Clinical trials: Atrial Fibrillation Catheter Ablation
Atrial Fibrillation
Left Atrial Appendage Closure in Combination With Catheter Ablation
This study is a prospective cohort study aimed at investigating the efficacy and safety of left atrial appendage closure in combination with catheter ablation in patients with atrial fibrillation.
- Trial name
- LAACablation (NCT03788941)
- Testing
- left atrial appendage closure and catheter ablation
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Atrial Fibrillation
Role of Cardiac Biomarkers in Prediction of Outcome in Atrial Fibrillation Patients Undergoing Catheter Ablation
The purpose of this study is to assess if pre-ablation levels of inflammatory biomarkers serve as independent predictors of procedure outcome To evaluate the inflammatory activation following catheter ablation by measuring…
- Trial name
- IMPACTII (NCT02208102)
- Testing
- Radio-frequency catheter ablation
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Persistent Atrial Fibrillation
Epicardial Mini-Maze Versus Catheter Ablation for the Management of Persistent Atrial Fibrillation
This study will assess the efficacy of catheter ablation versus the Wolf Mini-Maze surgical ablation for rhythm control in patients with persistent afib.
- Trial name
- EMMCAF (NCT03446222)
- Testing
- Catheter ablation, Mini-maze surgical procedure
- Where
- United States
- Sponsor
- The University of Texas Health Science Center, Houston
Arrhythmias, Cardiac
The MAGiC™ Cardiac Ablation European Study
The purpose of the first phase of this feasibility study is to gather safety and performance data on MAGiC to support European marketing approval.
- Trial name
- MAGiC-FESTPMCF (NCT06019845)
- Testing
- MAGiC™
- Where
- 4 sites in Denmark, Lithuania and 2 more
- Volunteers
- 150 people
- Sponsor
- Stereotaxis
Atrial Fibrillation, Ablation
The Deep Sedation for Ablation Study
Catheter ablation (CA) is an established therapeutic option for patients with symptomatic atrial fibrillation (AF). During the procedure, patients are usually sedated and analgesized, most commonly by administration of Propofol…
- Conditions
- Atrial Fibrillation, Ablation, Sedation, Propofol
- Trial name
- NCT03844841
- Testing
- Propofol, Dexmedetomidine
- Where
- Switzerland
- Volunteers
- 160 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Atrial Fibrillation (AF), Arrhythmia
Relaxin Therapy for Atrial Fibrillation
Atrial fibrillation (AF) is the most common heart rhythm disorder. The presence of AF increases the risk of death and is associated with a 5-6-fold increase in stroke incidence, due almost exclusively to thrombus formation in the…
- Conditions
- Atrial Fibrillation (AF), Arrhythmia, Oxidative Stress, Stroke
- Trial name
- Relax-in-AF (NCT07359872)
- Testing
- Relaxin
- Volunteers
- 208 people
- Sponsor
- Deeptankar DeMazumder
Atrial Fibrillation, Tachycardia, Supraventricular
TOCCATA - Touch+™ for Catheter Ablation
The main objective of this study is to demonstrate the clinical safety of a contact force sensing RF ablation catheter when used for the treatment of supraventricular tachycardia and atrial fibrillation.
- Trial name
- TOCCATA (NCT01223469)
- Testing
- Contact force assisted irrigated RF ablation
- Volunteers
- 77 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation
Short Term Warfarin Therapy for Radiofrequency Catheter Ablation of Atrial Fibrillation
We hypothesized that in patients with low CHADS-VASc score (2 or < 2), there is no difference in thromboembolic or bleeding events between patients with short term warfarin therapy (2 weeks after catheter ablation) and…
- Trial name
- NCT01991951
- Testing
- warfarin
- Where
- South Korea
- Volunteers
- 520 people
- Sponsor
- Korea University Anam Hospital
Atrial Fibrillation, Catheter Ablation
AF Ablation With High Power Short Duration RF
This is a prospective, multi-center, research study designed to evaluate the safety and efficacy of pulmonary vein (PV) isolation with high power short duration radiofrequency energy in patients with paroxysmal/persistent atrial…
- Trial name
- AIR HPSD (NCT05777551)
- Where
- 9 sites in France, Italy and 1 more
- Volunteers
- 850 people
- Sponsor
- Clinica Mediterranea
Atrial Fibrillation
Does VoltagE Guided Additional Ablation Improve Procedural Outcome of Atrial Fibrillation Ablation?
This study is designed to investigate whether pulmonary vein isolation(PVI) plus stepwise additional ablation approach based on the degree of low voltage area versus PVI only can improve procedure outcome in persistent atrial…
- Trial name
- NCT03377751
- Testing
- Additional posterior wall isolation, Voltage-guided substrate homogenization, PVI only group
- Where
- 3 sites in South Korea
- Volunteers
- 20 people
- Sponsor
- Korea University Guro Hospital
Atrial Fibrillation (AF), Atrial Arrhythmia
A Study of the TactiFlex SE Catheter and Volt PFA Generator in Subjects With PAF:
The objective of this clinical study is to demonstrate that ablation with the TactiFlex SE Ablation catheter, in conjunction with a compatible pulsed field ablation (PFA) and/or radio frequency (RF) generator, is safe and…
- Conditions
- Atrial Fibrillation (AF), Atrial Arrhythmia, Paroxysmal AF, Drug Refractory Paroxysmal Atrial Fibrillation
- Trial name
- FlexPulse IDE (NCT06676072)
- Testing
- PFA Ablation catheter
- Where
- 32 sites in United States, Austria and 2 more
- Volunteers
- 188 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation
Role of Subsequent Atrial Tachycardia in Mechanisms of Persistent AF
In this study, the investigators aim to examine the prognostic role of subsequent Atrial Tachycardias (ATs) in the mechanisms of atrial fibrillation (AF).
- Trial name
- NCT01896570
- Testing
- Catheter ablation of subsequent atrial tachycardia
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- Johannes Gutenberg University Mainz
Atrial Fibrillation, Pulmonary Hypertension
Catheter Ablation of Atrial Fibrillation in Patients With Pulmonary Hypertension Hypertension: a Randomised Study
Atrial fibrillation (AF) and atrial tachycardia (AT), including type I atrial flutter, are frequently observed in patients with pulmonary hypertension (PH).
- Trial name
- NCT04053361
- Testing
- Catheter ablation
- Where
- 3 sites in Czechia
- Volunteers
- 76 people
- Sponsor
- General University Hospital, Prague
Atrial Fibrillation (AF), PFA
Electrophysiologist-led Deep Sedation Protocols for Pulsed Field Ablation for Atrial Fibrillation Using a Bipolar Tip-Catheter: The DEEP-PFA Randomized Controlled Trial
The DEEP-PFA trial is an investigator-initiated, prospective, single-center, three-arm (1: 1: 1), randomized controlled study comparing three anesthesia regimens-midazolam + fentanyl (DS1), flurbiprofen + midazolam + fentanyl…
- Conditions
- Atrial Fibrillation (AF), PFA, Deep Sedation
- Trial name
- NCT07149545
- Testing
- Arm A (Fentanyl + Midazolam), Arm B (Flurbiprofen axetil + Fentanyl + Midazolam), Arm C (Fentanyl + Dexmedetomidine)
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation (AF)
Photoplethysmography (PPG) Algorithm with Smartwatch in Evaluation of Atrial Fibrillation Burden After Catheter Ablation
The purpose of this study is to evaluate the effectiveness of a smart electrocardiogram watch based on the PPG algorithm in monitoring the atrial fibrillation burden of patients after catheter ablation.
- Trial name
- Polaris-AFCA (NCT06842160)
- Testing
- intervention group
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation
High Frequency Jet Ventilation in AF Ablation
Atrial fibrillation (AF) is a cardiac condition that results in patients experiencing an irregular heart beat resulting in symptoms including palpitations and breathlessness.
- Trial name
- NCT02968147
- Testing
- High frequency jet ventilation, Conventional ventilation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Oxford University Hospitals NHS Trust
Persistent Atrial Fibrillation
The Study for Evaluate of Safety and Efficacy of Vein of Marshall RF Ablation
The goal of this clinical trial is to evaluate the initial safety and effectiveness of an investigational medical device. Electrode catheter ablation of the Marshall vein is performed using TIRA, a clinical trial medical device…
- Trial name
- NCT05854238
- Testing
- TIRA-VoM
- Where
- 2 sites in South Korea
- Volunteers
- 4 people
- Sponsor
- Tau-MEDICAL Co., Ltd.
Atrial Fibrillation, Hypertrophic Cardiomyopathy
Antiarrhythmic Therapy Versus Catheter Ablation for Atrial Fibrillation in Hypertrophic Cardiomyopathy
Paroxysmal or chronic atrial fibrillation (AF) develops in about 20- 25% of adult patients with hypertrophic cardiomyopathy (HCM) and represents an important complication in the clinical course of the disease, with adverse…
- Trial name
- NCT00821353
- Testing
- RF catheter ablation, Antiarrhythmic drugs
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Atrial Fibrillation (AF), Persistent Atrial Fibrillation (PersAF)
A Global Randomized Trial Evaluating the FARAFLEX™ Mapping and Pulsed Field Ablation System With Electrographic Flow Mapping in Patients Undergoing Repeat Ablation for Atrial Fibrillation
The goal of the ReDEFINE-AF Clinical Study is to evaluate the safety and effectiveness of the FARAFLEX™ Mapping and Pulsed Field Ablation System with electrographic flow mapping in subjects undergoing repeat ablation for atrial…
- Conditions
- Atrial Fibrillation (AF), Persistent Atrial Fibrillation (PersAF), Paroxysmal Atrial Fibrillation (PAF)
- Trial name
- ReDEFINE-AF (NCT07820930)
- Testing
- FARAFLEX Mapping and Pulsed Field Ablation System
- Volunteers
- 650 people
- Sponsor
- Boston Scientific Corporation
Atrial Fibrillation (AF), Paroxysmal AF
PulseMagic™ TrueForce™ PAF NMPA Study
This clinical investigation is intended to demonstrate safety and effectiveness of the PulseMagic™ TrueForce™ Ablation Catheter and the PulseMagic™Pulse Field Ablation (PFA) Generator, and Columbus™ 3D EP Navigation System with…
- Conditions
- Atrial Fibrillation (AF), Paroxysmal AF, Drug Refractory Paroxysmal Atrial Fibrillation, Atrial Arrhythmia
- Trial name
- PFATrueForce (NCT07720557)
- Testing
- PFA Ablation catheter
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shanghai MicroPort EP MedTech Co., Ltd.