Clinical trials: Atherosclerosis Cerebral
Vascular Diseases, Carotid Artery Diseases
Frailty in Vascular Patients Undergoing Surgery
An observational cohort study of the frailty of vascular surgery patients undergoing intervention and their outcomes.
- Conditions
- Vascular Diseases, Carotid Artery Diseases, Aneurysmal Disease, Peripheral Artery Disease
- Trial name
- NCT03668821
- Testing
- Questionnaire
- Where
- 2 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- Imperial College London
Peripheral Vascular Disease, Peripheral Artery Disease
Platelet Activity in Vascular Surgery for Thrombosis and Bleeding
The proposed PIVOTAL study will examine a panel of platelet/coagulation activity markers during the perioperative period. The goal is to develop a clinically useful assessment of platelet/coagulation activity for risk…
- Conditions
- Peripheral Vascular Disease, Peripheral Artery Disease, Carotid Stenosis, Aortic Aneurysm, Abdominal
- Trial name
- PIVOTAL (NCT01897103)
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- NYU Langone Health
Ischemic Stroke, Acute, Intracranial Atherosclerosis
Efficacy of Butylphthalide on Symptomatic Atherosclerotic Stenosis in Middle Cerebral Artery
Ischemic stroke with high incidence, mortality, disability and recurrence rate, has become the leading threat to the health worldwide.
- Trial name
- SICAS (NCT06331494)
- Testing
- Butylphthalide
- Where
- China
- Volunteers
- 140 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Stroke, Ischemic, Intracranial Atherosclerosis
Diagnostic Accuracy for Hemodynamically ICAS of MR-FFR Comparing With Pressure-wire-based FFR.
The aim of this study was to determine the diagnostic accuracy of MR-FFR to detect functionally significant ICAS comparing with pressure-wire-based FFR.
- Trial name
- NCT05631470
- Testing
- MR screening
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Xuanwu Hospital, Beijing
Carotid Stenosis, Carotid Artery Diseases
Carotid Stenosis Management During COVID-19 Era - Pilot Study
Carotid endarterectomy (CEA) and carotid stenting (CAS) are often performed for subgroups of patients for whom procedural benefit has not been established in randomised trials and despite evidence of serious procedural risk.
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Carotid Atherosclerosis, Carotid Embolus
- Trial name
- CASCOM-Pilot (NCT04947046)
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Zealand University Hospital
Carotid Artery Stenosis, Cerebral Infarction
Bacteria in Atherosclerotic Plaques and Adverse Events
This study is a prospective, multicenter cohort study conducted in western China. The registry study is primarily conducted at the Department of Neurosurgery, Tangdu Hospital, with participation from the Departments of…
- Conditions
- Carotid Artery Stenosis, Cerebral Infarction, Diabetes, Bacteria
- Trial name
- NCT06935279
- Testing
- Carotid Endarterectomy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tang-Du Hospital
HIV Infection, Carotid Atherosclerosis
Influence of Pravastatin on Carotid Artery Structure and Function in HIV-infected Patients Under Antiretroviral Therapy
The advent of new antiretroviral agents, in particular Highly Active Antiretroviral Therapy (HAART), spectacularly reduced HIV-associated morbidity and mortality.
- Conditions
- HIV Infection, Carotid Atherosclerosis, Dyslipidemia
- Trial name
- NCT00147797
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Saint Antoine University Hospital
Coronary Stenosis, Cerebral Stenosis
Combined Coronary and Cerebral Angiography and Intervention for Coronary and Cerebrovascular Atherosclerosis
Intracranial atherosclerosis is common vascular lesion in Asian acute stroke patients and intracranial atherosclerosis patients have high rate of coronary artery disease (CAD).
- Trial name
- NCT02315924
- Testing
- simultaneous coronary and cerebral intervention, staged coronary and cerebral intervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Capital Medical University
Cardiovascular Diseases, Heart Diseases
Early Atherosclerosis Change in Two Clinical Trials
To complete end point analysis for the Monitored Atherosclerosis Regression Study (MARS) and to compare coronary versus carotid treatment effect relationships in MARS to coronary versus carotid treatment effect relationships in…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Carotid Artery Diseases, Coronary Disease
- Trial name
- NCT00005696
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Atherosclerosis, Atherosclerotic Plaque
Indocyanine Green Fluorescence Uptake in Human Carotid Artery Plaque
This will be a pilot study of 9 patients undergoing standard-of-care clinically indicated carotid endarterectomy. The nine patients will receive an injection of Indocyanine green (ICG) at a dose of 0.25 mg/kg (maximum 25 mg) as…
- Conditions
- Atherosclerosis, Atherosclerotic Plaque, Carotid Stenosis
- Trial name
- BRIGHT-CEA (NCT01873716)
- Testing
- Indocyanine green
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Massachusetts General Hospital
Carotid Artery Stenosis Symptomatic, Ischemic Cerebral Infarction
Clinical Impact of Using IMPROVE to Select Patients for Carotid Revascularisation
Narrowing of the carotid artery due to atherosclerosis with an unstable plaque can cause a stroke. Patients with carotid artery disease who have had a TIA or minor stroke and are at high risk of another stroke are often treated…
- Conditions
- Carotid Artery Stenosis Symptomatic, Ischemic Cerebral Infarction, Stroke Ischemic, Atheroscleroses
- Trial name
- IMPROVE (NCT07556887)
- Testing
- IMPROVE Risk Model
- Where
- 10 sites in Netherlands
- Volunteers
- 613 people
- Sponsor
- Maastricht University Medical Center
Chronic Cerebral Ischemia, Intracranial Atherosclerosis
Optimized Remote Ischemic Conditioning (RIC) Treatment for Patients With Chronic Cerebral Ischemia
This prospective, randomized, single-center clinical trial is designed to figure out the most optimal algorithm of remote ischemic conditioning on patients with chronic cerebral ischemia.
- Trial name
- NCT03105141
- Testing
- Remote ischemic conditioning
- Where
- 2 sites in China
- Volunteers
- 600 people
- Sponsor
- Capital Medical University
Abdominal Aortic Aneurysm, Peripheral Artery Disease
A Study of Remote Ischaemic Preconditioning in Patients With Atherosclerosis Undergoing Vascular Surgery
The purpose of this study is to evaluate the effect of preoperative remote ischaemic preconditioning (RIPC) on organ damage and the functional characteristics of arteries in patients undergoing vascular surgery.
- Conditions
- Abdominal Aortic Aneurysm, Peripheral Artery Disease, Carotid Artery Stenosis
- Trial name
- NCT02689414
- Testing
- Remote ischaemic preconditioning, Control to RIPC
- Where
- Estonia
- Volunteers
- 98 people
- Sponsor
- Tartu University Hospital
Stroke, Acute, Stroke, Ischemic
Carotid Artery Stenting During Endovascular Treatment of Acute Stroke
Rationale: Approximately 20% of the patients with acute ischemic stroke due to an intracranial large vessel occlusion (LVO) has a high-grade stenosis in the ipsilateral cervical carotid artery.
- Conditions
- Stroke, Acute, Stroke, Ischemic, Carotid Stenosis, Carotid Atherosclerosis
- Trial name
- CASES (NCT06511089)
- Testing
- carotid artery stenting during EVT, no carotid artery stenting during EVT
- Where
- Netherlands
- Volunteers
- 600 people
- Sponsor
- University Medical Center Groningen
Stroke, Intracranial Atherosclerosis
PCSK9 Inhibition in Patients With Symptomatic Intracranial Atherosclerosis
This will be a randomized double blind placebo-controlled pilot study using a repeated measures design in which participants with acute ischemic stroke and intracranial atherosclerotic disease are randomized to either drug or…
- Conditions
- Stroke, Intracranial Atherosclerosis, Intraplaque Hemorrhage
- Trial name
- PINNACLE (NCT03507374)
- Testing
- Alirocumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Atherosclerosis Cardiovascular Disease, Chronic Kidney Disease
A Study of Orforglipron (LY3502970) on Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease (ATTAIN-Outcomes)
The purpose of this study is to measure cardiovascular outcomes with orforglipron compared with placebo in participants with atherosclerotic cardiovascular disease (ASCVD) and/or chronic kidney disease (CKD).
- Trial name
- NCT07241390
- Testing
- Orforglipron
- Where
- 566 sites in Argentina, Australia and 36 more
- Volunteers
- 7,140 people
- Sponsor
- Eli Lilly and Company
Cardiovascular Diseases, Carotid Artery Diseases
Carotid Atherosclerosis Follow-up Study
To determine whether the degree of carotid artery atherosclerosis, as measured by B-mode ultrasound, predicts the development of myocardial infarction, stroke, and all-cause mortality in patients with angiographically defined…
- Conditions
- Cardiovascular Diseases, Carotid Artery Diseases, Myocardial Infarction, Coronary Disease
- Trial name
- NCT00005189
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Stroke (CVA) or TIA, Carotid Artery Plaque
[18F]AlF-NOTA-octreotide PET/MRI in Carotid Artery Disease
This clinical trial aims to evaluate whether [¹⁸F]AlF-OC PET/MRI can characterize and quantify inflammation in carotid atherosclerotic plaques.
- Conditions
- Stroke (CVA) or TIA, Carotid Artery Plaque, Atherosclerosis Cardiovascular Disease, Carotid Arteriosclerosis
- Trial name
- NCT07104487
- Testing
- [18F]AlF-OC
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cryptogenic Stroke
Cardiac Abnormalities in Stroke Prevention and Risk of Recurrence
This is a multi-center retrospective analysis of consecutive adult patients with cryptogenic stroke patients following a comprehensive workup for the underlying stroke etiology.
- Trial name
- CASPR (NCT06398366)
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- The Cooper Health System
Intracranial Atherosclerosis, Stroke
ACOART Intracranial ISR Pilot:Intracranial DCB in the Treatment of Intracranial In-stent Restenosis
The purpose of the study is to evaluate the safety and feasibility of drug coated balloon in treatment of intracranial in-stent restenosis.
- Trial name
- NCT04627870
- Testing
- drug (paclitaxel) coated balloon, PTA balloon
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Acotec Scientific Co., Ltd