Clinical trials: Airway Disease
Airway Obstruction, Asthma
Effects of Combined Respiratory Muscle Training and Steam Inhalation
The purpose of this investigation is to obtain more information on the efficacy and safety of respiratory training methods with WellO2 in patients with asthma and COPD.
- Conditions
- Airway Obstruction, Asthma, COPD
- Trial name
- NCT04584398
- Testing
- Respiratory muscle training with steam inhalation
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- WellO2 Oy
Asthma, Obesity
Obesity, Metabolic Dysregulation and the Airway Epithelium in Asthmatics
The objective of this pilot study is to determine whether obesity and metabolic syndrome are in fact synergistic in relation to airway nitric oxide (NO) biology.
- Conditions
- Asthma, Obesity, Metabolic Syndrome
- Trial name
- NCT03215836
- Testing
- Bronchoscopy and Nasal Epithelium Brush Sampling
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Obstructive Sleep Apnea
CES-EES Clinical Score and a Wearable Ring Sensor for Obstructive Sleep Apnea: Individual and Combined Validation Against In-Laboratory Polysomnography
This study evaluates whether a clinical upper airway assessment tool (the Clinical Examination Score plus ENT Examination Score, CES-EES) and an artificial-intelligence wearable ring (Belun Ring, Belun Sleep System BLS-100) can…
- Trial name
- NCT07785999
- Testing
- Belun Ring (Belun Sleep System BLS-100), CES-EES Clinical Scoring
- Where
- Malaysia
- Volunteers
- 58 people
- Sponsor
- University of Malaya
Moderate COPD
Endobronchial Valves in Moderate COPD
Despite the best medical therapy many people with emphysema remain breathless and limited in their daily activities. In emphysema the lungs do not empty properly when the person breathes out.
- Trial name
- REMODEL (NCT01969734)
- Testing
- Zephyr endobronchial valve placement
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- Sherwood Forest Hospitals NHS Foundation Trust
Obesity, Asthma
Bariatric and Obstructive Lung Disease Study II
The prevalence of obesity and asthma has significantly increased over the past two decades. The purpose of this study is to try and understand the mechanism by which obesity leads to airway hyperresponsiveness (AHR), one of the…
- Trial name
- BOLD II (NCT01127399)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Bronchiolitis Obliterable Syndrome
Longitudinal Pulmonary Chronic Graft-versus-host-disease (GvHD) Assessment in Hematopoietic Stem Cell Transplantation (HSCT) Patients
Prospective observational study on the clinical characteristics of pulmonary graft-versus-host disease in patients after hematopoietic stem cell transplantation.
- Trial name
- NCT07297303
- Where
- Taiwan
- Volunteers
- 600 people
- Sponsor
- National Taiwan University Hospital
Obstructive Sleep Apnea, Sleep-disordered Breathing
Combination Upper-Airway Electrical and Pharmacological Stimulation for Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a common condition in which the airway repeatedly collapses during sleep, leading to poor sleep quality and reduced oxygen levels.
- Trial name
- NCT07577661
- Testing
- Combination device and drug: Unilateral hypoglossal nerve stimulation & atomoxetine-plus-oxybutynin (HGNS+AtoOxy), Unilateral hypoglossal nerve stimulation (HGNS), active comparator condition, Atomoxetine-plus-oxybutynin (80/5 mg) (AtoOxy), active comparator condition
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Brigham and Women's Hospital
Allergic Rhinitis, Asthma
Leukotriene D4 Nasal Provocation Test in Allergic Rhinitis
Leukotrienes play critical roles in the inflammatory process in allergic rhinitis and bronchial asthma, therefore, anti-leukotriene therapy is part of treatment for asthma.
- Trial name
- NCT01963741
- Testing
- leukotriene D4, histamine
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Sleep Apnea, Dyslipidemias
CPAP Effect on Lipid Profile and Hyperuricemia in Patients With Dyslipidemia and Moderate-severe Obstructive Sleep Apnea
Clinical Trial Phase IV Indication: Moderate-severe obstructive sleep apnea and dyslipidemia. Objectives: Main objective: To test whether 12 months of CPAP treatment associated with conventional pharmacological treatment improves…
- Conditions
- Sleep Apnea, Dyslipidemias, Hyperuricemia
- Trial name
- CPAPLIP (NCT06463561)
- Testing
- Continuous positive airway pressure, Hygienic-dietary recommendations and daily physical activity promotion
- Where
- Spain
- Volunteers
- 220 people
- Sponsor
- Hospital Universitario La Paz
Asthma
Effect of Benralizumab on Airway Remodeling in Asthma
The anti-interleukin (IL)-5 receptor benralizumab inhibits eosinophilic inflammation but its potential effect on airway remodeling remains unknown.
- Trial name
- BENRAMOD (NCT04365205)
- Testing
- Endobronchial biopsy
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Airway Obstruction, Difficult Intubation
Evaluation of the Use of Tracheal Intubation Through a Laryngeal Tube to Intubate Anesthetized Patients
Failed intubation is currently one of the most important factors leading to morbidity and mortality in anesthesia. The development of supraglottic airway devices (SGDs), such as the intubating laryngeal tube, has revolutionized…
- Trial name
- IKING (NCT03165461)
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Formacion Internacional para la Docencia e Investigación de la Vía Aérea
Sleep Apnea, Obstructive, Sleep Apnea
Transoral Daytime Neuromuscular Electrical Stimulation in Patients With Simple Snoring
Sleep Disordered Breathing (SDB) is a spectrum of conditions spanning from Simple Snoring to Severe Sleep apnea. SDB has multiple underlying mechanisms.
- Conditions
- Sleep Apnea, Obstructive, Sleep Apnea, Sleep, Snoring
- Trial name
- SnooZeal-snore (NCT03913494)
- Testing
- Transoral Neurostimulation Device (Snoozeal)
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- University of California, San Diego
Acute Respiratory Distress Syndrome, Acute Lung Injury (ALI)
Intrabronchial Airway Pressures in Intubated Patients During Bronchoscopy
The purpose of this study is to examine changes in ventilation and airway pressures during conventional bronchoscopy of intubated patients.
- Trial name
- NCT01078831
- Testing
- Bronchoscopy
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
OSA - Obstructive Sleep Apnea, Dysphagia
Effects of Surgery on Oral Frailty and Dysphagia in Patients With Obstructive Sleep Apnea
Dysphagia is a commonly reported complaint among patients with obstructive sleep apnea (OSA), particularly those who have undergone upper-airway (oropharyngeal) surgery.
- Conditions
- OSA - Obstructive Sleep Apnea, Dysphagia, Oral Frailty
- Trial name
- NCT07880067
- Testing
- Upper airway surgery for OSA, Non-surgical management
- Where
- Taiwan
- Volunteers
- 450 people
- Sponsor
- National Sun Yat-sen University
Obstructive Sleep Apnea
Targeted CPAP Therapy for Obstructive Sleep Apnea in Pregnancy
Prospective, randomized controlled trial. Pregnant women in early pregnancy will be randomized to either the Sleep Study + CPAP (Continuous Positive Airway Pressure Therapy) group or to a Standard Prenatal Care group.
- Trial name
- NCT02755831
- Testing
- CPAP, Pre-natal care
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Acute Lung Injury
Effects of Airway Conditioning Devices on Ventilator Associated Pneumonia:a Randomized Clinical Trial
The main hypothesis are: 1. Passive and Active-Passive airway conditioning devices reduce the incidence of ventilator associated pneumonia 2.
- Trial name
- AirconVAP (NCT01150864)
- Testing
- Airway Conditioning
- Where
- Italy
- Volunteers
- 190 people
- Sponsor
- Università degli Studi dell'Insubria
Respiratory Failure, Respiratory Disorders
Ventilator Hyperinflation and Hemodynamics
Ventilator hyperinflation (VHI) has been shown to be effective in improving respiratory mechanics, secretion removal, and gas exchange in mechanically ventilated patients; however, the literature is scarce concerning its safety…
- Trial name
- VHI-HD (NCT03557645)
- Testing
- Baseline Mechanical Ventilation, VHI With Inspiratory Pause, VHI Without Inspiratory Pause
- Where
- Brazil
- Volunteers
- 17 people
- Sponsor
- Centro Universitário Augusto Motta
Lung Cancer, Emphysema
CryoSpray Ablation(tm)Thoracic Patient Registry
The purpose of this study is to create a patient registry to collect and analyze information on subjects treated with the CryoSpray Ablation™ System post-510K approval.
- Conditions
- Lung Cancer, Emphysema, Chronic Bronchitis, COPD
- Trial name
- NCT00785239
- Sponsor
- CSA Medical, Inc.
Chronic Obstructive Pulmonary Disease (COPD), Severe Asthma
COINCIDE: Cardineurovascular dIsease and Obstructive Airway Disease
Patients with chronic obstructive pulmonary disease (COPD) and severe asthma frequently present with cardiovascular comorbidities that contribute substantially to morbidity and mortality.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Severe Asthma, Cardiovascular Diseases
- Trial name
- COINCIDE (NCT07856667)
- Testing
- Routine Clinical Care
- Volunteers
- 350 people
- Sponsor
- VASCage GmbH
Obstructive Sleep Apnea
Evaluation of Treatment Efficacy of a Modified Positive Airway Pressure Device to Treat Obstructive Sleep Apnea
This study will investigate the efficacy of the FPH modified positive airway pressure (PAP) device with or without SensAwake; and with different pressure support in OSA participants; in both an in-home and in-lab environment.
- Trial name
- NCT02971436
- Testing
- FPH Device with SensAwake On + Pressure Support A, FPH Device with SensAwake Off + Pressure Support A, FPH Device with SensAwake On + Pressure Support B
- Where
- 2 sites in New Zealand
- Volunteers
- 29 people
- Sponsor
- Fisher and Paykel Healthcare
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