Clinical trials: Adult
Smoking
Young Adults' Responses to Anti-smoking Messages
The purpose of this study is to determine whether anti-smoking messages based on promising smoking-related beliefs increase anti-smoking intentions more than messages based on less-promising beliefs.
- Trial name
- NCT01954407
- Testing
- Smoking-Related Messages
- Where
- United States
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Alpha1 Antitrypsin Deficiency, Alpha1-Proteinase Inhibitor Deficiency
Phase 4, Double-blind Study Evaluating the Response on Computed Tomography (CT) Lung Density Decline Rates of Respreeza / Zemaira Weekly for 3 Years in Adults With alpha1 Antitrypsin Deficiency (AATD)
This is a multicenter, parallel-group, double-blind, randomized phase 4 study designed to identify the optimal dose of CE1226 (2 active doses) to slow disease progression as assessed by reduced rates of annual lung density…
- Conditions
- Alpha1 Antitrypsin Deficiency, Alpha1-Proteinase Inhibitor Deficiency, Emphysema
- Trial name
- NCT07326592
- Testing
- CE1226
- Where
- 2 sites in Denmark
- Volunteers
- 270 people
- Sponsor
- CSL Behring
Relapsed Adult AML, Refractory AML
Venetoclax-Navitoclax With Cladribine-based Salvage Therapy in Patients With Relapsed/Refractory Acute Myeloid Leukemia
This is an open-label phase I study designed to evaluate the safety of venetoclax-navitoclax with cladribine-based salvage therapy.
- Trial name
- NCT06007911
- Testing
- Navitoclax Dose Level -1, Navitoclax Dose Level 0, Navitoclax Dose Level 1
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Dementia
Group Digital Gaming: Experiences of Older Adults Living With Dementia in an Activity for Cognitive Impairment
The study examines the effects of a group digital gaming intervention on cognitive function, mood, and behaviors in people with early to moderate levels of dementia, using Obie Technology by employing a pretest and posttest…
- Trial name
- PLwD (NCT07541144)
- Testing
- Group-Based Digital Gaming
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- George Mason University
Well-Being, Lifestyle, Healthy
An Exploratory Feasibility Study
This study explores the feasibility of ContextWell, a well-being education programme that combines an online webinar with an AI-powered behavioural nudging system.
- Conditions
- Well-Being, Lifestyle, Healthy, Young Adult, Behavior and Behavior Mechanisms
- Trial name
- Contextwell (NCT07009964)
- Testing
- ContextWell Educational Programme
- Where
- Ireland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Respiratory Distress Syndrome, Adult, Ventilator-Induced Lung Injury
Long Term Follow up of Children Enrolled in the REDvent Study
This is a prospective observational follow-up study of children enrolled in a single center randomized controlled trial (REDvent).
- Conditions
- Respiratory Distress Syndrome, Adult, Ventilator-Induced Lung Injury, Neurocognitive Dysfunction, Quality of Life
- Trial name
- NCT03709199
- Testing
- Ventilation Inhomogeneity, Diaphragm Ultrasound, Respiratory Inductance Plethysmography
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Children's Hospital Los Angeles
Stroke
Video-based Intervention to Address Disparities in Blood Pressure Control After Stroke
The purpose of this study is to examine the impact of a multidisciplinary telehealth-based model of outpatient stroke care on blood pressure control following stroke, and further, to evaluate its impact on racial disparities in…
- Trial name
- VIRTUAL (NCT05264298)
- Testing
- VIRTUAL, Standard care
- Where
- United States
- Volunteers
- 542 people
- Sponsor
- The University of Texas Health Science Center, Houston
Healthy Subjects
Drug-drug Interaction Study with TS-142 in Healthy Adult Subjects (concomitant Administration of Itraconazole)
This is an open-label, single-center, single-sequence study to evaluate the concomitant effects of the potent CYP3A inhibitor itraconazole on the single-dose pharmakokinetics, safety and tolerability of oral TS-142 in healthy…
- Trial name
- NCT04557163
- Testing
- TS-142, Itraconazole
- Where
- Japan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Taisho Pharmaceutical Co., Ltd.
Brain and Central Nervous System Tumors
Talampanel in Treating Patients With Recurrent High-Grade Glioma
RATIONALE: Drugs used in chemotherapy such as talampanel use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00064363
- Testing
- talampanel
- Where
- United States
- Sponsor
- National Institutes of Health Clinical Center (CC)
Presbyopia
Evaluate the Efficacy and Safety of CTO0307 in Adults With Presbyopia
This study was to compare the presbyopia correction effect between the treatment group and the control group, evaluated by the proportion of patients who achieved an improvement of 3 lines or more in mesopic binocular DCNVA at…
- Trial name
- NCT07723716
- Testing
- CTO0307 Eye drop
- Where
- South Korea
- Volunteers
- 167 people
- Sponsor
- Taejoon Pharmaceutical Co., Ltd.
Sickle Cell Crisis
Evaluation of the Efficacy of Intra-nasal Sufentanil for Analgesia of Vaso-occlusive Crisis in Sickle-cell Adults.
The analgesic treatment for vaso-occlusive crisis (VOC) in sickle-cell patients is an emergency. The reference treatment is morphine, which requires a venous way sometimes difficult to obtain in these patients.
- Trial name
- DREPSUFINDOL (NCT04076748)
- Testing
- Sufentanil, EMONO
- Where
- 8 sites in France, French Guiana and 1 more
- Volunteers
- 115 people
- Sponsor
- University Hospital, Bordeaux
Yellow Fever, Yellow Fever Immunisation
A Trial to Evaluate the Safety, Reactogenicity, and Immunogenicity of MVA-BN Yellow Fever Vaccine With and Without Montanide ISA-720 Adjuvant in 18-45 Year Old Healthy Volunteers
This study is a multi-center, double-blind, placebo-controlled, Phase I study to evaluate the safety, reactogenicity, tolerability, and immunogenicity of Modified Vaccinia Ankara-Bavarian Nordic-Yellow Fever (MVA-BN-YF) in…
- Trial name
- NCT02743455
- Testing
- ISA-720, MVA Smallpox Vaccine, MVA-BN Yellow Fever Vaccine
- Where
- 2 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy Adult
Vagal Nerve Stimulation for Interoception Modulation
Explore the effects of variable ingested volumes and auricular transcutaneous vagal nerve stimulation (taVNS) on brain and stomach outcomes in healthy adults.
- Trial name
- NCT03603730
- Testing
- taVNS
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Prodromal Alzheimer's Disease, Mild Cognitive Impairment
The Digital Memory Notebook
Compensatory aids (e.g., alarms, calendars) play an important supporting role when completing everyday tasks (e.g., appointments, medication management), and there is a growing body of scientific work suggesting that compensatory…
- Conditions
- Prodromal Alzheimer's Disease, Mild Cognitive Impairment, Subjective Cognitive Complaints
- Trial name
- DMN (NCT04240665)
- Testing
- Digital Memory Notebook (DMN) Application
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Davis
Quality of Life, Sleep
Effect of Simha Pranayama and Bhramari Pranayama Relaxation Technique on Sleep and Quality of Life
Day end work related mental and muscular tension is quite common among young healthy individuals. This tension dramatically disturb sleeping pattern which also effects QoL.
- Trial name
- NCT07729267
- Testing
- Simha pranayama, Bhramari Pranayama
- Where
- Pakistan
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Mohtishim Ahmed
Hepatitis C Infection With HIV Co-Infection
Safety and Efficacy of Ledipasvir/Sofosbuvir (LDV/SOF) Fixed-Dose Combination (FDC) for 6 Weeks in Adults With Acute Genotype 1 or 4 Hepatitis C Virus (HCV) and Chronic Human Immunodeficiency Virus (HIV)-1 Co-Infection
The primary objectives of this study are to determine the antiviral efficacy, safety, and tolerability of ledipasvir/sofosbuvir (LDV/SOF) fixed-dose combination (FDC) in adults with acute genotype 1 or 4 hepatitis C virus (HCV)…
- Trial name
- NCT02457611
- Testing
- LDV/SOF
- Where
- 4 sites in Germany, United Kingdom
- Volunteers
- 26 people
- Sponsor
- Gilead Sciences
Dementia, Neurocognitive Disorders
Prefrontal Cortex Dynamics of the Elderly During a Cognitive Stimulation Programme
This research aims to evaluate the effect of cognitive stimulation (CS) on the functioning of the prefrontal cortex (PFC), seeking an analysis of both cerebral hemodynamics in neuroplasticity and aspects related to the initiation…
- Conditions
- Dementia, Neurocognitive Disorders, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT04693611
- Testing
- Individual cognitive stimulation therapy (iCST), Functional near-infrared spectroscopy (fNIRS)
- Where
- Portugal
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- CEDIARA - Assoc. Solidariedade Social de Ribeira de Fráguas
Healthy Volunteers
A Study to Assess the Effects of Epetraborole on the QT Interval in Healthy Adult Subjects
A single-center, 4-way crossover study to evaluate the effect of single therapeutic and supratherapeutic oral doses of epetraborole on the heart rate (HR) corrected QT interval (QTc) by assessing concentration-QT (C-QT)…
- Trial name
- NCT05995444
- Testing
- Epetraborole, Moxifloxacin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AN2 Therapeutics, Inc
Pulmonary Tuberculosis
Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis With Clofazimine (C)-TMC207 (J)-PA-824 (Pa)-Pyrazinamide (Z)
The trial will evaluate the extended bactericidal activity of 14 consecutive days of oral administration of TMC207 plus PA-824 plus Pyrazinamide plus Clofazimine, TMC207 plus PA-824 plus Pyrazinamide, TMC207 plus PA-824 plus…
- Trial name
- NC-003 (NCT01691534)
- Testing
- TMC207 (J), PA-824 (PA), pyrazinamide (Z)
- Where
- 2 sites in South Africa
- Volunteers
- 105 people
- Sponsor
- Global Alliance for TB Drug Development
Vitamin D Concentration, Vitamin D Status
A Comparison of Capsules and Oral Spray Solution as Methods of Delivering Vitamin D3 and Raising Status
The aim of the study is to compare the effectiveness of a vitamin D3 oral spray solution with capsules at raising vitamin D status over winter.
- Trial name
- SCD3 (NCT02608164)
- Testing
- 3000IU(75μg) vitamin D3
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Ulster
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