Clinical trials: Ankylosing Spondylitis (AS)
Rheumatoid Arthritis, Ankylosing Spondylitis
Quality of Life Outcomes of HUMIRA in Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), Ankylosing Spondylitis (AS) After Unsustainable Response to Biologicals and Disease Modifying Antirheumatic Drugs
The aim of this post-marketing observational study is to obtain further data on the evaluation of quality of life outcomes of HUMIRA® in routine clinical use in patients with Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA)…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT01083693
- Where
- 20 sites in Austria
- Volunteers
- 162 people
- Sponsor
- Abbott
Crohn's Disease, Ulcerative Colitis (UC)
Impact of AbbVie Care Patient Support Program on Clinical, Health Economic and Patient Reported Outcomes, in Crohn's Disease, Ulcerative Colitis, Rheumatoid Arthritis, Psoriatic Arthritis, Psoriasis and Axial Spondyloarthritis, in the Portuguese National Health Service
This study aims to evaluate the impact of AbbVie Care 2.0 on adalimumab's compliance, patient reported outcomes and utilization of health resources over 12 months.
- Conditions
- Crohn's Disease, Ulcerative Colitis (UC), Rheumatoid Arthritis (RA), Psoriatic Arthritis
- Trial name
- IMPROVE (NCT03223012)
- Where
- 15 sites in Portugal
- Volunteers
- 116 people
- Sponsor
- AbbVie
Ankylosing Spondylitis
A Study to Evaluate the Efficacy and Safety of Different Doses of Bimekizumab in Subjects With Active Ankylosing Spondylitis
This is a study to evaluate the efficacy and safety of different doses of bimekizumab in subjects with active Ankylosing Spondylitis (AS).
- Trial name
- BE AGILE (NCT02963506)
- Testing
- Bimekizumab
- Where
- 74 sites in United States, Bulgaria and 8 more
- Volunteers
- 303 people
- Sponsor
- UCB Biopharma S.P.R.L.
Ankylosing Spondylitis, Axial Spondyloarthritis
Does Immunogenicity Have an Influence on the Efficacy of Anti-TNF Therapy in Patients With AS: An Inception Cohort Study
The purpose of this prospective cohort study is to evaluate the influence of serum drug levels and development of anti-drug antibodies on clinical response to anti-TNF agents in ankylosing spondylitis(AS) treatment.
- Trial name
- NCT02687620
- Where
- 13 sites in Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Izmir Katip Celebi University
Ankylosing Spondylitis
Work Productivity in Active Ankylosing Spondylitis (AS) Patients Treated With Enbrel.
Patients with Ankylosing spondylitis more frequently discontinue work. This study measures the impact of Enbrel on work participation.
- Trial name
- AS@WORK (NCT01421303)
- Testing
- Enbrel
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Pfizer
Ankylosing Spondylitis
Tramadol/Acetaminophen(Ultracet) AS add-on Therapy in the Treatment of Patients With Ankylosing Spondylitis
Tramadol 37.5 mg/APAP 325 mg combination tablets (ULTRACET®) were effective and safe as addon therapy with COX-2 NSAID for treatment of osteoarthritis (5) and chronic low back pain (6).There is no clinical trial regarding…
- Trial name
- CS07102 (NCT00647517)
- Testing
- Ultracet
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chung Shan Medical University
Osteoarthritis (OA), Rheumatoid Arthritis (RA)
Prevalence Study of Gastrointestinal Risk Factors in Patients With Osteoarthritis (OA), Rheumatoid Arthritis (RA) and Ankylosing Spondylitis (AS).
RATIONAL is a multinational, multicentre, observational, cross sectional study of adult patients in treatment with NSAID therapy for OA, RA or AS during for at least 2 weeks before study visit (at least one dose).
- Conditions
- Osteoarthritis (OA), Rheumatoid Arthritis (RA), Ankylosing Spondylitis (AS)
- Trial name
- RATIONAL (NCT01577563)
- Where
- 85 sites in Argentina, Colombia and 8 more
- Volunteers
- 5,383 people
- Sponsor
- AstraZeneca
Rheumatoid Arthritis, Inflammatory Arthritis
Therapeutic Response to Tumor Necrosis Factor-alpha (TNF-alpha) Antagonists in Rheumatoid Arthritis.
Rheumatoid arthritis (RA) is an autoimmune, chronic inflammatory disease and TNF-alpha has been recognized as a triggering cytokine in the induction of joints inflammation and is involved in the pathogenesis of RA.
- Conditions
- Rheumatoid Arthritis, Inflammatory Arthritis, Ankylosing Spondylitis
- Trial name
- TNF-alpha (NCT05379049)
- Testing
- Infliximab: Adalimumab; Etanercept;
- Where
- Iraq
- Volunteers
- 80 people
- Sponsor
- University of Sulaimani
Ankylosing Spondylitis, Osteoporosis
Treatment With Alendronate in Patients With Ankylosing Spondylitis (AS)
This prospective study will assess the effects of treatment with alendronate in osteoporotic patients with ankylosing spondylitis.
- Trial name
- NCT01104987
- Testing
- alendronate
- Where
- Sweden
- Volunteers
- 16 people
- Sponsor
- Göteborg University
Spondylitis, Spondylitis, Ankylosing
A Pilot Study of MSCs Iufusion and Etanercept to Treat Ankylosing Spondylitis
The purpose of this study is to evaluate the safety and clinical effect of mesenchymal stem cells (MSCs) derived from human bone marrow at a dose of 1.0E+6 MSC/kg in subject for the therapy of Ankylosing spondylitis (AS) and to…
- Conditions
- Spondylitis, Spondylitis, Ankylosing, Ankylosis, Arthritis
- Trial name
- NCT02809781
- Testing
- Intravenous infusion of MSCs, Etanercept
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Active Ankylosing Spondylitis
Evaluate the Preliminary Efficacy, Safety, and PK of Subcutaneous JS005 in Chinese Adult Patients With Active AS
The purpose of this study is to evaluate preliminary efficacy, safety pharmacokinetic (PK) characteristics, pharmacodynamics (PD) haracteristics and immunogenicity of JS005 at different doses in Chinese patients with active…
- Trial name
- NCT05212051
- Testing
- JS005
- Where
- 23 sites in China
- Volunteers
- 131 people
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Axial Spondyloarthritis, Ankylosing Spondylitis
A Study to Evaluate the Long-term Safety, Tolerability and Efficacy of Bimekizumab in Subjects With Active Axial Spondyloarthritis Including Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis
The purpose of the study is to demonstrate the long-term safety, tolerability and efficacy of bimekizumab in patients with active axial spondyloarthritis (axSpA, also known as radiographic axSpa (r-axSpA)) including ankylosing…
- Conditions
- Axial Spondyloarthritis, Ankylosing Spondylitis, r-axSpa, Nr-axSpa
- Trial name
- BE MOVING (NCT04436640)
- Testing
- Bimekizumab
- Where
- 75 sites in United States, Belgium and 12 more
- Volunteers
- 508 people
- Sponsor
- UCB Biopharma SRL
Ankylosing Spondylitis
Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study
This study will explore how genes may influence the severity of ankylosing spondylitis, a form of arthritis that affects the spine.
- Trial name
- NCT00056719
- Where
- United States
- Volunteers
- 299 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Ankylosing Spondylitis
D2E7-Early AS
Reduction of signs and symptoms in patients with moderate to severely early axial spondyloarthritis (without radiological sacroiliitis) who have had an inadequate response to or do not tolerate NSAID therapy.
- Trial name
- NCT00235105
- Testing
- Adalimumab 40 mg sc every other week
- Where
- 2 sites in Germany
- Volunteers
- 46 people
- Sponsor
- Charite University, Berlin, Germany
Ankylosing Spondylitis
Platelet and Red Blood Cell Volume Indices as Inflammatory Biomarkers in Ankylosing Spondylitis
this study aims to determine the relatioships among the NLR ,PLR ,MLR ,red cell volume and platelet volume indices levels as biomarkers in ankylosing spondylitis.
- Trial name
- NCT05997108
- Testing
- CBC
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sohag University
Spondylarthropathies; Spondylitis, Ankylosing
Safety of Etoricoxib (MK-0663) in Patients With Spondyloarthropathy (SpA)/Ankylosing Spondylitis (AS) in Sweden (EP07013.013.11.082)
The study is intended to provide additional post-marketing safety data regarding the use of etoricoxib for the indication of ankylosing spondylitis.
- Trial name
- NCT01327638
- Testing
- etoricoxib, Other COX-2 inhibitor, nsNSAIDs
- Volunteers
- 21,108 people
- Sponsor
- Organon and Co
Ankylosing Spondylitis
Progression of Spinal Fusion in Ankylosing Spondylitis
This study will evaluate: 1) whether computed tomography (CT) scanning is better than regular x-rays for measuring changes in the stiffness, or fusion, of the spine in patients with ankylosing spondylitis; and 2) if CT can be…
- Trial name
- NCT00085995
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Ankylosing Spondylitis (AS)
The Relationship Between Arterial Stiffness and Pulmonary and Extrapulmonary Features in Ankylosing Spondylitis
The aim of this study was to investigate the relationship between arterial stiffness and pulmonary and extrapulmonary features in patients with ankylosing spondylitis.
- Trial name
- NCT06739369
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
Anklyosing Spondylitis
16 Week Efficacy and 5 Year Long Term Efficacy, Safety and Tolerability of Secukinumab in Patients With Active Ankylosing Spondylitis
This study assessed the efficacy and safety of secukinumab in patients with active ankylosing spondylitis who were tolerant to or had an inadequate response to NSAIDs, DMARDs and / or TNFα inhibitor
- Trial name
- MEASURE2 (NCT01649375)
- Testing
- Secukinumab (75 mg), Secukinumab (150 mg)
- Where
- 53 sites in United States, Austria and 11 more
- Volunteers
- 219 people
- Sponsor
- Novartis Pharmaceuticals
Ankylosing Spondylitis
The Effect of Fecal Microbiota Transplantation in Ankylosing Spondylitis (AS) Patients.
Ankylosing spondylitis (AS) patients often have subclinical gut wall inflammation. Gut dysbiosis has been associated with both AS and Crohn disease, both of which have several features in common.
- Trial name
- ASGUT (NCT03726645)
- Testing
- Fecal microbiota transplantation
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Hospital District of Helsinki and Uusimaa