Clinical trials: Antibiotics Resistance
Staphylococcus Aureus Infection
Staph Intervention for Effective Local Defense
Indigenous persons experience a high burden of Staphylococcus aureus (SA) invasive disease and skin and soft tissue infections. SA carriage on the skin is factor for development of SA infections.
- Trial name
- SHIELD (NCT06210594)
- Testing
- Mupirocin + Nozin + chlorhexidine gluconate, Education + Household supplies
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Cough, Lower Respiratory Tract Infection (LRTI)
An Observational Study of Cough / Lower Respiratory Tract Infection (LRTI) in Primary Care
The overall objective of GRACE is to combat the resistance of drugs that kill bacteria and other germs (antimicrobial) through integrating centres of research excellence and using the study of the entire DNA in a cell (genomics)…
- Conditions
- Cough, Lower Respiratory Tract Infection (LRTI), Chest Infection
- Trial name
- NCT00353951
- Where
- United Kingdom
- Volunteers
- 3,402 people
- Sponsor
- Cardiff University
Intensive Care Unit (ICU) Admission
Biomarker Signature-Supported Antibiotic Treatment Decisions in ICU
The goal of this randomized clinical trial is to determine whether a biomarker-signature (BV) supported antibiotic treatment decision matrix can have a beneficial impact on antibiotic use and patient outcomes in an ICU population.
- Trial name
- BAST-ICU (NCT07481773)
- Testing
- Biomarker-signature supported antibiotic treatment recommendation, Clinical assessment for antibiotic treatment decision
- Where
- 4 sites in Canada
- Volunteers
- 1,200 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Chlamydia Trachomatis Infection, Neisseria Gonorrhoeae Infection
Optimizing Antibiotic Prescription in STI Clinics Using Rapid POCT
Sexually transmitted infections (STIs) caused by Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are increasing in France, with a significant proportion of asymptomatic infections.
- Conditions
- Chlamydia Trachomatis Infection, Neisseria Gonorrhoeae Infection, Sexually Transmitted Infections, Antimicrobial Resistance / Antibiotic Overuse
- Trial name
- OPTIMISE (NCT07884656)
- Testing
- cobas® Liat® CT/NG Point-of-Care Test
- Where
- 2 sites in France
- Volunteers
- 404 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Antibiotic Resistance, Bacterial
Antibiotic Resistance in Danish EDs.
The spread of multiresistant bacteria is an increasing problem which will mean increased costs, morbidity and mortality in the coming years.
- Trial name
- AB-RED (NCT03352167)
- Where
- 8 sites in Denmark
- Volunteers
- 5,117 people
- Sponsor
- University of Southern Denmark
Ventilator Associated Pneumonia
7-days Versus 14 Days of Antibiotics Therapy for Ventilator Associated Pneumonia
There is evidence that using shorter antibiotic regimens may help in decreasing antimicrobial resistance and reducing drug-related adverse events.6 Moreover, short-course treatments were found to be as effective as longer-course…
- Trial name
- NCT03477292
- Testing
- Duration of antibiotic
- Where
- 2 sites in India
- Volunteers
- 41 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Combination Study of Antibiotics With Enzalutamide (PROMIZE)
PROMIZE is an open-label, multi-centre, single-arm, Phase I/II clinical trial, evaluating the safety, tolerability and anti-tumuor efficacy of an antibiotic combination and enzalutamide in patients with metastatic…
- Trial name
- NCT06126731
- Testing
- Enzalutamide 40mg, Amoxicillin 500mg, Metronidazole 400mg
- Where
- 2 sites in Switzerland, United Kingdom
- Volunteers
- 39 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Gram Negative Infections, Antimicrobial Resistance (AMR)
PK/PD Relationship of CAZ/AVI and FOS in the Treatment of Patients With Infections Due to CRE
A multicenter international prospective observational pharmacological study in adult patients (≥18 years) treated with ceftazidime/avibactam (CAZ/AVI) alone or with CAZ/AVI plus fosfomycin (FOS) for infection due to…
- Trial name
- CAVIFOS (NCT06717594)
- Where
- 2 sites in Italy, Spain
- Volunteers
- 60 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Sepsis
Procalcitonin Monitoring May Decrease Antibiotic Use in the Intensive Care Unit
Sepsis is common and is associated with significant mortality, morbidity and health-care costs. Unfortunately, its diagnosis is not straightforward because its signs and symptoms are neither specific nor sensitive; in addition…
- Trial name
- NCT01085994
- Testing
- Literature search
- Where
- Greece
- Sponsor
- University of Athens
Acute Febrile Illnesses
Validation of Promising Biomarker Assays to Assess Their Diagnostic Performance Characteristics
This project aims to evaluate the performance characteristics of rapid tests to differentiate bacterial from non-bacterial infection in febrile adults and children presenting at OPDs (outpatient departments) i.e.("fever triage…
- Trial name
- NCT03047642
- Testing
- Biomarker assay
- Where
- 3 sites in Brazil, Gabon and 1 more
- Volunteers
- 2,000 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Antibiotic Resistant Infection
Modified Surface of PLGA Nanoparticles in Smart Hydrogel
Nanoparticles containing antibiotic were prepared and incorporated in in situ gel to treat recurrent endodontic infections
- Trial name
- NCT05442736
- Testing
- Ciprofloxacin
- Where
- Egypt
- Volunteers
- 55 people
- Sponsor
- British University In Egypt
Hospital-acquired Pneumonia, Antibiotic Resistant Infection
Chinese Hospital Acquired Pneumonia Collaboration Network: Epidemiology, Diagnosis and Treatment
The goal of this prospective and observatory study is to learn about the pathogen, clinical manifestations, prognosis, treatment and antibiotic resistance of bacteria in hospital-acquired pneumonia patients in China.
- Trial name
- CHAPTER (NCT06028217)
- Testing
- prognosis status
- Volunteers
- 4,000 people
- Sponsor
- Ruijin Hospital
Bacterial Infections and Mycoses
Infant Antibiotic Resistance and Implications for Therapeutic Decision-making
Escalating resistance to antibiotics among disease-causing community bacteria increasingly threatens our ability to treat patients' infections.
- Trial name
- NCT01781182
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- University Hospitals Cleveland Medical Center
Ventilator Associated Pneumonia
How COVID-19 Virus Outbreak Affects Antimicrobial Resistance in a Low-middle-income Country's ICU?
A previous study showed a high incidence of ventilator-associated pneumonia to multidrug resistant pathogens in our ICU. That has been related to lack of compliance to hand hygiene among health care providers in ou ICU.
- Trial name
- NCT04348227
- Testing
- Enhanced hygiene measures
- Where
- Tunisia
- Volunteers
- 120 people
- Sponsor
- Hôpital Universitaire Fattouma Bourguiba
Gram-Negative Bacterial Infections
Quantifying Gram-negative Resistance to Empiric Therapy in the Intensive Care Unit
Antimicrobial resistance is a global health emergency estimated to be responsible for 700,000 deaths per year worldwide, and it is well known that previous antibiotic exposure is the single most contributing factor.
- Trial name
- RESTART (NCT05171257)
- Testing
- IV antibiotic treatment from prior, differing IV antibiotic treatment
- Where
- United States
- Volunteers
- 197 people
- Sponsor
- Methodist Health System
Antimicrobial Resistance
A Multicentre Study of Wastewater and Antibiotic Resistance in Care Homes.
This study aims to model the relationship between the prevalence of ESBL-E and CPE carriage among nursing home residents and their respective concentrations in wastewater discharged from the facility.
- Trial name
- E-FLUENT (NCT07234331)
- Where
- 2 sites in France
- Volunteers
- 1,600 people
- Sponsor
- Nantes University Hospital
Enterobacteriaceae Infections, Multi-antibiotic Resistance
FMT for the Decolonization of Carbapenem-resistant Enterobacteriaceae
Rates of antimicrobial resistance are increasing worldwide. There is increasing evidence that physiological gut microbiota is a large reservoir of antibiotic-resistance genes.
- Trial name
- FMT-CRE (NCT04759001)
- Testing
- Donor FMT
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Abscess
Antibiotic Therapy After Incision and Drainage for Abscess
Background: Skin abscesses are a growing problem in the general pediatric population around the world. While the standard treatment for an abscess/boil is incision and drainage, many physicians also prescribe antibiotics, despite…
- Trial name
- NCT00900510
- Testing
- Incision and drainage, Trimethoprim/Sulfamethoxazole (Bactrim)
- Where
- United States
- Sponsor
- Wake Forest University
Staphylococcus Aureus Bacteremia, Anti-Bacterial Agents
Phase IIa Clinical Study of N-Rephasin® SAL200
This study is performed to evaluate safety and to explore the efficacy of a single intravenous dose of N-Rephasin® SAL200 (3 mg/kg) in addition to the conventional standard treatment, for persistent Staphylococcus aureus…
- Trial name
- NCT03089697
- Testing
- N-Rephasin® SAL200
- Where
- 2 sites in South Korea
- Volunteers
- 25 people
- Sponsor
- Intron Biotechnology, Inc.
Sepsis, Sepsis Mrsa
Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis
The goal of this quasi-experimental interventional study is to determine the effectiveness of a multifaceted stewardship intervention in reducing overall vancomycin use in five tertiary care Pediatric Intensive Care Units (PICU).
- Conditions
- Sepsis, Sepsis Mrsa, Sepsis Bacteremia, Antimicrobial - Induced Nephropathy
- Trial name
- REVAMP (NCT05975671)
- Testing
- Multifaceted de-implementation strategy to reduce vancomycin overuse
- Where
- 4 sites in United States
- Volunteers
- 52,500 people
- Sponsor
- Children's Hospital of Philadelphia