Clinical trials: Anti-bacterial Agents
Relapsing Remitting Multiple Sclerosis
Proof of Concept Study of RHB-104 as Add-On Therapy to Interferon Beta-1a in Relapsing Remitting Multiple Sclerosis (RRMS)
The investigators hypothesize that Mycobacterium avium paratuberculosis positive Relapsing Remitting MS subjects will have a greater response to Interferon beta-1a therapy plus RHB-104 than from Interferon beta-1a alone.
- Trial name
- CEASE-MS (NCT01717664)
- Testing
- RHB-104
- Where
- 2 sites in Israel
- Volunteers
- 18 people
- Sponsor
- RedHill Biopharma Limited
Dental Caries in Children
Evaluation of the Antibacterial Effect of Probiotics on Cariogenic Bacteria in Children
This randomized controlled clinical trial aims to evaluate the effect of oral probiotic lozenges containing Streptococcus salivarius, Lactobacillus reuteri, and Lactobacillus paracasei on cariogenic bacteria (Streptococcus…
- Trial name
- NCT07904221
- Testing
- Probiotic lozenges containing Streptococcus salivarius, Lactobacillus reuteri, and Lactobacillus paracasei, Xylitol-based moisturizing lozenges
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Antibiotic-Associated Diarrhea
Probiotics at the Treatment of Antibiotic Associated Diarrhea
The purpose of this study is to know the efficacy of the treatment with probiotics, Lactobacillus casei and Bifidobacterium breve, on clinical evidences and occurence of relapses on antibiotic-associated diarrhea.
- Trial name
- NCT00700557
- Testing
- Probiotics - Lactobacillus casei and Bifidobacterium breve, Maize starch
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Federal University of Uberlandia
Antibiotic Susceptibility Patterns
Impact of New CLSI Guidelines on Antibiotic Susceptability Pattern
Assessing the precise MIC for the Ceftriaxone using E-test. To determine what proportion of susceptibility reports will be reclassified based on the new CLSI guidelines.Antibiotic susceptibility reports of blood cultures, urine…
- Trial name
- NCT01352377
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Southern Nevada
Antibiotic Side Effect
Evaluation of Bifidobacterium Breve PRL2020 in Preventing Antibiotic-Associated Side Effects From Amoxicillin or Amoxicillin/Clavulanic Acid
This study aims to evaluate the efficacy and safety of the probiotic Bifidobacterium breve PRL2020 in preventing gastrointestinal and extra-intestinal side effects caused by Amoxicillin or Amoxicillin/Clavulanic Acid in pediatric…
- Trial name
- NCT06850714
- Testing
- Bifidobacterium breve PRL2020 (Brevicillin®), Amoxicillin or Amoxicillin/Clavulanic Acid
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- Liaquat University of Medical & Health Sciences
Obesity
Pharmacokinetics of Carbapenem Antibiotics in Obese Patients.
Tissue kinetics of ertapenem and meropenem in fatty tissue, intraperitoneal fluid and plasma.
- Trial name
- NCT01407965
- Testing
- microdialysis catheter
- Where
- 2 sites in Germany
- Volunteers
- 13 people
- Sponsor
- University of Ulm
Bone Infection, Joint Infection
Side Effects of Antibiotics in Bone and Joint Infections
Treatment for bone and joint infection (BJI) is not standardized, which allows a wide range of antibiotic therapy to potentially be given, most often in high doses over long periods of time.
- Trial name
- PROSEAB (NCT05927311)
- Where
- France
- Volunteers
- 73 people
- Sponsor
- University Hospital, Tours
Osteomyelitis
Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Patients With Osteomyelitis
This clinical study will be a multi-center, randomized, open-label, active-controlled, parallel-group study comparing dalbavancin to standard of care (SOC) therapy in osteomyelitis.
- Trial name
- NCT03091439
- Testing
- Dalbavancin, Standard of Care
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Allergan
Nasal Carriers of Staphylococcus Aureus
Clearance of Nasal Staphylococcus Aureus With Triple Antibiotic Ointment
Staphylococcus aureus, a bacteria that lives commonly in the anterior nostrils, is seen in about 30% of healthcare workers. Applying mupirocin ointment, a prescription, to the nostrils twice daily for 5 days is the current…
- Trial name
- NCT00997139
- Testing
- Neosporin (polymyxin B 5,000units, bacitracin 400 units, neomycin 3.5mg)
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Small Intestinal Bacterial Overgrowth
Antibiotic Treatment Trial for Small Intestinal Bacterial Overgrowth
This is a randomized, double-blind, placebo-controlled study to evaluate the efficacy of ciprofloxacin versus metronidazole versus placebo in eradication of small intestinal bacterial overgrowth (SIBO).
- Trial name
- NCT02458781
- Testing
- Metronidazole, Ciprofloxacin
- Volunteers
- 180 people
- Sponsor
- San Antonio Military Medical Center
Febrile Neutropenia
Early Versus Late Stopping of Antibiotics in Children With Cancer and High-risk Febrile Neutropenia
This randomised controlled trial will determine the non-inferiority of stopping empiric antibiotics prior to absolute neutrophil count (ANC) recovery (Early Stopping) versus stopping antibiotics upon ANC recovery (Standard of…
- Trial name
- ELSA-FN (NCT04948463)
- Testing
- Piperacillin and Tazobactam for Injection, Cefepime Injection, Ceftazidime Injection
- Where
- Australia
- Volunteers
- 55 people
- Sponsor
- Murdoch Childrens Research Institute
Blood Stream Infection, Blood Stream Infections
Evaluation of Diagnostic Accuracy and Clinical Performance of the UllCORE Bloodstream Infection (BSI) Test
This study is designed to evaluate the clinical performance of the UllCORE Bloodstream Infection (BSI) Test, an investigational molecular diagnostic test intended to detect microorganisms and selected antimicrobial resistance…
- Conditions
- Blood Stream Infection, Blood Stream Infections, Sepsis, Fungemia
- Trial name
- B-RAPID (NCT07859852)
- Testing
- UllCORE BSI Test
- Where
- 20 sites in United States, France and 3 more
- Volunteers
- 1,500 people
- Sponsor
- Deepull Diagnostics S.L.
Acute Mesenteric Ischemia
ORal Antibiotics in Acute Mesenteric Ischemia
Acute mesenteric ischemia (AMI) is a life-threatening condition with an increasing incidence (7-13/100000 PY). The mortality of AMI is associated with the development and extent of transmural intestinal necrosis (IN), ranging…
- Trial name
- ORIAMI (NCT06387147)
- Testing
- Gentamicin, Metronidazole
- Where
- 4 sites in France
- Volunteers
- 196 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Antibiotic Prescription
Prescription Pattern and Awareness About Antibiotic Prophylaxis and Resistance
To assess the knowledge of Pediatric dentists regarding the prescription of antibiotics, antibiotic prophylaxis and antibiotic resistance
- Trial name
- NCT04031443
- Where
- Egypt
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Cairo University
Ventilator Associated Pneumonia, Antibiotic Resistant Infection
Ceftolozane-tazobactam for the Treatment of Respiratory Infections Due to Extensively Drug-resistant Pseudomonas Aeruginosa Among Critically Ill Patients: a Retrospective Study.
The aim of this study is to report our experience with ceftolozane-tazobactam and to evaluate its safety and efficacy in the treatment of ICU dependent nosocomial respiratory tract infections due to extensively drug resistant…
- Trial name
- NCT04352855
- Testing
- Ceftolozane/tazobactam
- Where
- Hungary
- Volunteers
- 55 people
- Sponsor
- Semmelweis University
Asthma
ASTHMA (AntibioticS To Help Manage Asthma) Pilot Study
The ASTHMA Pilot Study is a randomized, controlled, parallel group clinical trial of 6 weekly doses of azithromycin (cumulative dose 4800 mg) or placebo as adjunctive treatment in addition to usual care for adults with stable…
- Trial name
- NCT00245908
- Testing
- azithromycin
- Volunteers
- 100 people
- Sponsor
- Wisconsin Research Network
Early-phase Safety and PK Study of a Vaginal Gel
FIH Lead-in Study of YASO GEL Followed by a Phase 1 Randomized, Double-blind Study to Assess Safety and Pharmacokinetics of YASO GEL
The goal of this clinical trial is to assess the safety and pharmacokinetics of YASO GEL in healthy adult participants. This is a first-in-human study designed to understand how the gel is absorbed and distributed in plasma and…
- Trial name
- PPCM-01 (NCT07281404)
- Testing
- YASO GEL
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Yaso Therapeutics Corporation
Recurrent Urinary Tract Infection
D Mannose in Recurrent Urinary Tract Infections
Background- In recurrent urinary tract infections (RUTIs) usual prophylactic antibiotic regimes do not change the long term risk of recurrence. Objective- D-Mannose is a sugar, it sticks to E.
- Trial name
- NCT01808755
- Testing
- D Mannose, trimethoprim/sulfamethoxazole
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Kidney Calculi, Urinary Tract Infections
Is it Necessary for Patients With a Positive Urine Culture to Achieve a Negative Result After Antimicrobial Treatment Before Undergoing Percutaneous Nephrolithotomy?
Objective: The current European Association of Urology (EAU) guidelines do not provide clear recommendations on whether patients with a positive urine culture(UC) should wait until the culture turns negative following…
- Conditions
- Kidney Calculi, Urinary Tract Infections, Sepsis
- Trial name
- NCT06210425
- Where
- China
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Junhao Zheng
Drug Resistance, Multiple, Bacterial Infections
Prediction of Multidrug-resistant Bacterial Infection in Patients with Cirrhosis
The aim of this study is to identify predictive factors of infections caused by multidrug-resistant organisms in patients with cirrhosis and to develop and validate (internally and externally) a predictive model that might be…
- Conditions
- Drug Resistance, Multiple, Bacterial Infections, Liver Cirrhosis
- Trial name
- NCT05641025
- Where
- Argentina
- Volunteers
- 1,774 people
- Sponsor
- Hospital Italiano de Buenos Aires
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