Clinical trials: Atelectasis, open to volunteers
ARDS, AHRF
HemodynamIc eFfects of Lung Collapse and overdIstension During ARDS
The management ARDS relies on ventilatory strategies aimed at limiting ventilator-induced lung injury (VILI). The setting of PEEP is still subject of debate, as randomized clinical trials comparing standardized higher versus…
- Trial name
- HI-FIVE (NCT07423520)
- Testing
- Change in PEEP
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Atelectasis, Postoperative, Cholecystitis; Gallstone
Ultrasound for Postop Lung Issues in Low-Flow Anesthesia
Detecting possible atelectasis and other respiratory problems that may develop immediately after extubation via lung ultrasonography can reduce pulmonary complications by performing necessary interventions such as oxygen support…
- Conditions
- Atelectasis, Postoperative, Cholecystitis; Gallstone, Pulmonary Atelectasis
- Trial name
- NCT06824506
- Testing
- No-intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Lung Ultrasound, Atelectasis
Surgical Positions and Postoperative Atelectasis: A Lung Ultrasound Study
The aim of this study is to prospectively evaluate the effect of surgical position on the development of postoperative atelectasis in patients undergoing surgery in supine, prone, lateral decubitus, and lithotomy positions using…
- Trial name
- NCT07654153
- Testing
- lung ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Atelectasis, Postoperative
Single-step vs Stepwise Lung Recruitment Maneuvers After Cardiopulmonary Bypass
This prospective randomized controlled trial aims to compare the hemodynamic and pulmonary effects of single-step and stepwise lung recruitment maneuvers in adult patients undergoing elective cardiac surgery with cardiopulmonary…
- Trial name
- NCT07432477
- Testing
- Single Step Lung Recruitment Maneuver, Stepwise Lung Recruitment Maneuver
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Ondokuz Mayıs University
Tracheomalacia, Bronchopulmonary Dysplasia (BPD)
Enhancing Lung Health in Kids With Structural Lung Damage and Malformations: Azithromycin (AZI) for Airway Infection Prevention
Children with lung and airway malformations or early structural lung damage face significant challenges, often leading to recurrent respiratory infections, hospitalizations, and decreased quality of life.
- Conditions
- Tracheomalacia, Bronchopulmonary Dysplasia (BPD), Vascular Ring, Cystic Lung Disease
- Trial name
- TRALULALA-AZI (NCT06409299)
- Testing
- Azithromycin 40 MG/ML
- Volunteers
- 150 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Respiratory Distress Syndrome (Neonatal)
Open-label Randomized Controlled Trial of Two Protocols for Weaning From High Frequency Oscillatory Ventilation in Preterm Neonates With Respiratory Distress Syndrome Admitted in the NICU of Mansoura University Children Hospital
Our study is a randomized controlled trial that compares two weaning protocols of preterm infants with respiratory distress syndrome who are ventilated on high frequency oscillatory ventilation in order to establish the best…
- Trial name
- NCT07202299
- Testing
- HFOV weaning protocol 1, HFOV weaning protocol 2
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Mansoura University Children Hospital
Acute Respiratory Distress Syndrome
EIT Assessment of Overdistension in ARDS Patients in Prone Position
Mechanical ventilation in ARDS requires protective ventilation with low VT and PEEP. PEEP titration can improve lung recruitment in the dependent lung but with a risk of overdistension in the non-dependant lung.
- Trial name
- DISTIE-DV (NCT06536543)
- Testing
- Acute Respiratory Distress Syndrom (ARDS) treated with Prone Position (PP) equipped with Electrical Impedance Tomography (EIT)
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Bordeaux
Surfactant, Respiratory Distress Syndrome (Neonatal)
Comparing Surfactant Administration Through Supraglottic Airway and Thin Catheter for Preterm Infants
What is this study about? This study is comparing two ways of giving surfactant, a medicine that helps premature infants breathe better.
- Trial name
- SALTI (NCT07030270)
- Testing
- Surfactant Administration through Laryngeal or Supraglottic Airway, Surfactant Administration through Thin Catheter
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Texas Southwestern Medical Center
Hypoxemia
Effect of Different Oxygen Concentrations Before Extubation After General Anesthesia on Hypoxemia After Extubation in Post-anesthesia Care Unit
Before extubation during the anesthesia recovery period, 100% oxygen is routinely inhaled to increase the oxygen reserves, maximizing the time window for anesthesiologists to adjust strategies when they encounter hypoxemia after…
- Trial name
- NCT07293286
- Testing
- 100% oxygen concentration inhaled, 30% oxygen concentration inhaled
- Where
- China
- Volunteers
- 590 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Total Laparoscopic Hysterectomy, Atelectasis, Postoperative
Effects of Ultrasound-guided Recruitment Manoeuvres on Postoperative Pulmonary Complications in OSA Patients Undergoing Total Laparoscopic Hysterectomy
This study aims to evaluate the lung-protective effects of ultrasound-guided lung recruitment maneuvers in patients with OSA undergoing total laparoscopic hysterectomy and to explore the efficacy of EELV measurement in assessing…
- Trial name
- NCT07362680
- Testing
- the sustained inflation recruitment maneuver, the incremental PEEP recruitment maneuver, the Ultrasound-guided recruitment maneuver
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Respiratory Distress Syndrome of Newborn, Threatened Premature Labor, Antepartum
Clinical Pharmacology of Dexamethasone in Pregnant Women With Preterm Labor
This study through to the pregnant woman blood concentrations of dexamethasone therapy after research, explore the pharmacokinetic data of dexamethasone in pregnant women, Chinese pregnant women dexamethasone pharmacokinetic…
- Trial name
- NCT05207852
- Where
- China
- Volunteers
- 288 people
- Sponsor
- Dongyang Liu
Hypotension Drug-Induced, General Anesthesia Using Endotracheal Intubation
Alveolar Recruitment Maneuver-Induced Hypotension: A Dynamic Consequence and Intraoperative Indicator of Fluid Responsiveness
This study investigates whether two simple bedside tests - the Passive Leg Raising (PLR) test and the Pleth Variability Index (PVI) - can predict a drop in blood pressure that sometimes occurs during a lung-opening procedure…
- Conditions
- Hypotension Drug-Induced, General Anesthesia Using Endotracheal Intubation, Atelectasis, Fluid Responsiveness
- Trial name
- NCT07766967
- Testing
- Alveolar Recruitment Maneuver (ARM), Passive Leg Raising (PLR) Test
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
Postoperative Atelectasis, Pulmonary Atelectasis
Fresh Gas Flow and Lung Ultrasonography in Laparoscopic Cholecystectomy
This prospective randomized clinical trial aims to evaluate the effects of different fresh gas flow rates on postoperative pulmonary aeration using lung ultrasonography in patients undergoing elective laparoscopic…
- Trial name
- NCT07753278
- Testing
- Low Fresh Gas Flow (0.5 L/min), High Fresh Gas Flow (4 L/min)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Adiyaman University
Lung Collapse, One-lung Ventilation
Brief Bronchial Suction for Lung Collapse During Uniportal VATS
The goal of this clinical trial is to learn whether a brief suction of the airway going to the surgical lung (bronchus) can help the lung collapse faster and more completely during uniportal video-assisted thoracoscopic surgery…
- Conditions
- Lung Collapse, One-lung Ventilation, Thoracic Anesthesia, Thoracic Surgery, Video-assisted
- Trial name
- NCT07660588
- Testing
- bronchial suction
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Intra-abdominal Surgery, Anesthesia
Open Lung Protective Extubation Following General Anesthesia
Perioperative respiratory complications are a major source of morbidity and mortality. Postoperative atelectasis plays a central role in their development.
- Conditions
- Intra-abdominal Surgery, Anesthesia, Lung Injury, Ventilator-Induced Lung Injury
- Trial name
- OLEXT-3 (NCT06296173)
- Testing
- Protective "open-lung" extubation, Conventional extubation
- Where
- 5 sites in Canada
- Volunteers
- 270 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Video-assisted Thoracoscopic Surgery (VATS), Lung Cancer (Diagnosis)
Intraoperative Paravertebral Block and Postoperative Complications
This study aims to evaluate the clinical association between intraoperative paravertebral block and the reduction of postoperative complications following thoracic surgery.
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Lung Cancer (Diagnosis), Pulmonary Infections, Respiratory Failure Without Hypercapnia
- Trial name
- IPVB and POCs (NCT07211529)
- Testing
- Paravertebral Block (PVB)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Tongji Hospital
Respiratory Distress Syndrome (Neonatal), Surfactant
Surfactant Using a Supraglottic Airway Device in Late Preterm to Early Term Infants
The purpose of this research is to learn new information that may help other infants that have respiratory distress syndrome and need breathing support after birth.
- Trial name
- SPLASH (NCT07176117)
- Testing
- Surfactant Administration Through Laryngeal or Supraglottic Airway (SALSA), Continuous Positive Airway Pressure (CPAP)
- Where
- 3 sites in United States
- Volunteers
- 422 people
- Sponsor
- Sharp HealthCare
Neonatal Respiratory Distress, Oxygenation
Neonatal Oximeter Bias Study
The study aims to determine if there is a systematic difference (bias) between pulse oximeters used in control systems for automated oxygen delivery (A-FiO2) and those used in monitoring systems.
- Trial name
- NOB (NCT06817850)
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- Czech Technical University in Prague
Atelectasis
VCV vs PRVC in Pediatric Anesthesia; an EIT- and LS-based Study
The primary objective of this study is to evaluate and compare the incidence and severity of intraoperative pulmonary atelectasis, measured by Lung Ultrasound Score (LUS) and EIT (Electrical Impedance Tomography), between two…
- Trial name
- VentiEIT_ped (NCT07182539)
- Testing
- PRVC ventilation, VCV ventilation
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Vittore Buzzi Children's Hospital
RDS of Prematurity, Surfactant Deficiency Syndrome Neonatal
Surfactant Administration by Insure or Thin Catheter
This trial evaluates the efficacy and safety of surfactant administration with thin catheter technique together with analgesic premedication in comparison with the established INSURE-strategy.
- Conditions
- RDS of Prematurity, Surfactant Deficiency Syndrome Neonatal, Analgesia
- Trial name
- SAINT (NCT04445571)
- Testing
- Thin catheter technique or standard ET-tube for surfactant administration
- Where
- Sweden
- Volunteers
- 160 people
- Sponsor
- Karolinska Institutet