Clinical trials: Analgesics, Opioid
Pain, Postoperative
Effect of Gabapentin on Postoperative Opioid Analgesic Use and Pain in Adolescents Undergoing Tonsillectomy
This study aims to determine if administration of gabapentin preoperatively followed by a standing postoperative course is effective in reducing and possibly eliminating the use of opioid analgesics following this procedure.
- Trial name
- NCT05024825
- Testing
- Gabapentin, hydrocodone, acetaminophen and ibuprofen
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Analgesic Drug Dependence, Sensory Deficit
Quantitative Sensory Testing in Chronic Pain Patients Undergoing Opioid Treatment and Opioid Tapering
Few studies have used quantitative sensory tests to study the effect of chronic opioid treatment on sensation. The investigators will test chronic pain patients who are on different MEDDs, normal volunteers, and patients…
- Trial name
- NCT03375216
- Testing
- sensory testing (Heat, cold, and pressure), Promis Survey
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Pain
A Study to Assess How the Body Processes a Strong Painkiller When it is Given Alongside a Drug That Counteracts the Side Effects of Strong Painkillers in a Fasted and Fed State.
To assess whether an opioid antagonist has any impact on the release of a strong painkiller in the blood when it is given to healthy volunteers when they have eaten and also when they have fasted.
- Trial name
- NCT02133820
- Testing
- 4 mg 12 hourly capsule - strong pain killer fasted, 4 mg 12 hourly capsule - strong pain killer fed, 12 hourly capsule strong painkiller with antagonist fasted)
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mundipharma Research Limited
Analgesia, Obstetrical, Postpartum Hemorrhage
Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery
In this randomized, double-blind control trial to evaluate the effect of ketorolac given at the time of cord clamp has on estimated blood loss and postcesarean pain control.
- Conditions
- Analgesia, Obstetrical, Postpartum Hemorrhage, Opioid Use, Nonsteroidals (NSAIDs)Toxicity
- Trial name
- NCT02509312
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Pain, Cannabis
Enhancing Medication-based Analgesia in Humans- STUDY 2
This is a single-group, within-subject, double-blind, double-dummy, placebo and active-controlled study evaluated whether the FDA-approved cannabinoid cannabidiol (CBD; Epidiolex) would enhance analgesia, subjective reports, and…
- Conditions
- Pain, Cannabis, Opioid Use
- Trial name
- NCT04036968
- Testing
- Within-subject test of blinded study medications
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Opioid Overdose, Drug Overdose
The Rhode Island Prescription and Illicit Drug Study
This study will test the efficacy of a novel drug-checking intervention to prevent fatal and non-fatal overdose among people who use drugs (PWUD), who are 18-65 years old at the time of enrollment.
- Trial name
- RAPIDS (NCT04372238)
- Testing
- RAPIDS Intervention, Standard OEND
- Where
- United States
- Volunteers
- 509 people, healthy volunteers welcome
- Sponsor
- Brown University
Primigravida in Labour Pains
Dosing Strategies for Automated Mandatory Intermittent Boluses Technique for Epidural Labour Analgesia
The purpose of this study is to determine how manipulation of the programmed intermittent time interval and volume influences total drug use, quality of analgesia, and patient satisfaction during maintenance of labor analgesia.
- Trial name
- NCT01205360
- Testing
- Bupivacaine-Fentanyl Mixture
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pravara Institute of Medical Sciences University
Diabetes Mellitus, Diabetic Neuropathy
Effects of Ankle Block on Postoperative Analgesia in Diabetic and Non-Diabetic Patients
This prospective observational study aims to evaluate the effects of ultrasound-guided ankle block on sensory and motor block characteristics and postoperative analgesic outcomes in patients undergoing lower extremity surgery.
- Conditions
- Diabetes Mellitus, Diabetic Neuropathy, Postoperative Pain Management
- Trial name
- ANKLE-DM (NCT07404124)
- Testing
- Ultrasound-Guided Ankle Block
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Pain Management, Postoperative Pain
Effects of S-ketamine on Perioperative Opioid Consumption
This study is a triple-blind randomized controlled trial conducted at a tertiary care hospital in Brussels. It investigates whether a single dose of S-ketamine can reduce opioid (morphine) consumption in the first 24 hours after…
- Conditions
- Pain Management, Postoperative Pain, Opioid Consumption, Postoperative, Opioid Analgesia
- Trial name
- NCT07528651
- Testing
- Esketamine at low dose, Saline (0.9% NaCl)
- Where
- Belgium
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Emergency Service, Hospital, Child/Adolescent Problem
A RCT of a Combination of Analgesics for Pain Management in Children With a Suspected Fracture
MSK-I is the most common cause for ED visits for children with pain, with a child's risk of sustaining a fracture ranging from 27-42% by the age of 16 years.
- Conditions
- Emergency Service, Hospital, Child/Adolescent Problem, Acute Pain, Fentanyl
- Trial name
- CAST (NCT02985177)
- Testing
- INF2.0 + IBU, INF1.0 + IBU
- Where
- 3 sites in Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Pain, Acute
Acetaminophen IV vs Hydromorphone IV in the ED
The purpose of the current study is to compare the analgesic efficacy of intravenous acetaminophen and intravenous hydromorphone in the treatment of acute pain in the ED.
- Trial name
- NCT03107481
- Testing
- Acetaminophen, Hydromorphone
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Sickle-Cell Disease with Crisis
Analgesic Effect of Parecoxib Versus Morphine in SCD Patients Presenting to the Emergency Department
Introduction: This study focuses on the treatment of painful crises in Sickle Cell Disease (SCD) patients using Paracoxib, a non-opioid, compared to Morphine.
- Trial name
- PASC (NCT06315920)
- Testing
- Parecoxib, Morphine
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Oman Medical Speciality Board
Postoperative Pain, Carpal Tunnel Release
Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries
The purpose of this study is to determine the efficacy of intra-operative administration of IV tylenol and/or IV toradol in minimizing post-operative pain for carpal tunnel patients and distal radius fracture patients.
- Conditions
- Postoperative Pain, Carpal Tunnel Release, Distal Radius Fracture
- Trial name
- NCT02313675
- Testing
- Acetaminophen, Ketorolac Tromethamine, Saline
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- John Fowler
Opioid Use, Pain Postoperative
Comparison of Pain Relief After Arthroscopic Knee Surgery: Adductor Canal Block and Genicular Nerve Block
This prospective randomized study aims to compare the analgesic efficacy of Adductor Canal Block (ACB) and Genicular Nerve Block (GNB) groups to relieve postoperative pain in participants between ages of 18-72 undergoing…
- Conditions
- Opioid Use, Pain Postoperative, Arthroscopic Knee Surgeries
- Trial name
- NCT06909851
- Testing
- Adductor Canal Block (ACB), Genicular Nerve Block (GNB)
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
CBD, Chronic Pain
Cannabidiol, Morphine, Pain
The purpose of the proposed study is to investigate the interaction of cannabidiol (CBD) and morphine effects on pain sensitivity.
- Trial name
- CMP (NCT04030442)
- Testing
- Immediate-release Oral Morphine Sulfate Tablets, Thermal and Pressure Nociceptive Sensitivity
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Pain, Postoperative, Opioid Use
Analgesic Efficacy of Intravenous Ketamine as a Continuous Infusion vs PCA in the Management of Acute Postoperative Pain in Major Orthopedic Surgery.
The goal of this clinical trial is to determine whether treating pain after surgery with ketamine is more effective when administered intravenously as a continuous infusion or through a patient-controlled analgesia (PCA) pump.
- Conditions
- Pain, Postoperative, Opioid Use, Major Surgery
- Trial name
- NCT06774274
- Testing
- Ketamine infusion, PCA Ketamine
- Where
- Colombia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Chronic Pain, Cancer Survivor
Better Options for Chronic Cancer Pain
This proposal is relevant to the 240,000 cancer survivors who continue to use opioids long after they have successfully completed treatment for cancer at the VHA, placing them at risk of opioid addiction and overdose, and other…
- Conditions
- Chronic Pain, Cancer Survivor, Opioid Dependence
- Trial name
- NCT06574009
- Testing
- Multimodal pain care, Medication optimization, Buprenorphine rotation
- Where
- 2 sites in United States
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Analgesic Effects, Systemic Stress Response
Bilateral Ultrasound Guided Pectoralis Nerve Block Induces Hemodynamic Stability With Reducing Systemic Stress Response for Off-pump Coronary Artery Bypass Graft
Opioids used in attenuation of the neuroendocrine stress response in patients undergoing off-pump coronary artery bypass graft (OPCAB) it produces predictable satisfactory analgesia and sedation but with side effects such as…
- Conditions
- Analgesic Effects, Systemic Stress Response, Hemodynamic Stability
- Trial name
- NCT03734848
- Testing
- Bilateral Ultrasound Guided Pectoralis Nerve Block.
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tanta University
Pain Management
Search to Advance Limited Use of Opioids Pilot: Optimization of Non-Opioid Therapy With a Steroid
To provide health care professionals, including dentists, with the best possible evidence for clinical decision making when deciding upon analgesics and use of corticosteroid for acute post-surgical pain management; a pilot…
- Trial name
- SAILS-Steroid (NCT06074263)
- Testing
- Dexamethasone 8mg
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Healthy
Bioequivalence Trial of a New Opioid Combination Compared to Reference
The purpose of this study is to demonstrate bioequivalence of a new formulation to a reference
- Trial name
- NCT00460785
- Testing
- Opioid
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH