Clinical trials: Axillary Dissection
Breast Cancer
Ideal Marker for Targeted Axillary Dissection
A multicentre prospective comparative study, comparing the use of various markers (magnetic marker Magseed, iodine seed 125I, carbon suspension) for marking a pathological lymph node in patients with breast carcinoma prior to…
- Trial name
- IMTAD (NCT04580251)
- Testing
- Targeted axillary dissection
- Where
- 5 sites in Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Ostrava
Breast Cancer
Positive Node Traced Before Neoadjuvant Chemotherapy (NAC)
To investigate this regression model by injecting and tracing carbon nanoparticles (CNs) into the fusion node prior to NAC in patients with breast cancer.
- Trial name
- NCT03355261
- Testing
- complete remission (CR) group, partial remission (PR) group, stable disease (SD) group
- Where
- 3 sites in China
- Volunteers
- 110 people
- Sponsor
- Shengjing Hospital
Breast Cancer, Chemotherapy Effect
Delayed SLND for Patients With Breast Cancer Undergoing Primary Systemic Treatment
The goal of this study was to assess the feasibility of SLND by superparamagnetic iron oxide nanoparticles (SPIO) in patients with early breast cancer planned for primary systemic therapy (PST) and whether this is affected by the…
- Conditions
- Breast Cancer, Chemotherapy Effect, Sentinel Lymph Node
- Trial name
- MagNeo (NCT05985551)
- Testing
- SLND or TAD by the magnetic technique (SPIO)
- Where
- Sweden
- Volunteers
- 114 people
- Sponsor
- Uppsala University
Breast Cancer
Fluorescent Dyes for Lymph Node Mapping
The goal of this clinical research study is to find lymph nodes before surgery using a dye called indocyanine green (IC-Green). Objectives: 1.
- Trial name
- NCT01095913
- Testing
- Indocyanine green (ICG)
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer Lymphedema, Shoulder Injury
Interhospital Variability in Programmes to Prevent Axillary Lymphadenectomy Sequels in Breast Cancer Patients.
This study aims to determine the effectiveness of the different programmes of four Spanish hospitals about prevention of axillary lymphadenectomy sequels in breast cancer patients.
- Trial name
- NCT03300349
- Testing
- Fulfillment of a preventive programme, No fulfillment of a preventive programme
- Where
- 5 sites in Spain
- Volunteers
- 276 people
- Sponsor
- Violeta Pajero Otero
Breast Cancer
Impact of a Surgical Sealing Patch on Lymphatic Drainage After ALND for Breast Cancer
Axillary lymph node dissection remains an integral part of surgical treatment of primarily node-positive invasive breast cancer.
- Trial name
- NCT02311543
- Testing
- TachoSil® patches
- Where
- 16 sites in Switzerland
- Volunteers
- 142 people
- Sponsor
- Swiss Cancer Institute
Breast Cancer
Does Scar Massage Improve Postoperative Pain and Function in Women With Breast Cancer?
All patients undergoing breast cancer surgery are left with scars which can significantly affect their physical and psychological well being.
- Trial name
- NCT00175344
- Testing
- Scar massage.
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- University of British Columbia
Breast Cancer
Study of the ICG Distribution in Breast Tumours or in Axillary Lymph Nodes of Patients After Neoadjuvant Therapy
We will verify if IV injected ICG may colour breast tumors and axillary lymph nodes after neoadjuvant therapy (chemo- or hormonotherapy)
- Trial name
- NCT02032563
- Testing
- Indocyanine Green
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Jules Bordet Institute
Pain
Morphine for the Treatment of Pain in Patients With Breast Cancer
RATIONALE: Morphine helps to relieve the pain associated with cancer surgery. Giving morphine in different ways may offer more pain relief.
- Trial name
- NCT00003000
- Testing
- fentanyl citrate, morphine sulfate
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Roswell Park Cancer Institute
Mastectomy, Mastectomy Plus Axillary Lymph Node Dissection
Effect of Serratus and Pectoralis II Plane Block Versus Pectoralis II Alone on Acute Postoperative Pain After Mastectomy
The goal of this randomized controlled clinical trial is to determine whether adding a serratus anterior plane block (SAPB) to a pectoralis II (PECS II) block improves pain relief and reduces the need for opioids in adult women…
- Conditions
- Mastectomy, Mastectomy Plus Axillary Lymph Node Dissection, Nerve Block; Pain Medication, Pectoralis Nerve Block
- Trial name
- PECS (NCT07881237)
- Testing
- Serratus Anterior Plane Block (SAPB) group, Pectoral nerve block (PECS)
- Where
- Lebanon
- Volunteers
- 80 people
- Sponsor
- Lebanese American University
Breast Cancer Invasive
Precision Regional Node Irradiation for Sentinel Node-positive Breast Cancer
Axillary lymph node dissection has long been regarded as standard if treatment of the axilla is indicated for patients with a positive sentinel node.
- Trial name
- NCT06583655
- Testing
- SLND(clinical low risk), SLND(clinical high risk, genomic low risk), SLND alone ,clinical high risk and genomic high risk group
- Where
- China
- Volunteers
- 205 people
- Sponsor
- Ruijin Hospital
Breast Neoplasm, Chemotherapy Effect
Magnetic Marker Localization for Occult Breast Cancer and Target Axillary Dissection in Node-positive Breast Cancer Post-neoadjuvant Chemotherapy
The use of neoadjuvant chemotherapy in breast cancer is expanding in the recent decade. Patients with good response to neoadjuvant chemotherapy could benefit from de-escalation of breast and axilla operation.
- Trial name
- MaCTAD (NCT05427071)
- Testing
- Magnetic seed localization
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- The University of Hong Kong
Breast Cancer
Sentinel Lymph Node Biopsy in Patients With Breast Cancer After Neoadjuvant Therapy
The aim of this study is to create clear indications for Sentinel Lymph Node Biopsy (SLNB) or Axillary Dissection (AD) in women with breast carcinoma after neoadjuvant therapy by studying the false negative rate of SLNB.
- Trial name
- NCT03556397
- Testing
- Sentinel lymph node biopsy (SLNB), Axillary dissection
- Where
- 2 sites in Czechia
- Volunteers
- 61 people
- Sponsor
- University Hospital Ostrava
Breast Cancer
Preoperative and Intraoperative Quantification of Axillary Tumoral Load
At present, patients diagnosed of a breast cancer with infiltration of the axillary lymph-nodes are submitted to axillary lymph-node dissection (ALND).
- Trial name
- NCT02197949
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Parc de Salut Mar
Axillary Lymph Node Dissection, ALND
Evaluating Hemopatch in Reducing Seroma Related Complications Following Axillary Lymph Node Dissection: a Pilot Study
To evaluate if the use of Hemopatch in axillary lymph node dissection shows potential in reducing clinically significant seroma and seroma related complications, which might serve as a basis for a randomized controlled trial.
- Conditions
- Axillary Lymph Node Dissection, ALND, Axillary Clearance, Seroma
- Trial name
- HEIDI (NCT04185480)
- Testing
- Hemopatch
- Where
- Netherlands
- Volunteers
- 62 people
- Sponsor
- Zuyderland Medisch Centrum
Pain, Breast Diseases
T3AI-Pain After Breast Surgery
Current standard of care for post-operative analgesia after breast surgery in CDHA is Tylenol #3® (300 mg acetaminophen, 30 mg codeine, 15 mg caffeine per tablet).
- Trial name
- T3AI (NCT00299039)
- Testing
- acetaminophen plus codeine, acetaminophen plus ibuprofen
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Nova Scotia Health Authority
Seroma Following Procedure
Use of Glubran 2 ® in Axillary Lymphadenectomy Without Drain
Axillary lymphadenectomy in breast cancer continues to be a common practice in certain patients. The use of sealants and drains continues to be a source of disagreement among the scientific community.
- Trial name
- GALA (NCT05280353)
- Testing
- Glubran 2
- Where
- Spain
- Volunteers
- 134 people
- Sponsor
- Omphis Foundation
Breast Cancer
Nodal Burden and Nodal Recurrence in Patients With Isolated Tumor Cells After Neoadjuvant Chemotherapy Treated With Axillary Dissection or Nodal Radiation: the OPBC-05/EUBREAST-14R/ICARO Study
The purposes of this multicenter retrospective cohort study are to determine the residual nodal burden in patients with isolated tumor cells detected in the SLN or the clipped node after NAC and to determine oncologic outcomes in…
- Trial name
- ICARO (NCT06464341)
- Testing
- Observational study no intervention
- Where
- 62 sites in United States, Austria and 16 more
- Volunteers
- 583 people
- Sponsor
- University Hospital, Basel, Switzerland
Breast Neoplasm Female
Sentinel Node Biopsy Alone or With Axillary Dissection After Primary Chemotherapy
Many doctors believe that breast cancer patients scheduled for pre-operative chemotherapy whose cancer has spread to the axilla (determined by palpation plus ultrasound) should not receive sentinel node biopsy after chemotherapy…
- Trial name
- NCT04436809
- Testing
- Sentinel Node Biopsy, Axillary Dissection
- Volunteers
- 353 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Melanoma
Fibrin Melanoma Axillary Node Study in Patients With Melanoma
Primary Objective: To determine whether the use of a fibrin sealant applied to axillary soft tissues following node dissection can result in earlier drain removal.
- Trial name
- NCT00504582
- Testing
- Fibrin Sealant
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- M.D. Anderson Cancer Center