Clinical trials: Aneurysmal Subarachnoid Hemorrhage
Ischemic Stroke, Subarachnoid Hemorrhage, Aneurysmal
Effect of Targeted Temperature Management on Cerebral Autoregulation in Patients With Neurocritical Diseases
Change and effect of cerebral autoregulation during targeted temperature management in neurocritical patients
- Conditions
- Ischemic Stroke, Subarachnoid Hemorrhage, Aneurysmal, Sepsis, TBI (Traumatic Brain Injury)
- Trial name
- NCT04728438
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xiangya Hospital of Central South University
Cognitive Dysfunction
Cognitive Dysfunction After Aneurysmal Subarachnoid Haemorrhage
This is a longitudinal, multi-center, prospective study of aneurysmal subarachnoid haemorrhage patients in neurosurgical units in Hong Kong.
- Trial name
- NCT01038193
- Testing
- Cognitive assessment
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Aneurysmal Subarachnoid Hemorrhage
Long-term Prognosis of Emergency Aneurysmal Subarachnoid Hemorrhage
Rupture of intracranial aneurysms can lead to extensive subarachnoid hemorrhage (SAH), a potentially fatal neurological emergency with mortality rates ranging from 8 to 67%.
- Trial name
- LongTEAM (NCT04785976)
- Testing
- Surgical clipping and endovascular coiling
- Where
- 2 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Beijing Tiantan Hospital
Subarachnoid Hemorrhage, Aneurysmal
Mild Hypothermia During Intracranial Aneurysm Clipping
The purpose of this study is to determine whether mild hypothermia causes reduction of vasoconstriction in microcirculation after clipping of aneurysms, and affects the blood flow in small diameter arteries at operating site…
- Trial name
- NCT02544256
- Testing
- Mild hypothermia
- Where
- Czechia
- Sponsor
- University Hospital Hradec Kralove
Delayed Cerebral Ischemia, Aneurysmal Subarachnoid Hemorrhage
Micro- and Macrovascular Parameters in Delayed Cerebral Ischemia
Delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH) results from a complex combination of macro- and microvascular processes.
- Trial name
- PDMMS (NCT05483751)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Maastricht University Medical Center
Aneurysmal Subarachnoid Hemorrhage
Admission Bio-clinical Score to Predict One-year Outcomes in Coiled Subarachnoid Hemorrhage (SAH)
The goal of this observational study is to develop and validate a predictive score of 1-year outcomes in subarachnoid hemorrhage (SAH) patients receiving aneurism coiling.
- Trial name
- ABCSAH (NCT01357057)
- Where
- France
- Volunteers
- 530 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aneurysmal Subarachnoid Hemorrhage
Pharmaceutical Treatment of Fatigue After Aneurysmal Subarachnoid Hemorrhage
Many people who have undergone subarachnoid hemorrhage from an aneurysm (an artery of a vein in the brain) struggle with a pronounced fatigue as well as a number of other sequelae such as impaired concentration, memory deficits…
- Trial name
- NCT03209830
- Testing
- OSU 6162
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Oslo University Hospital
Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Detecting Sepsis in Patients With Severe Subarachnoideal Hemorrhage
The study aims to evaluate the suitability of the SOFA score implemented by the Sepsis 3 guideline to detect sepsis in patients suffering from subrarachnoid hemorrhage.
- Conditions
- Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal, Sepsis Syndrome, Sepsis
- Trial name
- NCT05246969
- Testing
- Sepsis detection
- Where
- Germany
- Volunteers
- 58 people
- Sponsor
- Goethe University
Injuries, Acute Brain, Severe Trauma Brain Injury (sTBI)
Bioavailability of Medium Chain Triglycerides (MCTs) in Comatose Patients With Acute Brain Injury (ABI)
This study will be targeting patients suffering from acute brain injury (ABI), including those with severe trauma brain injury (sTBI) and those with aneurysmal sub arachnoid hemorrhage (aSAH).
- Conditions
- Injuries, Acute Brain, Severe Trauma Brain Injury (sTBI), Subarachnoid Hemorrhage, Aneurysmal
- Trial name
- MCTs and ABI (NCT02716532)
- Testing
- Peptamen AF
- Where
- Switzerland
- Volunteers
- 17 people
- Sponsor
- Société des Produits Nestlé (SPN)
Vasospasm Intracranial
Therapeutic Hypercapnia After Aneurysmal Subarachnoid Hemorrhage - Optimum Duration of Hypercapnia
Temporary hypercapnia leads to a reproducible increase of cerebral blood flow (CBF) and brain tissue oxygenation (StiO2) as shown in a previous study (Trial-Identification: NCT01799525).
- Trial name
- NCT04687605
- Testing
- Temporary hypercapnia
- Volunteers
- 12 people
- Sponsor
- University of Wuerzburg
Intracranial Aneurysm, Subarachnoid Hemorrhage
Deferoxamine in Aneurysmal Subarachnoid Hemorrhage Trial
Aneurysmal subarachnoid hemorrhage (SAH) is a form of stroke in which secondary neurological deterioration is an important cause of mortality and morbidity.
- Trial name
- DASH (NCT02875262)
- Testing
- Deferoxamine
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Aneurysmal Subarachnoid Hemorrhage
Aneurysmal Subarachnoid Hemorrhage Multi-Omics Research Program
Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening cerebrovascular emergency with high mortality and disability rates.
- Trial name
- aSAH-Omics (NCT07270419)
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Xiaolin Chen, MD
Hypothermia, Aneurysmal Subarachnoid Hemorrhage
Trial of Long-term Therapeutic Hypothermia for Poor-grade Aneurysmal Subarachnoid Hemorrhage
This study is a prospective, multi-centre, randomized,controlled trial to compare the efficacy of long-term mild hypothermia with normothermic intensive management in patients with poor-grade aneurysmal subarachnoid hemorrhage.
- Trial name
- NCT03442608
- Testing
- Zoll 2000 and/or CureWrap 3500 cooling system
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Aneurysmal Subarachnoid Hemorrhage
Prevention of Ischemia in Aneurysmal Subarachnoid Hemorrhage Through Remote Ischemic Preconditioning
Aneurysmal subarachnoid hemorrhage (SAH) is a severe form of stroke caused by bleeding around the brain. Despite early treatment of the initial hemorrhage, many patients develop delayed cerebral ischemia several days later, which…
- Trial name
- HMA (NCT07761520)
- Testing
- Remote Ischemic Preconditioning
- Volunteers
- 140 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Subarachnoid Hemorrhage, Aneurysmal, Headache
Infusion of Lidocaine and Steroids in Middle Meningeal Artery for Pain in Subarachnoid Hemorrhage
The goal of this clinical trial is to learn if an infusion of lidocaine, with or without steroids, into the middle meningeal artery (MMA) helps relieve severe headaches in patients with spontaneous subarachnoid hemorrhage (SAH).
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Headache, Opiate Dependence, Opioid Use
- Trial name
- NCT07294118
- Testing
- Lidocaine, Lidocaine and Dexamethasone
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Aneurysmal Subarachnoid Hemorrhage
Early Versus Ultra Early Surgical Treatment of Ruptured Intracranial Aneurysms
The goal of this clinical trial is to determine the most effective timing for clipping in adults with ruptured intracranial aneurysms.
- Trial name
- NCT06457347
- Testing
- Ultra early (<24 hours) ruptured aneurysm clipping, Early (24-72 hours) ruptured aneurysm clipping
- Volunteers
- 100 people
- Sponsor
- Revaz Dzhindzhikhadze
Aneurysmal Subarachnoid Hemorrhage
Transdermal Nicotine Replacement in Smokers With Acute Aneurysmal Subarachnoid Hemorrhage
All patients with acute aneurysmal hemorrhage are treated in accordance with our institutional protocol. After securing of the aneurysm, some smokers with acute aneurysmal hemorrhage are randomly assigned to transdermal nicotine…
- Trial name
- NRT-SAH (NCT02350335)
- Testing
- Nicotine (transdermal)
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Aneurysmal Subarachnoid Hemorrhage
Erythropoietin Therapy for Subarachnoid Hemorrhage
ABSTRACT: Delayed ischemic deficits (DID) and strokes caused by low cerebral blood flow (CBF) are major sources of poor outcome following aneurysmal subarachnoid hemorrhage (SAH).
- Trial name
- NCT00140010
- Testing
- erythropoietin beta
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Cambridge
Subarachnoid Hemorrhage, Aneurysmal
Endothelin-1 and Methabolites Concentrations in Mycrodialysis and Cerebrospinal Fluid in Subarachnoid Hemorrhage Patients
Endothelin-1 (ET-1) seems to be involved in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage. However measurements of cerebrospinal fluid concentrations (CSF) of ET-1 are not sensitive enough to predict the…
- Trial name
- NCT01686763
- Volunteers
- 35 people
- Sponsor
- University of Turin, Italy
Subarachnoid Hemorrhage, Aneurysmal
Molar Sodium Lactate Filling in Severe Meningeal Hemorrhage
Subarachnoid hemorrhage by aneurysmal rupture is a serious condition associated with a high mortality rate. Among the complications presented by these patients, vasospasm is one of the main causes of secondary aggravation, in…
- Trial name
- NCT04141371
- Testing
- Molar Sodium Lactate, physiological serum
- Where
- 3 sites in France
- Volunteers
- 3 people
- Sponsor
- Centre Hospitalier Universitaire de Nice