Clinical trials: Atheromatosis
Peripheral Arterial Disease
Influence of Rivaroxaban for Intermittent Claudication and Exercise Tolerance in Patients With Symptomatic PAD
The aim of the conducted research is to evaluate the protective effect of rivaroxaban (trade name of the Xarelto medicinal product), administered together with acetylsalicylic acid (ASA), in comparison with the effectiveness of…
- Trial name
- PAD_RIV_CLI (NCT04305028)
- Testing
- Rivaroxaban, Aspirin
- Volunteers
- 100 people
- Sponsor
- Poznan University of Medical Sciences
Atherosclerosis
Effect of Darapladib on Cantharidin-Induced Inflammatory Blisters in Subjects With Type 2 Diabetes Mellitus (T2DM)
This will be an exploratory, open-label, single sequence, two part study (Part A and an optional Part B). The aim of this study will be to assess whether systemic inhibition of Lipoprotein associated phospholipase A2 (Lp-PLA2) in…
- Trial name
- NCT02058641
- Testing
- Darapladib
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- GlaxoSmithKline
Metabolic Disease, Obesity
Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System
Background: Researchers are interested in studying individuals who have known or suspected metabolic, inflammatory or genetic diseases that may put them at a high risk for heart diseases or diseases of their blood vessels.
- Conditions
- Metabolic Disease, Obesity, Li-Fraumeni Syndrome, Cardiomyopathy
- Trial name
- NCT01143454
- Testing
- NSR IDE-MRI: Research pulse sequences
- Where
- 3 sites in United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Risk Factor, Metabolic Complication
Cold Water Immersion and Atherosclerosis, Inflammation, Fat Accumulation and Lipid Profile Parameters
The impact of the environment on human health is considerable. An important factor is the effect of temperature on the human body, where either the effects of short-term exposure to extreme temperatures (cryotherapy, sauna, etc.)…
- Conditions
- Cardiovascular Risk Factor, Metabolic Complication, Endocrine; Complications, Immune System Diseases
- Trial name
- NCT04642066
- Testing
- Cold water immersion, No cold water immersion
- Where
- Slovakia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pavol Jozef Safarik University
Chronic Limb-threatening Ischemia, Endovascular Therapy
Prospective Multicenter Registry on the Endovascular Treatment in Critical Limb Threatening Ischemia With Below the Knee Lesions With Wound, Ischemia, and Foot Infection (WIFI) Assessment
This is a prospective multicenter clinical study that used WIFI grading scores at different periods to evaluate the therapeutic value of endovascular therapy and this grading system for Chronic limb-threatening ischemia.
- Trial name
- NCT04710420
- Testing
- Endovascular therapy
- Where
- China
- Volunteers
- 842 people
- Sponsor
- Xuanwu Hospital, Beijing
Peripheral Arterial Disease, Quality of Life
Patient-centered Outcomes Related to TReatment Practices in Peripheral Arterial Disease: Investigating Trajectories (PORTRAIT)
An estimated 8 million individuals in America are affected by peripheral arterial disease (PAD), blockages of the leg arteries that can cause excruciating calf pain when walking.
- Conditions
- Peripheral Arterial Disease, Quality of Life, Quality of Care
- Trial name
- PORTRAIT (NCT01419080)
- Where
- 10 sites in United States
- Volunteers
- 797 people
- Sponsor
- Saint Luke's Health System
Peripheral Arterial Disease, Intermittent Claudication
Exercise Rehabilitation in Veterans With PAD
Peripheral artery disease (PAD) results in blockages of arteries (blood vessels) and decreased blood flow to the legs. This may cause difficulty or pain with walking or other activities that use leg muscles.
- Trial name
- NCT02607046
- Testing
- Exercise training, NMES
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Aortic Aneurysm, Aortic Aneurysm Abdominal
Prophylactic Suture Line Sealing With NE'X Glue R-eco in Cardiac and Vascular Surgery
This clinical study aims to evaluate the effectiveness and safety of using NE'X Glue R-eco to seal suture lines. The adhesive will be applied to reduce the risk of suture line bleeding in cardiac or vascular repair surgeries, a…
- Conditions
- Aortic Aneurysm, Aortic Aneurysm Abdominal, Valve Stenoses, Aortic, Valve Regurgitation, Mitral
- Trial name
- CLOSURE (NCT06918496)
- Testing
- Surgical placement of a prosthetic or biologic graft (patch), or an allograft for cardiac and (cardio)vascular repair.
- Where
- 2 sites in Belgium, Poland
- Volunteers
- 60 people
- Sponsor
- Grena Biomed Limited
Ischemic Heart Disease, Atherosclerosis
Graft Patency as a Predictor of Health-related Quality of Life.
The health-related quality of life questionnaire "EQ-5D" has been collected in connection with several interventional and observational studies where the no-touch vein harvesting technique in CABG has been used.
- Trial name
- NCT02547194
- Where
- Sweden
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Örebro County Council
Peripheral Arterial Disease
Clinical Trial Investigating the Combination Therapy With Luminor DCB and iVolution Stent in TASC C and D Femoropopliteal Lesions
The T.I.N.T.I.N. study investigates the safety and efficacy of the combination therapy with the Luminor drug coated balloon (DCB) and the iVolution stent in the treatment of TASC C and D femoropopliteal lesions.
- Trial name
- TINTIN (NCT03347383)
- Testing
- Combination therapy DCB + stent
- Where
- 9 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- ID3 Medical
Stroke, Transient Ischemic Attack
Prospective Evaluation of Carotid Free-floating Thrombus
Hardened plaque located in the carotid arteries can cause stroke or transient ischemic attack (TIA). This type of plaque is linked to unstable free-floating thrombi (FFT).
- Trial name
- NCT02405845
- Testing
- Computed Tomographic Angiogram
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Ottawa Hospital Research Institute
Atherosclerosis
Study to Determine the Effect of 14 Days Dosing With Darapladib (SB-480848) on Carotid Plague Composition in Patients With Planned Carotid Endarterectomy
The primary objective is to determine Lp-PLA2 activity in atherosclerotic carotid plaques after 14 (+/-4) days treatment with darapladib, compared to placebo.
- Trial name
- NCT01916720
- Testing
- SB-480848 40 mg, SB-480848 80 mg
- Volunteers
- 103 people
- Sponsor
- GlaxoSmithKline
Peripheral Arterial Disease
L-Citrulline in Peripheral Artery Disease
Some studies have reported improved vascular function with the supplementation of L-arginine in participants with cardiovascular disease (CVD).
- Trial name
- CIPER (NCT02521220)
- Testing
- L-citrulline
- Where
- 3 sites in Germany, Netherlands
- Volunteers
- 49 people
- Sponsor
- Maastricht University
Atherosclerotic Vascular Disease
Colchicine in Vascular Inflammation Assessed With PET Imaging
The purpose of this trial is to assess the effects of colchicine on vascular inflammation measured by (FDG)-PET imaging in patients with atherosclerotic vascular disease.
- Trial name
- COLPET (NCT02162303)
- Testing
- Colchicine
- Where
- Canada
- Volunteers
- 106 people
- Sponsor
- Montreal Heart Institute
Cardiovascular Disease, Hypertension
Stop Atherosclerosis in Native Diabetics Study
Compared to standard treatment goals achieving lower targets for LDL cholesterol (bad cholesterol) and blood pressure in people with diabetes will slow the progression of atherosclerosis as measured by carotid artery thickness…
- Conditions
- Cardiovascular Disease, Hypertension, Hyperlipidemia, Diabetes
- Trial name
- SANDS (NCT00147251)
- Testing
- FDA approved drugs to treat blood pressure and cholesterol
- Where
- 4 sites in United States
- Volunteers
- 548 people, healthy volunteers welcome
- Sponsor
- Cynthia West
Type 2 Diabetes
Carotid Intima-media Thickness (IMT) and Large-vessel Atherosclerosis by Multidetector Computed Tomography (MDCT)
The aim of this study was to investigate whether carotid IMT can predict the presence of more advanced atherosclerosis such as carotid stenosis, coronary or intracranial artery disease by MDCT and whether MDCT could be useful…
- Trial name
- NCT00949169
- Where
- South Korea
- Volunteers
- 71 people
- Sponsor
- Eulji University Hospital
Foot Ulcers, Arteriosclerosis Obliterans
HELP-Apheresis in Diabetic Ischemic Foot Treatment (H.A.D.I.F)
Diabetic foot (DF) is a common, severe and costly complication of diabetes. DF is underlied by neuropathy, atherosclerosis of distal arteries and infection, which result in tissue ulcers and necrosis.
- Conditions
- Foot Ulcers, Arteriosclerosis Obliterans, Diabetes Mellitus
- Trial name
- HADIF (NCT01518205)
- Testing
- LDL-apheresis
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Universita di Verona
Peripheral Arterial Disease
Carnosine for Peripheral Arterial Disease Patients
Oral supplementation of L-carnosine will increase muscle carnosine, stabilize HIF1-alpha promote angiogenesis, and thus improve the functioning of lower extremities in PAD patients.
- Trial name
- CAR-PAD (NCT05371145)
- Testing
- Carnosine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Shahid Baba
Intracranial Atherosclerosis, Optical Coherence Tomography
Optical Coherence Tomography for Intracranial Atherosclerotic Stenosis
To evaluate the clinical significance of optical coherence tomography (OCT) in interventional treatment of intracranial atherosclerotic stenosis (ICAS).
- Conditions
- Intracranial Atherosclerosis, Optical Coherence Tomography, Plaque, Atherosclerotic, Artery Stenosis
- Trial name
- OCT-ICAS (NCT05550077)
- Testing
- Optical Coherence Tomography, Percutaneous transluminal angioplasty and stenting
- Where
- China
- Volunteers
- 400 people
- Sponsor
- jiaoliqun
Coronary Arterial Disease (CAD), Plaque
Intracoronary Cryotherapy Effect on Stabilization of Vulnerable Plaque in Patients With Stable Angina or ACS - A Traditional Feasibility Study
ICECAP is a multi-centre, prospective, single-arm, interventional, traditional feasibility clinical investigation to evaluate the efficacy and safety of intra-coronary cryotherapy on vulnerable or high-risk plaque (HRP), using…
- Conditions
- Coronary Arterial Disease (CAD), Plaque, Vulnerable Plaque, Cryotherapy
- Trial name
- ICECAP (NCT06939374)
- Testing
- Intracoronary Cryotherapy
- Where
- 3 sites in Belgium, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cryotherapeutics SA
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