Clinical trials: Azoospermia, Nonobstructive
Azoospermia, Nonobstructive
TESE and Non Obstructive Azoospermia
Azoospermia is complete absence of sperm in the ejaculate. It accounts for 10-15% of male infertility cases. It is classified as obstructive and non-obstructive azoospermia (NOA). NOA constitutes 60% of all cases of azoospermia.
- Trial name
- NCT03146260
- Testing
- Conventional TESE, Microdissection TESE
- Volunteers
- 148 people
- Sponsor
- Assiut University
Azoospermia, Nonobstructive
TeSE (Testicular Sperm Extraction) in Azoospermic Patients: m-TeSE vs. l-TeSE
The aim of the study is to compare surgical outcomes (intra and post-operative complications) and sperm retrieval rates between conventional microsurgical-assisted testicular sperm extraction (m-TeSE - Group A) and testicular…
- Trial name
- NCT06702397
- Testing
- Microscope, Surgical loupes
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Azoospermia, Nonobstructive
The Potential of Sperm Retrieved by Micro-TESE to Fertilize Vitrified/Warmed Oocytes
Couples referred for microdissection-TESE (m-TESE) due to Klinefelter's syndrome, maturation stop in the spermatogenesis, or failed retrieval of testicular spermatozoa by conventional techniques with needle or TruCut are…
- Trial name
- NCT03809026
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Azoospermia, Nonobstructive, Teratospermia
Study of Tolerability, Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of the Medicinal Product MediReg®
The study is open to patients with severe forms of male infertility (non-obstructive disorders of spermatogenesis, including azoospermia).
- Conditions
- Azoospermia, Nonobstructive, Teratospermia, Oligospermia, Men Infertility
- Trial name
- MARS (NCT06869863)
- Testing
- Medicinal product MediReg® (Human Mesenchymal Stromal Cell Secretome), lyophilizate for preparation of solution for injection in patients with severe spermatogenesis disorders, Clostilbegit (clomiphene) 50 mg 1 tablet x 1 p a day - 3 months, Triovit - 1 tablet x 1 p a day - 3 months, Folic acid - 1 tablet x 1 p a day - 3 months.
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Lomonosov Moscow State University Medical Research and Educational Center
Azoospermia, Nonobstructive, Oligozoospermia
Effect of Letrozole on Seminal Parameters in Men With Non Obstructive Azoospermia and Severe Oligozoospermia.
The investigators hope to learn if Letrozole is effective and safe in improving severe male infertility by increasing testosterone, decreasing oestradiol and stimulating sperm production thereby improving sperm motility…
- Trial name
- NCT02900105
- Testing
- Letrozole
- Where
- Singapore
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Azoospermia, Nonobstructive
Interest of Clomiphene Citrate in Patients With Non-obstructive Azoospermia on the Quantity of Sperm Cells
In the absence of sperm in the semen (azoospermia), there is no chance of natural paternity. It is found in about 1% of men and is either due to an obstruction of the seminal tracks (obstructive azoospermia (OA)) in 1/3 of the…
- Trial name
- CLOMINOA (NCT03615547)
- Testing
- Clomifene Citrate
- Where
- France
- Sponsor
- Hospices Civils de Lyon
Azoospermia
GnRHa Combined With hCG and hMG for Treatment of Patients With Non-obstructive Azoospermia
Preliminary reports showed that hormonal treatment may improve the chance of retrieving viable testicular sperm from men with NOA.
- Trial name
- NCT02544191
- Testing
- GnRHa/ hCG/ hMG
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jinling Hospital, China
Azoospermia, Nonobstructive, Varicocele
Seminal TEX101 as a Predictor of Recovery of Spermatogenesis in Azoospermic Men With Palpable Varicocele
The aim of the study is to assess if seminal TEX 101 can predict the restoration of spermatogenesis and appearance of sperms in the ejaculate after micro-surgical varicocelectomy among azoospermic patients.
- Trial name
- NCT04397887
- Testing
- micro-surgical varicocelectomy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Oligospermia, Azoospermia, Nonobstructive
Isotretinoin vs hCG for Male Infertility Due to Low or Absent Sperm
This study compares two medical treatments to see how well they improve sperm production in men with infertility due to low sperm counts (oligospermia) or no sperm in the semen due to non-obstructive causes (nonobstructive…
- Conditions
- Oligospermia, Azoospermia, Nonobstructive, Infertility
- Trial name
- NCT07481370
- Testing
- isotretinoin, Human chorionic gonadotrophin (hCG)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Nebraska
Azoospermia, Nonobstructive, Non-obstructive Azoospermia
Inhibin B/FSH Ratio as a Predictor of Testicular Pathology in NOA
This retrospective observational study evaluated the diagnostic and predictive value of serum Inhibin B (INHB), follicle-stimulating hormone (FSH), and the INHB/FSH ratio in differentiating histopathological subtypes of…
- Trial name
- NCT07415928
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Azoospermia, Nonobstructive
Hormonal Stimulation of Spermatogenesis
Urologists and reproductive specialists are often challenged when facing patients with severe male infertility scenarios. In particular, the treatment of men with NOA demands a deeper insight. In such cases, .
- Trial name
- NCT05483621
- Testing
- Beta-hCG
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Egymedicalpedia
Infertility, Male, Azoospermia, Nonobstructive
Machine Learning Based-Personalized Prediction of Sperm Retrieval Success Rate
Non-obstructive azoospermia (NOA) stands as the most severe form of male infertility. However, due to the diverse nature of testis focal spermatogenesis in NOA patients, accurately assessing the sperm retrieval rate (SRR) becomes…
- Trial name
- NCT06358794
- Testing
- Machine learning-based predictive model
- Where
- China
- Volunteers
- 2,612 people
- Sponsor
- Peking University Third Hospital
Microdissection Testicular Sperm Extraction
Timing of Oocyte Retrieval and Micro Testicular Sperm Extraction
This is a retrospective study to assess outcomes of micro-TESE performed 24 or 48 hours before oocyte retrieval and ICSI.
- Trial name
- NCT07268235
- Where
- Canada
- Volunteers
- 129 people
- Sponsor
- Clinique Ovo
Non-obstructive Azoospermia
Effect of Age on Sperm Recovery of Microdissection Testicular Sperm Extraction in Nonobstructive Azoospermia Patients
Males with non-obstructive azoospermia (NOA) have an opportunity to obtain sperm by treatment with microdissection testicular sperm extraction (mTESE), gold-standard surgical technique for them.
- Trial name
- NCT05958576
- Where
- China
- Volunteers
- 3,104 people
- Sponsor
- Peking University Third Hospital
Azoospermia, Nonobstructive
2015-Metabolomics&Microbiome-infertility
The study aims to carry out a translational analysis of the microbiome and metabolomics in patients suffering from non-obstructive azoospermia, with the aim of investigating prognostic factors predictive of the possible finding…
- Trial name
- NCT06181851
- Testing
- Analysis of microbiome and metabolomics
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- IRCCS San Raffaele
Azoospermia, Nonobstructive
The Effects of Intratesticular PRP Injection in Men With Azoospermia or Cryptozoospermia
The study will be conducted in men with a diagnosis of non-obstructive azoospermia or cryptozoospermia after obtaining written informed consent.
- Trial name
- NCT04237779
- Testing
- PRP injection into at least one testis
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Acibadem University
Cancer, Hematologic Diseases
Autologous Transplantation of Human Cryopreserved Testis Tissue
For pre-pubertal boys undergoing gonadotoxic therapies, freezing immature testicular tissue (ITT) containing spermatogonial stem cells (SSCs) is currently the only option to potentially preserve future fertility.
- Conditions
- Cancer, Hematologic Diseases, Infertility, Male, Azoospermia, Nonobstructive
- Trial name
- ReSTORE (NCT07364409)
- Testing
- Autologous Transplantation of Testis Tissue
- Where
- Denmark
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Herlev and Gentofte Hospital
Azoospermia, Nonobstructive
Seminal Level of Clusterin Before Testicular Sperm Extraction
Measurement of clusterin level in the semen of infertile males undergoing testicular sperm extraction.
- Trial name
- NCT03857828
- Testing
- semen sample
- Volunteers
- 88 people
- Sponsor
- Assiut University
Male Infertility, Nonobstructive Azoospermia
Platelet Rich Plasma Testis Treatment for Infertile Men
Investigate the effect of intratesticular injection of autologous platelet rich plasma (PRP) on sperm retrieval rates and IVF outcomes in infertile men who already underwent a negative sperm retrieval.
- Conditions
- Male Infertility, Nonobstructive Azoospermia, Azoospermia
- Trial name
- NCT05479474
- Testing
- Platelet rich plasma
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Beta-hCG Positivity, Clinical Pregnancy
Evaluation of Assisted Reproductive Technology (ART) Outcomes in Couples With Nonobstructive Azoospermia, Cryptozoospermia, and Severe Oligozoospermia
This study aims to compare the In Vitro Fertilization (IVF/ICSI) outcomes of patients with a sperm concentration of <5 million/mL (severe oligozoospermia) and <1 million/mL (cryptozoospermia) to those diagnosed with…
- Conditions
- Beta-hCG Positivity, Clinical Pregnancy, Miscarriage, Multiple Pregnancy
- Trial name
- ART (NCT07897279)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Duzce University