Clinical trials: Acute Cardiac Syndrome
Acute Coronary Syndrome
Comparison of Low-Dose, Standard-Dose Ticagrelor and Clopidogrel for Inhibition of Platelet Reactivity in Patients With Acute Coronary Syndromes
The purpose of this study is to compare Low-Dose, Standard-Dose Ticagrelor and Clopidogrel for Inhibition of Platelet Reactivity in Patients with Acute Coronary Syndromes
- Trial name
- OPTIMA (NCT02319941)
- Testing
- ticagrelor, clopidogrel
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Seung-Jung Park
COVID-19
The RAPID COVID-19 TRIAGE Algorithm
This study is being conducted to study the use and application of a point-of-care (POC) Covid-19 test developed by Spartan BioSciences and recently approved for clinical use by Health Canada.
- Trial name
- NCT04353154
- Testing
- Spartan Cube Point-of Care Covid-19 test
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Gastrointestinal Dysfunction, Cardiac Surgery Intensive Care Treatment
Prognosis and Diagnosis of Acute Gastrointestinal Dysfunction in Cardiac Surgery Patients
The purpose of this prospective observational clinical cohort study is to develop a scientifically based approach to the prediction and early diagnosis of intestinal dysfunction in cardiac surgery patients.
- Conditions
- Gastrointestinal Dysfunction, Cardiac Surgery Intensive Care Treatment, Cardiac Surgery, Cardiac Surgery in Adult Patient
- Trial name
- PREDICT-GICS (NCT07422246)
- Testing
- additional blood testing for specific and non-specific markers of intestinal dysfunction, ultrasound examination of abdominal organs and measurement of intra-abdominal pressure
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Acute Coronary Syndrome
MDCO-216 Infusions Leading to Changes in Atherosclerosis: A Novel Therapy in Development to Improve Cardiovascular Outcomes - Proof of Concept Intravascular Ultrasound (IVUS), Lipids, and Other Surrogate Biomarkers Trial
This study will be a proof-of-concept, placebo-controlled, double-blind, randomized trial in participants with a recent acute coronary syndrome (ACS) to evaluate the efficacy, pharmacokinetics, safety, tolerability, disease…
- Trial name
- PILOT (NCT02678923)
- Testing
- MDCO-216
- Where
- 20 sites in Canada, Czechia and 3 more
- Volunteers
- 126 people
- Sponsor
- The Medicines Company
Stable Chronic Angina, Ischemic Heart Disease
Effect of Tertiary A-level Hospital Remote Intervention on MACCE, Adherence to Drugs and Risk Factors Control in Patients With Stable Coronary Artery Disease Compared With Traditional Community Hospital Follow-up
The study was a multicenter, two-arm, parallel, open label, prospective study intended for to compare effect of offline community hospital intervention on adherence to drugs and risk factors control in patients with stable…
- Conditions
- Stable Chronic Angina, Ischemic Heart Disease, Acute Coronary Syndrome
- Trial name
- CHIPCHAT (NCT04795505)
- Testing
- Intervention, Control
- Where
- China
- Volunteers
- 1,424 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Acute Coronary Syndromes
Efficacy and Safety of the YUKON Drug Eluting Stent in Diffuse Coronary Artery Disease
Polymer carried by drug-eluting stents may increase inflammatory response and thrombosis. Our previous study showed that polymer-free rapamycin-coated stents brings dose-dependent reduction in restenosis.
- Trial name
- NCT01418794
- Testing
- High dose rapamycin stent, Low dose rapamycin stent
- Where
- 4 sites in China
- Volunteers
- 606 people
- Sponsor
- Shenyang Northern Hospital
Acute Coronary Syndrome, Nursing
Acute Coronary Syndrome and Acupressure
This study aims to examine the effect of acupressure on physiological parameters and anxiety levels in individuals diagnosed with Acute Coronary Syndrome (ACS).
- Trial name
- NCT06300294
- Testing
- acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Sepsis, Septic Shock
Central Venous Catheter Colonisation Among Critically Ill Patients in Intensive Care Units
Background: Central Venous catheter insertion technique and indwelling time are major risk factors for CVC colonisation. Colonisation occurs through microbial migration and biofilm formation along the catheter insertion tract.
- Conditions
- Sepsis, Septic Shock, Post-cardiac Surgery, Post-Cardiorespiratory Arrest Coma
- Trial name
- NCT03270774
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makerere University
Acute Coronary Syndrome, Myocardial Infarction
High-Sensitivity Troponin in the Evaluation of Patients With Acute Coronary Syndrome
In patients with chest pain the diagnosis of a heart attack (myocardial infarction) is made where there is evidence of heart muscle damage using a blood test to measure the heart muscle protein troponin.
- Trial name
- High-STEACS (NCT01852123)
- Testing
- High-sensitivity troponin I assay
- Where
- United Kingdom
- Volunteers
- 48,282 people
- Sponsor
- University of Edinburgh
Infection, Acute Coronary Syndrome
Association Between Levels of D-Dimer, Fibrinogen and PAI-1 in Elderly Patients With Infection and Occurrence of Cardio- and Cerebro-vascular Disease After Discharge
The association between the levels of d-dimer, fibrinogen and PAI-1 in plasma of elderly patients admitted to internal medicine departments because of infection and the occurrence of cardio- and cerebro-vascular disease after…
- Conditions
- Infection, Acute Coronary Syndrome, Cerebrovascular Disease
- Trial name
- NCT00512603
- Volunteers
- 52 people
- Sponsor
- Wolfson Medical Center
Acute Coronary Syndrome (ACS)
Preventive Drug-coated Balloon Angioplasty in Vulnerable Atherosclerotic Plaque (RESTORE Trial)
The objective of this multicenter, prospective, open-label, controlled, randomized trial is to demonstrate the superiority of drug-coated balloon (DCB) treatment on non-flow limited vulnerable plaque as compared to…
- Trial name
- NCT06365502
- Testing
- Drug-coated balloon, Guideline-directed medical treatment
- Where
- 18 sites in China
- Volunteers
- 1,860 people
- Sponsor
- Harbin Medical University
Acute Coronary Syndrome Comorbid With Cerebral Atherosclerosis
Tanhuo Decoction for Acute Coronary Syndrome With Cerebral Atherosclerosis in Elderly Patients
The goal of this clinical trial is to learn if Tanhuo decoction works to treat acute coronary syndrome combined with cerebral atherosclerosis in the elderly. It will also learn about the safety of Tanhuo decoction.
- Trial name
- NCT07445581
- Testing
- Tanhuo decoction, standard Western medicine
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Jinggang Xia, MD
Myocardial Infarction, Sex Differences
Hs-cTn - Optimizing the Diagnosis of Acute Myocardial Infarction/Injury in Women
The project is focussed on evaluating the impact of using a female-specific threshold in the diagnosis of myocardial infarction. This female threshold is lower than the overall hs-cTn threshold currently in use.
- Conditions
- Myocardial Infarction, Sex Differences, High Sensitivity Troponin
- Trial name
- CODE-MI (NCT03819894)
- Testing
- Introduction of a lower female hs-cTn threshold
- Where
- Canada
- Volunteers
- 24,000 people
- Sponsor
- BC Centre for Improved Cardiovascular Health
Acute Coronary Syndromes
Impact of Atorvastatin Versus Rosuvastatin on 25 Hydroxy Vitamin D Levels in Patients With Acute Coronary Syndrome
there will be 2 groups of patients with acute coronary syndrome. The patients will receive one of the 2 study drugs and impact on raising Vitamin D level will be seen after 6 months
- Trial name
- NCT06765265
- Testing
- Rosuvastatin 20 mg/day, Atorvastatin 40 mg
- Where
- Pakistan
- Volunteers
- 152 people
- Sponsor
- King Edward Medical University
Acute Myocardial Infarction
Clopidogrel Efficacy and Acute Coronary Syndromes
The purpose of this study is to compare clopidogrel effectiveness between severe hemodynamically unstable versus stable patients with acute myocardial infarction.
- Trial name
- NCT00839267
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- Charles University, Czech Republic
Acute Coronary Syndrome
Serum Concentration of Wnt2 and Wnt4 in Patients With Acute Coronary Syndrome
This study aims to find the change of serum wnt effectory moleculars and the association with Hs-CRP，cTnI and Prognosis in Patients with Acute Coronary Syndrome.
- Trial name
- NCT03342131
- Testing
- Circulating wnt 2 and wnt 4 concentration
- Where
- China
- Volunteers
- 450 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Acute Coronary Syndrome (ACS)
Optimum Troponin Cutoffs for ACS in the ED
Blood tests may be able to quickly identify and exclude patients that are having a heart attack. Using these tests in the Emergency Department (ED) may lead to faster treatment, a reduced wait time, and quicker discharge for…
- Trial name
- ROMI-3 (NCT01994577)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Canadian Institutes of Health Research (CIHR)
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Acute Coronary Syndromes
AI-Assisted Coronary Syndrome Subtyping From Admission History of Present Illness: A Clinician Reader Study
This study will evaluate whether an OCR-LLM-based clinical decision support framework improves clinicians' accuracy in classifying coronary syndrome subtypes from admission history of present illness.
- Conditions
- Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Acute Coronary Syndromes, ST-segment Elevation Myocardial Infarction (STEMI), Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)
- Trial name
- OCR-LLM-CHD (NCT07449429)
- Testing
- OCR-Prompt-LLM Information Extraction and Classification Workflow (OCR-Prompt-LLM), Manual Clinical Data Review
- Where
- China
- Volunteers
- 10 people
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Coronary Syndrome
BAY81-8781, I.V. Aspirin in the Indication of Acute Coronary Syndrome (ACS)
The objective of this study is to investigate whether intravenous administration (injected into a vein) of acetylsalicylic acid (Aspirin) in doses of 250 and 500 mg is superior to oral treatment of ACS with tablets containing 300…
- Trial name
- ACUTE (NCT00910065)
- Testing
- D,L-lysine acetylsalicylate (Aspirin, BAY81-8781) 500 mg IV, D,L-lysine acetylsalicylate (Aspirin, BAY81-8781) 250 mg IV, Acetylsalicylic acid (Aspirin, BAYe4465) 300 mg Tablet
- Where
- 37 sites in China, Germany and 2 more
- Volunteers
- 270 people
- Sponsor
- Bayer
Coronary Artery Dissection, Spontaneous
Spontaneous Coronary Artery Dissection anaLysIs of the Brazilian Updated Registry
A retrospective and prospective registry will evaluate demographic and angiographic data in patients with spontaneous coronary artery dissection (SCAD) using medical records, invasive coronary angiography, intravascular imaging…
- Trial name
- SCALIBUR (NCT03398850)
- Where
- Brazil
- Volunteers
- 250 people
- Sponsor
- Hospital Israelita Albert Einstein
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