Clinical trials: Antibiotic Resistance, Microbial
Acute Respiratory Tract Infections
Optimisation of Antibiotic Prescription in Acute Noncomplicated Respiratory Tract Infections in Children (OptimAP Study)
Background: High-volume antibiotic prescribing in primary care is a major driver of antibiotic resistance. Education of physicians and patients can lower prescribing levels, but it frequently relies on highly trained staff.
- Trial name
- OptimAP (NCT05166369)
- Testing
- Communication skills training, Mobile phone application on RTI
- Where
- 4 sites in Spain
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Antibiotic Reaction
Antibiotic Prescribing Behavior Among French Intensivist: Construction and Validation of a Questionnaire
Antibiotic resistance is a major threat in modern medicine. Overuse of antibiotics is an important driver of antibiotic resistance.
- Trial name
- NCT04820062
- Testing
- Content Validity
- Where
- France
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Antibiotic Resistance, Antibiotic Use
Antibiotics, Antibiotic Resistance, and Prescribing Practices Among Periodontists: Cross Sectional KAP Study
Antibiotic resistance is a global health threats that require attention from all healthcare providers. In Periodontology, antibiotic is prescribed in many clinical situations.
- Conditions
- Antibiotic Resistance, Antibiotic Use, Periodontitis
- Trial name
- NCT06371560
- Testing
- Questionnaire
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Disease, Periodontitis
Antibiotic Resistance Genes in Periodontitis
Antimicrobial resistance (AMR) is a major global public health concern, and the oral microbiome may serve as an important reservoir of antibiotic resistance genes (ARGs).
- Conditions
- Periodontal Disease, Periodontitis, Antibiotic Resistance Genes
- Trial name
- NCT07887204
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Staphylococcal Infections
Bacterial Phenotype of Staphylococcus Aureus Has no Effect on Patients' Clinical Outcome in Orthopedic Device Related Bone Infections
This was a prospective study performed between November 2011 and September 2013. Patients with a confirmed S. aureus infection after fracture fixation or prosthetic joint infection were included.
- Trial name
- StaphType (NCT02971657)
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- BG Unfallklinik Murnau
Intensive Care Unit
Intestinal Microbiota and Their Antibiotic Resistance Genes of ICU Health Care Workers
In this study, metagenomic sequencing (10G) results of stool samples from health care workers in ICU and non-medical professionals were compared to observe whether there are significant differences in community diversity…
- Trial name
- NCT06524765
- Testing
- Living conditions
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Healthy Volunteer
An Open Study to Assess the Safety and Pharmacokinetics of Fluorothyazinone as a Single-Dose Administration or a Treatment Course in Healthy Volunteers
The current Phase I clinical trial has been developed to assess the safety and tolerability of the Fluorothyazinone drug used as a single-dose administration and a treatment course in healthy volunteers.
- Trial name
- NCT03205462
- Testing
- Fluorothyazinone 300 mg, Fluorothyazinone 600 mg, Fluorothyazinone 3900 mg
- Where
- Russia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
Healthy Volunteers
Selection of Antibiotic Resistance by Azithromycin and Clarithromycin in the Oral Flora
Resistance to antibiotics is a major public-health problem and studies linking antibiotic use and resistance have shown an association not a causal effect.
- Trial name
- NCT00354952
- Testing
- Macrolides (azithromycin or clarithromycin)
- Where
- Belgium
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Escherichia Coli; Infection, Intestinal
Study of the Ecological and Evolutionary Dynamics of Escherichia Coli in the Digestive Commensal Flora
Escherichia coli (E. coli) poses a major public health problem. E. coli is not only a commensal of the digestive tract but also a major opportunistic pathogen, first cause of urinary tract infections, first cause of bacteremia.
- Trial name
- EVE (NCT05153824)
- Where
- 2 sites in France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Resistance Bacterial, Increased Drug Resistance
Decreasing Irrational Antimicrobial Use in Bangladesh: A Digital Intervention Program
We developed 'SmartAMR', a digital pharmacy system featuring real-time records, symptom checks, telemedicine, counselling, and medication reminders.
- Conditions
- Resistance Bacterial, Increased Drug Resistance, Drug Resistance, Microbial
- Trial name
- SmartAMR (NCT06313619)
- Testing
- SmartAMR
- Where
- Bangladesh
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Dysbiosis
A Pilot Study Assessing Intestinal Microbiota Diversification and Changes After Travel to South(East) Asia From the US
This prospective, observational pilot study is designed to assess feasibility, refine the target population, and quickly test qualitative and quantitative changes in the microbiome after short-term travel to South or Southeast…
- Trial name
- ABROAD (NCT03043300)
- Testing
- Screening Criteria Review, Pre-Travel Questionnaire, Pre-Travel Stool Specimen Collection
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Emory University
Nasopharyngeal Carriage of Streptococcus Pneumoniae
Pneumococcal Carriage, Serotypes, and Antibiotic Resistance in Malaysian Children: A Multi-Centre Study
The goal of this observational study is to determine the prevalence, serotype distribution, and antimicrobial resistance patterns of nasopharyngeal carriage of Streptococcus pneumoniae in Malaysian children aged ≤5 years…
- Trial name
- MY-PNEUMO2 (NCT07545876)
- Where
- 4 sites in Malaysia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- IMU University, Malaysia
Pneumonia, Pneumococcal, Community-acquired Pneumonia
Quantitative Polymerase Chain Reaction for Improved Detection of Pneumococci in CAP "CAPTAIN"
The purpose of this study is to evaluate the added diagnostic value of a quantitative polymerase chain reaction targeting the lytA gene in detecting pneumococci in patients with community-acquired pneumonia.
- Trial name
- CAPTAIN (NCT03315403)
- Testing
- LytA targeted quantitative polymerase chain reaction (qPCR)
- Where
- 2 sites in Netherlands
- Volunteers
- 922 people, healthy volunteers welcome
- Sponsor
- Medical Center Alkmaar
Enterobacteriaceae, Infection
Carriage Of Multiresistant Bacteria After Travel
Objectives: Prospectively study the influence of foreign travel and associated risk factors on the acquisition of AMR in the endogenous microbiota of healthy individuals and the subsequent persistence of AMR carriage and…
- Trial name
- COMBAT (NCT01676974)
- Where
- 3 sites in Netherlands
- Volunteers
- 2,215 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Antibiotic Use
Testing Interventions Designed to Improve How Members of the General Public Follow Instructions to Take Antibiotics
Antimicrobial resistance (AMR) is a global public health challenge. Due to overuse of antibiotics, bacteria are becoming resistant to antibiotics, which creates infections that can't be treated by modern medicine.
- Trial name
- NCT07111754
- Testing
- Behavioural Message, Behavioural message + positive framing, Behavioural message + negative framing
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Infection
Antibiotic Prophylaxis for Transrectal Prostate Biopsy
This study is being conducted in men scheduled to undergo transrectal ultrasound-guided prostate biopsy (TRUSP). Traditionally prior to prostate biopsy, an antibiotic, ciprofloxacin, has been given to men to prevent…
- Trial name
- NCT01659866
- Testing
- Ciprofloxacin, trimethoprim-sulfamethoxazole, cefuroxime
- Where
- United States
- Volunteers
- 563 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Antibiotic Prescription
Prescription Pattern and Awareness About Antibiotic Prophylaxis and Resistance
To assess the knowledge of Pediatric dentists regarding the prescription of antibiotics, antibiotic prophylaxis and antibiotic resistance
- Trial name
- NCT04031443
- Where
- Egypt
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Cairo University
Antibiotic Resistant Bacteria
Effect of Minocycline & Amoxicillin on Antibiotic Resistant Bacteria and Indigenous Microbiotas
A randomised, open labelled study design is selected in order to determine the emergence and persistence of antibiotic resistant bacteria in humans and on the composition of the indigenous microbiotas at various body sites.
- Trial name
- ANTIRESDEV (NCT02030912)
- Testing
- 3 doses of amoxicillin daily for 7 days, 2 doses of minocycline daily for five days
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Helperby Therapeutics Ltd
Antibiotic Abuse
Antibiotic Abuse Patterns in Gharbia, Egypt
Antimicrobial resistance (AMR) represents a serious problem described by the World Health Organization (WHO) as "a global public health concern".
- Trial name
- NCT06503055
- Testing
- Questionnaire
- Where
- Egypt
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Rania Mamdouh Elkafoury
Infection
Allergy Antibiotics And Microbial Resistance
ALBAMA study is designed to find out if the effects of Penicillin allergy assessment pathway (PAAP) intervention is on penicillin prescribing
- Trial name
- ALABAMA (NCT04108637)
- Testing
- penicillin allergy assessment pathway
- Where
- United Kingdom
- Volunteers
- 823 people, healthy volunteers welcome
- Sponsor
- University of Leeds