Clinical trials: Age-related Functional Decline
Age-Related Cognitive Decline, Age-Related Memory Disorders
Memory Improvement With Docosahexaenoic Acid Study (MIDAS)
The purpose of this study is to investigate the effect of docosahexaenoic acid (DHA, 22:6n-3) in improving cognitive functions in subjects with age-related cognitive decline.
- Trial name
- MIDAS (NCT00278135)
- Where
- 14 sites in United States
- Volunteers
- 485 people
- Sponsor
- dsm-firmenich Switzerland AG
Frail Elderly Subjects
Omega-3 Fatty Acids and/or Multi-domain Intervention in the Prevention of Age-related Cognitive Decline
Epidemiological and fundamental research carried out in recent years has highlighted the role played by omega-3 fatty acids in the process of cognitive decline that accompanies advancing age and Alzheimer's disease.
- Trial name
- MAPT (NCT00672685)
- Testing
- omega-3, multi-domain intervention
- Where
- 13 sites in France, Monaco
- Volunteers
- 1,680 people
- Sponsor
- University Hospital, Toulouse
Age-related Cognitive Decline
Study on the Chronic and Acute Effects of Nordic Berry Beverage on Cognitive Function
The aim of the current study is to investigate whether acute and 12-weeks daily intake of Nordic berries can improve cognitive abilities of adults without cognitive disease, and whether the effect can be linked to changes in…
- Trial name
- SCANBerry (NCT05693441)
- Testing
- Active berry product, Reference berry-like product
- Where
- Sweden
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Aventure AB
Aging, Physical Activity
Effects of Regular Exercise on Cerebrovascular Reserve in Older Adults
While it is well established that physical inactivity is a modifiable risk factor for vascular disease and cognitive decline, the mechanism by which exercise exerts its protective effect on the cerebral circulation and cognition…
- Conditions
- Aging, Physical Activity, Cognitive Function
- Trial name
- BIM (NCT03158337)
- Testing
- Aerobic exercise
- Where
- Canada
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Subjective Cognitive Decline
Effects of Online Training Aimed at Increasing Participation in Everyday Life During a Pandemic (SCD Online).
This study evaluates the efficacy of Real-World Strategy Training (RWST) compared to a psycho-education workshop for improving everyday life performance in older adults with subjective cognitive decline (SCD).
- Trial name
- NCT04439500
- Testing
- Real World Strategy Training, Brain Education
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Baycrest
Age-Related Memory Disorders
A Safety and Efficacy Study of Ispronicline (TC-1734-112) in Subjects With Age Associated Memory Impairment (AAMI)
The purpose of this Phase II study is to evaluate the efficacy and safety of ispronicline (TC-1734-112) compared to placebo (inactive substance pill) in patients with age associated memory impairment (AAMI).
- Trial name
- NCT00109564
- Testing
- ispronicline (nicotinic acetylcholine receptor agonist)
- Where
- 15 sites in United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Targacept Inc.
Age-related Functional Decline, Mild Cognitive Impairment
Health Benefits of Nutraceutical Supplementation in Older Adults.
This study examines a multi-ingredient nutraceutical designed to support several areas of health in older adults, including muscle strength, cognitive function, immune response, and inflammation.
- Trial name
- NCT07534878
- Testing
- Powder containing whey isolate and herbal extracts (30g sachet)
- Where
- India
- Volunteers
- 23 people
- Sponsor
- GPLIFE HEALTHCARE PRIVATE LIMITED
Age-related Cognitive Decline
Cognitive Multi-Tasking Training in Healthy Older Adults
This study evaluated the feasibility of a remote web-based ecological cognitive training protocol to healthy older adults. The training protocol involves 5 training sessions.
- Trial name
- NCT04195230
- Testing
- Multi-tasking Training
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Columbia University
Ageing
Effectiveness of the WHO ICOPE (Integrated Care for Older People) Program in Preventing Age-related Functional Decline (ICOPE Trial.Fr)
The World Health Organization (WHO) has designed an integrated care program (ICOPE) aimed at maintaining the functions of elderly people to preserve their autonomy.
- Trial name
- ICOPE Fr (NCT06676839)
- Testing
- the complete ICOPE program
- Where
- 6 sites in France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Toulouse
Cognitive Decline, Healthy
The Effects of Attentional Filter Training on Working Memory
The investigators are interested in how attentional filter training/ distractor inhibition training could influence cognitive functions like working memory, executive control, problem solving, decision making and attentional…
- Conditions
- Cognitive Decline, Healthy, Age-related Cognitive Decline
- Trial name
- DIIN (NCT03228446)
- Testing
- filter training, memory training, no training (control)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- German Center for Neurodegenerative Diseases (DZNE)
Older People
Study of the Cognitive and Neurophysiological Effects of the Activ4Brain Program for Older Adults
This study aims to examine the cognitive, neuronal, and physical effects of the Activ4Brain program in older men and women between 55 and 75 years of age.
- Trial name
- Activ4Brain (NCT07108413)
- Testing
- Activ4Brain Program, Aerobic Exercise Program
- Where
- Portugal
- Volunteers
- 72 people
- Sponsor
- University of Coimbra
Alzheimer's Disease
Effects of Triglycerides on Age-Related Cognitive Function Decline in Older Subjects
This is a single centre, 2 part study in older subjects. Part 1 (Pharmacokinetic [PK] Assessment) is a double blind, randomized, placebo-controlled 4-period crossover study investigating the PK profile of four different doses of…
- Trial name
- NCT01702480
- Testing
- GSK2981710
- Where
- United Kingdom
- Volunteers
- 116 people
- Sponsor
- GlaxoSmithKline
Perimenopause, Perimenopause-Related Depression
Intra Ovarian Muse Cell Injection for Perimenopause Symptom Relief and Ovarian Function Restoration (MUSE-OVARY)
This observational study examines the safety and effects of injecting Muse cells (a type of naturally occurring stem like cells found in adult tissues such as fat or bone marrow) directly into the ovaries of women aged 28 to 70…
- Conditions
- Perimenopause, Perimenopause-Related Depression, Premature Ovarian Insufficiency, Premature Ovarian Failure (POF)
- Trial name
- MUSE-OVARY (NCT07511660)
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- Healing Hope International
Age-related Cognitive Decline
ItaliaN Study With Tailored Multidomain Interventions to Prevent Functional and Cognitive Decline in Community-dwelling Older Adults
The goal of this interventional non-pharmacological study is to investigate the effects of a multi-domain intervention ( "active intervention"), compared to that followed by normal clinical practice ("self-guided intervention")…
- Trial name
- IN TeMPO (NCT06248723)
- Testing
- Nutritional intervention, Physical exercise, Cognitive training
- Where
- Italy
- Volunteers
- 1,340 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
Subjective Cognitive Decline, Cognitive Performance
Modulation of Attention in Event Related Potential (ERPs) as a Marker of Early Cognitive Decline by Ginkgo Biloba
The objective of this study is to simultaneously establish the metrological characteristics of the new executive function markers (decision making and multiple flow management) derived from repeated ERP variations and to identify…
- Conditions
- Subjective Cognitive Decline, Cognitive Performance, Functional Capacity, Age-related Cognitive Decline
- Trial name
- AgilGinkgo (NCT04121728)
- Testing
- Ginkgo biloba extract
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Jean-François Démonet
Obesity (Disorder), Obesity
Effect of Vitamin D on Body Composition and Functionality of Older Adults
Older adults with obesity often experience a gradual loss of muscle mass and muscle strength, a condition sometimes described as sarcopenic obesity.
- Conditions
- Obesity (Disorder), Obesity, Sarcopenia, Sarcopenia in Elderly
- Trial name
- NCT07275177
- Testing
- Vitamin D
- Where
- Mexico
- Volunteers
- 29 people
- Sponsor
- Universidad Autónoma Benito Juárez de Oaxaca
Functional Decline, Hospitalization-associated Disability
Incidence and Risk Factors for Hospitalization-Associated Disability
This prospective cohort study aims to determine the incidence of hospitalization-associated disability and its association with risk factors at the patient level and with care and hospital processes.
- Conditions
- Functional Decline, Hospitalization-associated Disability, Iatrogenic Disease
- Trial name
- NCT02572999
- Testing
- Not applicable (observational design)
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Aging, Cognitive Change
Cardiorespiratory Fitness, Apolipoprotein E Genotype, and Cognitive Functions: A Prospective Study
The current research project aims to investigate the interaction of cardiorespiratory fitness (CRF) and the ApoE genotype with neurocognitive functions.
- Trial name
- NCT05652140
- Testing
- Data collections
- Where
- Taiwan
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Age-related Cognitive Decline
Cognitive Engagement and Aging Mind
The purpose of this research is to examine whether and to what extent training of different types of cognitive engagement will improve performance on fluid cognitive abilities that typically decline with age.
- Trial name
- NCT05924490
- Testing
- Real-time strategy-based videogame training, Semantic Knowledge training
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Alzheimer Disease, Old Age; Dementia
Blood Biomarkers for Alzheimer Disease and Neuro-injury to Estimate the Association With Cognitive/Functional Decline and Mortality in a Real-world Population of GERiatric Hospitalized Patients (BAD-GER)
The BAD-GER study is a multicenter, prospective, three-arm observational study serving to validate a prognostic biomarker algorithm for mortality and hospital readmission; this algorithm will be developed through the…
- Trial name
- BAD-GER (NCT07435467)
- Testing
- collection of blood samples
- Where
- 3 sites in Italy
- Volunteers
- 400 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani