Clinical trials: Adolescent
Attention Deficit Hyperactivity Disorder, ADHD
Imaging Stimulant and Non Stimulant Treatments for ADHD: A Network Based Approach
The growing number of medications used to treat attention-deficit/hyperactivity disorder (ADHD) raises important questions about whether different medications have similar or different therapeutic mechanisms of action.
- Trial name
- NCT01678209
- Testing
- fMRI scans, Atomoxetine arm, Methylphenidate arm
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Poliomyelitis, Diphtheria
Safety and Immunogenicity of a Booster Dose of GSK Biological's Boostrix-Polio Vaccine
Subjects aged 9 to 13 years who participated in the 711866/001 study 5 years ago will be evaluated for immune persistence and will receive a combined dTpa-IPV booster dose that will be evaluated in terms of immunogenicity, safety…
- Conditions
- Poliomyelitis, Diphtheria, Tetanus, Acellular Pertussis
- Trial name
- NCT00635128
- Testing
- Boostrix-Polio
- Where
- 38 sites in Germany
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
HIV Infections
Safety of and Immune Response to Dolutegravir in HIV-1 Infected Infants, Children, and Adolescents
Dolutegravir (DTG) is an HIV drug in the integrase inhibitor drug class. This study evaluated the pharmacokinetics (PK), safety, tolerability of and immune response to DTG when used concurrently with optimized background therapy…
- Trial name
- NCT01302847
- Testing
- DTG film-coated tablets, DTG granules for suspension, DTG dispersible tablets
- Where
- 33 sites in United States, Botswana and 6 more
- Volunteers
- 181 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Adolescent Behavior, Hiv
Data-informed Stepped Care (DiSC) to Improve Adolescent HIV Outcomes (UH3)
The investigators will conduct a Phase III cluster randomized controlled trial (cRCT) to evaluate the effectiveness of the implementation of a data-informed stepped care (DiSC) intervention for HIV treatment management among…
- Trial name
- NCT05007717
- Testing
- Data-informed Stepped Care (DiSC)
- Where
- 24 sites in Kenya
- Volunteers
- 1,911 people
- Sponsor
- University of Washington
Underage Drinking, Alcohol Use, Underage
REAL Parenting Alcohol and Substance Use App
High school students' alcohol, nicotine, and marijuana use are major public health problems. Among the many consequences of these risky behaviors are impaired driving and impaired passenger fatalities as well as increased health…
- Trial name
- RP (NCT03932097)
- Testing
- REAL Parenting, Active Control Materials
- Where
- United States
- Volunteers
- 612 people, healthy volunteers welcome
- Sponsor
- Real Prevention, LLC
Bipolar I Disorder, Schizophrenia
Study in Adolescents With Schizophrenia or Bipolar Disorder
Open-label safety study of oral olanzapine treatment in adolescents, aged 13 to 17 years, with bipolar I disorder (manic or mixed episodes) or schizophrenia.
- Trial name
- NCT00982020
- Testing
- Olanzapine, Standard behavioral weight intervention, Intense behavioral weight intervention
- Where
- 14 sites in United States, Poland and 2 more
- Volunteers
- 203 people
- Sponsor
- Eli Lilly and Company
Bipolar Disorder
Open-Label Study of N-Acetylcysteine in Children and Adolescents 5-17 With Bipolar Spectrum Disorders
Children between the ages of 5-17 years old who have or display symptoms of emotional dysregulation (explosiveness, mood swings, irritability, and/or violent behavior) are invited to participate in a 12-week research study to…
- Trial name
- NCT02357290
- Testing
- Open-label Treatment with N-Acetylcysteine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Psychiatric Diagnosis
A Digital Intervention to Improve Physical Activity and Sleep Behaviors in Youth With Psychiatric Diagnoses
The goal of "GamerFit" is to test the delivery of a theory-based mHealth app that utilizes social support, exergaming, and telehealth coaching to improve PA levels, sleep, and psychiatric symptoms among youth participants (ages…
- Trial name
- GamerFit (NCT05505578)
- Testing
- GamerFit Condition, Comparator Condition
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- Pennington Biomedical Research Center
Pain
A Study to Look at Tapentadol Tablets in Children and Adolescents in Pain
Tapentadol has already been studied in adults. This study is needed to find out if tapentadol works and is safe to use in children and adolescents with long-term pain.
- Trial name
- NCT02151682
- Testing
- Tapentadol prolonged release, Morphine prolonged release
- Where
- 23 sites in Belgium, Bulgaria and 8 more
- Volunteers
- 73 people
- Sponsor
- Grünenthal GmbH
Transition-age Youth, Developmental Disabilities
Evaluation of Project TEAM (Teens Making Environmental and Activity Modifications)
The purpose of this study is to determine the extent to which Project TEAM (Teens making Environment and Activity Modifications) is an effective, socially valid, and feasible intervention that prepares youth with developmental…
- Conditions
- Transition-age Youth, Developmental Disabilities, Cerebral Palsy, Autism
- Trial name
- ProjectTEAM (NCT02714868)
- Testing
- Project TEAM, Matched Comparison
- Volunteers
- 82 people
- Sponsor
- Boston University Charles River Campus
ART Adherence, HIV-1-infection
Call for Life Youth ART Adherence Study
Study purpose: To assess effect of mHealth Call for life Uganda tool (CFLU) on ART adherence among youth measured by interactive voice response to daily adherence calls mapped in the database and proportion with viral suppression…
- Conditions
- ART Adherence, HIV-1-infection, mHealth
- Trial name
- C4L-Youth (NCT04718974)
- Testing
- mHealth call for life system/ tool using IVR ( interactive voice response)
- Where
- Uganda
- Volunteers
- 206 people
- Sponsor
- Makerere University
Cancer
Individualized High Dose Methotrexate to Treat Cancer in Children Who Have a Significant Risk for Side Effects to Methotrexate
Pediatric cancer patients are being asked to take part in this study who have a cancer that is treated with high doses of the drug methotrexate (MTX).
- Trial name
- NCT02076997
- Testing
- Methotrexate
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Baylor College of Medicine
Diabetes Mellitus, Type 1, Nephropathy
Copeptin in Adolescent Participants With Type 1 Diabetes and Early Renal Hemodynamic Function
Over 1.25 million Americans have type 1 diabetes (T1D), increasing risk for early death from cardiorenal disease. The strongest risk factor for cardiovascular disease (CVD) and mortality in T1D is diabetic kidney disease (DKD).
- Conditions
- Diabetes Mellitus, Type 1, Nephropathy, Diabetic Nephropathies, Juvenile Diabetes
- Trial name
- CASPER (NCT03618420)
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 mg/mL
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Surgery, Anesthesia
Accuracy of the NICCI™ Monitor in Children and Adolescents
This is a prospective study that will compare the blood pressure readings from an arterial cannula with those obtained non-invasively by the NICCI device.
- Trial name
- NCT04373746
- Testing
- NICCI
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Joseph D. Tobias
Childhood Obesity
Summer Harvest Adventure: A Garden-based Obesity Prevention Program for Children Residing in Low-resource Communities
The objective of this study is to implement and test the efficacy of the "Summer Harvest Adventure," a comprehensive garden-based behavioral, social, and environmental intervention for children (ages 8-11 years) residing in…
- Trial name
- SHA (NCT05367674)
- Testing
- Summer Harvest Adventure, My Summer Plate (MSP)
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Metastatic Breast Cancer, Parenting
Fathers and Mothers Invested in Lives of Their Youth (FAMILY) Study: A Pilot Intervention
This is a single-arm pilot study to evaluate the feasibility and acceptability of a novel psychosocial intervention to improve psychosocial outcomes for parents with advanced cancer and their co-parents.
- Trial name
- FAMILY (NCT04092816)
- Testing
- FAMILY Intervention
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Pregnancy in Adolescence, Counseling
Reducing Adolescent Pregnancy
This multi-site study is employing a brief contraception counseling intervention in the Emergency Department (ED) to shed light on factors that affect decision making as well as barriers and facilitators to conception initiation…
- Conditions
- Pregnancy in Adolescence, Counseling, Contraception Behavior
- Trial name
- NCT04120376
- Testing
- Contraception Counseling
- Where
- 2 sites in United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Meningococcal Disease, Meningococcal Meningitis
A Study to Evaluate the Persistence and Immune Response to a Booster Dose of MenACWY
The primary objective is to evaluate the persistence of bactericidal antibodies in adolescent subjects who completed study V59P6 in which they received either Novartis Meningococcal (MenACWY) Conjugate Vaccine or Licensed…
- Trial name
- NCT01018732
- Testing
- Novartis Meningococcal (MenACWY-CRM) vaccine
- Where
- 3 sites in United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Atopic Dermatitis
Evaluation of Upadacitinib in Adolescent and Adult Patients With Moderate to Severe Atopic Dermatitis (Eczema)
The objective of this study is to assess the efficacy and safety of upadacitinib for the treatment of adolescent and adult participants with moderate to severe atopic dermatitis (AD) who are candidates for systemic therapy.
- Trial name
- Measure Up 1 (NCT03569293)
- Testing
- Upadacitinib
- Where
- 180 sites in United States, Argentina and 23 more
- Volunteers
- 912 people
- Sponsor
- AbbVie
Mother to Child Transmission, Pregnancy in Adolescence
Digital Intervention to Address Stigma Among Pregnant Adolescents Living With HIV
Pregnant adolescents living with HIV (ALHIV) in Kenya frequently experience stigma and difficulty telling a family member about their HIV and pregnancy status.
- Conditions
- Mother to Child Transmission, Pregnancy in Adolescence, Social Stigma, Self Disclosure
- Trial name
- NCT05383755
- Testing
- Digital intervention for pregnant adolescents living with HIV
- Where
- Kenya
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Pacific Institute for Research and Evaluation