Clinical trials: Autotransplantation
Relapsing-Remitting Multiple Sclerosis
High-Dose Immunosuppression and Autologous Transplantation for Multiple Sclerosis (HALT MS) Study
The purpose of this study is to determine the effectiveness of a new treatment for multiple sclerosis (MS), a serious disease in which the immune system attacks the brain and spinal cord.
- Trial name
- NCT00288626
- Testing
- Granulocyte-colony stimulating factor (G-CSF) and prednisone, Carmustine, etoposide, cytarabine, and melphalan (BEAM), Autologous hematopoietic stem cell transplant
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Intervertebral Disc Degeneration
Comparison of nanOss Cervical IBF System to C-Plus PEEK IBF Device With Autograft
This is a post-market, prospective, randomized clinical investigation to evaluate the performance of the nanOss Cervical Interbody Fusion (IBF) device with nanOss Bioactive Bone Void Filler for the treatment of cervical disc…
- Trial name
- NCT02586116
- Testing
- nanOss, C-Plus
- Where
- Belgium
- Volunteers
- 11 people
- Sponsor
- RTI Surgical
Chronic and Accelerated Silicosis
Safety of Stem Cells Intrabronchial Instillation for Silicosis
The aim of this study was to analyze the safety, pulmonary function, and quality of life data of patients with silicosis treated with intrabronchial instillation of bone marrow derived mononuclear cells (BMDMC, 2x107) through…
- Trial name
- SilicStemCell (NCT01239862)
- Testing
- Autologous cell transplantation
- Where
- Brazil
- Volunteers
- 5 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Osteoarthritis of the Knee
Autograft Versus Calcium Phosphate Macroporous Bioceramics as Bone Substitute for Tibial Valgus Osteotomy
The aim of the study is to compare radiological behavior of blocks of macroporous phosphocalcium as bone substitute in comparison with iliac crest autograft in tibial valgus osteotomy.
- Trial name
- NCT00200603
- Testing
- calcium phosphate macroporous bioceramics
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Nantes University Hospital
Oral Mucositis
Prevention of Oral Mucositis Using Photobiomodulation Therapy
Oral mucositis is a significant and common toxicity experienced by patients who receive high-dose chemotherapy as a preparatory regimen for a hematopoietic cell transplant (HCT).
- Trial name
- NCT04227340
- Testing
- Photobiomodulation Therapy (PBM), Pain and Oral Function Assessment, Parent-Reported Satisfaction Survey
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- St. Jude Children's Research Hospital
Gingival Recessions
Evaluation of the Clinical Efficacy of De-Epithelialized Free Gingival Graft in the Treatment of Gingival Recessions
The aim of this study is to evaluate the clinical effectiveness of three techniques used in combination with the tunnel method for the treatment of multiple gingival recessions: subepithelial connective tissue graft (SCTG Group)…
- Trial name
- NCT07100808
- Testing
- Using the tunnel technique in the treatment of gingival recession
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
ACL Injury, Anterior Cruciate Ligament Rupture
Prospective Clinical Results of 3 Different Femoral Fixation in ACL Reconstruction
Anterior cruciate ligament (ACL) tears are one of the most common injuries of the knee. In today's world, due to developing sports industry , the increase in sports traumas of both genders and ages ACL injuries and treatments are…
- Trial name
- NCT04677218
- Testing
- Arthroscopic ACL reconstruction with retensioned hamstring autograft, Arthroscopic ACL reconstruction with retensioned and knotted hamstring autograft
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Emre Kocazeybek
Degenerative Lumbar Spine Diseases, Lumbar Degenerative Disc Disease
Kore Fiber PLF Study
This is a prospective, randomized controlled trial evaluating Kore Fiber® versus autograft in adults undergoing posterolateral lumbar fusion (PLF).
- Conditions
- Degenerative Lumbar Spine Diseases, Lumbar Degenerative Disc Disease, Lumbar Spinal Stenosis, Spondylolisthesis
- Trial name
- NCT07868510
- Testing
- Kore Fiber, Autologous bone graft
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Kolosis Bio, LLC
Bone Tumors
Vascular CT Assessment of Structural Autograft and Allograft Healing
The purpose of this study is to determine the ability of a cone beam CT to measure bone healing.
- Trial name
- NCT00594776
- Testing
- Cone Beam CT Scan
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Rochester
Blood Diseases
Efficacy of Biosimilar Filgrastim on the Mobilization of Hematopoietic Stem Cell CD34+ (Cluster of Differentiation 34) and on the Kinetic Engraftment
The endogenous growth factor granulocyte (G-CSF) stimulates the proliferation and differentiation of hematopoietic progenitors commissioned to mature as neutrophils and activated granulocytes mature neutrophils.
- Trial name
- NCT02806791
- Testing
- FILGRASTIM
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Azienda Ospedaliera San Giovanni Battista
Multiple Myeloma, Renal Failure
High Dose Therapy Followed by Autologous Transplantation for Myeloma Patients With Severe Renal Impairment
Multiple myeloma (MM) is a malignant plasma cell disorder, characterized by the presence of more than 10 % of clonal plasma cells in the bone marrow.
- Trial name
- IRMYG (NCT03234335)
- Testing
- Data collection
- Where
- 33 sites in Algeria, Belgium and 2 more
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
Arthroscopic ACL Reconstruction: Hamstring Versus Quadriceps
The use of hamstrings and quadriceps autografts as an alternative option for reconstruction of the anterior cruciate ligament has good clinical results: however, both techniques have not been compared among them, which is why…
- Trial name
- NCT04137250
- Testing
- Hamstring, Quadriceps tendon
- Where
- Mexico
- Volunteers
- 28 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Recurrent Pterygium, Micro-Conjunctival Autografting Combined With Amniotic Membrane Transplantation
Micro-Conjunctival Autografting Combined With Amniotic Membrane Transplantation Treating Recurrent Pterygium Trial
To observe the effect of micro-conjunctival autografting combined with amniotic membrane transplantation on the postoperative recurrence, complications and ocular surface symptoms among patients with recurrent pterygium.
- Trial name
- NCT05362253
- Testing
- Micro-Conjunctival Autograft Combined with Amniotic Membrane Transplantation, Conventional Autologous Conjunctival Transplantation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yifeng Yu
Spinal Cord Injury
Autologous Mesenchymal Stem Cells Transplantation for Spinal Cord Injury- A Phase I Clinical Study
The conventional treatment of spinal cord injury (SCI) includes physical therapy and rehabilitation and in some cases may require surgical intervention.
- Trial name
- NCT02482194
- Testing
- mesenchymal stem cells
- Where
- Pakistan
- Volunteers
- 9 people
- Sponsor
- National Institute of Blood and Marrow Transplant (NIBMT), Pakistan
Pain
Pain Relief at Iliac Crest Bone Harvest Sites in Spine Surgery Using Bupivacaine
The use of iliac crest bone graft (ICBG) remains the gold-standard in spinal reconstructive surgery for achieving fusion. Major complications from the harvesting of ICBG are rare, but chronic pain has been reported in 10-39%.
- Trial name
- NCT01087931
- Testing
- Bupivacaine, Normal Saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University
ACL Reconstruction
Effect of Internal Brace on Outcomes Following ACL Reconstruction With BTB Autograft
The purpose of this study is to assess Anterior Cruciate Ligament (ACL) healing through analyzing clinical, radiographic, functional and patient-reported outcomes following ACL reconstruction with bone-tendon-bone autograft with…
- Trial name
- NCT06542705
- Testing
- Arthrex Internal Brace, ACL Reconstruction
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- NYU Langone Health
Multiple Myeloma, Plasma Cell Neoplasm
Vorinostat and Lenalidomide After Autologous Stem Cell Transplant in Treating Patients With Multiple Myeloma
RATIONALE: Vorinostat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Lenalidomide may stop the growth of multiple myeloma by blocking blood flow to the cancer.
- Trial name
- NCT00729118
- Testing
- lenalidomide, vorinostat
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
High-Risk Breast Cancer
Adjuvant Breast Cancer Study of the Netherlands Working Party for Autotransplantation in Solid Tumors
Objectives of the study: This randomized multicenter phase II study compares the tolerability, toxicity and quality of life between two high-dose chemotherapy regimens based on cyclophosphamide, thiotepa and carboplatin.
- Trial name
- NCT00851110
- Testing
- stem cell reinfusion, Chemotherapy
- Where
- 10 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- University Medical Center Groningen
Myeloma
Treatment of Myeloma in Patients <= 65 Years Old With Response >= 50% After HSC Autotransplant by Allogenic Transplant Genoidentical or Phenoidentical After Reduced Intensity Conditioning
Donor mobilization : Donor will be mobilized with G-CSF (Granocyte) sub-cutaneous 10 µg/kg/day during 5 to 6 days. Hematopoïetic Stem Cell Harvest: By 1, 2, or 3 aphaeresis, a number of 4 x 106 cellules CD34+ /kg is required.
- Trial name
- IFM 2005-03 (NCT00466674)
- Testing
- reduced intensity conditioning
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Hospices Civils de Lyon
Non Union Diaphyseal Fractures
A Randomized Controlled Cost Study of Infuse BMP 2 vs Iliac Crest Autograft for Non Union of Long Bone Fractures
We are inviting individuals such as yourself, who have diaphyseal fracture (broken bone) with a non union to participate in this research study.
- Trial name
- Infuse (NCT00856479)
- Testing
- Infuse Bone Morphogenic Protein (BMP) 2, iliac crest autograft
- Where
- Canada
- Sponsor
- Ross Leighton