Clinical trials: Arthritis, Unspecified
Knee Osteoarthritis
Evaluating the Efficacy of Lateral Heel Wedges of Osteoarthritis of the Knee
This study is looking at the efficacy of a sloped insole in patients with knee osteoarthritis. Regularly wearing a sloped insole over the course of one year will result in a wider joint space by x-ray in 60% of the subjects, a…
- Trial name
- NCT02254473
- Testing
- Wedge Insert, Flat Insert
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Rheumatoid Arthritis
99mTc-3PRGD2 SPECT/CT in Rheumatoid Arthritis Patients
This is an open-label SPECT/CT (single photon emission computed tomography/computed tomography) study to investigate the diagnosis and efficacy evaluation performance of 99mTc-3PRGD2 in rheumatoid arthritis patients.
- Trial name
- TRGDRA (NCT02723760)
- Testing
- 99mTc-3PRGD2
- Where
- China
- Volunteers
- 4 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Low Back Pain, Platelet Rich Plasma
Comparison of IntraArticular Platelet-Rich-Plasma to Corticosteroid Injections for Patients With Zygapophyseal Joint (Z-Joint) Low Back Pain Confirmed by Dual Intra-Articular Local Anesthetic Injections
Comparison of IntraArticular Platelet-Rich-Plasma to Corticosteroid Injections for Patients with Zygapophyseal Joint (Z-Joint) Low Back Pain Confirmed by Dual Intra-Articular Local Anesthetic Injections: A Triple Blinded…
- Conditions
- Low Back Pain, Platelet Rich Plasma, Zygapophyseal Joint Arthritis
- Trial name
- NCT05188820
- Testing
- PRP - platelet rich plasma injection, Cortisone injection
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Osteoarthritis of the Knee
Study to Characterize the PK and Local Extent and Duration of Exposure From FX006 in Patients With OA of the Knee
The objectives of this study were to characterize the local extent and duration of exposure of TA from FX006 and TCA IR, characterize the systemic PK of FX006 and TCA IR, and assess the safety and general tolerability of a single…
- Trial name
- NCT02637323
- Testing
- FX006 32 mg, TCA IR 40
- Where
- 4 sites in United States
- Volunteers
- 81 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis, Obesity
Multi-parametric Imaging of the Knee in Obese Patients With Knee Osteoarthritis; Weight Maintenance
This is a substudy to a randomised trial investigating the effect of liraglutide on body weight and pain in overweight or obese patients with knee osteoarthritis (NCT02905864).
- Trial name
- IM-LOSEIT-II (NCT02928679)
- Testing
- Liraglutide 3 mg (Saxenda)
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Henrik Gudbergsen
Rheumatoid Arthritis
The Study of Abatacept in Combination With Etanercept
The Study was designed to look at the safety and efficacy of abatacept in combination with etanercept.
- Trial name
- NCT00162279
- Testing
- Abatacept
- Where
- 35 sites in United States
- Volunteers
- 141 people
- Sponsor
- Bristol-Myers Squibb
Osteoarthritis
Single-use Efficiency Instruments With Patient Specific Technique (MyKnee®) Versus Traditional Metal Instruments With Conventional Surgical Technique
To compare economic factors and the rate of adverse events between two types of instrumentation used for total knee replacement: Single-use Efficiency Instruments with Patient Specific Technique (MyKnee®) Traditional Metal…
- Trial name
- NCT03148379
- Testing
- Customized patient instruments, Traditional Metal Instruments
- Where
- 5 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medacta USA
Type 2 Diabetes
Impact of Rheumatoid Arthritis on the Course of Type 2 Diabetes During a Longitudinal Follow-up of 5 Years
The purpose of this study is to determine whether patients with rheumatoid arthritis and type 2 diabetes experience a more severe disease course compared to control patients with osteoarthritis and type 2 diabetes
- Trial name
- INSPIRED (NCT02639988)
- Where
- France
- Volunteers
- 176 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Arthritis
Restoration of Leg Length, Offset, and Center of Rotation in Total Hip Replacement
The investigators aim to demonstrate the ability to accurately measure and restore leg length, offset, and center of rotation during a total hip replacement through a new technique that uses the femoral component as a measurement…
- Trial name
- NCT00738803
- Testing
- Total hip replacement
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tennessee Orthopedic Alliance
Gout
A Study to Evaluate the Safety, Tolerability, PK, and PD Properties of PRX-115 in Adult Volunteers With Elevated Uric Acid Levels
This is a Phase 1, double-blind, placebo-controlled, single ascending dose study in participants with elevated uric acid levels.
- Trial name
- NCT05745727
- Testing
- PRX-115
- Where
- 2 sites in New Zealand
- Volunteers
- 64 people
- Sponsor
- Protalix
Ankylosing Spondylitis, Aerobic Exercise
The Effects of Aerobic Exercise in Patients With Ankylosing Spondylitis
The aim of our study is to investigate the effects of aerobic exercise and stretching exercises applied in high-intensity interval training protocol on disease activity, quality of life, spinal mobility and calprotectin…
- Conditions
- Ankylosing Spondylitis, Aerobic Exercise, Disease Activity
- Trial name
- NCT05968469
- Testing
- Aerobic exercises with cycling ergometry, Stretching exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Afyonkarahisar Health Sciences University
Knee Osteoarthritis
Study on the Rehabilitation Treatment of Knee Osteoarthritis Based on ICF
To solve the existing Knee osteoarthritis;KOA) clinical norms and guidelines have low operability, Disconnection between treatment plan and specific evaluation results, difficulty in achieving individualized intervention and…
- Trial name
- NCT04951414
- Testing
- ICF core set
- Where
- 2 sites in China
- Volunteers
- 600 people
- Sponsor
- Peking University Third Hospital
Lower Limb Deformity
Phenotyping the Alignment of the Lower Limb
In the international literature there are only few publication about the normal biomechanical parameters of the lower limb examined prospectively in healthy population.
- Trial name
- NCT05108116
- Testing
- EOS
- Where
- Hungary
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Infection, Hand Injury Wrist
Vancomycin Tissue Concentrations by Bier Block or Intravenous Administration
The purpose of this study is to determine whether or not giving a lower dose of antibiotics (Vancomycin) in the area where it is needed (upper extremity) is more effective at preventing infection than the current standard dose…
- Conditions
- Infection, Hand Injury Wrist, Hand Injuries, Hand Injuries and Disorders
- Trial name
- NCT04673877
- Testing
- Systemic IV Vancomycin, Bier Block, Vancomycin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Knee Injuries, Knee Osteoarthritis
Walking Gait Biomechanics Following Knee Joint Effusion
The purpose of this study is to determine the sensitivity of a wearable sensor to detect changes in knee joint loading using an experimental knee joint effusion as a model for a common clinical physiological alteration in joint…
- Trial name
- NCT03805464
- Testing
- Knee Joint Effusion
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Duke University
Osteoarthritis, Pain
Study of Efficacy, Safety of Fulranumab Monotherapy for OA of Hip or Knee, PAI3002
The purpose of this study is to demonstrate the efficacy, safety, and tolerability of fulranumab as Monotherapy compared with placebo in participants with signs and symptoms of osteoarthritis of the hip or knee that are not…
- Trial name
- NCT02336698
- Testing
- Fulranumab 1 mg, Fulranumab 3 mg
- Where
- 32 sites in United States, Poland and 2 more
- Volunteers
- 18 people
- Sponsor
- Janssen Research & Development, LLC
Rheumatoid Arthritis
Study Evaluating the Analgesic Efficacy and Safety of ADL5859 in Participants With Rheumatoid Arthritis
The purpose of this study is to evaluate the effectiveness of ADL5859 in relieving pain associated with rheumatoid arthritis (RA) compared with placebo and naproxen (similar to Aleve®).
- Trial name
- NCT00626275
- Testing
- ADL5859, Naproxen
- Where
- 8 sites in United States
- Volunteers
- 46 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Acromioclavicular Joint Arthritis
Distal Clavicle Resection With Rotator Cuff Repair
The purpose of this study is to determine whether distal clavicle resection is effective treatments in patients with acromioclavicular joint pain accompanied by rotator cuff tear.
- Trial name
- NCT01040065
- Testing
- distal clavicle resection
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Gout
MRI and Ultrasound Findings in Patients With Gout and Normal Plain Radiographs
Radiographic imaging plays a key role in managing the long-term effects of hyperuricemia on the skeletal system. Two of the accepted indications for prophylactic urate-lowering drugs in patients with hyperuricemia are gouty tophi…
- Trial name
- NCT00584311
- Testing
- MRI and Ultrasound
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of South Florida
Rheumatoid Arthritis
A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to a Single Anti-TNF Inhibitor
This study will evaluate the efficacy and safety of MabThera in patients with active rheumatoid arthritis who have had an inadequate response to one prior anti-TNF alpha inhibitor.
- Trial name
- NCT02079532
- Testing
- rituximab [MabThera]
- Where
- 69 sites in Germany
- Volunteers
- 302 people
- Sponsor
- Hoffmann-La Roche
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