Clinical trials: Acute Respiratory Failure With Hypoxia
Respiratory Failure, COPD
Comparison of Humidification Devices During Non Invasive Ventilation, in Acute Respiratory Failure
Comparison of humidification devices during non invasive ventilation, in acute respiratory failure. The hypothesis was, due to dead space, lower humidification, a reduced efficiency of the technique (NIV) when HME are used in…
- Conditions
- Respiratory Failure, COPD, Hypoxemia, Non Invasive Ventilation
- Trial name
- NCT00190346
- Testing
- Humidification devices: HH vs HME
- Where
- 14 sites in Canada, France and 2 more
- Volunteers
- 250 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Covid19, Urine
Risk Stratification of COVID-19 Using Urine Biomarkers
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in infected patients, it produces symptoms which range from completely asymptomatic to those expressing severe…
- Conditions
- Covid19, Urine, Biomarker, Acute Respiratory Failure With Hypoxia
- Trial name
- NCT04681040
- Where
- 7 sites in United States, Brazil and 3 more
- Volunteers
- 964 people
- Sponsor
- National Center for Global Health and Medicine, Japan
COPD Exacerbation, Hypoxia
Automated Oxygen Delivery by O2matic to Patients Admitted With an Exacerbation in COPD
The aim of the study is to examine if automated oxygen delivery with O2matic is better than manually controlled oxygen therapy for patients admitted to hospital with an exacerbation in Chronic Obstructive Pulmonary Disease…
- Conditions
- COPD Exacerbation, Hypoxia, Hyperoxia, Respiratory Failure
- Trial name
- O2MATIC (NCT03464695)
- Testing
- O2matic
- Where
- 2 sites in Denmark
- Volunteers
- 20 people
- Sponsor
- Hvidovre University Hospital
Oxygen Toxicity, COPD Exacerbation
Automated Adjustment of Oxygen on Patient With Acute COPD Exacerbation - FreeO2 HypHop
The aim of this study is to evaluate if automated adjustment of oxygen (with FreeO2 device) can reduce the hospital length of stay for acute exacerbation of COPD with comparison of manual oxygen titration.
- Conditions
- Oxygen Toxicity, COPD Exacerbation, Hyperoxia, Hypoxemia
- Trial name
- FreeO2 HypHop (NCT03835741)
- Testing
- FreeO2, manual titration
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- Laval University
Acute Respiratory Failure With Hypoxia, Acute Respiratory Distress Syndrome
The Acute Respiratory Intervention StudiEs in Africa (ARISE-AFRICA) Study
The dearth of Intensive care units in low resource settings portends for poor outcomes amongst patients with acute hypoxemic respiratory failure (AHRF) .
- Conditions
- Acute Respiratory Failure With Hypoxia, Acute Respiratory Distress Syndrome, Acute Lung Injury
- Trial name
- ARISE-AFRICA (NCT04693403)
- Testing
- HFNC, CPAP, Standard Oxygen
- Where
- 17 sites in Uganda
- Volunteers
- 705 people
- Sponsor
- Makerere University
Oxygen Deficiency, Coronavirus Infection
Awake Proning in COVID-19 Patients With Hypoxemic Respiratory Failure
The purpose of this study is to retrospectively review clinical data to determine whether awake proning improves oxygenation in spontaneously breathing patients with COVID-19 severe hypoxemic respiratory failure.
- Trial name
- NCT04408222
- Testing
- Awake proning
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Columbia University
Pneumonia, Community-Acquired Infections
Helmet Continuous Positive Airway Pressure Versus Oxygen Venturi in Acute Respiratory Failure in CAP: CAPOVeRSO
The purpose of this study is to compare the efficacy of CPAP application by a helmet and O2 administration by a Venturi mask in terms of gas exchanges improvement in patients with acute respiratory failure due to…
- Conditions
- Pneumonia, Community-Acquired Infections, Respiratory Insufficiency, Acute Lung Injury
- Trial name
- CAPOVeRSO (NCT00603564)
- Testing
- Castar Starmed (CPAP) delivered by a helmet
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- University of Milan
Acute Respiratory Failure With Hypoxia
High-flow Oxygen Therapy vs Non-invasive Ventilation: Comparison of Alveolar Recruitment in Acute Respiratory Failure
This physiological study showed an increase in regional ventilation with NIV but no difference in alveolar recruitment as compared to HFNC in patients with hypoxemic ARF.
- Trial name
- IRAvista (NCT04664322)
- Testing
- non invasive ventilation and high flow nasal canulae oxygen therapy
- Where
- France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Rouen
SARS-CoV-2 Infection, Respiratory Failure With Hypoxia
Automated Quantification of Radiologic Pulmonary Alteration During Acute Respiratory Failure
Automated quantification of the pulmonary volume impaired during acute respiratory failure could be helpful to assess patient severity during COVID-19 infection or perioperative medicine, for example.
- Trial name
- QUANTICO-RETRO (NCT04534400)
- Testing
- thoracic CT-scan
- Where
- 2 sites in France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Strasbourg, France
Acute Respiratory Failure With Hypoxia
ARDS Caused by COVID-19
Patients with the acute respiratory distress syndrome (ARDS) have markedly varied clinical presentations. Main characteristics of mechanically ventilated ARDS caused by COVID-19, and adherence to lung-protective ventilation…
- Trial name
- NCT04368975
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital Clinic of Barcelona
Acute Respiratory Failure With Hypoxia, Oxygen Inhalation Therapy
Prehospital High-Flow Nasal Oxygen Therapy
The purpose of the present project is to compare High-Flow Nasal Oxygen therapy with Standard Oxygen therapy, initiated in the prehospital setting in patients with acute hypoxemia respiratory failure, in terms of oxygenation at…
- Conditions
- Acute Respiratory Failure With Hypoxia, Oxygen Inhalation Therapy, Prehospital Setting
- Trial name
- PRHOXY-1 (NCT03326830)
- Testing
- High-flow nasal oxygen, Standard oxygen therapy
- Where
- 2 sites in France
- Volunteers
- 58 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Severe Acute Respiratory Distress Syndrome, Refractory Hypoxemia
ECMO for Critically Ill Patients With Respiratory Failure and/or Circulatory Failure
Extracorporeal membrane oxygenation (ECMO) had been used to treat refractory hypoxemia associated with acute respiratory distress syndrome (ARDS).
- Trial name
- NCT04031794
- Testing
- Extra Corporeal Membrane Oxygenator (ECMO)
- Where
- Thailand
- Volunteers
- 250 people
- Sponsor
- Mahidol University
Acute Respiratory Failure With Hypoxia
Positive Pressure During Bronchoscopy
It has been demonstrated the application of noninvasive positive pressure ventilation (NPPV) to assist spontaneous breathing through a face mask during fiberoptic bronchoscopy (FOB) with bronchoalveolar lavage (BAL) in severely…
- Trial name
- NCT02167542
- Testing
- Noninvasive Positive Pressure Ventilation, CPAP valve (Boussignac)
- Where
- Portugal
- Volunteers
- 24 people
- Sponsor
- Hospital Sao Joao
Acute Respiratory Failure
Correlation Between Trans Esophageal Pressure and Non-invasive Respiratory Support Failure in Patients With Acute Hypoxic Respiratory Failure
This study aims at assessing the correlation between trans esophageal pressure and related respiratory mechanics (including, among others, nasal pressure-Pnose) and non-invasive respiratory support failure in patients with acute…
- Trial name
- TEMPO (NCT03826797)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Modena and Reggio Emilia
Acute Respiratory Failure With Hypoxia
NAVA Helmet in Pediatric Respiratory Failure
Neurally Adjusted Ventilatory Assist (NAVA) is a new form of partial support wherein the machine applies positive pressure throughout inspiration in proportion to the electrical activity of the diaphragm (EAdi), Because…
- Trial name
- NCT02050217
- Testing
- Neurally Adjusted Ventilatory Assist
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
H1N1 Pneumonia, Hypoxemia
Rapamune Improves Outcomes of Severe H1N1 Pneumonia
Severe H1N1 pneumonia with acute respiratory failure shows hyperactive immune cells infiltration of lung. Rapamune, a mTOR inhibitor, modulates the immune response by blocking activation of T- and B-cells.
- Trial name
- NCT01620307
- Testing
- Sirolimus (Rapamune 2mg/day, Pfizer)
- Volunteers
- 38 people
- Sponsor
- Chang Gung Memorial Hospital
Covid19, Hypoxemia
A Study of Micro Dose Ambrisentan in Hospitalized Patients With Respiratory Insufficiency Due to COVID-19
Patients with COVID-19 frequently develop lower respiratory complications. Difficulty breathing and a low concentration of oxygen in the blood are of concern in patients with COVID-19, as they indicate that the lungs may be…
- Trial name
- NCT04771000
- Testing
- Ambrisentan
- Where
- 13 sites in Croatia, Spain
- Volunteers
- 88 people
- Sponsor
- Noorik Biopharmaceuticals AG
Hypoxemia
Therapy With High-flow Oxygen by Nasal Cannula vs Noninvasive Ventilation in Patients With Acute Hypoxemic Respiratory Failure: a Crossover Physiologic Study
Background and rationale: A large multicenter randomized controlled trial demonstrated that in patients with hypoxemic non-hypercapnic respiratory failure treatment with nasal high flow oxygen (NHF) resulted in a reduction of the…
- Trial name
- THIFON (NCT03865056)
- Testing
- Optiflow (High-flow Nasal Cannula), Non-invasive Ventilation
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Respiratory Failure With Hypoxia, Respiratory Failure, ICU
Weaning From High Flow Nasal Oxygen in Acute Respiratory Failure : a Target Trial Emulation
Acute respiratory failure is a frequent reason for admission to the intensive care unit (ICU). It is associated with high healthcare consumption and mortality.
- Conditions
- Respiratory Failure With Hypoxia, Respiratory Failure, ICU, High-Flow Nasal Oxygen Therapy
- Trial name
- HFNO-Weaning (NCT07030413)
- Where
- 3 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Poitiers University Hospital
Respiratory Failure With Hypoxia
Assessment of Tidal Volume During Non Invasive Oxygenation Techniques
High Tidal volume is one of the main mechanisms that lead to lung injuries under mechanical ventilation (ventilator induced lung injury: VILI).
- Trial name
- VOLHYPOX (NCT03445455)
- Testing
- Tidal volume measurement
- Volunteers
- 25 people
- Sponsor
- Henri Mondor University Hospital