Clinical trials: Anti-bacterial Agents
Psoriasis
Characterization of Cutaneous Microbiota in the Psoriasis Pathogenesis
The skin harbors a complex and dynamic microbiota constituted by numerous microorganisms that live in symbiosis with the host. The specific etiology of psoriasis is still not-well understood; nonetheless several studies…
- Trial name
- MICROBIOTA (NCT03475914)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Dental Caries
the Antibacterial Effect of Zinc ,Silver and Fluoride
natural teeth will be filled with the 3 different material then the dentin sample will be collected ,bacterial culture and elementary analysis will be done
- Trial name
- NCT04329858
- Testing
- silver modified glass ionomer, zinc modified, conventional glass ionomer
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Sepsis, Severe Sepsis
Gram Type Infection-Specific Sepsis Identification Using Machine Learning
The focus of this study will be to conduct a prospective, randomized controlled trial (RCT) at Cape Regional Medical Center (CRMC), Oroville Hospital (OH), and UCSF Medical Center (UCSF) in which a Gram type infection-specific…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT03734484
- Testing
- InSight
- Volunteers
- healthy volunteers welcome
- Sponsor
- Dascena
Colorectal Cancer
Does Administration of Antibiotics in Patients Undergoing Surgery for Colorectal Cancer Result in Less Complications and Better Prognosis?
The primary objectives of this randomized clinical trial are to evaluate if perioperative SDD can reduce clinical anastomotic leakage rate and its septic consequences as well as other infectious complications.
- Trial name
- SELECT (NCT01740947)
- Testing
- Selective decontamination of the digestive tract (SDD) (colistin sulfate, tobramycin, amphotericin B)
- Where
- 5 sites in Netherlands
- Volunteers
- 485 people
- Sponsor
- H. Jaap Bonjer, PhD
Pneumonia, Ventilator-Associated, Pneumonia, Hospital Acquired
FilmArray Pneumonia Panel for Antimicrobial Treatment of HAP/VAP in Intensive Care Units
Microbiologic diagnosis of pneumonia is often limited by a long turnaround time of cultures. This randomized trial aims to evaluate the impact of BioFire FilmArray Pneumonia panel on (1) the proportion of appropriate/optimal…
- Conditions
- Pneumonia, Ventilator-Associated, Pneumonia, Hospital Acquired, Critically Ill
- Trial name
- FilmArray (NCT05214716)
- Testing
- FilmArray Pneumonia panel
- Where
- South Korea
- Volunteers
- 41 people
- Sponsor
- Kyungmin Huh
Antibiotic Reaction
Antimicrobial Resistance Rate In Escherichia Coli And Klebsiella Pneumonia : A Retrospective Study
Antibiotics are medicines used to avoid and treat bacterial infections. Antibiotic resistance is increasing to dangerous level globally.
- Trial name
- NCT04196387
- Testing
- urine culture
- Volunteers
- 1,000 people
- Sponsor
- Batool Mutar
Severe Sepsis, Septic Shock
Comparison of Two Antibiotic Regimen (Meropenem Versus Meropenem+Moxifloxacin)in the Treatment of Severe Sepsis and Septic Shock
Severe sepsis and septic shock are diseases of infectious origin with a high risk of death. Antibiotic therapy is mandatory but it is unknown whether one antibiotic alone is sufficient for initial therapy.
- Trial name
- MaxSep (NCT00534287)
- Testing
- meropenem, meropenem, moxifloxacin
- Where
- 52 sites in Germany
- Volunteers
- 600 people
- Sponsor
- Kompetenznetz Sepsis
Pneumonia - Bacterial
Impact of BioFire FilmArray Pneumonia Panel vs Routine Diagnostics on Antimicrobial Outcomes (DOOR-MAT)
Multidrug-resistant bacterial infections are a growing global health concern. Hospital-acquired pneumonia is one of the most common infections occurring during hospitalization and can be associated with high mortality, reaching…
- Trial name
- NCT07585604
- Testing
- Multiplex PCR-based pneumonia panel (BIOFIRE® FILMARRAY® Pneumonia Panel)
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Recurrent Diffuse Large B-Cell Lymphoma, Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements
Fecal Microbiome Transplant to Remodel Intestinal Microbiota for Patients With Relapsed or Refractory Lymphoma With Exposure to High-Risk Antibiotics Who Are Receiving Chimeric Antigen Receptor T Cells
This phase II trial tests how well fecal microbiome transplantation works to remodel intestinal microbiota for patients with lymphoma that has come back after a period of improvement (relapsed) or that does not respond to…
- Conditions
- Recurrent Diffuse Large B-Cell Lymphoma, Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements, Recurrent Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma, Refractory Diffuse Large B-Cell Lymphoma
- Trial name
- NCT07042438
- Testing
- Axicabtagene Ciloleucel, Biospecimen Collection, Chemotherapy
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- City of Hope Medical Center
Respiratory Tract Infections
Patient Centered Communication Training to Reduce Antibiotic Use in Acute Respiratory Tract Infections
The purpose of this study is to evaluate the effectiveness of a short training program for general practitioners in patient-centered communication to reduce antibiotic prescription for acute respiratory tract infections (ARTI).
- Trial name
- NCT00105248
- Testing
- patient-centered communication training
- Where
- Switzerland
- Volunteers
- 900 people
- Sponsor
- University Hospital, Basel, Switzerland
Colorectal Surgery
Prospective Randomized Clinical Trial on Oral and Intravenous Antibiotic Prophylaxis in Colorectal Surgery.
Elective colon surgery is considered a clean-contaminated procedure, with a Surgical Site Infection (SSI) rate not inferior to 10%.
- Trial name
- COLORAL1 (NCT04438655)
- Testing
- Oral antibiotic drugs, Parenteral prophylaxis
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- University of Turin, Italy
Hospital-acquired Pneumonia
Impact of Antimicrobial Stewardship on Outcomes of Patients With Hospital-acquired Pneumonia Due to Gram-negative Bacilli - A Before-after Study
Hospital-acquired pneumonia (HAP) is one of the most frequent complications and the main cause of antibiotics use in hospitalized patients, particularly in intensive care units (ICUs).
- Trial name
- ORACLE (NCT04937075)
- Testing
- No intervention
- Where
- 2 sites in France
- Volunteers
- 420 people
- Sponsor
- Nantes University Hospital
Liver Transplant Infection, Surgical Site Infection
Pharmacological Study of Cefazolin Antibioprophylaxis in Liver Transplantation
This study describes Cefazolin pharmacokinetics variation to target levels during liver transplantation.
- Conditions
- Liver Transplant Infection, Surgical Site Infection, Antibiotic Prophylaxis, Cephazolin Adverse Reaction
- Trial name
- ProCeTH (NCT04280237)
- Testing
- Blood samples
- Where
- France
- Sponsor
- University Hospital, Tours
Solid Tumor
Effectiveness of Antibiotic Prophylaxis for Totally Implantable Venous Access Device
This randomized trial is determining the role of antibiotic prophylaxis in the prevention of the infectious complications in patients carrying out totally implantable venous access device.
- Trial name
- TIVAD (NCT00867295)
- Testing
- cefazolin Sodium
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Istanbul University
Effects of the Elements
Effect of Removal of Double Antibiotic Paste on Post Operative Pain
Recruited patients with necrotic pulp after application of double antibiotic paste are assigned to group (XP Endo Finisher file) and group( Passive ultrasonic irrigation) and group (conventional syringe irrigation with side…
- Trial name
- NCT04327453
- Testing
- double antibiotic paste with XP-endo Finisher file, double antibiotic paste with Irrisafe Ultrasonic tip, double antibiotic paste with side vented needle
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Minia University
Gangrenous Appendicitis
Prophylaxis With Single Versus Five Dose of Antibiotic Therapy as Treatment of Patients With Gangrenous Acute Appendicitis
A prospective, randomized controlled clinical trial was conducted at the Hospital Universitario de Santander to test the effectiveness of providing a single 1-dose therapy of antibiotic prophylaxis versus a 5-day antibiotic…
- Trial name
- NCT01115153
- Testing
- prophylaxis, therapy
- Where
- Colombia
- Volunteers
- 150 people
- Sponsor
- Universidad Industrial de Santander
Pulmonary Sepsis
Personalized Optimization of Antibiotic Therapy in Pulmonary Sepsis Critically Ill Patients Through Application of Rapid Microbiological Diagnostic Technologies and Pharmacokinetic/Pharmacodynamic Modelling
Severe community-acquired and nosocomial pneumonia are associated with substantial morbidity and mortality. Early and appropriate antimicrobial therapy (AAT) is consistently the most effective intervention for reducing mortality.
- Trial name
- IDAST (NCT06956053)
- Testing
- Rapid ID/AST method, Conventional biological methods
- Volunteers
- 658 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Wear of Articular Bearing Surface of Internal Prosthetic Joint, Infection Prosthetic
Percutaneous Punch Biopsy for Diagnosis of Septic and Aseptic Prosthetic Joint Failure
The aim of the superiority study is to establish a reproducible, minimally invasive, cost-effective way of sample collection for microbiological and pathomorphological processing in a clinical setting with avoidance of…
- Conditions
- Wear of Articular Bearing Surface of Internal Prosthetic Joint, Infection Prosthetic, Infections Joint Prosthetic, Prosthetic Joint Infection
- Trial name
- SHARP (NCT04620395)
- Testing
- Punch biopsy
- Where
- Germany
- Volunteers
- 132 people
- Sponsor
- Vivantes Netzwerk für Gesundheit GmbH
Antibiotic-Associated Diarrhea
Probiotics at the Treatment of Antibiotic Associated Diarrhea
The purpose of this study is to know the efficacy of the treatment with probiotics, Lactobacillus casei and Bifidobacterium breve, on clinical evidences and occurence of relapses on antibiotic-associated diarrhea.
- Trial name
- NCT00700557
- Testing
- Probiotics - Lactobacillus casei and Bifidobacterium breve, Maize starch
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Federal University of Uberlandia
Cholecystitis, Acute
Necessity of Preoperative Empirical Antibiotic Use in Acute Cholecystitis
In this study, the investigators compared the surgical outcomes according to the type of antibiotics before surgery in patients who did not have evidence of systemic infection during acute cholecystitis.
- Trial name
- NCT04661371
- Testing
- Laparoscopic cholecystectomy
- Where
- South Korea
- Volunteers
- 180 people
- Sponsor
- Seoul St. Mary's Hospital
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