per oral endoscopic myotomy (POEM) in improving the symptoms of children with achalasia in short and long term Presently most guidelines such as American Society for…
- Trial name
- NCT07167355
- Testing
- POEM, BALLOON DILATATION
- Volunteers
- 70 people
- Sponsor
- Asian Institute of Gastroenterology, India
Achalasia Cardia, Esophageal Cancer (EsC)
INCIDENCE, PREVALENCE AND OVERALL RISK OF ESOPHAGEAL CANCER IN ACHALASIA: A PROPENSITY-MATCHED POPULATION-BASED STUDY FROM A LARGE MULTICENTER DATABASE
Esophageal Achalasia has been investigated as a potential risk factor for esophageal cancer (EC). Longstanding disease, repeated treatment, age and male sex seem the most relevant risk factors, but no clear effect size estimation…
- Trial name
- RECAP (NCT07022886)
- Testing
- achalasia treatments
- Where
- Italy
- Volunteers
- 47,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Achalasia, Achalasia Cardia
Electrosurgical Modes for Endoscopic Submucosal Dissection in Peroral Endoscopic Esophageal Myotomy
Peroral endoscopic esophagel myotomy (POEM) is a third space endoscopy technique that depends on creating a submucosal tunnel to expose the esophageal muscle and eventually perform an esophageal myotomy.
- Trial name
- NCT06189859
- Testing
- endoscopic submucosal dissection using SPRAY COAG mode, endoscopic submucosal dissection using Precisect mode
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Cairo University
Achalasia Cardia
Endoscopic Versus Robotic Myotomy for Treatment of Achalasia
Achalasia is a primary esophageal motor disorder of unknown etiology characterized by degeneration of the myenteric plexus, resulting in impaired relaxation of the esophagogastric junction (EGJ), along with loss of peristalsis in…
- Trial name
- ERMA (NCT06290882)
- Testing
- Robotic Heller Myotomy, Peroral Endoscopic Myotomy
- Where
- Spain
- Volunteers
- 144 people
- Sponsor
- Germans Trias i Pujol Hospital
Achalasia, Achalasia Cardia
Nasogastric Tube After Laparoscopic Heller-Dor Myotomy
The goal of this prospective observational study is to evaluate the role of nasogastric tube (NGT) in patients with achalasia underwent to Heller-Dor laparoscopic.
- Trial name
- NCT05729971
- Testing
- nasogastric tube
- Where
- Italy
- Volunteers
- 79 people
- Sponsor
- Federico II University
Achalasia Cardia, Gastroesophageal Reflux
To Investigate the Incidence of Reflux in Patients After Per-oral Endoscopic Myotomy in Achalasia Cardia Patients
Achalasia is a rare motility disorder of the oesophagus that is characterized by aperistalsis of the oesophagal body and dysrelaxation of the lower oesophagal sphincter (LES).
- Trial name
- NCT04951739
- Testing
- Peroral endoscopic myotomy
- Where
- India
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Achalasia Cardia
Randomised Trial Between LHM Alone Vs LHM With Anterior Fundoplication In Achalasia Cardia
Back ground: Achalasia Cardia (AC) manifests with major symptom dysphagia. Surgery as the treatment modality relieves dysphagia in most of the patients.
- Trial name
- NCT03438838
- Testing
- Laparoscopic Heller's myotomy, Anterior Fundoplication
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Govind Ballabh Pant Hospital
Achalasia Cardia
Single-Versus Multiple-dose Antimicrobial Prophylaxis for Peroral Endoscopic Myotomy in Achalasia
Achalasia cardia is a primary oesophageal motility disorder of unknown etiology. Recently, peroral endoscopic myotomy (POEM) has gained widespread acceptance as an effective treatment modality for achalasia.
- Trial name
- SMAPP (NCT03784365)
- Testing
- One dose of Cefo-perazone Sulbactum
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Asian Institute of Gastroenterology, India
Achalasia Cardia
Randomized Clinical Trial Comparing Short Versus Long Oesophageal Myotomy in POEM for Achalasia Cardia.
Aim of this study is to compare the outcomes of a short esophageal myotomy extending from 3 cm cephalad to the EGJ, to 3 cm distal to it with a long esophageal myotomy with an additional proximal extension (at least 6 cm cephalad…
- Trial name
- NCT03186248
- Testing
- Per oral endoscopic myotomy
- Where
- India
- Volunteers
- 71 people
- Sponsor
- Asian Institute of Gastroenterology, India
Achalasia Cardia
POEM Versus Pneumatic Dilatation in Achalasia Cardia
The aim of this study is to compare efficacy of POEM and pneumatic dilatation in treatment of achalasia cardia.
- Trial name
- NCT02025790
- Testing
- Per Oral Endoscopic Myotomy (POEM), Pneumatic Dilatation
- Where
- India
- Volunteers
- 140 people
- Sponsor
- Asian Institute of Gastroenterology, India