Clinical trials: Axillary Dissection
Lymphedema, Breast Cancer
The LYMPH Trial - Microsurgical Versus Conservative Treatment of Chronic Breast Cancer Associated Lymphedema
The aim of this study is to test whether lymphatic surgery provides better QoL (assessed with the Lymph-ICF-UL, (Lymphedema Functioning Disability and health questionnaire for upper limb lymphedema)) 15 months after randomization…
- Trial name
- LYMPH (NCT05890677)
- Testing
- Surgical Intervention, Conservative Complex Physical Decongestion Therapy
- Where
- 36 sites in United States, Austria and 13 more
- Volunteers
- 280 people
- Sponsor
- University Hospital, Basel, Switzerland
Breast Cancer Lymphedema
Effect of ALND With Vein Branches Reservation on Postoperative Upper Limb Edema and Dysfunction in Breast Cancer
The purpose of this study is to compare the effects of axillary lymph node dissection with or without axillary vein branches reservation on the affected upper limb edema and dysfunction in breast cancer patients, and to explore…
- Trial name
- PLEDGE-Surgery (NCT05120180)
- Testing
- axillary lymph node dissection with vein branches reservation, axillary lymph node dissection without vein branches reservation
- Where
- 3 sites in China
- Volunteers
- 258 people
- Sponsor
- Xiangyun Zong
Breast Cancer, Mastectomy, Modified Radical
Comparison of Operation Time, Drain Duration, and Seroma Formation After Modified Radical Mastectomy Using Ultrasonic Dissector Versus Electrocautery in Women With Breast Cancer
The goal of this clinical trial was to compare two surgical techniques-ultrasonic dissector and electrocautery-for performing axillary dissection in women undergoing modified radical mastectomy (MRM) for breast cancer.
- Conditions
- Breast Cancer, Mastectomy, Modified Radical, Mastectomy Plus Axillary Lymph Node Dissection, Seroma Following Procedure
- Trial name
- NCT07050329
- Testing
- Electrocautery, Ultrasonic dissector
- Where
- Pakistan
- Volunteers
- 138 people
- Sponsor
- Quaid-e-Azam Medical College
Breast Cancer, HER2-positive Breast Cancer
Radiation Omission in Patients With HER2 Overexpressing Tumors With Pathologic Complete Response
The purpose of this study is to evaluate the feasibility, based on recruitment rate over a 3-year period, of enrolling patients for the omission of post-operative breast radiation following breast conserving surgery and sentinel…
- Trial name
- NCT05371860
- Testing
- Omit breast radiation
- Where
- United States
- Sponsor
- Armando Giuliano
Breast Cancer, Breast-conserving Surgery
Hemopatch Versus Axillary Drainage After Axillary Lymphadenectomy
Aspirative drainage continues to be the "gold standard" for the management of this post-surgical complication, even though it can lead to complications such as obstruction of the drainage, peritubal leakage of the seroma, etc.
- Conditions
- Breast Cancer, Breast-conserving Surgery, Axillary Lymph Node Dissection
- Trial name
- REDHEMOPACH (NCT04487561)
- Testing
- hemopatch, Aspirative drainage
- Where
- Spain
- Volunteers
- 228 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Breast Neoplasms
Omitting Completion Axillary Treatment in Sentinel Node Positive Breast Cancer Patients Undergoing a Mastectomy
STUDY AIM To decrease the number of breast cancer patients receiving overtreatment of the axilla, in order to positively influence the axillary morbidity rate and quality of life.
- Trial name
- NCT02112682
- Testing
- Completion axillary treatment
- Where
- 31 sites in Netherlands
- Volunteers
- 52 people
- Sponsor
- Maastricht University Medical Center
Breast Cancer
Selective Axillary Lymph Node Dissection Vs Complete Axillary Dissection: A Randomised Clinical Trial to Assess the Prevention of Lymphedema in Breast Cancer Treatment
This is a pilot study at the National Cancer Institute (INT) of Milan evaluated the feasibility of selective axillary dissection (SAD) which preserved the lymphatic drainage of the arm.
- Trial name
- NCT03083314
- Testing
- SELECTIVE AXILLARY LYMPH NODE DISSECTION (SAD), COMPLETE AXILLARY DISSECTION (ALND)
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Breast Cancer, Chronic Pain
Reducing Pain and Disability After Breast Cancer Surgery
The purpose of this study is to determine if the combination of thoracic paravertebral block and multimodal analgesia will decrease chronic pain and arm morbidity in patients undergoing breast cancer surgery with lymph node…
- Trial name
- RELIeF (NCT01089933)
- Testing
- Thoracic Paravertebral Block (TPVB), Local Anesthetic
- Where
- Canada
- Volunteers
- 129 people
- Sponsor
- Ottawa Hospital Research Institute
Early-Stage Breast Cancer
Tangential Radiation Therapy Without Axillary Dissection in Breast Cancer
The purpose of this study is to evaluate whether treatment to the axilla (area under the arm) can be safely minimized by omitting axillary surgery and full axillary radiation therapy and replacing it with radiation therapy to the…
- Trial name
- NCT00165243
- Testing
- Tangential radiation
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer
A Study Evaluating the Feasibility and Compliance of Manual Lymphatic Drainage Comparing Indocyanine-Green (ICG) Guided vs. Traditional Guided in Patients Undergoing Axillary Node Dissection for the Treatment of Breast Cancer
Breast cancer is estimated to affect approximately 300,000 women in the US in 2023. Studies demonstrate that 1 in 5 will develop breast cancer related lymphedema secondary to the treatments that they receive.
- Trial name
- NCT06327490
- Testing
- ICG-guided manual lymphatic drainage, Traditional manual lymphatic drainage, Indocyanine green
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Melanoma, Complication
Early Complications After Axillary and Inguinal Lymph Node Dissection in Stage III Melanoma Patients
This prospective randomized non-inferiority study is designed to compare the rate and severity of complications after axillary and inguinal lymph node dissection in stage III melanoma patients in a study group where the drain is…
- Trial name
- NCT04680182
- Testing
- Suction drain
- Where
- Norway
- Volunteers
- 104 people
- Sponsor
- Oslo University Hospital
Breast Cancer
T1-T2 Breast Cancer: Comparison Between Removal and Preservation of Axillary Lymph Nodes (SINODAR ONE)
Italian Multicentric non inferiority two-arm randomized clinical trial to verify that the experimental treatment (omission of axillary lymph node intervention) in the presence of sentinel lymph node metastases does not lead to a…
- Trial name
- SINODAR ONE (NCT05160324)
- Testing
- Removal of axillary lymph nodes., Preservation of axillary lymph nodes
- Volunteers
- 889 people
- Sponsor
- Fondazione Humanitas per la Ricerca
Breast Cancer, Breast Neoplasms
Augmented-Reality ICG Fluorescence Second-Look for Residual Nodal Disease After Axillary Dissection in Breast Cancer
This study tests whether special imaging goggles can help surgeons find lymph nodes that may be left behind during breast cancer surgery.
- Conditions
- Breast Cancer, Breast Neoplasms, Sentinel Lymph Node, Lymphatic Metastasis
- Trial name
- AR4SLN (NCT07696754)
- Testing
- Augmented-reality ICG fluorescence second-look imaging
- Where
- North Macedonia
- Volunteers
- 30 people
- Sponsor
- Ss. Cyril and Methodius University of Skopje
Hemopatch, Breast Cancer
The Effectiveness of Hemopatch® in the Reduction of Post-surgical Serous Drainage
Hemopatch is an alternative to reduce morbidity associated with axillary lymphadenectomy surgery, possibly contributing to improved patient management, clinical outcomes, and hospital costs.
- Conditions
- Hemopatch, Breast Cancer, Axillary Lymphadenectomy
- Trial name
- NCT04904653
- Testing
- Hemopatch, Control group
- Where
- Spain
- Volunteers
- 118 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Sentinel Lymph Node, Breast Cancer
TAD After Chemotherapy in Locally Advanced Breast Cancer
This is an observational study to validate target axillary dissection (TAD) in locally advanced tumors (cN2 and/or cT4).
- Conditions
- Sentinel Lymph Node, Breast Cancer, Locally Advanced
- Trial name
- NCT05763641
- Testing
- Target Axillary Dissection
- Where
- 2 sites in Spain
- Volunteers
- 162 people
- Sponsor
- Hospital Universitari de Bellvitge
Breast Cancer Lymphedema
Does Immediate Lymphatic Reconstruction Decrease the Risk of Lymphedema After Axillary Lymph Node Dissection
The researchers are doing this study to see if having immediate lymphatic reconstruction after axillary lymph node dissection (ALND) can decrease the development of lymphedema, a side effect of ALND.
- Trial name
- NCT04241341
- Testing
- Axillary Lymph Node Dissection with Immediate Lymphatic Reconstruction, Axillary Lymph Node Dissection without Immediate Lymphatic Reconstruction, quality-of-life questionnaires
- Where
- 7 sites in United States
- Volunteers
- 180 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Axilla Node Dissection
Axillary Lymphadenectomy. A Randomized Trial Comparing Bipolar Vessel Sealing To Conventional Technique
lymphorrehea remains the most frequent complication after axillary lymphadenectomy. we hyphothesize that the use of a bipolar vessel sealing may reduce the rate of lymph collection compared to the traditional surgical technique
- Trial name
- NCT01286337
- Testing
- bipolar vessel sealing, control
- Where
- Italy
- Volunteers
- 116 people
- Sponsor
- University of Milano Bicocca
Breast Neoplasms
Study of Fluorodeoxyglucose (FluGlucoScan) in Patients With Breast Cancer: Correlation With Histologic Findings of Sentinel Node Biopsies and Axillary Dissection
Breast cancer affects many women. One of the places to which it can spread is the lymph glands under the arm. The type of treatment offered to patients often will depend on whether those lymph glands have cancer in them or not.
- Trial name
- NCT00123799
- Testing
- Positron Emission Tomography Imaging
- Where
- Canada
- Volunteers
- 199 people
- Sponsor
- AHS Cancer Control Alberta
Breast Cancer, Breast Neoplasms
Different Volumes of Erector Spinae Plane Block for Breast Surgery
Postoperative pain is an important issue in female patients underwent breast surgery. Postoperative effective pain treatment provides early mobilization and shorter hospital stay.
- Conditions
- Breast Cancer, Breast Neoplasms, Breast Diseases
- Trial name
- NCT05232084
- Testing
- Bupivacaine + Fentanyl
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Medipol University
Lymphorrhea
Extended-release of Octreotide (LF-PB) for the Treatment of Lymphorrhea
This is a phase II, multicenter, double-blind, double-dummy, parallel-group, placebo-controlled, study to evaluate LF-PB versus placebo in female patients with brest cancer who are undergoing breast surgery with axillary…
- Trial name
- NCT01754285
- Testing
- LF-PB
- Where
- 13 sites in Italy
- Volunteers
- 114 people
- Sponsor
- Chemi S.p.A.