Clinical trials: Aortic Arch Replacement
Aortic Aneurysm, Aortic Dissection
A Novel Wire-Reinforced Fenestration of a Hybrid Frozen Elephant Trunk Device for Supra-Aortic Branch Vessel Stenting During Aortic Arch Replacement
The goal of this prospective, non-randomized trial is to determine the safety and technical success of a novel modification to a U.S.
- Conditions
- Aortic Aneurysm, Aortic Dissection, Penetrating Aortic Ulcer (PAU), Aortic Pseudoaneurysm
- Trial name
- SA-FET (NCT07885865)
- Testing
- Modified Supra-Aortic Frozen Elephant Trunk (SA-FET) Device
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Maryland, Baltimore
Aortic Dissection
Optimal Strategy for Repair of Type A Acute Aortic Dissection
Acute type A aortic dissection (TAAD) persists as a clinicopathologic entity with high lethality in the current era. Several procedures are presently used to repair the TAAAD.
- Trial name
- TARAD (NCT05912608)
- Testing
- Conservative TAAAD-R, Extensive TAAAD-R
- Where
- France
- Volunteers
- 900 people
- Sponsor
- Centre Cardiologique du Nord
Aortic Arch Replacement, Hemi Arch Replacement
Neurologic Injury Following Aortic Arch Replacement
Investigators are seeking to learn how well different cooling temperatures along with different blood flow pathways to the brain reduce the risk of injury to the brain in participants planning to undergo elective aortic arch and…
- Trial name
- NCT02750423
- Testing
- DHCA+RCP, MHCA + SACP
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Atrial Fibrillation (AF), Aortic Arch Replacement
Cardiac Denervation in Aortic Arch Replacement
Atrial fibrillation (AF) is one of the most common clinical arrhythmias, particularly after cardiac surgery, where its incidence can reach as high as 10% to 40%, significantly impacting patients' prognosis.
- Trial name
- NCT06927908
- Testing
- Partial Cardiac Denervation
- Volunteers
- 570 people
- Sponsor
- Beijing Anzhen Hospital
Residual Dissection After Repair for Type A Aortic Dissection
Effectiveness and Safety of a Type A Dissection Total Endovascular Reconstruction System in Promoting Favorable Distal Aortic Remodeling
This is a prospective, multicenter, randomized controlled clinical study. A total of 198 eligible subjects will be enrolled and randomly assigned in a 1:1 ratio to either the Study Group or the Control Group.
- Trial name
- REFORM-TAD (NCT07402252)
- Testing
- surgical treatment, Standard of Care (Investigator Choice)
- Where
- China
- Volunteers
- 198 people
- Sponsor
- West China Hospital
Type A Aortic Dissection, Ascending Aortic Dissection
Outcomes of Aortic Dissection Repair
Type A aortic dissection (TAAD) is a potentially life-threatening pathology associated with significant risk of mortality and morbidity.
- Conditions
- Type A Aortic Dissection, Ascending Aortic Dissection, Aortic Diseases, Aortic Arch
- Trial name
- STAAD (NCT05927090)
- Testing
- Conservative Root- Sparing Aortic Valve Resuspension with or without Hemiarch Repair, Extensive Ascending Aorta Replacement (AAR) with Aortic Root Replacement (ARR), Extensive Ascending Aorta Replacement (AAR) with Total Arch Replacement (TARP)
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Centre Cardiologique du Nord
Acute Aortic Dissection
Triple-branch Stent Graft Placement and Total-arch Replacement for the Treatment of Acute DeBakey I Aortic Dissection
The purpose of this study is to compare triple-branched stent placement with total-arch replacement in the treatment of acute DeBakey I aortic dissection .
- Trial name
- TBSGPATART (NCT02622750)
- Testing
- triple-branched stent graft, four-branched Dacron graft
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Liang-Wan Chen MD
Aortic Aneurysm, Aortic Dissection
Thoraflex™ Hybrid IDE Study
The study will assess the effectiveness, safety and clinical outcomes of the Thoraflex™ Hybrid Device in the treatment of aortic disease affecting the aortic arch and the descending thoracic aorta, with or without involvement of…
- Conditions
- Aortic Aneurysm, Aortic Dissection, Aortic Rupture
- Trial name
- NCT02724072
- Testing
- Thoraflex™ Hybrid Device
- Where
- 12 sites in United States
- Volunteers
- 84 people
- Sponsor
- Bolton Medical
Aortic Aneurysm and Dissection
Guo's Endovascular Aortic Arch Replacement of Aortic Dissection by WeFlow-Tribranch Endoprothesis: a Multicenter Pilot Study(GRAFT Study)
To explore the effect and prognosis of endovascular interventional therapy in high-risk patients with aortic arch dissection and aneurysm
- Trial name
- NCT05754541
- Testing
- WeFlow-Tribranch Aortic Arch Stent Graft System
- Where
- 4 sites in China
- Volunteers
- 20 people
- Sponsor
- Hangzhou Endonom Medtech Co., Ltd.
Use of Dexmedetomidine in Cardiac Surgery (CABG, Valve Replacement or Total Aortic Arch Replacement)
Effect of Dexmedetomidine on Hemodynamics in Cardiac Surgery
It is important to establish a stable haemodynamics in patients undergoing cardiac surgery. Haemodynamic depression is common during induction of anaesthesia [1].
- Trial name
- NCT06958913
- Testing
- Propofol group, Dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Pamukkale University
Type A Aortic Dissection, Circulatory Arrest
Antegrade Cerebral Perfusion and Retrograde Inferior Vena Caval Perfusion for Total Aortic Arch Replacement
This study is designed as a multicenter, randomized, assessor- blinded clinical trial.The primary aim of this trial is to assess whether retrograde inferior venal caval perfusion combined selective antegrade cerebral…
- Conditions
- Type A Aortic Dissection, Circulatory Arrest, Hypothermia
- Trial name
- CARTAR (NCT03607786)
- Testing
- Retrograde Inferior Vena Caval Perfusion, Select antegrade cerebral perfusion
- Where
- China
- Volunteers
- 600 people
- Sponsor
- West China Hospital
Aortic Intramural Hematoma
AAR/AAR+HAR vs AAR+TAR+FET for Type A Aortic Intramural Hematoma
This is a prospective, randomized, non-inferiority clinical trial designed to compare the efficacy and safety of two surgical strategies for acute type A aortic intramural hematoma (TAIMH): (1) ascending aorta replacement or…
- Trial name
- NCT07272655
- Testing
- Ascending Aorta Replacement / Ascending Aorta Plus Hemiarch Replacement, Ascending Aorta Replacement With Total Arch Replacement and Frozen Elephant Trunk
- Volunteers
- 400 people
- Sponsor
- Second Hospital of Jilin University
Acute Type A Aortic Dissection, Hypothermia
Arch-Clamping Technique Under Mild Hypothermia in Treating With Acute Type A Aortic Dissection
The study is a multicenter, three-arm, open-label, randomized, parallel-controlled trial, which plans to enroll 306 participants diagnosed with acute type A aortic dissection (ATAAD) from 7 hospitals in China.
- Conditions
- Acute Type A Aortic Dissection, Hypothermia, Total Aortic Arch Replacement, Frozen Elephant Trunk
- Trial name
- AHEAD (NCT07150559)
- Testing
- Arch-Clamping Technique under Mild Hypothermia, Arch-Clamping Technique under Moderate Hypothermia, Total Arch Replacement combined Frozen Elephant Trunk Implantation using Bilateral Antegrade Cerebral Perfusion under Moderate Hypothermic Circulatory Arrest
- Where
- China
- Volunteers
- 306 people
- Sponsor
- Beijing Anzhen Hospital
Aortic Dissection Type A
Total Arch Replacement With Frozen Elephant Trunk Versus Hemiarch Replacement in the Management of Acute Type A Aortic Dissection
Acute Type A aortic dissection (ATAAD) and its complications are life-threatening conditions that cause more than 1400 hospital admissions and 300 deaths every year in Hong Kong and cause 172,927 deaths globally in 2019.
- Trial name
- TARFET-TAAD (NCT06676371)
- Testing
- Conventional hemiarch replacement, E-vita® Open Neo; Artivion, Thoraflex Hybrid; Terumo
- Where
- 3 sites in Austria, Hong Kong and 1 more
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
Aortic Dissection, Aortic Arch
Repair Versus Non-repair of the Aortic Arch in Type A Aortic Dissection
Acute Stanford type A aortic dissection (TAAD) is a life-threatening clinical status requiring surgery that is usually performed as a salvage procedure.We planned a multicenter study to evaluate the balance between the patient's…
- Conditions
- Aortic Dissection, Aortic Arch, Aortic Dissection Rupture, Aortic Dilatation
- Trial name
- AoArch (NCT05912634)
- Testing
- Conservative TAAD-R, Extensive TAAD- R
- Where
- France
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Centre Cardiologique du Nord
Aortic Arch Aneurysm, Aortic Arch Dissection
Clinical Study to Evaluate the Safety and Effectiveness of Arcevo LSA
The goal of this clinical trial is to learn if the Arcevo LSA stent graft can safely and effectively treat patients that have an acute or chronic aortic dissection and/or aneurysm that involves the aortic arch and the descending…
- Conditions
- Aortic Arch Aneurysm, Aortic Arch Dissection, Chronic Aortic Dissection, Acute Aortic Dissection
- Trial name
- ARTIZEN (NCT07089576)
- Testing
- Arcevo™ LSA Hybrid Stent Graft System
- Where
- 26 sites in United States, Germany and 1 more
- Volunteers
- 132 people
- Sponsor
- Artivion Inc.
Aortic Arch; Aneurysm, Dissecting
Study of the Thoraflex™ Hybrid Device for the Treatment of Aneurysm/Dissection of the Descending Thoracic Aorta
The purpose of this national observational study is to evaluate the Thoraflex™ Hybrid vascular prosthesis in the replacement of the aortic arch and the treatment of aneurysm/dissection of the descending thoracic aorta in relation…
- Trial name
- NCT03735472
- Testing
- Thoraflex™ Hybrid
- Where
- 37 sites in France
- Volunteers
- 351 people
- Sponsor
- Vascutek Ltd.
Acute Type A Aortic Dissection
Three-Vessel Versus Unilateral Antegrade Cerebral Perfusion in Emergency Total Arch Replacement for Acute Type A Aortic Dissection
This single-centre retrospective observational cohort study describes the technical feasibility of direct three-vessel antegrade cerebral perfusion, designated modified antegrade cerebral perfusion (MACP), during emergency total…
- Trial name
- MACP (NCT07043777)
- Testing
- Direct Three-Vessel Antegrade Cerebral Perfusion (MACP), Unilateral Right Axillary Antegrade Cerebral Perfusion (uACP)
- Where
- Taiwan
- Volunteers
- 201 people
- Sponsor
- China Medical University Hospital
Peri-operative Mortality
Open Repair Versus Branched Endograft Repair for Treatment of Residual Chronic Aortic Arch Dissection During Follow-up After Open Type A Acute Ascending Aorta Replacement: Results From an International Multicenter Study.
This study aims to evaluate peri-operative mortality and main post-operative complications (for example cardiovascular, respiratory and renal) in patients treated with frozen elephant trunk techinque.
- Trial name
- NCT04014907
- Testing
- Frozen Elephant Trunk Technique
- Where
- Italy
- Volunteers
- 170 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Aneurysm of Aortic Arch
Prospective Randomized Study of Brain Protection During Aortic Arch Replacement
The purpose of this research study is to evaluate two standard approaches of supplying blood and oxygen to your brain during open heart surgery.
- Trial name
- NCT00606190
- Testing
- Retrograde brain perfusion, Antegrade brain perfusion
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic