Clinical trials: Aggression
Violence Risk, Early Psychosis
BRAVE Program to Improve Safety and Reduce Violence Risk in Early Psychosis
This study evaluates the feasibility and acceptability of BRAVE, a manualized cognitive behavioral therapy (CBT)-based intervention designed to address dynamic risk factors for violence among young adults with early psychosis.
- Trial name
- BRAVE (NCT07417904)
- Testing
- BRAVE (Behavioral Response Against Violence Engagement), Treatment As Usual (TAU)
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Howard University
Aggression Childhood, Bullying Victimization
Examining the Efficacy of the PRAISE With Coaching Program
The PReventing Aggression In Schools Everyday (PRAISE) Program has evidence of impact when run by research staff. PRAISE was adapted using community-based participatory research to a coaching model whereby school-staff are…
- Conditions
- Aggression Childhood, Bullying Victimization, Social Behavior
- Trial name
- NCT07191782
- Testing
- Universal, classroom-based, Bullying and Aggression Prevention Program
- Where
- United States
- Volunteers
- 1,008 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Sexual Behavior, Alcohol Drinking
Alcohol & Men's Sexual Risk Behaviors
This project extends the investigators' previous research regarding the intersecting risks of alcohol, sexual risk behavior (SRB), and sexual aggression (SA) in male drinkers who have sex with women by examining the mediating and…
- Conditions
- Sexual Behavior, Alcohol Drinking, Sexual Aggression, Emotions
- Trial name
- NCT06158880
- Testing
- Alcoholic Beverage, Non-alcoholic Beverage, Partner Negative Mood Manipulation
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- Arizona State University
Aggression, Self-injurious Behavior
Refinements of Functional Communication Training
Although treatments for problem behavior, like functional communication training (FCT), can be highly effective in the clinic, changes in the way the FCT is implemented (e.g., when transferring treatment to the home, when…
- Trial name
- NCT04045600
- Testing
- Trad FCT, Mult FCT, Mult FCT + Stimulus Fading
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Rutgers, The State University of New Jersey
Autism Spectrum Disorder, Irritability
Behavior Therapy for Irritability in Autism
This is a clinical trial of a novel intervention, Behavioral Therapy for Irritability and Aggression (BTIA), for adolescents on the autism spectrum.
- Conditions
- Autism Spectrum Disorder, Irritability, Disruptive Behavior, Anger
- Trial name
- BTIA (NCT04654260)
- Testing
- Behavioral Therapy for Irritability in Autism, Psychoeducation and Supportive Therapy (PST)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Yale University
Schizophrenia Disorder, Schizoaffecitve Disorder
A Virtual Reality Mindfulness Application for Aggression in Schizophrenia
The study investigates whether a virtual reality-based mindfulness based intervention can reduce impulsive aggression in individuals with schizophrenia or schizoaffective disorder.
- Conditions
- Schizophrenia Disorder, Schizoaffecitve Disorder, Aggression
- Trial name
- NCT07434479
- Testing
- Mindfulness-Based Virtual Reality Intervention
- Where
- 2 sites in United States
- Volunteers
- 58 people
- Sponsor
- Manhattan Psychiatric Center
Workplace Violence, Health Professionals
Chatbot to Support Healthcare Professionals Experiencing Workplace Aggression
This study aims to design, develop, and validate a chatbot (SANIDAD SEGURA) intended to support healthcare professionals who experience workplace aggression.
- Conditions
- Workplace Violence, Health Professionals, Chatbot, Digital Health
- Trial name
- Sanidad-Segura (NCT07473531)
- Testing
- Chatbot SANIDAD SEGURA
- Where
- Spain
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Distrito Sanitario Almeria
Mental Health, Psychological Trauma
Pathway-Matched Resilience-Oriented Therapy in Rwanda
This pragmatic, pathway-stratified, cluster-randomized waitlist-controlled trial evaluated Resilience-Oriented Therapy (RoT), a culturally adapted group-based psychosocial intervention for post-genocide Rwanda.
- Conditions
- Mental Health, Psychological Trauma, Stress Disorders, Post-Traumatic, Depression
- Trial name
- RoT-CRT (NCT07621731)
- Testing
- Resilience-Oriented Therapy - Emotion-Regulation Variant, Resilience-Oriented Therapy - Identity-Development Variant, Resilience-Oriented Therapy - Behavioural Self-Management Variant
- Where
- 5 sites in Rwanda
- Volunteers
- 427 people
- Sponsor
- Alexandros Lordos, PhD
Aggression, Critical Care Staff
Intensive Care Unit Conflict Mediation Study
To evaluate the impact of a structured, multidisciplinary conflict management program incorporating an interprofessional Singular Care Plan *PAS* Committee and a Conflict Mediation Team on the incidence and severity of conflicts…
- Conditions
- Aggression, Critical Care Staff, Workplace Violence
- Trial name
- "GIRAFFE" (NCT07621874)
- Testing
- SEM DESTINO
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital Israelita Albert Einstein
Aggression
NIH R01 Friend to Friend With Coaching
This study examines the effectiveness of the Friend to Friend (F2F) program when conducted by teachers and counselors with active coaching from the research team.
- Trial name
- NCT04164472
- Testing
- Friend to Friend (F2F) with Coaching
- Where
- United States
- Volunteers
- 5,250 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Conduct Disorder, Antisocial Behavior
The Effectiveness of Forensic Outpatient Systemic Therapy: a Multiple Case Experimental Design
The purpose of this study is to investigate the effectiveness and mediators of Forensic Outpatient Systemic Therapy (FAST).
- Conditions
- Conduct Disorder, Antisocial Behavior, Aggression, Behavioral Disorder
- Trial name
- FAST (NCT06032520)
- Testing
- FAST
- Where
- 2 sites in Netherlands
- Volunteers
- 21 people
- Sponsor
- Utrecht University
Alzheimer Disease, Agitation in Dementia
Human Mesenchymal Stem Cells (hMSC) in Behavioral Problems Due to Alzheimer's Disease.
The purpose of this research study is to test if adding one infusion of mesenchymal stem cells to the current treatment with antipsychotic medication may help control behavioral problems in people with a diagnosis of moderate to…
- Trial name
- NCT06781333
- Testing
- hMSC
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Bernard (Barry) Baumel
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health in Tavua, Fiji
Ambient air temperatures in Fiji are increasing due to climate change. Solutions are needed to build heat resilience in communities and adapt.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- NCT07592117
- Testing
- Cool roof
- Where
- Fiji
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Autism, Intellectual Disability
Cognitive-Behavioral Therapy for Irritability in Children With Autism Spectrum Disorder and Intellectual Disability
In addition to the core symptoms, children and adolescents with Autism Spectrum Disorder (ASD) often exhibit disruptive behavior problems including irritability, tantrums, noncompliance, and aggression.
- Trial name
- NCT02914951
- Testing
- Cognitive-Behavioral Therapy, Functional magnetic resonance imaging (fMRI)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Yale University
Problem Behavior, Aggression
Manualized Assessment and Treatment Model of Challenging Behavior
Despite decades of mounting single-case-design evidence for the efficacy of applied behavior analysis (ABA) and other approaches for the assessment and treatment of challenging behavior, an evidence-based comprehensive approach…
- Conditions
- Problem Behavior, Aggression, Self-Injury
- Trial name
- NCT05928247
- Testing
- Functional Communication Training (FCT), Non-Contingent Reinforcement (NCR), Competing Items and Response Blocking
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Conduct Disorder, Mentalization Based Therapy
Using Mentalization Based Therapy to Support Children and Adolescents Referred to Specialist Mental Health Services in the NHS for Aggressive and/or Violent Behaviour
The MICA Study is a research project that has been designed to work out how helpful mentalisation based therapy is. This is a new type of support that helps young people make sense of their own behaviours and feelings, and those…
- Conditions
- Conduct Disorder, Mentalization Based Therapy, Violent Behavior, Aggressive Behaviour
- Trial name
- MICA (NCT07091721)
- Testing
- Mentalization based therapy (MBT), Support as usual
- Where
- 8 sites in United Kingdom
- Volunteers
- 632 people
- Sponsor
- Anna Freud
Anger, Aggression
Mindfulness for Anger in Veterans With PTSD
Research has consistently shown that Veterans with PTSD are more likely to experience higher levels of anger and commit aggressive acts compared to Veterans without PTSD.
- Trial name
- NCT02882802
- Testing
- Mindfulness Based Stress Reduction, Trauma Recovery Education Class
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-Traumatic, Depression
Resettled Refugee Families for Healing
The goal of this type I hybrid effectiveness-implementation trial is to test a family strengthening (FS) model delivered through multiple family groups (MFG) combined with a virtual peer mentoring program called TeenAge Health…
- Conditions
- Stress Disorders, Post-Traumatic, Depression, Antisocial Personality Disorder, Anxiety
- Trial name
- RRF4H (NCT06176638)
- Testing
- RRF4H Combination Intervention
- Where
- United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Problem Behavior, Aggression
Basic and Applied Research on Extinction Bursts
Although highly effective, treatments like FCT include extinction, which can have adverse side effects. The extinction burst, an increase in the frequency or intensity of destructive behavior at the start of treatment, is the…
- Conditions
- Problem Behavior, Aggression, Self Injury
- Trial name
- NCT05925101
- Testing
- Extinction-only condition, Rate-drop condition, Rate-hold condition
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Bullying Behavior, Aggressive Behavior
Dramatic Play and Bullying Behaviors in Preschool Children
This study aims to examine the effect of dramatic play-based activities on bullying behaviors in preschool children; and to evaluate the effects of these activities on empathy levels and social interaction skills, thereby…
- Trial name
- DRAMA-BULLY (NCT07371884)
- Testing
- dramatic play intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ataturk University