Clinical trials: Aging Frailty
Frailty, Frailty Syndrome
Prevalence, Determinants and Natural History of Frailty and Pre-frailty in Elderly People
Frailty syndrome (i.e. frailty) is a geriatric syndrome which relies on the reduction of multisystem reserve capacity. Frail people have a lower potential to respond to external stressors and various life incidents as well as…
- Conditions
- Frailty, Frailty Syndrome, Frail Elderly Syndrome, Fragility
- Trial name
- FRAILPOL (NCT04518423)
- Where
- Poland
- Volunteers
- 1,093 people, healthy volunteers welcome
- Sponsor
- The Opole University of Technology
Quality of Life, Syndromes
Long-term Follow-up of the Helsinki Businessmen Study
The Helsinki Businessmen Study (HBS) is a clinico-epidemiological longitudinal study started in 1964. It also included a 5-year randomized, controlled multifactorial primary prevention trial of cardiovascular diseases between…
- Conditions
- Quality of Life, Syndromes, Aging, Cardiovascular Disease
- Trial name
- HBS (NCT02526082)
- Testing
- Intervention
- Volunteers
- 3,490 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
HIV
mHealth Physical Activity Trial for Older HIV-infected Adults (mFIT)
This pilot study will examine the effect of a mobile health text messaging platform linked to a digital physical activity tracker on physical activity among persons living with HIV and frailty.
- Trial name
- NCT03708640
- Testing
- Digital Activity Tracker, Smart Text Messaging, Physical Activity Counseling
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
HIV Infections, Frailty
Sleep Quality and Frailty Among People Living With HIV
With effective antiretroviral therapy (ART), people living with HIV (PLWH) are living longer and are increasingly experiencing aging-related conditions such as frailty and sleep problems.
- Conditions
- HIV Infections, Frailty, Sleep Quality, Oral Frailty
- Trial name
- NCT07880054
- Testing
- No intervention (observational assessments)
- Where
- Taiwan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National Sun Yat-sen University
Aging, Frailty
A Randomized Controlled Trial Comparing Whole Body Vibration Therapy With Usual Care and Usual Care to Improve Muscle Health in Older Adults
This study is a randomized controlled trial where participants would be randomly assigned to one of 2 groups. One group would receive Whole body vibration therapy and usual care and the other group only usual care.
- Conditions
- Aging, Frailty, Sarcopenia, Muscle Strength
- Trial name
- NCT07205133
- Testing
- Whole Body Vibration Training, Otago Exercise
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Changi General Hospital
Diabetes, Hypertension
Electronic-Nutrition-Optimizer for Personalized Prevention
This study aims to develop and validate a tool for immediate nutrition assessment and to test its user feasibility in routine clinical practice for health promotion.
- Conditions
- Diabetes, Hypertension, Frailty, Dementia
- Trial name
- eNO (NCT04866264)
- Testing
- eNutrition Optimizer
- Where
- Switzerland
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Heike Bischoff-Ferrari
Aging, Frailty
Renal Ageing-sarcopenia Network
Frailty is a syndrome in which the accumulation of small, individually insignificant deficits leads to heightened vulnerability to adverse events and predisposes to potential catastrophic decompensation.
- Conditions
- Aging, Frailty, Hypertension, CKD
- Trial name
- NCT04630132
- Where
- Italy
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Frailty, Physical Inactivity
Effectiveness of Graded Training in the Vivifrail Exercise Program Among Long-Term Care Residents
This study evaluates the effectiveness of the Vivifrail multicomponent physical exercise program among elderly residents with different levels of frailty in long-term care centers.
- Conditions
- Frailty, Physical Inactivity, Aging
- Trial name
- NCT06975449
- Testing
- Multicomponent Physical Exercise Program (Vivifrail)
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Aging, Fall
Hydraulic Resistance and Older Adults
The goal of this quasi-experimental study using a pre and post test design is to learn about the effect of participating in an exercise program with hydraulic exercise equipment on fall risk in the older adult population.
- Conditions
- Aging, Fall, Old Age; Debility, Muscle Weakness
- Trial name
- NCT06353438
- Testing
- Exercise Program
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- College of Staten Island, the City University of New York
Aging, Functional Status
Remote Physical and Cognitive Training Effects in Older Adults at Increased Risk of Clinical-functional Vulnerability
This study is a randomized, single-blind, parallel, controlled, superiority trial. The main objective is to verify the chronic effects of a remote 12-week low-intensity physical training program alone or in combination with…
- Trial name
- NCT05309278
- Testing
- Physical training, Cognitive training
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Old Age; Debility
Older People Gait: Physiomechanics and Functionality
The aim of study is to investigate gait in active elderly people regarding the kinematic parameters of gait, indicators of physical fitness and quality of life.
- Trial name
- NCT04348539
- Testing
- Balance training
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Nursing Caries, Old Age; Debility
Multifactorial Study of the Relationship Between the Conditions of Life and the Incidence of Risk of Falling
HYPOTHESIS: The incidence of risk of falls is related to the living conditions of elderly people in the community. OBJECTIVES: To study the relationship between living conditions and the incidence of risk of falls in older adults…
- Conditions
- Nursing Caries, Old Age; Debility, Aging Disorder
- Trial name
- NCT04301713
- Testing
- Evaluation of rik of falls
- Where
- Spain
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Dance, Older Adults
Dose-response Effect of Community Dance Programme
The goal of this interventional study is to examine the dose-response effect of Community Dance Programme (CDP) on the physical, cognitive and psychological health of pre-frail and mildly frail community-dwelling older adults.
- Conditions
- Dance, Older Adults, Frailty at Older Adults, Active Ageing
- Trial name
- NCT07081191
- Testing
- Dance, Active Control
- Where
- Singapore
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Frailty, Frail Elderly Syndrome
Education for Prevention and Treatment of Frailty
Frailty is a condition with a high prevalence in older adults, leading to higher vulnerability and increasing the risk of adverse health outcomes and disabilities.
- Trial name
- FRAGSALUD (NCT05610605)
- Testing
- Health intervention programme: FRAGSALUD
- Where
- Spain
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- University of Cadiz
Frailty, Emergencies
ER2 Frailty Levels and Incident Adverse Health Events in Older Community Dwellers
Older adults' health and functional status are heterogeneous because of the various cumulative effects of chronic diseases and physiologic decline, contributing to a vicious cycle of increased frailty 1-4.
- Conditions
- Frailty, Emergencies, Aging
- Trial name
- NCT04431986
- Testing
- No intervention: secondary use of a database
- Volunteers
- 1,741 people, healthy volunteers welcome
- Sponsor
- Jewish General Hospital
Frail Elderly Syndrome, Mood
FOCUS Guidelines and Adherence to Physical Activity in Ageing Women.
The study aimed at assessing whether the guidelines from the European project FOCUS had an effect on adherence to a physical activity program in older women.
- Conditions
- Frail Elderly Syndrome, Mood, Quality of Life, Cognitive Decline
- Trial name
- NCT03981965
- Testing
- Physical activity
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Frail Elderly Syndrome
Development of Clinical Indicators From the Swiss RAI-HC
The project aims at deriving frailty (FI) and complexity (CI) indices from data collected with the Resident Instrument Assessment - Home Care adapted for Switzerland (RAI-HC).
- Trial name
- IndiRAI (NCT03139162)
- Testing
- Swiss RAI-HC assessment
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- School of Health Sciences Geneva
Health Services Accessibility, Rural Health
Health Ahead Comparative Effectiveness Study
The Health Ahead Comparative Effectiveness Study is a pragmatic, parallel-arm interventional platform that systematically compares successive changes to preventive health screening on the path toward a fully automated screening…
- Conditions
- Health Services Accessibility, Rural Health, Medically Underserved Area, Preventive Health Services
- Trial name
- HACE (NCT07669168)
- Testing
- AI-Assisted Screening Interpretation (AI Reads), Human-Only Screening Interpretation
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- William Brandenburg, MD
Frailty, Ageing Well
Healthy Older Adults Through Movement and Engagement
The HOME Project evaluates the effects of structured health dialogues with individuals aged 67-84 years in the municipality of Borgholm, Sweden.
- Conditions
- Frailty, Ageing Well, Prevention Intervention, Health Related Quality of Life
- Trial name
- HOME (NCT07136168)
- Testing
- Health dialogue
- Where
- Sweden
- Volunteers
- 2,952 people, healthy volunteers welcome
- Sponsor
- Linkoeping University
Aging, Frailty
Mitophagy and Autophagy in Elderly Subjects
In recent years, evidence has shown that mitochondrial dysfunction plays an important role in the development of age-related muscle decline that may lead to frailty.
- Conditions
- Aging, Frailty, Mitophagy
- Trial name
- NCT02472340
- Testing
- Muscle Biopsy
- Where
- Netherlands
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Amazentis SA