Clinical trials: Acid Base Disorder
Type2 Diabetes, Ketonemia
Effects of Ketone Bodies on Cognition in Type 2 Diabetes
Diabetes negatively affects cognition and increases the risk of developing overt dementia. Decreased cerebral glucose metabolism may be contributing to this effect, thus providing a glucose substitute using ketone bodies might…
- Conditions
- Type2 Diabetes, Ketonemia, Cognitive Change
- Trial name
- KETOCOGNITION (NCT03657537)
- Testing
- Ketone infusion, Saline infusion
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Bispebjerg Hospital
Acidosis, Oxidative Stress
Effects of Zeolite + Dolomite on Performance and Acidosis
Purpose: This study investigates the effects of dietary zeolite + dolomite on performance, exercise-induced acidosis, oxidative stress, inflammation and intestinal barrier dysfunction in trained people.
- Conditions
- Acidosis, Oxidative Stress, Inflammation
- Trial name
- NCT01831492
- Testing
- zeolite + dolomite, cellulose
- Where
- Austria
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Green Beat
Healthy Volunteers and Diabetes Participants
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PAL-119 in Healthy Volunteers and Adult Participants With Type 1 or Type 2 Diabetes
This is a Phase 1/2 randomized study of oral doses of PAL-119 in healthy volunteers and participants with diabetes.
- Trial name
- NCT07901595
- Testing
- PAL-119
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Paulex Bio Inc.
Diabetic Ketoacidosis
Association of Systemic Immune-inflammation Index and Severity of Diabetic Ketoacidosis in Type 1 Diabetes Mellitus
Diabetic ketoacidosis (DKA) is the most serious metabolic complication of type 1 diabetes mellitus (T1DM). Insulin deficiency and inflammation play a role in the pathogenesis of DKA.
- Trial name
- NCT06251895
- Testing
- DKA protocol
- Where
- Kuwait
- Volunteers
- 241 people
- Sponsor
- Jahra Hospital
Ketonemia, Ketosis
Exogenous Ketone Supplementation and Exercise Performance
20 healthy recreationally active men and woman aged 18-35 will participate in the study. There will be three treatments involved: Caffeinated ketone supplements, non-caffeinated ketone supplement and water-placebo.
- Trial name
- NCT03895892
- Testing
- 20 km time trial, Wingate test, Ketone/Caffeine
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Cardiac Arrest (CA), Cardiogenic Shock
Evaluation of Acid-base Disorders and Ventilation Settings in Cardiogenic Shock and Post-cardiac Arrest Patients: Comparison With VentilO Algorithm
This study aims to better understand how mechanical ventilation settings affect patients admitted to the coronary care unit after cardiac arrest or with cardiogenic shock.
- Conditions
- Cardiac Arrest (CA), Cardiogenic Shock, Mechanical Ventilation, Acid Base Disorder
- Trial name
- VentilO CU (NCT07484828)
- Testing
- Initiation of mechanical ventilation
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Laval University
Type 2 Diabetes, Ketoses, Metabolic
Keto Drinks as a Meal Primer in Patients With Type 2 Diabetes
The main objective of this clinical trial is to study the effects of orally administered ketone drinks containing the ketone body, 3-hydroxybutyrate (3-OHB), just before a meal in patients with type 2 diabetes.
- Trial name
- NCT05263401
- Testing
- 3-hydroxybutyrate
- Where
- Denmark
- Volunteers
- 14 people
- Sponsor
- University of Aarhus
Heart Failure With Preserved Ejection Fraction, Diabetes Mellitus, Type 2
Modulation of Circulating Levels of the Ketone Body 3-hydroxybutyrate in Patients With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction: Cardiovascular Effects.
Heart failure (HF) is among the most common causes of death in patients with type 2 diabetes (T2D). Ketones, 3-hydroxybutyrate (3-OHB), have shown to have beneficial hemodynamics effect in patients with hearth failure with…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Diabetes Mellitus, Type 2, Ketonemia
- Trial name
- KETO-HFpEF (NCT05236335)
- Testing
- Ketone ester
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- University of Aarhus
Pulmonary Disease, Chronic Obstructive, Obesity Hypoventilation Syndrome
Treatment of Metabolic Alkalosis With Acetazolamide. Effect on the Length of Mechanical Ventilation.
The purpose of this study is to analyze whether the treatment of metabolic alkalosis with acetazolamide in intubated patients with chronic obstructive pulmonary disease (COPD) or with obesity hypoventilation syndrome (OHS)…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Obesity Hypoventilation Syndrome, Metabolic Alkalosis
- Trial name
- TRAMA (NCT01499485)
- Testing
- Acetazolamide
- Where
- 8 sites in Spain
- Volunteers
- 140 people
- Sponsor
- Hospital Son Llatzer
Schizophrenia, Schizophrenia and Related Disorders
Ketogenic Metabolic Therapy in Schizophrenia, Bipolar Disorder, Major Depressive Disorder: Deep Omic Profiling
The goal of this randomized clinical trial is to be adequately powered to evaluate the effect of ketogenic metabolic therapy on the quality of life in serious mental illness, schizophrenia, bipolar disorder, major depressive…
- Conditions
- Schizophrenia, Schizophrenia and Related Disorders, Bipolar Disorder, Bipolar and Related Disorders
- Trial name
- NCT06748950
- Testing
- LCHF Ketogenic Diet, Diet-as-Usual (DAU)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Stanford University
Metabolic Acidosis
Meglimine Sodium Succinate for Correction of Metabolic Acidosis in Critically Ill Patients
An acid-base imbalance, called metabolic acidosis (acid-base disorder lasting from several minutes to several days, caused by a decrease in serum bicarbonate ion (HCO3) concentration), is often observed in critically ill patients…
- Trial name
- NCT05147051
- Testing
- Meglumine Sodium Succinate
- Where
- 6 sites in Russia
- Volunteers
- 140 people
- Sponsor
- POLYSAN Scientific & Technological Pharmaceutical Company
Respiratory Insufficiency, Alkalosis
Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis
Respiratory failure is a common consequence of chronic obstructive pulmonary disease (COPD). A concurrent metabolic alkalosis may worsen the respiratory failure, as a higher pH in blood (and thus in cerebrospinal fluid) results…
- Trial name
- NCT00222534
- Testing
- Acetazolamide
- Where
- 5 sites in Norway
- Volunteers
- 70 people
- Sponsor
- University of Oslo School of Pharmacy
Ketogenic Diet, Weight Loss
Impact of Exogenous Ketones on Indices of Keto-Adaptation in Obese Subjects on Weight Reducing Diets.
This project will be a three-group controlled 6-wk feeding study where all meals are prepared and provided to obese participants. All participants will be fed a 25% energy-restricted diet.
- Trial name
- STAK (NCT06449287)
- Testing
- Diet, Blood Draw, Ketone/Glucose Monitoring
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Lipedema
Effect of Ketosis on Pain and Quality of Life in Patients With Lipedema
Lipedema is a female progressive fat disorder, characterized by a symmetrical increase in subcutaneous adipose tissue in the lower extremities with the exception of the waist.
- Trial name
- Lipodiet (NCT04632810)
- Testing
- Ketogenic low energy diet, non-ketogenic low energy diet
- Where
- 2 sites in Norway
- Volunteers
- 70 people
- Sponsor
- Helse Nord-Trøndelag HF
Diabetes Type 2, DKA
Diabetic Ketoacidosis From New SGLT2i: Can Genomics Estimate Risk
Sodium glucose co-transporter 2 (SGLT2) inhibitors have revolutionized care for people living with type 2 diabetes mellitus (T2DM).
- Conditions
- Diabetes Type 2, DKA, Diabetic Ketoacidosis
- Trial name
- DaNGER (NCT05402579)
- Testing
- Genomic analysis
- Where
- 2 sites in Canada
- Volunteers
- 63 people
- Sponsor
- Mount Sinai Hospital, Canada
Anemia, Antenatal Care
Effects of Video-based Health Education on Maternal and Child Health in Ethiopia
Low adherence to recommended health and nutrition strategies during the critical 1000 day-window of opportunity is multifactorial but low quality communication is key limitation.
- Conditions
- Anemia, Antenatal Care, Birth Outcomes, Worm Infection
- Trial name
- MCH (NCT04414527)
- Testing
- Standard counselling, Health-Video
- Where
- Ethiopia
- Volunteers
- 675 people
- Sponsor
- University Ghent
Alzheimer's Disease, Primary Progressive Non-fluent Aphasia
A Medium Chain Triglyceride Intervention for Patients With Alzheimer Disease
The purpose of this study is to determine safety, tolerability, and pharmacokinetics/dynamics of a ketogenic dietary supplement containing medium chain triglycerides (MCTs) in patients with Alzheimer disease (AD).
- Conditions
- Alzheimer's Disease, Primary Progressive Non-fluent Aphasia, Frontotemporal Dementia (FTD)
- Trial name
- MINT-01 (NCT02912936)
- Testing
- Ketogenic medium chain triglyceride drink (MCT drink)
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- University of British Columbia
Optimal Sweep Gas Flow, Determination of Optimal Sweep Gas Flow for Different Phases of Cardiopulmonary Bypass
Re-Adjustment of Sweep Gas Flow to the During the Rewarming Period of the Cardiopulmonary Bypass
The investigators designed this prospective observational study with the theory that alkalosis caused by decreased CO2 solubility due to temperature increase during the rewarming period of the Cardiopulmonary Bypass could be…
- Trial name
- NCT06013189
- Testing
- Gas Flow Adjustment
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Acıbadem Atunizade Hospital
Metabolic Acidosis
Correction of Metabolic Acidosis in End Stage Renal Disease (ESRD)
The investigators want to evaluate whether an original action based on the administration of alkali (mainly sodium bicarbonate) is able to significantly modify renal death and to reduce mortality due to cardiovascular events.
- Trial name
- UBI (NCT01640119)
- Testing
- Bicarbonate
- Where
- 2 sites in Italy
- Volunteers
- 728 people
- Sponsor
- Azienda Sanitaria ASL Avellino 2
Stroke, Diabetic Ketoacidosis
Descriptive Analysis of Near Infrared Spectroscopy in Critically Ill and Injured Pediatric and Neonatal Patients
This study involves looking at Cerebral oximetry measurements in pediatric and neonatal patients who are experiencing a critical illness. Such as Altered mental status, seizures, trauma, sepsis, etc.
- Conditions
- Stroke, Diabetic Ketoacidosis, Increased Intracranial Pressures, Altered Mental Status
- Trial name
- NIRSCI (NCT02950181)
- Testing
- NIRS
- Where
- United States
- Volunteers
- 299 people
- Sponsor
- Arkansas Children's Hospital Research Institute