Clinical trials: Angiography, open to volunteers
Coronary Artery Disease, Coronary Artery Bypass Grafting
CCTA-Based vs CAG-Based CABG: A Multicenter Pragmatic Non-Inferiority Trial
The goal of this clinical trial is to find out if using a non-invasive heart scan (called coronary computed tomography angiography, or CCTA) to plan coronary artery bypass grafting (CABG) works as well as the standard invasive…
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass Grafting, Coronary Computed Tomography Angiography, Coronary Angiography (CAG)
- Trial name
- CtaCAB (NCT07769008)
- Testing
- CCTA-based CABG, CAG-based CABG
- Where
- China
- Volunteers
- 826 people
- Sponsor
- Ruijin Hospital
Coronary Angiography, Virtual Reality
Breathing Meditation and VR Nature Videos in Angiography Patients: Effects on Anxiety, Comfort, and Physiology
This study was designed to evaluate the effects of breathing meditation, accompanied by virtual reality (VR)-enhanced nature videos, on anxiety, comfort, pain, and physiological parameters in patients undergoing angiography.
- Conditions
- Coronary Angiography, Virtual Reality, Meditation
- Trial name
- NCT07892456
- Testing
- Breathing Meditation Combined with Virtual Reality-Enhanced Nature Videos
- Where
- Turkey (Türkiye)
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- University of Yalova
Coronary Angiography (CAG)
The Effect of Virtual Reality Glasses on Vital Signs and State Anxiety in Patients Undergoing Coronary Angiography
Virtual reality (VR) is an effective, safe, and non-pharmacological intervention for reducing anxiety, with strong scientific evidence and no known adverse effects.
- Trial name
- NCT07032935
- Testing
- Virtual Reality (VR) Intervention
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kutahya Health Sciences University
OCT Angiography, Retinal Microcirculation
Chorioretinal Imaging, Vascular Biomarkers, and Ultra-Trail: A Pilot Study
Retinal and choroidal microcirculation is a relevant biomarker of systemic vascular health and lies at the heart of eye-heart interactions.
- Conditions
- OCT Angiography, Retinal Microcirculation, Choroidal Microcirculation, Physical Exercion
- Trial name
- UTMA-RETINA (NCT07748936)
- Testing
- Retinal imaging evaluation of both eyes without dilation before and after the Mont Afrique Ultra Trail, Retinal imaging evaluation of both eyes without dilation, performed in two stages (T0 and T0+11/24H)
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
FFR-CT, CT Angiography
Spectral and Ultra High Resolution CT Systems for Non-Invasive Detection of Myocardial Ischemia: Stress CT Perfusion VS. FFR-CT
Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Coronary Computed Tomography angiography (CCTA) gained a pivotal clinical role for excellent sensitivity in rule-out CAD, but has limited…
- Conditions
- FFR-CT, CT Angiography, CT Perfusion, Coronary Arterial Disease (CAD)
- Trial name
- SURE-CT (NCT07544277)
- Where
- 2 sites in Italy
- Volunteers
- 142 people
- Sponsor
- IRCCS San Raffaele
Myocardial Infarction, Percutaneous Coronary Intervention (PCI)
Investigation to Assess the Effects of Drug-COATED Balloons for Treatment of Plaques Erosions Causing Acute Coronary Syndromes
Drug eluting balloon angioplasty might be a better alternative than medical treatment or stenting in subjects with plaque erosion, which is the second most common cause of myocardial infarction.
- Conditions
- Myocardial Infarction, Percutaneous Coronary Intervention (PCI), Medical Treatment, Coronary Computed Tomographic Angiography
- Trial name
- DCB-PE (NCT07783880)
- Testing
- PCI with size matched DCB, GP IIbIIIa inhibitor or heparin & dual antiplatelet therapy
- Where
- Poland
- Volunteers
- 62 people
- Sponsor
- 3W-Research Collaboration Group
Homozygous Familial Hypercholesterolemia (HoFH), Coronary Computed Tomography Angiography
Assessing the Impact of Intensification of Lipid Lowering Therapy With Guidelines-based Evinacumab Administration on Coronary Plaque Volumes Measured by Coronary Computed Tomography Angiography (CCTA) in Patients With Homozygous Familial Hypercholesterolemia (HoFH)
This observational, multicenter, retrospective and prospective study aims to evaluate the impact of intensified lipid-lowering therapy including Evinacumab on coronary atherosclerotic plaque burden in patients with Homozygous…
- Trial name
- EVOLVE-HoFH (NCT07447648)
- Where
- 13 sites in France, Italy and 2 more
- Volunteers
- 52 people
- Sponsor
- Fondazione SISA (Societa Italiana per lo Studio della Arteriosclerosi)
Coronary Artery Disease, Coronary Angiography
HEMOSTATİC PAD AND SANDBAG
The aim of this study is to compare bleeding outcomes, pain, comfort levels, sleep quality, and associated factors among patients receiving a chitosan-based hemostatic pad versus a sandbag following femoral coronary angiography…
- Conditions
- Coronary Artery Disease, Coronary Angiography, Vascular Access Site Complications
- Trial name
- NCT07771127
- Testing
- Chitosan-Based Hemostatic Pad, Sandbag Application
- Where
- Turkey (Türkiye)
- Volunteers
- 480 people
- Sponsor
- Uludag University
Coronary Angiogram, Early Discharge Trans Radial Angiography
Potassium Ferrate Hemostatic Sealant-Assisted Early Radial Hemostasis After Transradial Coronary Angiography and PCI
This study aims to evaluate patients undergoing coronary angiography by comparing the use of Potassium Ferrate Hemostatic Sealant (PFHS) in addition to the standard of care (SOC) pneumatic radial compression device versus SOC…
- Trial name
- MAHI-SEAL-60 (NCT07768839)
- Testing
- Experimental: PFHS + pneumatic radial compression device, Pneumatic radial compression device alone.
- Volunteers
- 300 people
- Sponsor
- University of Alberta
Transradial Access(TRA), Coronary Angiography (CAG)
Serpentine vs Traditional Hydrophilic Guidewire Tracking in Complex Radial Anatomy
Coronary angiography and angioplasty are commonly performed through the radial artery. In some patients, anatomical variations of the radial and brachial arteries, such as loops, increased tortuosity or sharp angulations may pose…
- Conditions
- Transradial Access(TRA), Coronary Angiography (CAG), Percutaneous Coronary Intervention (PCI), Radial Artery Loop
- Trial name
- S-TRACK (NCT07707427)
- Testing
- Serpentine Technique, Hydrophilic Technique
- Where
- Greece
- Volunteers
- 204 people
- Sponsor
- University Hospital of Patras
Angiography, Digital Subtraction, Robot-assisted Therapy
Robot-Assisted vs Manual Transradial Cerebral Angiography
This is a prospective, randomized controlled clinical trial designed to compare the safety and effectiveness of robot-assisted transradial cerebral angiography versus manual operation performed by experienced neurosurgeons.
- Trial name
- RCT (NCT07696936)
- Testing
- Robot-assisted angiographic system, Manual controlled transradial artery angiography
- Where
- China
- Volunteers
- 156 people
- Sponsor
- The First Hospital of Hebei Medical University
Pulmonary Hypertension, Precapillary Pulmonary Hypertension
Correlation Between CT Pulmonary Angiography Metrics and Right Heart Catheterization Parameters in Pre-Capillary Pulmonary Hypertension
Pulmonary hypertension (PH) is a hemodynamic and pathophysiological condition defined by a mean pulmonary artery pressure (mPAP) greater than 20 mmHg at rest, as confirmed by right heart catheterization (RHC) (1).
- Conditions
- Pulmonary Hypertension, Precapillary Pulmonary Hypertension, Right Heart Catheterisation, CT Angiography
- Trial name
- NCT07667595
- Testing
- right heart catheter
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Caffeine, Alcohol
Investigating the Effect of Caffeine and Alcohol on Pupil Dynamics
The goal of this study is to understand how caffeine and alcohol affect the ocular and physiological systems, especially how the pupil (the aperture in the colored part of the eye) responds to light.
- Conditions
- Caffeine, Alcohol, Pupillary Response, Eye Movements
- Trial name
- PAC (NCT07625358)
- Testing
- Caffeine administration, Alcohol (Ethanol)
- Where
- Singapore
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Coronary Artery Disease, Coronary Computed Tomography Angiography
Trustworthy, Integrated Artificial Intelligence Tools for Predicting High-risk CORonary PlaqueS
Coronary artery disease (CAD) is among the leading cause of death and disability. Identification of patients at high risk of cardiovascular events is pivotal.
- Trial name
- AI-CORPS (NCT06410690)
- Where
- 2 sites in Italy
- Volunteers
- 4,000 people
- Sponsor
- Centro Cardiologico Monzino
Coronary Angiography, Percutaneous Coronary Intervention
Timing of Anticoagulant Administration During Radial Access Percutaneous Coronary Intervention: the HERA-PCI Study (Heparin Early for Radial Access Percutaneous Coronary Intervention)
While the reduced hemorrhagic risk of radial access for percutaneous coronary intervention compared to femoral access is well-established, its main complication remains radial artery occlusion, which can occur in up to 30% of…
- Conditions
- Coronary Angiography, Percutaneous Coronary Intervention, Radial Artery Occlusion, Bleeding
- Trial name
- HERA-PCI (NCT06890312)
- Testing
- Administration of heparin after sheath insertion, Administration of heparin prior to sheath insertion
- Where
- France
- Volunteers
- 550 people
- Sponsor
- University Hospital, Strasbourg, France
Coronary Arteries Disease, Chronic Coronary Syndrome
Computed Tomography Angiography Based Procedural Planning in PeRcutaneOus Coronary InterVEntion
The goal of this clinical trial is to learn whether coronary CT angiography (CCTA)-guided planning improves the efficiency and outcomes of percutaneous coronary intervention (PCI) in adults with coronary artery disease.
- Conditions
- Coronary Arteries Disease, Chronic Coronary Syndrome, Acute Coronary Syndromes (ACS), Myocardial Ischemia
- Trial name
- CT-PROVE (NCT07592312)
- Testing
- CCTA-Guided Percutaneous Coronary Intervention, Standard Percutaneous Coronary Intervention
- Volunteers
- 200 people
- Sponsor
- University of Galway
Coronary Artery Disease, Atherosclerotic Plaque
Changes in Plaque Characteristics After Short-term Statin Therapy as Assessed With Coronary CT
INTENSE Trial is a prospective, double-blind, randomized, placebo-controlled, single-center study with two arms (40 mg intensified statin therapy vs matching placebo for rosuvastatin) among statin-naive patients referred to…
- Conditions
- Coronary Artery Disease, Atherosclerotic Plaque, Coronary Computed Tomography Angiography, Statin Therapy
- Trial name
- INTENSE (NCT06603363)
- Testing
- Rosuvastatin 40mg, Coronary Computed Tomography Angiography (Coronary CTA), Blood test
- Where
- Hungary
- Volunteers
- 140 people
- Sponsor
- Prof. Maurovich-Horvat Pál
Coronary Artery Disease (CAD), Computed Tomography Angiography
AI-assisted CT for Risk Stratification in Coronary Artery Disease (ACTION)
The goal of this observational study is to learn if AI-assisted cardiac CT imaging can improve cardiovascular risk stratification and prediction of future coronary events in an adult population undergoing clinically indicated…
- Conditions
- Coronary Artery Disease (CAD), Computed Tomography Angiography, Biomarkers, AI (Artificial Intelligence)
- Trial name
- ACTION (NCT07577609)
- Where
- Ireland
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Galway
Major Adverse Cardiovascular Events (MACE), Prevention
Serial Coronary CTA-based Plaque Progression Detection for Management of Coronary Heart Disease
The primary objective of this study is to evaluate whether a management strategy based on coronary computed tomography angiography (CCTA) for patients with non-obstructive coronary artery disease can improve the LDL-C target…
- Conditions
- Major Adverse Cardiovascular Events (MACE), Prevention, Coronary Artery Disease(CAD), CT Angiography
- Trial name
- SUCCESS (NCT06843005)
- Testing
- Coronary Computed Tomography Angiography, Current clinical guidelines
- Where
- China
- Volunteers
- 3,100 people
- Sponsor
- Zhang longjiang,MD
Coronary Artery Disease, CT Angiography
Further Lipid-Lowering With PCSK9 Inhibitors for Cardiovascular Outcomes in High-Risk Coronary Plaques Assessed by CT Angiography
The primary objective was to evaluate the effect of PCSK9 inhibitors in addition to the background lipid-modifying therapy (LMT), compared with standard LMT in terms of clinical outcomes in patients with coronary CT angiography…
- Conditions
- Coronary Artery Disease, CT Angiography, PCSK9, Cardiovascular Events
- Trial name
- FLAVOUR IV (NCT06863545)
- Testing
- PCSK9 inhibitors and background lipid-modifying therapy, Standard lipid-modifying therapy
- Where
- 6 sites in China, South Korea
- Volunteers
- 3,596 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine