Clinical trials: Analgesia, Epidural
Obstetric Pain
Effect of Preemptive Epidural Analgesia in Labor on Cytokine Production
During labor there is an increased production of inflammatory mediators called cytokines. Higher concentration of certain cytokines has been linked to adverse neonatal and maternal outcomes.
- Trial name
- NCT00361712
- Testing
- Preemptive epidural analgesia, Standard of care
- Where
- Israel
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Pain Control After Elective Hepatectomy
Epidural Versus Paravertebral Block Analgesia After Hepatectomy
The best mode of analgesia delivery after hepatectomy is currently unknown. Many institutions routinely use continuous epidural analgesia (CEA) for pain control in this patient population.
- Trial name
- NCT02909322
- Testing
- Bupivacaine and Hydromorphone, Ropivacaine and Hydromorphone
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Dr. Anthony Ho
Lumbosacral Radicular Pain
Corticosteroid Lumbar Epidural Analgesia for Radicular Pain 2
This is a research study of SP-102, an experimental medication designed to relieve pain in patients with moderate to severe sciatica (pain in the lower back, hips, buttocks and legs).
- Trial name
- CLEAR 2 (NCT07579351)
- Testing
- SP-102, Dexamethasone Sodium Phosphate 10 MG/ML
- Volunteers
- 755 people
- Sponsor
- Semnur Pharmaceuticals, Inc.
Morbid Obesity, Postoperative Pain
Patients-Controlled Epidural Analgesia After Gastric Bypass for Morbid Obesity Using Morphine-Levobupivacaine Regimens
Adequate postoperative analgesia can facilitate recovery following gastric bypass surgery for morbid obesity. The efficacy and safety of intravenous patient - controlled analgesia has been studied, but up to date no data are…
- Conditions
- Morbid Obesity, Postoperative Pain, Postoperative Bowel Function, Postoperative Ambulation
- Trial name
- NCT01249872
- Testing
- GROUP A : 0 mg MORPHINE-0.1% LEVOBUPIVACAINE, GROUP B : 1 mg MORPHINE- 0.1% LEVOBUPIVACAINE, GROUP C : 2 mg MORPHINE-0.1% LEVOBUPIVACAINE
- Where
- Greece
- Volunteers
- 96 people
- Sponsor
- University of Patras
Pain, Postoperative
Different Epidural Initiation Volumes
The aim of this study is to compare the effect of different epidural initiation volumes on postoperative pain scores, local anesthetic requirements, and motor block in patients who undergo patient controlled epidural analgesia…
- Trial name
- NCT03156322
- Testing
- 5 mL epidural initiation volume (bupivacaine + fentanyl), 10 mL epidural initiation volume (bupivacaine + fentanyl), 20 mL epidural initiation volume (bupivacaine + fentanyl)
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Inonu University
Hypospadias, Postoperative Pain
Caudal Epidural Block and DPNB in Hypospadias
Hypospadias, seen in every 200-300 births, is one of the most common congenital anomalies of the penis and is defined as the urethral meatus being located in the ventral part of the penis instead of its normal place.
- Trial name
- NCT04215874
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Labour Analgesia, Epidural Anaesthesia
An Observational Study Investigating the Positioning of Epidural Catheters and Their Function During Labour Analgesia
This is a small observational study investigating the physical changes that occur to epidural catheters after insertion for obstetric anaesthesia.
- Trial name
- NCT02924779
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rotkreuzklinikum München gGmbH
Cesarean Section
A Comparison of Meperidine for Post-Cesarean Analgesia: Bolus Versus Infusion and Bolus
The purpose of this study is to determine if epidural meperidine administered by patient-controlled bolus button is equivalent to a low dose infusion plus patient-controlled bolus.
- Trial name
- NCT01741259
- Testing
- Meperidine
- Where
- United States
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- Mercy Research
Labor Pain, Induced; Birth
Spinal Fentanyl or Epidural Analgesia in the Early First Phase of Induced Labor
A total of 60 parturients undergoing induction of labour will be consented to participate in the study where they will be randomized to receive either spinal fentanyl (20 µg) or epidural analgesia (fentanyl 100µg and lidocaine 80…
- Trial name
- NCT04645823
- Testing
- Fentanyl Citrate, Lidocaine 1% Injectable Solution
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Women's Hospital HUS
Labor Active Dilated Cm
Analgesia in Labor, a Prospective Parallel Study to Compare Regional Analgesia and Intravenous (IV) Pethidine Analgesia
To compare combined spinal epidural, epidural and IV pethidine analgesia and their effects on the mother, fetus, newborn and the course of labor.
- Trial name
- NCT01290289
- Testing
- Epidura, CSE & IV
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Pain
Determination of the Effective Volume of 0.125% Bupivacaine-fentanyl 5mcg/mL in Labour Epidurals
Different medications can be used as analgesics in labor epidurals. Bupivacaine is one of the most commonly used drugs for that purpose. The efficacy of a certain medication injected epidurally depends on the dose that is given.
- Trial name
- NCT01972269
- Testing
- Bupivacaine-fentanyl, Lidocaine
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Coronary Artery Bypass Surgery
A Comparison of Two Anaesthetic Methods of Protecting Heart Tissue During Cardiac Surgery
To compare two different methods of protecting heart muscle from damage caused by a decreased blood supply. Exposure to the anaesthetic agent sevoflurane can allow the heart muscle to resist longer periods of low blood or oxygen…
- Trial name
- NCT00244283
- Testing
- Sevoflurane, High thoracic epidural analgesia
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Golden Jubilee National Hospital
Labor Pain
Epidural Fentanyl for 2nd Stage Labor Analgesia
This study is being done to investigate if there is more effective pain relief during the latter stages of labor and delivery when epidural fentanyl 100mcg is administered compared to epidural fentanyl 20mcg.
- Trial name
- NCT03120780
- Testing
- Fentanyl 20 mcg, Fentanyl 100 mcg
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Ohio State University
Hip Surgery, Post Operative Pain Control
Post Operative Pain Control After Pediatric Hip Surgery
Hip surgery in children is painful and the optimal modality for managing post-operative pain has not been established. This prospective randomized controlled trail compares lumbar plexus catheter (LPC), lumbar epidural catheter…
- Trial name
- NCT03435692
- Testing
- Lumbar Plexus Catheter, Lumbar Epidural Catheter, Patient Controlled Analgesia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Anesthesia, Recovery Period
TAPB vs. Caudal for Lower Abdominal Surgery in Children: A Double-Blinded Randomized Controlled Trial
Transversus abdominis plane block (TAPB) has emerged as a safe and effective regional anesthesia technique for providing postoperative lower abdominal analgesia.
- Trial name
- NCT02160821
- Testing
- Caudal Epidural, Transversus Abdominis Plane Block
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Nemours Children's Clinic
Liver Neoplasms, Hepatic Resection
Erector Spinae Plane Block Versus Thoracic Epidural Analgesia for Open Liver Resection
Background: Open liver resection is associated with severe postoperative pain. While thoracic epidural analgesia (TEA) is considered the gold standard for pain control, its clinical application is often limited by postoperative…
- Conditions
- Liver Neoplasms, Hepatic Resection, Liver Cancer
- Trial name
- NCT07642336
- Testing
- Continuous Erector Spinae Plane block, Thoracic Epidural Analgesia (TEA)
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Nguyen Toan Thang
Epidural Related Maternal Fever, Analgesia, Epidural
The Impact of Local Anesthetic Solution Temperature on Epidural-related Maternal Fever
This study investigates how the temperature of local anesthetics affects maternal fever related to epidural analgesia during childbirth.
- Conditions
- Epidural Related Maternal Fever, Analgesia, Epidural, Fever, Intrapartum Fever
- Trial name
- NCT06682416
- Testing
- In the context of epidural analgesia, the temperature of the local anesthetic solution is elevated to 37°C utilizing a blood transfusion and infusion warmer.
- Where
- 2 sites in China
- Volunteers
- 424 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Labor Pain, Epidural Analgesia
Epidural vs. Dural Puncture Epidural in Labor Analgesia
Childbirth is an intense physical and psychological experience. Epidural analgesia (EP) remains the gold standard in labor pain management.
- Trial name
- NCT06849726
- Testing
- Standard Epidural Analgesia, Dural Puncture Epidural Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Medipol University
Labor Analgesia
Effect of Epidural Catheter Retention Depth on Labor Analgesia Performed in DPE Combined With PIEB Model
The purpose of this study is to observe the appropriate indwelling depth of epidural catheter when labor analgesia is performed in the mode of DPE combined with PIEB, and then shorten the onset time of labor analgesia and reduce…
- Trial name
- NCT06602440
- Testing
- The indwelling length of epidural catheter is 3 centimeters., The indwelling length of epidural catheter is 5 centimeters., The indwelling length of epidural catheter is 7 centimeters.
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University
Labor Pain
Epidural Tap in Labor Analgesia FOR LABOR ANALGESIA
The dural epidural tap method is performed by creating a dural perforation with a spinal needle placed through epidural needle, followed by placement of a catheter into the epidural space.
- Trial name
- NCT05499234
- Testing
- Dolantin, Paracetamol
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Medipol University