Clinical trials: Azoospermia
Azoospermia, Nonobstructive
TESE and Non Obstructive Azoospermia
Azoospermia is complete absence of sperm in the ejaculate. It accounts for 10-15% of male infertility cases. It is classified as obstructive and non-obstructive azoospermia (NOA). NOA constitutes 60% of all cases of azoospermia.
- Trial name
- NCT03146260
- Testing
- Conventional TESE, Microdissection TESE
- Volunteers
- 148 people
- Sponsor
- Assiut University
Abnormal Spermatogenesis, Azoospermia
Study of Synapsis and Recombination in Male Meiosis and the Implications in Infertility
The aim of this study was to assess meiotic recombination in primary spermatocytes, synaptonemal complex length and the correlation with chromosomal abnormalities in testicular spermatozoa from infertile men with idiopathic…
- Trial name
- NCT02339272
- Testing
- non interventional
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Igenomix
Obstructive Azoospermia, Obstetric Complication
Is the Lack of Prior Exposure to Sperm Antigens Associated With Worse Neonatal and Maternal Outcomes?
The objective of this study is to determine if the lack of exposure to sperm antigens is associated with worse maternal and neonatal outcomes in pregnancies obtained after ICSI (intracytoplasmic sperm injection)-TESE (testicular…
- Trial name
- NCT04852237
- Volunteers
- 400 people
- Sponsor
- Istituto Clinico Humanitas
Male Infertility
MSCs For Treatment of Azoospermic Patients
In this study, we performed autologous BMDMSC transplantation to the testis of Azoospermic patients in a trial to enhance and activate the spermatogonial stem cells of the testis and aiming to produce motile sperm.
- Trial name
- NCT02025270
- Testing
- Stem Cells
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
Azoospermia
Testis Needle Aspiration of Sperm in Men With Azoospermia
Needle aspiration of the epididymis causes rupture and irreversible damage to the duct. Recurring punctures and needle aspirations of fluid and tissue during Testicular Fine Needle Aspiration (TEFNA) procedure cause irreparable…
- Trial name
- NCT02418832
- Testing
- Sperm cell aspiration and TEFNA
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Hadassah Medical Organization
Oligospermia, Azoospermia
Genetic Studies Spermatogenic Failure
The proposed study is designed to test the following hypotheses: 1. Mouse autosomal or X-linked genes which are exclusively expressed in mouse spermatogonia are also spermatogonia-specific in human. 2.
- Conditions
- Oligospermia, Azoospermia, Male Infertility
- Trial name
- NCT00548977
- Testing
- Drawing blood to study genetic polymorphism
- Where
- Taiwan
- Volunteers
- 283 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Non-obstructive Azoospermia
Intra-Testicular Transplantation of Autologous Stem Cells for Treatment of Non-Obstructive Azoospermia Male Infertility.
This is an open label, single arm, single center investigation to assess the safety and efficacy of purified adult autologous, bone marrow derived, highly specialized, differentiation specific into spermatogonial lineages, and…
- Trial name
- NCT02641769
- Testing
- Stem Cell Transplantation
- Where
- Jordan
- Volunteers
- 600 people
- Sponsor
- Stem Cells Arabia
Azoospermia, Nonobstructive
TeSE (Testicular Sperm Extraction) in Azoospermic Patients: m-TeSE vs. l-TeSE
The aim of the study is to compare surgical outcomes (intra and post-operative complications) and sperm retrieval rates between conventional microsurgical-assisted testicular sperm extraction (m-TeSE - Group A) and testicular…
- Trial name
- NCT06702397
- Testing
- Microscope, Surgical loupes
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Non-obstructive Azoospermia
Testicular Proteins for Sperm Retrieval Prediction Protein1, Testis-Expressed Gene 101, and Lectin Galactoside-binding Protein in Predicting Surgical Sperm Retrieval in Men With Non-Obstructive Azoospermia
Generally, azoospermia is characterized as obstructive (OA) or nonobstructive (NOA). Surgical spermatozoa retrieval results vary in success rates.
- Trial name
- Genomics (NCT06154954)
- Testing
- Semen analysis
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Non Obstructive Azoospermia
Standard IV Cannula Aspiration (SIVCA): A Novel, Efficient and Minimally Invasive Testicular Sperm Aspiration Technique
Study question: Can enough testicular tissue be aspirated for sperm retrieval in non-obstructive azoospermia (NOA), using a wide bore 14-G Standard IV cannula in comparison to micro-TESE? Summary answer: Standard IV cannula…
- Trial name
- NCT05247723
- Testing
- Standard IV Cannula for aspiration of testicular sperm, Micro-TESE
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Cairo University
Azoospermia Anogenital Distance AMH
Relationship Between Anogenital Distance, Serum AMH, and mTESE in Klinefelter Syndrome
Azoospermia, the absence of sperm in the ejaculate, affects approximately 1% of males and 15% of infertile men. Non-obstructive azoospermia (NOA) accounts for 60% of azoospermic patients, who rely solely on testicular sperm…
- Trial name
- KS (NCT06396117)
- Testing
- mTESE (microscopic testicular sperm extraction)
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Cairo University
Azoospermia, Nonobstructive
The Potential of Sperm Retrieved by Micro-TESE to Fertilize Vitrified/Warmed Oocytes
Couples referred for microdissection-TESE (m-TESE) due to Klinefelter's syndrome, maturation stop in the spermatogenesis, or failed retrieval of testicular spermatozoa by conventional techniques with needle or TruCut are…
- Trial name
- NCT03809026
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Varicocele, Male Infertility
Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele
Varicose veins in the scrotum (varicocele) are responsible for >20% of male infertility in the US. Varicocele are associated with decreased sperm number and markedly reduced sperm fertilizing ability.
- Conditions
- Varicocele, Male Infertility, Hypospermatogenesis, Non-Obstructive Azoospermia
- Trial name
- NCT00044369
- Testing
- Varicocele repair
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Infertility, Male, Azoospermia
Testicular Sperm Aspiration (TESA) vs. Microfluidic Sperm Separation (MSS)
Normal embryonic development relies on the correct transmission of genetic information, and sperm DNA plays a crucial part in this process.
- Conditions
- Infertility, Male, Azoospermia, Reproductive Disorder
- Trial name
- TESA vs Zymot (NCT05866484)
- Where
- Canada
- Volunteers
- 280 people
- Sponsor
- Clinique Ovo
Klinefelter Syndrome, Hypergonadotropic Hypogonadism
Androgen for Leydig Cell Proliferation
Patients with infertility often presents alterations at ultrasonographic examination of the testis. These alterations include a much higher incidence of small, multiple, non-palpable hypoechoic micro-nodules that can show…
- Conditions
- Klinefelter Syndrome, Hypergonadotropic Hypogonadism, Hypergonadotropic Azospermia, Hypergonadotropic Cryptozoospermia
- Trial name
- ALCeP (NCT01206270)
- Testing
- Testosterone undecanoate, Castor Oil
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- University of Roma La Sapienza
HPV in Testis Tissue
HPV as a Possible Cause of Azoospermia
Azoospermia is found in 5-20% of all men suffering from infertility, and in more than 20% azoospermia remains unexplained. The investigators suggest, that HPV may be an etiological factor in azoospermia and reduced sperm…
- Trial name
- NCT02329275
- Testing
- Testicular biopsy
- Where
- Denmark
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Azoospermia, Nonobstructive, Teratospermia
Study of Tolerability, Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of the Medicinal Product MediReg®
The study is open to patients with severe forms of male infertility (non-obstructive disorders of spermatogenesis, including azoospermia).
- Conditions
- Azoospermia, Nonobstructive, Teratospermia, Oligospermia, Men Infertility
- Trial name
- MARS (NCT06869863)
- Testing
- Medicinal product MediReg® (Human Mesenchymal Stromal Cell Secretome), lyophilizate for preparation of solution for injection in patients with severe spermatogenesis disorders, Clostilbegit (clomiphene) 50 mg 1 tablet x 1 p a day - 3 months, Triovit - 1 tablet x 1 p a day - 3 months, Folic acid - 1 tablet x 1 p a day - 3 months.
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Lomonosov Moscow State University Medical Research and Educational Center
Azoospermia, Nonobstructive, Oligozoospermia
Effect of Letrozole on Seminal Parameters in Men With Non Obstructive Azoospermia and Severe Oligozoospermia.
The investigators hope to learn if Letrozole is effective and safe in improving severe male infertility by increasing testosterone, decreasing oestradiol and stimulating sperm production thereby improving sperm motility…
- Trial name
- NCT02900105
- Testing
- Letrozole
- Where
- Singapore
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Azoospermia, IVF
Laser Assisted Sperm Selection of Viable Immotile Testicular Sperm in Azoospermic Infertile Men
This study aims to investigate the outcome of ICSI after using LAISS for selection of viable immotile testicular sperm in azoospermic infertile men. Patients will be randomly assigned to 2 groups.
- Trial name
- NCT04675164
- Testing
- Laser Assisted Immotile Sperm Selection, Hypo-osmotic Swelling Test
- Where
- Egypt
- Volunteers
- 168 people
- Sponsor
- Sohag University
Infertility, Non-obstructive Azoospermia
PET-MRI for Functional Imaging of the Testis: A Feasibility Study
The primary objective of this study is to explore feasibility of testis functionality assessment and testis imaging obtained from Positron Emissions Tomography (PET) /Magnetic Resonance Imagine (MRI).
- Conditions
- Infertility, Non-obstructive Azoospermia, Vasectomy
- Trial name
- NCT02669108
- Testing
- PET/ MRI of the Testis
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health