Clinical trials: Acute Cerebrovascular Accident
Stroke Acute
NeVa Retrospective Comparative SR Study
To compare safety and effectiveness of NeVa Stent Retriever (SR) to Control SR in the treatment of stroke caused by large vessel occlusion.
- Trial name
- NITRO (NCT06964724)
- Testing
- Mechanical thrombectomy
- Where
- 5 sites in Argentina, Belgium and 3 more
- Volunteers
- 800 people
- Sponsor
- Vesalio
Stroke
Progesterone in the Treatment of Acute Hemorrhagic Stroke
A large number of preclinical studies have confirmed that progesterone and its metabolites have strong neuroprotective effects. As a neuroprotective agent, progesterone has been effective in several animal models of nerve injury…
- Trial name
- NCT04143880
- Testing
- Progesterone, saline
- Volunteers
- 184 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Stroke, Dysphagia
Improving SWAllowing After Stroke With Transcranial Direct Current Stimulation
In the acute phase of stroke, dysphagia (difficulty/inability to swallow) is a common problem that can have serious consequences such as aspiration pneumonia, increased lenght of hospitalisation, and death.
- Trial name
- iSWAT (NCT01758991)
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital of Mont-Godinne
Ischemic Stroke
Prevalence of Cerebral Large Vessel Occlusion Among Acute Ischemic Stroke Patients in Assiut University Hospitals
Prevalence of Large Vessel Occlusion among acute ischemic stroke patients in Assiut University hospitals 1. Study Objectives Primary Objective: To determine the prevalence of LVO among acute ischemic stroke (AIS) patients…
- Trial name
- NCT07326410
- Volunteers
- 300 people
- Sponsor
- Assiut University
Stroke, Acute Ischemic, Endovascular Procedures
Triage of Patients With Acute Ischemic Stroke Due to Large Vessel Occlusions-2
The objective of this study is to create a comprehensive, real-world, multi-center observational registry of consecutive patients admitted to hospitals with acute ischemic stroke (AIS) caused by large vessel occlusions (LVO), who…
- Conditions
- Stroke, Acute Ischemic, Endovascular Procedures, Large Vessel Occlusion
- Trial name
- TRACK-LVO-2 (NCT05659160)
- Testing
- Endovascular Therapy
- Where
- 4 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Tianjin Huanhu Hospital
Acute Ischemic Stroke From Large Vessel Occlusion
The Preliminary Efficacy and Safety of Intra-Arterial Albumin as Adjunct to Mechanical Thrombectomy in Acute Ischemic Stroke
Albumin-assisted therapy has demonstrated good safety and potential neuroprotective effects following mechanical thrombectomy. To further systematically evaluate its efficacy and safety, we are conducting a Phase IIa clinical…
- Trial name
- NCT07294391
- Testing
- Human serum albumin infusion 20%
- Volunteers
- 60 people
- Sponsor
- Tianjin Huanhu Hospital
Stroke
Cord Blood Infusion for Ischemic Stroke
This is a phase one study investigating the safety of a single, intravenous infusion of banked allogeneic umbilical cord blood in subjects following an acute ischemic stroke.
- Trial name
- NCT02397018
- Testing
- allogeneic umbilical cord blood
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Joanne Kurtzberg, MD
Acute Coronary Syndrome
Ticagrelor Compared to Clopidogrel in Acute Coronary Syndromes
The McGill University Health Center (MUHC) Division of Cardiology, with funding from the Canadian Institute of Health Research, is performing this randomized controlled trial to determine which dual antiplatelet therapy (DAPT)…
- Trial name
- TC4 (NCT04057300)
- Testing
- Ticagrelor 90mg, Clopidogrel 75mg, acetylsalicylic acid (ASA) 81mg
- Where
- Canada
- Volunteers
- 1,038 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Stroke, Acute
Optimising 3D pH-Weighted CEST MRI in Acute Ischaemic Stroke (CEST in Stroke)
CEST in Stroke is an observational magnetic resonance imaging (MRI) study in acute ischaemic stroke patients. Ischaemic stokes are the most common type of stroke and occur when a blood clot blocks the flow of blood and oxygen…
- Trial name
- NCT04282330
- Testing
- 3D CEST imaging
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- King's College Hospital NHS Trust
Ischemic Stricture of Intestine
Safety and Effectiveness Evaluation of the ISS System in Treatment of Acute Ischemic Stroke
The primary objective of this pilot study is the assessment of the safety of the ISS500 System in patients who have experienced an acute ischemic stroke within the anterior circulation.
- Trial name
- ImpACT-1 (NCT03733236)
- Testing
- ISS Active Stimulation
- Where
- 2 sites in India
- Volunteers
- 98 people
- Sponsor
- BrainsGate
Acute Stroke
Early Functional Training in Acute Stroke Inpatient Ward
To investigate the difference between two models of an early intervention program (focused on mobility function) in the functional recovery 3 months post stroke in a group of patients with acute ischemic stroke while in acute…
- Trial name
- NCT04488692
- Testing
- Early intervention (Mobility functional training)
- Where
- Taiwan
- Volunteers
- 142 people
- Sponsor
- Chung Shan Medical University
Heart Failure, Respiratory Insufficiency
A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients
The purpose of this study is to evaluate the efficacy and safety of rivaroxaban compared with placebo in the prevention of symptomatic venous thromboembolism (VTE) events and VTE-related death post-hospital discharge in…
- Conditions
- Heart Failure, Respiratory Insufficiency, Stroke Acute, Infectious Diseases
- Trial name
- MARINER (NCT02111564)
- Testing
- Rivaroxaban, 10 mg, Rivaroxaban, 7.5 mg
- Where
- 593 sites in United States, Argentina and 35 more
- Volunteers
- 12,024 people
- Sponsor
- Janssen Research & Development, LLC
Stroke, Acute, Stroke, Ischemic
Neuroimaging in Acute Stroke
The main aim of this study is to identify the predictive value of CT parameters (e-ASPECTS, CTP, collateral vessel status, volume, and location of ischemic lesion volume) at a 3-month functional outcome defined by the modified…
- Trial name
- e-Stroke (NCT05864495)
- Where
- Czechia
- Volunteers
- 500 people
- Sponsor
- University Hospital Ostrava
Brain Edema, Stroke, Acute
Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction
The primary objective of Part 1 of the study is to determine if BIIB093 improves functional outcome at Day 90 as measured by the modified Rankin Scale (mRS) when compared with placebo in participants with Large Hemispheric…
- Trial name
- CHARM (NCT02864953)
- Testing
- BIIB093
- Where
- 250 sites in United States, Australia and 22 more
- Volunteers
- 535 people
- Sponsor
- Remedy Pharmaceuticals, Inc.
Infarction, Middle Cerebral Artery
Study of Autologous Stem Cell Transplantation for Patients With Ischemic Stroke
This is a open label study to assess the safety of autologous bone marrow transplantation in patients with a ischemic stroke in the middle cerebral artery territory within 90 days from symptoms onset.
- Trial name
- NCT00473057
- Testing
- Autologous cell transplantation
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Acute Ischemic Stroke, Transient Ischemic Attack
The Extended CTA for the Successful Screening of Cardioaortic Thrombus in Acute Ischemic Stroke and TIA (DAYLIGHT) Trial
Embolic strokes of undetermined source (ESUS) represent a subset of cryptogenic strokes that are suspected to have an occult embolic source.
- Conditions
- Acute Ischemic Stroke, Transient Ischemic Attack, Intracardiac Thrombus
- Trial name
- DAYLIGHT (NCT05522244)
- Testing
- extended CTA
- Where
- Canada
- Volunteers
- 830 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Post-stroke Cognitive Impairment
Edaravone Dexborneol Sublingual Tablet for the PSCI in Acute Ischemic Stroke Patients
This is a multicenter, randomized, double-blind, placebo-controlled, exploratory Phase II clinical trial. The goal of this clinical trial is to assess the safety and efficacy of edaravone dexborneol sublingual tablets for…
- Trial name
- NCT06315231
- Testing
- Edaravone dexborneol sublingual tablet
- Where
- 21 sites in China
- Volunteers
- 226 people
- Sponsor
- Simcere Pharmaceutical Co., Ltd
Acute Ischemic Stroke
Umbilical Cord-derived Mesenchymal Stem Cell Infusion for Treating Acute Ischemic Stroke
The goal of this clinical trial is to learn if drug mesenchymal stem cells (umbilical cord) injection works to treat acute ischemic stroke in adults.
- Trial name
- UMERIS (NCT06518902)
- Testing
- mesenchymal stem cells (umbilical cord) injection
- Volunteers
- 18 people
- Sponsor
- National Engineering Center of Cell Products
Acute Coronary Syndrome, Ischemic Stroke
Study to Assess Pharmacokinetics, Pharmacodynamics and Safety of Tiprogrel in Healthy Subjects
This study is designed to evaluate the pharmacokinetics, pharmacodynamics and safety in healthy subjects with multiple administration of Tiprogrel.
- Trial name
- NCT06584812
- Testing
- Tiprogrel, Clopidogrel, Ticagrelor
- Where
- China
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Tianjin Institute of Pharmaceutical Research Co., Ltd
Acute Ischemic Stroke
Fructose for Acute Ischemic Stroke
This is a single-center, prospective, randomized, open-label, blinded-endpoint exploratory clinical study enrolling 46 patients with acute ischemic stroke.
- Trial name
- FRUCTOSE-AIS (NCT07626541)
- Testing
- 10% Fructose Injection
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Ji Xunming,MD,PhD
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