Clinical trials: Anti-bacterial Agents
COPD Exacerbation, COPD
PCT-guided Treatment Regarding Antibiotic Use for Acute COPD Exacerbations
This study the investigators will examine whether procalcitonin-guided treatment regarding antibiotic therapy is non-inferior to usual care in patients who are admitted because of an acute COPD exacerbation when it comes to…
- Conditions
- COPD Exacerbation, COPD, Acute Copd Exacerbation
- Trial name
- PRECISION (NCT05854901)
- Testing
- Procalcitonin, Physician's decision
- Where
- 11 sites in Netherlands
- Volunteers
- 693 people
- Sponsor
- Erasmus Medical Center
Pregnancy Preterm, Pregnancy Prom
Outpatient Antibiotics Following Previable Rupture of Membranes (pPPROM) Between 18 0/7 and 22 6/7 Weeks Gestational Age
A randomized, controlled, non-placebo trial to primarily assess the effect of oral, outpatient antibiotics (i.e., azithromycin and amoxicillin) on latency (i.e., proportion of patients that deliver within 28 days from membrane…
- Conditions
- Pregnancy Preterm, Pregnancy Prom, PROM, Preterm (Pregnancy), PROM (Pregnancy)
- Trial name
- NCT05345457
- Testing
- Azithromycin Pill, Amoxicillin Pill
- Where
- 3 sites in United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Wounds and Injuries, War-Related Injuries
Wound Bacterial Microbiota and Their Antibiotic Resistance
The purpose of the study is to explore the microbiology in war-associated wounds of hospitalized patients from the Syrian armed conflict. Cultures collected from acute wounds with clinical signs of infection will be analyzed.
- Conditions
- Wounds and Injuries, War-Related Injuries, Wound Infection, Wounds, Penetrating
- Trial name
- NCT02744144
- Where
- Jordan
- Volunteers
- 457 people
- Sponsor
- Karolinska Institutet
Bacteremia
Rapid Antimicrobial Susceptibility Testing with MIC Directly from Positive Blood Cultures with ASTar
The investigators want to investigate the clinical impact of early antimicrobial susceptibility results for gram negative bacilli isolated from blood cultures on antimicrobial choices and early switches of antimicrobial therapy.
- Trial name
- RASTA (NCT06218277)
- Testing
- ASTAR
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- University Hospital, Ghent
Antimicrobial Resistance
Metaphors to Enhance Antibiotic Appropriate Use Knowledge and Behaviours to Reduce Educational Disparities
A randomized controlled survey experiment was conducted from October to November 2024 to assess the effectiveness of metaphor-based health education in improving Chinese parents' knowledge and behavioural intentions regarding…
- Trial name
- NCT07352371
- Testing
- metaphorical messages, conventional messages
- Where
- China
- Volunteers
- 866 people, healthy volunteers welcome
- Sponsor
- Bo Yan
Plaque, Gingivitis
Study to Investigate Toothpaste on Antibacterial Effects in the Different Regions of the Mouth
The clinical study will examine the effects of brushing with randomly assigned test toothpaste on the bacteria on the dental plaque, tongue, cheek, gum surface, and in saliva
- Trial name
- NCT07458464
- Testing
- stannous fluoride toothpaste, 0.76% Sodium Monofluorophosphate (Na MFP) toothpaste
- Where
- 2 sites in Thailand
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gastric Diffuse Large B-cell Lymphoma
First-line Antibiotic Therapy for Early-stage HP(+) Gastric Pure DLBCL
Aims: A nationwide study to prospectively validate 1. The complete histological and molecular remission rate for antibiotics as 1st-line therapy for early-stage Hp-positive gastric pure (de novo) DLBCL 2.
- Trial name
- NCT02388581
- Testing
- Lansoprazole, Amoxicillin, Clarithromycin, Metronidazole
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Health Research Institutes, Taiwan
Malaria, Pneumonia
Assessment of Use of Rapid Diagnostic Testing in the Context of Home Management With ACTs
This study is to assess the value of incorporating a malaria RDT based strategy in HMM. The primary activity of the study wil be a two armed cluster randomised trial in two study sites in Uganda, one in Ghana and one in Burkina…
- Trial name
- NCT00720811
- Testing
- Artemether-lumefantrine combination, amoxycillin, paracetamol
- Where
- 4 sites in Burkina Faso, Ghana and 1 more
- Volunteers
- 6,456 people
- Sponsor
- Mbarara University of Science and Technology
Alteration in Quality of Life of CF Patients, Following Change of Treatment From Antibiotic Inhalation to Antibiotic Inhaler
Switching From Tobramycin Inhalation Treatment to Tobramycin Inhaler Treatment: The Effect on CF Patients' Adherence and Quality of Life
Pseudomonas is a common and virulent respiratory bacteria in patients with Cystic Fibrosis (CF). With time, the infection with Pseudomonas becomes chronic and very difficult to eradicate.
- Trial name
- NCT01749644
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Wound Heal, Wound Healing Delayed
An Exploratory Research on the Efficacy and Safety of Antibacterial Absorbable Dressing in Chronic Non-healing Wounds
Antimicrobial absorbable wound dressing is a novel polyester-based degradable dressing. Previous preclinical studies have demonstrated promising efficacy, with a 3-week wound area reduction rate of 63.53% in large animal models…
- Trial name
- NCT07261501
- Testing
- antimicrobial absorbable wound dressing
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University Third Hospital
Dental Caries
Use of Antibacterial Cement in Infected Dentin
Dental materials with antibacterial properties can prevent the harmful effects caused by oral cariogenic bacteria. This double-blind controlled clinical trial evaluated the performance of antibacterial cement for sealing infected…
- Trial name
- AC (NCT01449136)
- Testing
- Antibacterial cement
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- University of Pernambuco
Neonatal Early-onset Sepsis, Neonatal Late-onset Sepsis
A Pilot Randomized Controlled Trial for Antibiotic Exposure in Neonatal Sepsis Using Neutrophil CD64
Unnecessary and prolonged antibiotic therapy in newborn babies can have serious consequences including development of necrotizing enterocolitis (a serious, potentially life-threatening gastrointestinal illness in premature…
- Trial name
- NCT01825421
- Testing
- Intervention is to stop antibiotics at 24h .
- Where
- United States
- Sponsor
- Yale University
Preoperative Skin Preparation
Effectiveness of an Antimicrobial Agent for Preoperative Skin Preparation
Objective of this study is to compare the antimicrobial properties of an investigational agent to an active control and a negative control when applied to specific body locations.
- Trial name
- NCT03224299
- Testing
- OCT - clear, OCT- tinted, ChloraPrep
- Where
- 2 sites in United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Becton, Dickinson and Company
Urinary Tract Infection, Bacteriuria
Prophylactic Antibiotics on Urethral Catheter Withdrawal
Urinary-tract infection (UTI) is the most common type of hospital-acquired infection (30% of all). The purpose of this study is to determine whether antibiotic prophylaxis for urinary catheter removal is useful at preventing…
- Trial name
- NCT00126698
- Testing
- trimethoprim-sulfamethoxazole, ciprofloxacin
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- St. Antonius Hospital
Bacterial Infections, Ceftazidime
Serum Ceftazidime Concentrations in Hemodialysis Patients
There is evidence that the current dosing recommendations of ceftazidime in hemodialysis patients may not reach the critical pharmacokinetic/pharmacodynamics thresholds associated with maximal efficacy.
- Conditions
- Bacterial Infections, Ceftazidime, Renal Failure Chronic Requiring Hemodialysis
- Trial name
- CEFTAHEMOD (NCT03634904)
- Testing
- Drug bood sampling
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Charleroi
Antimicrobial Stewardship Program
Effects of an Antimicrobial Stewardship (AMS) Program, on the Prevalence of Multidrug-resistant Gram - Negative Pathogens, in an Area of High Consumption of Antibiotics and High Resistance Rates
1. To evaluate the long-term effect of the AMS program on the consumption of broad-spectrum antibiotics and on the consumption of antibiotics in general (sustainability of the efficacy of the program).
- Trial name
- NCT04261348
- Testing
- No intervention
- Where
- Greece
- Volunteers
- 500 people
- Sponsor
- Laikο General Hospital, Athens
Conjunctival Bacterial Flora
Effectiveness of Topical 0.5% Levofloxacin to Reduce the Conjunctival Bacterial Flora Before Intraocular Surgery
The purpose of this study is to determine whether additional topical application of 0.5% levofloxacin is more effective in reducing the load of the conjunctival bacterial flora in patients scheduled for intraocular surgery than…
- Trial name
- NCT00491049
- Testing
- 0.5% levofloxacin eye drops
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Ludwig-Maximilians - University of Munich
SARS-CoV-2 Infection
Asymptomatic COVID-19 Trial
The coronavirus disease-2019 (COVID-19) is spreading throughout the United States. While there are no known therapies to treat those who have become sick, there have been some reports that a medication currently used to treat…
- Trial name
- ACT (NCT04374552)
- Testing
- Hydroxychloroquine sulfate &Azithromycin
- Where
- United States
- Sponsor
- Rutgers, The State University of New Jersey
Healthy Volunteers
Selection of Antibiotic Resistance by Azithromycin and Clarithromycin in the Oral Flora
Resistance to antibiotics is a major public-health problem and studies linking antibiotic use and resistance have shown an association not a causal effect.
- Trial name
- NCT00354952
- Testing
- Macrolides (azithromycin or clarithromycin)
- Where
- Belgium
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
GBS
The Implementation of Real-time PCR - Intrapartum GBS (Group B Streptococcus) Colonization to Reduce Antibiotic Prophylaxis
The implementation of real-time PCR for detection of intrapartum GBS (group B Streptococcus) colonization as a way to reduce antibiotic prophylaxis usage.
- Trial name
- NCT03936816
- Testing
- GBS vaginal double swab
- Where
- Israel
- Volunteers
- 303 people
- Sponsor
- Carmel Medical Center
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