Clinical trials: Acid Base Disorder
Neonatal Encephalopathy, Cell Damage
Inflammation and Metabolic Acidosis at Birth (AGAIN: AutophaGy AcIdosis Newborn)
Protection of brain development is a major aim in the Neonatal Intensive Care Unit. Neonatal encephalopathy (NE) occurs in 1.8 to 7.7 infants per 1000 births.
- Conditions
- Neonatal Encephalopathy, Cell Damage, Metabolic Acidosis, Inflammation
- Trial name
- AGAIN (NCT03897101)
- Where
- 2 sites in Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital of Ferrara
Ketosis, Blood Glucose
The Effect of Different Ketone Supplements on β-OHB and Blood Glucose in Healthy Individuals
Ketone bodies are a fuel source and signaling molecule that are produced by your body during prolonged fasting or if you consistently eat at low-carbohydrate diet.
- Trial name
- NCT05273411
- Testing
- (R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester, Beta-hydroxybutyric acid, 1,3-Butanediol
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Ketogenic Dieting, Ketoses, Metabolic
Ketogenic Diet Health and Longevity
The goal of this pilot intervention is to learn about how a well-formulated ketogenic diet (WFKD) impacts various health factors in generally healthy adults.
- Conditions
- Ketogenic Dieting, Ketoses, Metabolic, Ketosis
- Trial name
- KDHL (NCT05939011)
- Testing
- Well-formulated Ketogenic Diet
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Ketosis, Metabolic
Effect of Diet Induced Ketosis on LDL Turnover Rates
There have been concerning case reports of marked elevations of LDL-c in some individuals consuming a KD and Dr. Lewis has been referred a number of these cases to his lipid clinic, some of whom have had extreme elevations of LDL…
- Trial name
- NCT05103761
- Testing
- Study diet, Low glycemic index treatment diet
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Dehydration
Effects of Amino Acid/Electrolyte-based Beverages on Hydration Status
Older adults typically do not drink later in the day to avoid the necessity of interrupting sleep to urinate. Sometimes they also limit ingestion of fluids to avoid the need to urinate when engaged in certain activities such as…
- Trial name
- NCT03559101
- Testing
- Distilled water, Medical Food 1, Medical Food 2
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- W. Larry Kenney
Hypoxia, Ketosis
Ketone Esters for Optimization of Cognitive Performance in Hypoxia
This study will investigate the effects of ketone ester drinks on cognitive performance in hypoxia.
- Trial name
- NCT03659825
- Testing
- Ketone Ester, Hypoxic exposure
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- HVMN Inc
Cognition, BDNF
Investigating the Evolutionary Impact of Metabolic Flexibility on Physical Activity-Dependent BDNF and Cognition: Insights From the Val66Met Polymorphism
The goal of this clinical trial is to learn if a state of ketosis and physical activity will increase serum BDNF concentrations and improve cognition, specifically in individuals who possess the Met allele from the BDNF Val66Met…
- Trial name
- NCT07218497
- Testing
- d-beta-hydroxybutrate
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Ketonemia, Mental Fatigue
Exogenous Ketone Supplementation and Cognitive Function During Exercise
15 healthy trained males will volunteer to participate in this study. there will be 2 treatments: Ketone esters supplementation and iso-caloric carbohydrate.
- Conditions
- Ketonemia, Mental Fatigue, Ketosis
- Trial name
- NCT04576026
- Testing
- mental fatiguing task, 45 - minute simulated soccer game, cognitive function
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Healthy Adults
Ketone Production With Acute Caffeine Intake
Evaluate the effect of a caffeine supplement on the stimulation of lipolysis and the production of ketones in healthy adults (N=10).
- Trial name
- NCT02694601
- Testing
- Control, Caffeine low dose, Caffeine high dose
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Power, Metabolic Disturbance
Effect of 8-week Intake of 2S-hesperidin on Performance, Body Composition and Biochemicals Markers in Amateur Cyclists
This clinical study evaluates the effect of 500 mg of 2S-hesperidin for 8 weeks on performance (power generated in different metabolic zones), body composition (fat and muscle mass) and biochemical (antioxidant, inflammatory…
- Conditions
- Power, Metabolic Disturbance, Change, Body Weight, Changes Fatty
- Trial name
- HESPERFORMAN (NCT04597983)
- Testing
- 2S-hesperidin
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Francisco Javier Martínez Noguera
Heart Failure, Systolic, Ketonemia
Ketones in Heart Failure - Effects on Cardiac Efficiency
Ketones may have beneficial effects on myocardial metabolism and hemodynamics. In the present study, healthy test subjects and patients with heart failure with reduced ejections fraction will be investigated in a randomized…
- Trial name
- NCT03073356
- Testing
- Infusion of 3-OHB
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obesity
What is the Maximum Amount of Carbohydrates That is Still Able to Induce Ketosis and Suppress Appetite?
Two dietary approaches, very low energy diets (VLEDs) and ketogenic low carbohydrate diets (KLCDs), have the ability to suppress appetite.
- Trial name
- NCT02944253
- Testing
- Low energy diet 70 gram carbohydrates, Low energy diet 100 gram carbohydrates, Low energy diet 130 gram carbohydrates
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Acidosis, Oxidative Stress
Effects of Zeolite + Dolomite on Performance and Acidosis
Purpose: This study investigates the effects of dietary zeolite + dolomite on performance, exercise-induced acidosis, oxidative stress, inflammation and intestinal barrier dysfunction in trained people.
- Conditions
- Acidosis, Oxidative Stress, Inflammation
- Trial name
- NCT01831492
- Testing
- zeolite + dolomite, cellulose
- Where
- Austria
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Green Beat
Healthy Volunteers and Diabetes Participants
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PAL-119 in Healthy Volunteers and Adult Participants With Type 1 or Type 2 Diabetes
This is a Phase 1/2 randomized study of oral doses of PAL-119 in healthy volunteers and participants with diabetes.
- Trial name
- NCT07901595
- Testing
- PAL-119
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Paulex Bio Inc.
Ketonemia, Ketosis
Exogenous Ketone Supplementation and Exercise Performance
20 healthy recreationally active men and woman aged 18-35 will participate in the study. There will be three treatments involved: Caffeinated ketone supplements, non-caffeinated ketone supplement and water-placebo.
- Trial name
- NCT03895892
- Testing
- 20 km time trial, Wingate test, Ketone/Caffeine
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Ketogenic Diet, Weight Loss
Impact of Exogenous Ketones on Indices of Keto-Adaptation in Obese Subjects on Weight Reducing Diets.
This project will be a three-group controlled 6-wk feeding study where all meals are prepared and provided to obese participants. All participants will be fed a 25% energy-restricted diet.
- Trial name
- STAK (NCT06449287)
- Testing
- Diet, Blood Draw, Ketone/Glucose Monitoring
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Sport Performance, Acid Base Imbalance
Effects of Single Sodium Bicarbonate Supplementation on National-Level Finswimming Performance
This randomized, double-blind, placebo-controlled crossover trial will investigate the acute effects of sodium bicarbonate supplementation on performance, stroke biomechanics, and selected physiological and perceptual responses…
- Conditions
- Sport Performance, Acid Base Imbalance, Ergogenic Support, Sodium Bicarbonate
- Trial name
- NCT07135934
- Testing
- Sodium Bicarbonate (NaHCO3)
- Where
- Czechia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Palacky University
Complementary Feeding Recommendation, Linear Programming,
Effect of Enhanced Counseling Using Complementary Feeding Recommendation Based on Linear Programming on Nutritional Status,Omega-3 Fatty Acids, Malondialdehyde, and Alpha-Tocopherol in Overweight Children in East Jakarta
The epidemic of pediatric obesity has become a public health burden in both developed and developing countries, due to its serious health consequences, including an increased risk of type 2 Diabetes Mellitus and heart disease.
- Conditions
- Complementary Feeding Recommendation, Linear Programming,, Nutritional Status, Omega-3 Fatty Acids
- Trial name
- NCT02592109
- Testing
- Enhanced Counseling using CFR based on Linear Programming
- Where
- Indonesia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Dyslipidemia, Diabetes
Meta-analyses of Fructose and Cardiometabolic Risk
Diabetes and heart associations continue to discourage high intakes of dietary fructose, a constituent part of the sucrose molecule that is found in fruits and vegetables as a natural sugar and in some processed foods and…
- Conditions
- Dyslipidemia, Diabetes, Prediabetes, Dysglycemia
- Trial name
- NCT01363791
- Testing
- Dietary fructose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- John Sievenpiper
Exercise, Ketosis
The Effects of Acute Ketone Monoester Supplementation on 20-Minute Time-Trial Performance in Trained Cyclists
Diet can alter blood ketone levels and this in turn may affect exercise capacity. This study will determine if the acute ingestion of a ketone supplement alters cycling time trial performance.
- Trial name
- NCT05226962
- Testing
- Ketone monoester
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- McMaster University