Clinical trials: Bicuspid Valve Disorder
Ascending Aorta Aneurysm, Dilation of the Ascending Aorta
Study of Treatment of Thoracic Aortic Aneurysms and Dilatation in Combination With Tricuspid and Bicuspid Aortic Valves.
Clarification of indications for surgical correction in patients with borderline expansion of the ascending aorta
- Trial name
- NCT04372563
- Testing
- aortic prosthetics
- Where
- 2 sites in Russia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Dental Caries
Clinical Performance of Incremental and Bulk Fill Composites in Class II Restorations
This study will examine the clinical performance of Class II restorations over a three year period with 3 composite resins - a conventional composite resin, a flowable composite resin and a bulk placed and cured composite resin.
- Trial name
- NCT02889835
- Testing
- Supreme Universal Restorative, Supreme Flowable Restorative, Bulk Fill Flowable Restorative
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Bicuspid Aortic Valve
Identification of Genetic Causes of Bicuspid Aortic Valve Disease
BAVgenetics is a partnership between Investigators at Boston University, Brigham and Women's Hospital, and Massachusetts General Hospital dedicated to discovering the genetic causes of bicuspid aortic valve disease and associated…
- Trial name
- BAV Genetics (NCT01026571)
- Where
- United States
- Volunteers
- 11,000 people, healthy volunteers welcome
- Sponsor
- Boston University
Orthodontic Extraction
Comparison of Rate and Amount of Orthodontic Space Closure
The goal of this clinical trial is to compare rate and amount of space closure among fresh vs healed extraction sites during fixed orthodontic treatment in patients with all first premolar's extraction Primary outcome measure is…
- Trial name
- Premolar (NCT07445321)
- Testing
- Space Closure
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Hypertrophic Obstructive Cardiomyopathy
Hyp Obst Cardiomyopathy
Hypertrophic Obstructive cardiomyopathy (HOCM) is the most common genetic cardiomyopathy, heterogeneous in phenotype and clinical course.
- Trial name
- NCT04329689
- Testing
- The Septal myectom
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Assiut University
Heart Disease, Mitral Regurgitation
Using Beta Blockers to Treat Mitral Regurgitation
The purpose of this study tests whether beta-blocker will benefit asymptomatic patients with chronic primary mitral regurgitation.
- Conditions
- Heart Disease, Mitral Regurgitation, Heart Valve Disease, Mitral Valve Insufficiency
- Trial name
- REGURG (NCT00700947)
- Testing
- Beta-blocker therapy (TOPROL-XL® )
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Mitral Valve Prolapse, Genetic Disease
Genetic and Phenotypic Characteristics of Mitral Valve Prolapse
Phenotypic characterisation of MVP by echocardiography in families. Identification of genes involved in MVP.
- Trial name
- MVP (NCT03884426)
- Where
- 3 sites in France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Mitral Valve Insufficiency, Dilated Cardiomyopathy
Prospective Study Looking at Quality of Life Measures in Non-ischaemic Cardiomyopathy After Mitral Valve Repair
Chronic severe mitral regurgitation can lead to symptoms and left ventricular dysfunction. The purpose of this study is to prospectively follow patients with non-ischaemic cardiomyopathy who are eligible for mitral valve repair…
- Conditions
- Mitral Valve Insufficiency, Dilated Cardiomyopathy, Congestive Heart Failure
- Trial name
- NCT00483236
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Non-maintainable Posterior Tooth (Molars and Premolars)
Clinical and Dimensional Outcomes of Sealing Socket Abutment Combined to Alveolar Ridge Preservation
objectives The aim of this study was to assess the implant outcomes as well as hard and soft tissue dimensional changes of immediate implant placement in posterior sites using a custom-made sealing socket abutment (SSA) combined…
- Trial name
- NCT04553146
- Testing
- Immediate implantation in posterior region with alveolar ridge preservation combined with sealing socket abutment
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Liege
Mitral Valve Stenosis
Ventricular-arterial Coupling of the Heart Among Patients With Mitral Stenosis Undergoing Percutaneous Trans-luminal Mitral Commissurotomy. Cardiac Magnetic Resonance Study
Although the incidence of rheumatic fever and its complications has declined in developed countries, the disease remains a major health problem in many developing countries.
- Trial name
- NCT06054568
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Assiut University
Valvular Heart Disease, Mitral Valve Disease
Prevalence Study of Cardiovascular Diseases in a Population ≥ 65 Years in Italy
This registry is a large-scale epidemiological study (PREVASC) aimed at estimating the prevalence of symptomatic and asymptomatic valvular hear disease in men and women aged over 65 years randomly selected in Italy.
- Conditions
- Valvular Heart Disease, Mitral Valve Disease, Aortic Valve Stenosis, Aortic Valve Insufficiency
- Trial name
- PREVASC (NCT05892588)
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Pathological Processes, Cardiomyopathies
Adenosine as an Adjunct to Blood Cardioplegia
Myocardial protection is a major issue in cardiac surgery, since inadequate protection increases the risk of postoperative cardiac dysfunction.
- Trial name
- NCT02681913
- Testing
- Adenosine
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Amphia Hospital
Mitral Valve Prolapse
Exercise Capacity Evaluation in Patients With Non-rheumatic Mitral Valve Prolapse (MVP)
Mitral valve prolapse (MVP) is a relatively common cardial problem in which one or more of the leaflets of the mitral valve prolapse during systole into the left atrium.
- Trial name
- NCT02499419
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Coronary Artery Disease, Arterial Stiffness, Blood Pressure
Expanded Studies on the SCAPIS Stockholm Reexamination Cohort
The Swedish CArdioPulmonary bioImage Study (SCAPIS) is a unique, large-scale national research initiative involving 30,000 randomly selected individuals aged 50-64, recruited between 2014 and 2018.
- Conditions
- Coronary Artery Disease, Arterial Stiffness, Blood Pressure, AORTIC VALVE DISEASES, Mitral Valve Stenosis and/or Insufficiency
- Trial name
- SCAPIS-ReEx (NCT07476703)
- Testing
- Coronary computer tomography (CCTA), Echocardiograhy and aortic ultrasound, Liver elastography
- Where
- Sweden
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Danderyd Hospital
Aortic Valve Stenosis, Mitral Regurgitation
Phono- and Electrocardiogram Assisted Detection of Valvular Disease
The diagnosis of valvular heart disease (VHD), or its absence, invariably requires cardiac imaging. A familiar and inexpensive tool to assist in the diagnosis or exclusion of significant VHD could both expedite access to…
- Conditions
- Aortic Valve Stenosis, Mitral Regurgitation, Heart Murmurs, Valvular Heart Disease
- Trial name
- PEA-Valve (NCT03458806)
- Testing
- AS Algorithm 1, AS Algorithm 2, MR Algorithm 1
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Aortic Valve Stenosis, Aortic Valve Calcification
SLOW-Slower Progress of caLcificatiOn With Vitamin K2
A randomized 12-month trial will include two groups of 100 individuals aged over 50 years, with asymptomatic mild to moderate Aortic valve stenosis (AVA > 1 cm2, Vmax < 4 m/s).
- Conditions
- Aortic Valve Stenosis, Aortic Valve Calcification, Mitral Annular Calcification, Mitral Valve Calcification
- Trial name
- NCT04429035
- Testing
- Vitamin K2
- Where
- 2 sites in Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Valvular Heart Disease
Age and Sex-Specific PREValence of AcqUirEd VALVular Heart DiseasE
The PREVUE-VALVE study will establish reliable, population-based estimates of Valvular Heart Disease (VHD) prevalence among older Americans and allow for the development and validation of several innovative tools to aid in the…
- Trial name
- PREVUE-VALVE (NCT05357404)
- Where
- United States
- Volunteers
- 2,870 people, healthy volunteers welcome
- Sponsor
- Cardiovascular Research Foundation, New York
Bicuspid Aortic Valve
Whole Exome Sequencing in Bicuspid Aortic Valve Patients
Bicuspid aortic valve (BAV), congenital anomaly present in 2% of the population, is defined by the presence of two sigmoid valves instead of three.
- Trial name
- NCT02899624
- Testing
- Extra blood draw samples, additional tissue samples
- Where
- France
- Volunteers
- 427 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Heart Murmurs, Mitral Valve Prolapse
Automatic Differentiation of Innocent and Pathologic Murmurs in Pediatrics
The purpose of this preliminary clinical study is to assess the quality of a computational algorithm that automatically classifies murmurs of phonocardiograms (PCGs) as either pathologic (AHA class I) or as no- or innocent (AHA…
- Conditions
- Heart Murmurs, Mitral Valve Prolapse, Systolic Murmurs
- Trial name
- NCT02512341
- Testing
- Computer Aided Auscultation (CAA)
- Where
- Canada
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- CSD Labs GmbH
Mitral Regurgitation, Mitral Valve Disease
Munich Transcatheter Mitral Valve Safety and Effectiveness
The Munich Trascatheter Mitral Valve System is intended for beating heart, mitral valve replacement in patients with a diseased, damaged, or malfunctioning mitral valve.
- Trial name
- MUSE (NCT05871983)
- Testing
- MUNICH TRANSCATHETER MITRAL VALVE REPLACEMENT SYSTEM
- Where
- 10 sites in Argentina, Brazil and 1 more
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- P+F Products + Features GmbH