Clinical trials: Attachment Loss, Periodontal
Periodontitis, Periodontal Inflammation
PRF as Adjunct to Subgingival Instrumentation in Step 2 Periodontal Therapy
Periodontitis is characterized by a chronic, multifactorial inflammatory process driven by dysbiotic plaque biofilms. It is recognized as the most common chronic inflammatory non-communicable disease in humans.
- Conditions
- Periodontitis, Periodontal Inflammation, Periodontal Attachment Loss
- Trial name
- PRFSTEP2 (NCT07013682)
- Testing
- PRF as adjunct to non-surgical mechanical debridement, Control, non-surgical mechanical debridement alone
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Bern
Periodontal Attachment Loss, Periodontal Bone Loss
Platelet-Rich Fibrin and Anorganic Bovine Bone vs Collagen Membrane and Anorganic Bovine Bone in Intrabony Defects
The primary outcome of periodontal reconstructive therapy is to regenerate all tissues of the periodontium including a functional periodontal ligament, alveolar bone and cementum.
- Conditions
- Periodontal Attachment Loss, Periodontal Bone Loss, Periodontal Diseases
- Trial name
- NCT03715374
- Testing
- Periodontal Surgery with PRF+ABB, Periodontal Surgery with Collagen Membrane +ABB
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Periodontitis, Localized Aggressive, Periodontal Diseases
Accuracy of Pulp Sensibility Test on Teeth With Deep Periodontal Pocket
The aim of this study is to evaluate the accuracy of pulp test in teeth presenting with deep periodontal pocket. The null hypothesis is no significant effect of periodontitis on the accuracy of pulp test.
- Conditions
- Periodontitis, Localized Aggressive, Periodontal Diseases, Endodontic Disease, Endodontic Inflammation
- Trial name
- NCT04399135
- Testing
- Orthopantomogram X-ray view, Endo-Ice, Electric Pulp Tester (EPT)
- Where
- Saudi Arabia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Qassim University
Periodontitis
Regeneration of Human Intrabony Defects With rhFGF-2/HA
BACKGROUND: Periodontal disease is an infection that results in progressive loss of dental support, which may lead to tooth loss..
- Trial name
- NCT02337166
- Testing
- a gel containing 4mg/ml rhFGF-2 in sodium hyaluronate, Periodontal flap surgery
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Periodontal Diseases, Periodontal Attachment Loss
Low-level Laser Therapy as an Adjunct to Non-surgical Periodontal Treatment
The present study aimed to investigate the effects of low-level laser therapy (LLLT) as an adjunct to non-surgical periodontal treatment (NSPT) on the plasminogen-activating system in Stage 3-4, Grade C periodontitis patients.
- Conditions
- Periodontal Diseases, Periodontal Attachment Loss, Periodontal Disease, AVDC Stage 3, Periodontal Inflammation
- Trial name
- NCT05233501
- Testing
- low level laser therapy, non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Beykent
Periodontitis, Periodontal Diseases
Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis
The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis).
- Conditions
- Periodontitis, Periodontal Diseases, Periodontal Inflammation, Gingival Diseases
- Trial name
- NCT07536204
- Where
- Chile
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Chile
Periodontal Diseases, Chronic Periodontitis
Photodynamic Therapy During Supportive Periodontal Therapy
27 subjects on SPT, each with at least two residual pockets ≥5mm, were recruited for this randomised, split-mouth controlled trial, providing a total of 72 sites.
- Conditions
- Periodontal Diseases, Chronic Periodontitis, Periodontal Attachment Loss
- Trial name
- NCT02666573
- Testing
- Fotosan 630, CMS Dental, Copenhagen, Denmark, Scaling and root planing
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Gingival Recession, Periodontal Attachment Loss
Flap Thickness Upon Root Coverage With the Use of Acellular Dermal Matrix
OrACell has been tested as a barrier in bone regenerative procedures showing promising results in new bone formation after socket preservation, but no data is available on root coverage procedures.
- Conditions
- Gingival Recession, Periodontal Attachment Loss, Periodontal Diseases, Soft Tissue Injuries
- Trial name
- NCT04802473
- Testing
- Mucogingival surgery
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Attachment Loss, Periodontal, Teeth, Impacted
Verify if Amelogenins Had Some Benefits in Improving Lower 2nd Molar Periodontal Healing After 3rd Molar Extraction
Background: Prevention of periodontal defects after the extraction of lower third molars remains a challenge. Various methods have been proposed in the literature, but there are no studies which evaluated the effectiveness of…
- Trial name
- NCT04314726
- Testing
- Amelogenin
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Tooth Loss
Initial Stability of Posterior Maxillary Implants With Bicortical Fixation
The primary purpose of this study is to 1. determine whether dental implant engaging both the alveolar crest cortical bone and sinus floor using vertical stopper drill and self-threading concept (bi-cortical fixation) increases…
- Trial name
- NCT01237184
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Interdental Papilla Recession
Interdental Guided Creeping Technique
The aim of this randomized clinical trial is to treat interdental papillary deficiency with minimally invasive interdental guided creeping technique (IGCT) comparing collagen membrane versus connective tissue graft.
- Trial name
- NCT06264869
- Testing
- Interdental guided creeping technique (IGCT) and connective tissue graft (CTG), Interdental guided creeping technique (IGCT) and collagen membrane (CM)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- October 6 University
Cleft Lip and Palate, Periodontal Pocket
Periodontal Changes Following Mid Maxillary Distraction
To evaluate the health status of the periodontium and dentition at the distraction osteogenesis site in CLP subjects using mid maxillary distraction (MMD).
- Conditions
- Cleft Lip and Palate, Periodontal Pocket, Attachment Loss, Periodontal
- Trial name
- NCT03686761
- Testing
- A Involvement with the osteotomy site of the surgery
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alexandria
Periodontitis, Gingivitis and Periodontal Diseases
Salivary Free Amino Acid Profiles in Periodontitis: Associations With Clinical Parameters and Dynamic Responses to Non Surgical Therapy
# Brief Summary (Word count: 198) This combined observational and interventional study investigates salivary amino acid profiles and their connections to periodontal conditions, as well as how these substances change after…
- Conditions
- Periodontitis, Gingivitis and Periodontal Diseases, Periodontal Debridement, Periodontal Attachment Loss
- Trial name
- FAA-CP-SRP (NCT07669233)
- Testing
- Non-surgical periodontal therapy
- Where
- China
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Zhang, Yuwei
Periodontitis, Adult, Periodontal Pocket
Effect of Photodynamic Therapy on Gingival Crevicular Cytokines in Periodontitis Patients
Systemically healthy periodontitis patients were recruited in this single-blind, split-mouth, randomized controlled clinical trial. After SRP, PDT was applied at probing depth (PD) ≥ 4 mm at test quadrant.
- Conditions
- Periodontitis, Adult, Periodontal Pocket, Periodontitis, Periodontal Attachment Loss
- Trial name
- NCT03453476
- Testing
- SRP and Fotosan 630
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Gingival Recession, Gingival Diseases
Influence of Anatomical Factors Upon Root Coverage
Introduction: Gingival recession is a lesion characterized by the loss of attachment of root surface of the tooth, resulting in an apical migration of the gingival margin that occasionally generates aesthetic problems…
- Conditions
- Gingival Recession, Gingival Diseases, Periodontal Attachment Loss
- Trial name
- NCT04813302
- Testing
- Coronally advanced flap and connective tissue graft
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Periodontal Attachment Loss, Periodontal Bone Loss
Added Benefit of L-PRF to Autogenous Bone Graft in the Treatment of Mandibular Degree II Furcation Defects
Different therapeutic approaches have been proposed for the treatment of furcation defects and the regeneration of periodontium within the furcation area is considered one of the most challenging aspect of surgical periodontal…
- Trial name
- NCT03756493
- Testing
- Periodontal Surgery with OFD+ABG+L-PRF, Periodontal Surgery with OFD+ABG, Periodontal Surgery OFD
- Where
- Italy
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Periodontal Diseases, Periodontal Attachment Loss
Efficacy of Camel Whey Protein and Camel Whey Protein Nanoparticles for Treating Intra-bony Periodontal Defects
Intraosseous bone defects (IOBDs) are a significant challenge in the treatment of periodontal disease. Several bone graft materials can be used for bone defect regeneration.
- Trial name
- NCT07358104
- Testing
- only open flap debridement, scaffold material, CWP
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Anxiety Disorders, Oral Disease
Effect of Trait Anxiety in Women on Oral Health Status and Oral Health Care-Seeking Behavior
Trait anxiety is the tendency of an individual to perceive environmental stimuli such as different events and situations as threatening; it's stable and reflects how an individual generally feels.
- Conditions
- Anxiety Disorders, Oral Disease, Periodontal Diseases, Periodontal Attachment Loss
- Trial name
- NCT04274855
- Where
- Egypt
- Volunteers
- 451 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Periodontal Diseases, Periodontal Bone Loss
Entire Papilla Preservation Technique in the Treatment of Periodontal IntraBony Defects: a 1-year Follow-up Study
The aim of this study was to investigate the radiographic and clinical outcomes associated with the whole papilla preservation technique in the treatment of isolated intraosseous defects in patients with stage III periodontitis.
- Trial name
- EPP (NCT06744348)
- Testing
- ENTİRE PAPİLLA PRESERVATİON
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Attachment Loss, Tooth,Non Vital
Immediate Verses Delayed Surgical Periodontal Therapy After Endodontic Treatment in Endo Perio Lesion With Communication
The aim of the study is to conduct a prospective randomized clinical trial to evaluate the effect of immediate and delayed surgical periodontal therapy after non-surgical endodontic treatment on periodontal healing of the…
- Trial name
- NCT02630745
- Testing
- Immediate periodontal surgery, Delayed periodontal surgery
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak