Clinical trials: BDNF
Cognitive Change
An Open-label, Exploratory Study to Investigate the Efficacy of BDNF Essentials® on Cognition
The objective of this open-label, exploratory study is to investigate the efficacy of BDNF Essentials® on cognition in a healthy adult population with self-reported memory complaints.
- Trial name
- NCT04860778
- Testing
- BDNF Essentials
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Researched Nutritionals LLC
Memory
BDNF Levels After Bacopa
Brain-derived neurotrophic factor (BDNF) is a well-known neurotrophic factor important for learning, memory, and synaptogenesis.
- Trial name
- NCT03974399
- Testing
- Bacopa Monnieri
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Roskamp Institute Inc.
Bipolar
Genetic Association Study Between Single Nucleotide Polymorphisms (SNPs) and Cognitive Performance in Young Bipolar Type I Patients: LICAVALGENE
This is a genetic association study of cognitive impairment in young bipolar disease type I patients without medications in mania, depression, hypomania or mixed states.
- Trial name
- Licavalgene (NCT00969930)
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Athletic Performance, Sports Performance
Effects of Afternoon Napping, Caffeine, and Standardised Active Recovery on Evening Athletic Performance
This study evaluated whether afternoon napping, caffeine ingestion, and a standardised active recovery and nutritional protocol could influence evening physical and cognitive performance in healthy university athletes.
- Conditions
- Athletic Performance, Sports Performance, Exercise Performance, Circadian Rhythm
- Trial name
- NAP-CAF-REC (NCT07652424)
- Testing
- Afternoon Nap, Caffeine, Standardised Active Recovery and Nutritional Protocol
- Where
- Tunisia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Higher Institute of Sport and Physical Education of Sfax
Healthy
Explore the Nature Factors Relevant to Learning-Pioneering Natural Factors That Influences Science Learning II
Genetic research has provided the most exciting breakthroughs in neuroscience and cognitive science. Partially genetically determined cognitive impairments have been described in people with COMT, 5HT6, BDNF (Swillen et al.…
- Trial name
- NCT00713570
- Where
- Taiwan
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Healthy Volunteers
Anti-Platelet Drugs and Brain-derived Neurotrophic Factor (BDNF) in Human Serum and Plasma
The impact of anti-platelet drugs on the concentrations of Brain-derived neurotrophic factor (BDNF) in human plasma and serum is unknown.
- Trial name
- NCT01264640
- Testing
- Aspirin and Clopidogrel
- Where
- Germany
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Rostock
Cognitive Function
Resistance Training on Growth Factors
The goal of this clinial trial study is to explore the effect of high or low intensity resistance training (LIRT) under similar training volume on change in serum levels of BDNF, IGF-1, VEGF, irisin, and plasma Hcy in young…
- Trial name
- NCT06114550
- Testing
- High intensity resistance training, Low intensity resistance training
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Borderline Personality Disorder
Methylation Status of BDNF Gene After Dialectical Behavior Therapy in BPD
Borderline personality disorder (BPD) is a chronic and debilitating syndrome associated with considerable morbidity, mortality, and high rates of medical and psychiatric utilization services.
- Trial name
- NCT02134223
- Testing
- Dialectical behavior therapy, Treatment as Usual: any other drug or psychotherapy offered to participants, except DBT
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
Executive Dysfunction, Motor Activity
The Role of Brain-derived Neurotropic Factor in the Relationship Between Executive Function and Physical Training
This doctoral thesis has the aim to identify the role of Brain-derived neurotropic factor in the relationship between physical fitness/activity and executive functions in typically developing children and children with Autism…
- Conditions
- Executive Dysfunction, Motor Activity, Child
- Trial name
- NCT02503579
- Testing
- physical training
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Ghent
Exercise Training, BDNF
Effects of Different Types of Exercise on BDNF and Cognitive Performance (Exercise-BDNF)
Purpose The purpose of this study is to determine the acute effects of different exercise intensities (low, moderate, high) on brain-derived neurotrophic factor (BDNF) levels, trail making test performance, and perceived…
- Conditions
- Exercise Training, BDNF, Cognitive Functions, Lactate Blood Increase
- Trial name
- Exercise-BDNF (NCT07137611)
- Testing
- Low Exercise, Moderate-Intensity Exercise, HIIT Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Aksaray University Training and Research Hospital
Obesity, Genetic Disorder
Brain-Derived Neurotrophic Factor in Obesity and Brain Function
Background: Prader-Willi syndrome (PWS) and MC4R genetic mutations are two conditions that can cause problems with appetite regulation. People with PWS often have behavior and thinking problems.
- Conditions
- Obesity, Genetic Disorder, Mental Retardation, Developmental Delay
- Trial name
- NCT01517048
- Where
- 2 sites in United States, Canada
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Healthy Aging, Brain Health
Assessing the Influence of Habitual Beef Intake on Key Molecular Markers of Brain Health
his study investigates whether eating lean beef every day can help support brain health and healthy aging in older adults. As people age, protecting memory and cognitive function becomes increasingly important.
- Conditions
- Healthy Aging, Brain Health, Cardiometabolic Health, Normal Aging
- Trial name
- NCT07623785
- Testing
- Lean Beef, Non-Beef Control
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- South Dakota State University
Schizophrenia
Clinical Symptoms of Schizophrenia and Physical Exercise
Schizophrenia is a severe mental illness, of psychosis being the most prevalent in society, affecting 1% of the population. The treatment of schizophrenia is basically done with antipsychotic drugs, although other…
- Trial name
- NCT01674543
- Testing
- Resistance Training, Concurrent Training, Control
- Where
- Brazil
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Overactive Bladder
Urinary Neurotrophin Levels as Potential Biomarkers for Overactive Bladder: A Case-Control Study
Overactive bladder is a prevalent urological disorder marked by symptoms such as urinary urgency, increased frequency of urination, and nighttime urination (nocturia).
- Trial name
- urinary (NCT06563193)
- Testing
- NERVE GROWTH FACTOR
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Erzincan Binali Yildirim Universitesi
Oxidative Stress
Lithia Water Study: Effects of Lithia Water on BDNF and Oxidative Stress Markers in Healthy Male Participants
This study investigates the effects of daily use of lithia water on blood tests of neuronal oxidative stress, mood, and well-being.
- Trial name
- NCT01257867
- Testing
- Lithia water, Natural spring water with negligible lithium levels
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Vision Disorders
Bridging Animal and Human Models of Exercise-induced Visual Rehabilitation
This study will determine whether blood biomarker changes predict sight-saving benefits of exercise.
- Trial name
- NCT02911805
- Testing
- Aerobic exercise, Balance exercise
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Physical Conditioning, Human, Cognition
Effects of Aerobic Exercise on Cognitive Function and Brain-derived Neurotrophic Factor in Young Adults
The present study will investigate the effects of aerobic exercise on cognition and growth factors including brain-derived neurotrophic factor (BDNF) in young adults aged 15-21 years.
- Trial name
- NCT02075944
- Testing
- High intensity aerobic exercise, Low intensity aerobic exercise
- Where
- Denmark
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Cognitive Function, Healthy Volunteers
Nutraceutical Clinical Trial to Evaluate the Effects of Different Blends in Cognitive Functions of Healthy Volunteers
The present research is a randomized, sex-stratified, cross-over and placebo-controlled clinical trial, designed to evaluate the effect of daily intake of a dietary supplement (Premium®) on cognitive function and psychological…
- Trial name
- REVIVE (NCT07879703)
- Testing
- Polyphenol-rich fruit and vegetable nutraceutical
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Internet Gaming Disorder, Internet Addiction
Neurotrophic Factors, Impulsivity, and Reward Sensitivity in Children With Internet Gaming Disorder
Research and knowledge regarding the neurobiology of behavioral addictions and Internet Gaming Disorder (IGD) remain limited compared to substance and alcohol use disorders.
- Trial name
- NCT07590180
- Testing
- Clinical Evaluation and Biochemical Sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul Saglik Bilimleri University
Late-perimenopause, Menopause
Time-Restricted Eating in Combination With a Low Glycaemic Index Diet on Cognitive Function, Biological Ageing and Metabolic Health in Perimenopause and Menopause.
The goal of this randomised controlled trial is to investigate whether Time-Restricted Eating (TRE) combined with a Low Glycaemic Index Mediterranean Diet can improve cognitive function, metabolic health, and biological ageing in…
- Conditions
- Late-perimenopause, Menopause, Perimenopause
- Trial name
- NutriAge (NCT07378787)
- Testing
- Time-Restricted Low-Glycaemic Index Diet
- Where
- 2 sites in Croatia, Cyprus
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Nicosia