Clinical trials: Apical Periodontitis
Acute Pulpitis With Apical Periodontitis, Postoperative Pain
The Impact Of Different Final Irrigation Activation Techniques On Postoperative Pain
The trial was conducted to assess the impact of passive ultrasonic irrigation, XP endo finisher, AF max file, and manual dynamic agitation on postoperative pain and analgesic consumption at 6 h., 12 h., 24 h., 48 h., 72 h., and a…
- Trial name
- NCT06501703
- Testing
- Instruments
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sinai University
Dental Caries
Selective Caries Removal (SCR) Versus Pulpotomy in Preventing Pulp Necrosis and Apical Periodontitis
The study design is a randomized controlled trial and up to 120 teeth, 50 in each of the 2 groups, will be enrolled from the patients at the National University Centre for Oral Health Singapore (NUCOHS) Endodontic unit.
- Trial name
- NCT04672070
- Testing
- Selective Caries Removal, Pulpotomy
- Where
- Singapore
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Periapical Periodontitis, Endodontic Microsurgery
Healing After Endodontic Microsurgery Using a Rotary Bur Versus Piezoelectric Unit for Osteotomy and Root Resection
The goal of this clinical trial is to compare bone healing after using apical tooth microsurgery to remove root end infection, either by use of rotary burs for cutting bone and root end, or by use of piezoelectric surgery for the…
- Conditions
- Periapical Periodontitis, Endodontic Microsurgery, Osteotomy
- Trial name
- BURVSPIEZO (NCT07197658)
- Testing
- endodontic microsurgery / rotary bur osteotomy, Endodontic microsurgery / piezo osteotomy, Endodontic microsurgery / bone window
- Where
- 2 sites in Greece
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Radiographic Healing of Periapical Lesions Following Ultrasonic Activation of Heated Sodium Hypochlorite Without Instrumentation of Root Canals
Minimally Invasive Root Canal Treatment With Active Disinfection on Single Rooted Teeth With Periapical Lesions
A novel form of root canal treatment RCT, referred as minimally invasive endodontics MIE, has emerged recently to adopt a unique approach that emphasize reducing tooth structural changes post-treatment (32).
- Trial name
- NCT06467643
- Testing
- non-instrumented root canal treatment with passive ultrasonic activation of heated sodium hypochlorite, conventional root canal treatment with passive ultrasonic activation of heated sodium hypochlorite
- Where
- Lebanon
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Chronic Apical Periodontitis
A Cone Beam Computed Tomographic Evaluation of Healing of Apicomarginal Defects Using Autologous Platelet Aggregates
This study will evaluate the effect of PRF (platelet rich fibrin) on the healing of apicomarginal defects. Healing of the defects will be assessed 2 dimensionaly by periapical radiograph and 3 dimensionaly using CBCT.
- Trial name
- NCT04389346
- Testing
- Periapical surgery using autologous platelet aggregate, Periapical surgery without autologous platelet aggregate
- Where
- India
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Postoperative Pain
Pain After PRP Revascularization and Endodontic Treatment of Non-vital Mandibular Molars With Apical Periodontitis
randomized clinical trial which Evaluate thr Post-operative Pain Following Platelet Rich Plasma (PRP) Revascularization versus Conventional Endodontic Treatment of Non-vital Mature Mandibular Molars with Chronic Peri-apical…
- Trial name
- NCT03350841
- Testing
- Platelet rich plasma PRP, root canal treatment
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Necrotic Pulp, Apical Periodontitis
Effect of Diclofenac Sodium Versus Calcium Hydroxide as Intracanal Medication on the Intensity of Postoperative Pain, Bacterial Load Reduction and MMP-9 Levels in Patients With Necrotic Pulp.
the aim of this study is to compare the effect of using Diclofenac Sodium Versus Calcium Hydroxide as Intracanal medication on intensity of postoperative pain, bacterial load reduction after root canal preparation and periapical…
- Trial name
- NCT05582421
- Testing
- Diclofenac Sodium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Apical Periodontitis, i-PRF
Effect of I-PRF Application on ALP and MMP-9 Levels in Teeth With Apical Periodontitis
The aim of this study was to evaluate the effect of injectable platelet rich fibrin (i-PRF) injection, in addition to routine root canal treatment, on alkaline phosphatase (ALP) and matrix metalloproteinase-9 (MMP-9) levels in…
- Conditions
- Apical Periodontitis, i-PRF, Biomarkers, MMP-9
- Trial name
- NCT07320898
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Endodontic Disease
Effect of Three Mechanical Systems on Removal of Endotoxins From Necrotic Teeth
The patients will be randomly assigned into two equal groups Group : OneShape Group: ProtaperNext Endodontics procedure steps: Patient will be anesthetized by using infiltration local anesthesia or nerve block according to the…
- Trial name
- RCT2019 (NCT04200638)
- Testing
- ProTaper Next
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Apical Periodontitis, Wound Heal
The Effect of MTA and PRF Application in Periapical Lesions
A total of 40 periapical lesions from the 33 patient undergoing apical surgery were randomly selected from December 2016-November 2017. Patients were informed about the surgical procedure and signed a consent form.
- Trial name
- NCT03743987
- Testing
- control group, MTA group, PRF group
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Root Canal Therapy, Periapical Periodontitis
Comparision of Non Surgical Retreatment and Endodontic Surgery of Failed Root Canal Treated Teeth
To the best of our knowledge, only two studies are available which have provided a direct comparison between outcome of nonsurgical retreatment and endodontic surgery. The results of the two studies are contradictory in nature.
- Trial name
- NCT03918733
- Testing
- surgical treatment, Non surgical retreatment
- Where
- India
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periapical Abscess
Resolution of Pain and Swelling After the Use of Neem Leaf Extract Compared to Chlorhexidine Gluconate as an Intracanal Irrigant During Pulpectomy
The trial is to test the resolution of pain, swelling and other signs of periapical infection and the antimicrobial efficacy when using the neem leaf extract compared to chlorhexidine as root canal irrigant in Pulpectomy…
- Trial name
- NCT02943759
- Testing
- Neem leaf extract, Chlorhexidine gluconate
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Apical Periodontitis, Dental Pulp Necrosis
Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial)
The goal of this clinical trial is to learn which of three common root-canal rinsing (irrigation) methods removes bacteria most effectively in adult patients who need root-canal treatment.
- Conditions
- Apical Periodontitis, Dental Pulp Necrosis, Root Canal Infection
- Trial name
- CHITO-PRE RCT (NCT07048028)
- Testing
- Chitosan Low Molecular Weight (20-200 Mpa.S), Sodium Hypochlorite, EDTA chelating agents
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- ESRA DAĞCI
Endodontic-Periodontal Lesions, Apical Periodontitis
The MTA Effect on Healing and Biomarkers in Endo-Perio Lesions
This project is a randomized controlled clinical study investigating the effect of Mineral Trioxide Aggregate (MTA) used as an apical plug in root canal obturation on periodontal healing and inflammatory biomarkers in teeth with…
- Conditions
- Endodontic-Periodontal Lesions, Apical Periodontitis, Periapical Disease
- Trial name
- NCT07653997
- Testing
- Root Canal Treatment with MTA Apical Plug, Root Canal Treatment with Resin-Based Sealer (AH Plus), Periodontal Therapy (Scaling and Root Planing)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Apical Periodontitis
2% Chlorhexidine (CHX) vs CaOH2 (CH) Calcium Hydroxide Paste as an Intracanal Medicament
This is a Pilot Phase III single-blind randomized controlled clinical trial in patients, aged 18 years and older, presenting with symptoms of apical periodontitis.
- Trial name
- NCT03700788
- Testing
- Chlorhexidine, Calcium Hydroxide
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Pulp and Periapical Tissue Disease
Gingival Crevicular Fluid Biomarkers and Healing After Root Canal Treatment in Asymptomatic Apical Periodontitis
This prospective observational cohort study will evaluate whether changes in gingival crevicular fluid osteoprotegerin (OPG) , RANKL/OPG ratio ,IL10,IL8and CxCL10 after primary nonsurgical root canal treatment are associated with…
- Trial name
- NCT07468643
- Testing
- Primary Nonsurgical Root Canal Treatment
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Root Canal Infection, Periapical Abscess
Comparing Different Single and Combination Chelating Agents on Sealer Penetration and Dentin Erosion.
The basic aim of root canal treatment is to reduce the microbial content and prevent further recontamination in the canal. Every tooth has a variable, complex canal anatomy consisting of ramifications, accessory and lateral…
- Conditions
- Root Canal Infection, Periapical Abscess, Irreversible Pulpitis, Apical Periodontitis
- Trial name
- NCT05778227
- Testing
- Ethylene Diamine Tetra Acetic acid, smearOFF, Etidronic acid /sodium hypochlorite
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Periapical Periodontitis, Polymerase Chain Reaction
Quantitative Assessment of the Efficacy of Sweeps Laser Activation Systems
Aim of the present study was to determine the intraradicular microbiota of previously root canal-treated teeth with apical periodontitis using droplet digital polymerase chain reaction (ddPCR) and to investigate the antibacterial…
- Conditions
- Periapical Periodontitis, Polymerase Chain Reaction, Enterococcus Faecalis Infection
- Trial name
- NCT05718596
- Testing
- sweeps laser to use irrigation activation, PUI to use irrigation activation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Seyda Ersahan, DDS, PhD
Apical Periodontitis
Apical Periodontitis and Glycemic Control in Diabetic and Non-diabetic Egyptian Sub-population
This observational cross-sectional study aims to assess the prevalence of apical periodontitis in diabetic and non-diabetic adult Egyptian patients and to evaluate its association with glycemic control measured by glycated…
- Trial name
- NCT07856186
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Cairo University
Apical Periodontitis
Expression of IL-8 Before and After Root Canal Treatment in Patients With Symptomatic Apical Periodontitis
This clinical study aimed to Compare the levels of Interleukin 8 before and after root canal treatment in patients with apical periodontitis Diagnosis Local anesthesia Isolation and disinfection of the tooth Two-staged access…
- Trial name
- NCT05653947
- Testing
- Root canal instrumentation, 2.5% NaOCl irrigation
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University