Clinical trials: Biliary Stenosis
Choledocholithiasis, Common Bile Duct Neoplasms
Prospective Multicenter Evaluation of a New Short-access-cholangioscope for Biliary Duct Strictures and Gall Stones
Karl Storz GmbH (Gesellschaft mit beschränkter Haftung) company developed a cholangioscopic device, which is designed to give a better flexibility to the cholangioscopy tip in order to enable optimal diagnostic and therapeutic…
- Conditions
- Choledocholithiasis, Common Bile Duct Neoplasms, Cholestasis
- Trial name
- SAC (NCT01683240)
- Testing
- cholangioscopy (Frimberger)
- Where
- 5 sites in Germany
- Volunteers
- 59 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Biliary Strictures
Prospective, Multi-Center All-Comer Biliary Canadian WallFlex Registry
The purpose of this study is to document stent functionality and practice patterns in Canada pertaining to indications for use and stent type selection for self-expanding biliary metal stents (SEMS) when used per standard of…
- Trial name
- NCT02261623
- Testing
- WallFlex™ Biliary RX Fully Covered Stent System RMV, WallFlex™ Biliary RX Partially Covered Stent System, WallFlex™ Biliary RX Uncovered Stent System
- Where
- 12 sites in Canada
- Volunteers
- 415 people
- Sponsor
- Boston Scientific Corporation
Biliary Stones, Cholangiocarcinoma, Intrahepatic
Percutaneous Cholangiopancreatoscopy Registry
The Percutaneous Cholangiopancreatoscopy (PCPS) registry is an observational, multicentric, prospective, and retrospective registry of patients undergoing the percutaneous cholangiopancreatoscopy procedure at sites across the…
- Conditions
- Biliary Stones, Cholangiocarcinoma, Intrahepatic, Biliary Stricture, Cholelithiasis
- Trial name
- NCT05210322
- Testing
- Percutaneous cholangiopancreatoscopy
- Where
- United States
- Volunteers
- 679 people
- Sponsor
- Johns Hopkins University
Cholangiocarcinoma, Biliary Stricture
Digital Single-operator Cholangioscopy and Intraductal Ultrasound for Nonicteric Biliary Strictures
This study aims to evaluate the usefulness of disposable digital single-operator cholangioscopy (SOC) and intraductal ultrasound (IDUS) for the accurate diagnosis of indeterminate biliary stricture.
- Trial name
- Spy+IDUS (NCT06369896)
- Volunteers
- 36 people
- Sponsor
- Soonchunhyang University Hospital
Secondary Cholangitis, Bile Duct Strictures of Unknown Origin
Biliary Candidiasis - Optimization of Diagnostics and Therapy
Biliary obstruction and cholangitis are common problems in gastroenterology and need specific therapeutic interventions. Besides a variety of potential causes, infections of the biliary tract with Candida and other fungal species…
- Trial name
- NCT01109550
- Testing
- ERCP
- Where
- Germany
- Volunteers
- 123 people
- Sponsor
- University Hospital Muenster
Gastrointestinal Disease, Endoscopy
Development and Validation of an Artificial Intelligence-based Biliary Stricture Navigation System in MRCP-based ERCP
In this study, the investigators proposed an artificial intelligence-based biliary stricture navigation system in MRCP-based ERCP, which can instruct the direction of guide wire and the position of stent placement in real time.
- Conditions
- Gastrointestinal Disease, Endoscopy, Artificial Intelligence, Endoscopic Retrograde Cholangiopancreatography
- Trial name
- NCT04903444
- Testing
- Artificial intelligence assistant system
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Renmin Hospital of Wuhan University
Biliary Strictures
Comparison of Diagnostic Accuracy Before or After Stricture Dilation in Biliary Stricture
Biliary strictures present a diagnostic and therapeutic challenge to clinicians due to unsatisfied accuracy of sampling modality.
- Trial name
- NCT02465229
- Testing
- Multimodal tissue-sampling methods before and after stricture dilation
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Endoscopic Retrograde Cholangiopancreatography (ERCP), Miniforceps Biopsy
Comparison of Dual-lumen Catheter-guided Mini-forceps Biopsy and Brush Cytology with Vacuum Aspiration in Suspicious Biliary Strictures
In this randomized crossover trial involving patients with indeterminate biliary strictures, we aimed to compare the diagnostic performance of the dual-lumen catheter-guided miniforceps biopsy (CMB) device with that of brush…
- Conditions
- Endoscopic Retrograde Cholangiopancreatography (ERCP), Miniforceps Biopsy, Biliary Strictures, Brush Cytology
- Trial name
- NCT06612931
- Testing
- Dual-lumen catheter-guided mini-forceps biopsy is performed first, Biliary brush cytology with vacuum aspiration is performed first
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Cholangiocarcinoma Non-resectable, Gall Bladder Cancer
Primary Percutaneous Stenting Above the Ampulla Versus Endoscopic Drainage for Unresectable Malignant Hilar Biliary Obstruction
The goal of this clinical randomized controlled trial is to perform primary percutaneous stenting (PPS) in patients with malignant hilar biliary obstruction (MHBO).
- Conditions
- Cholangiocarcinoma Non-resectable, Gall Bladder Cancer, Liver Metastasis, Malignant Hilar Stricture
- Trial name
- TESLA RCT (NCT06671418)
- Testing
- Primary percutaneous stenting (PPS), Endoscopic biliary drainage
- Where
- Netherlands
- Volunteers
- 148 people
- Sponsor
- Erasmus Medical Center
Complication of Transplanted Liver
Donor Specific HLA Alloantibodies in Liver Transplantation
The aim is to evaluate the impact of donor specific HLA alloantibodies (DSA) on all-cause mortality and re-transplantation, early allograft dysfunction, acute and chronic rejection, fibrosis, vascular, and biliary complications.
- Trial name
- NCT02784080
- Testing
- HLA-alloantibodies exposure
- Where
- 5 sites in Denmark, Finland and 2 more
- Volunteers
- 858 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Biliary Obstruction, Oddi's Sphincter Constriction
clınıcal Effects of High-flow Nasal Oxygen Use ın gerıatrıc patıents
It is designed to monitor the efficacy of nasal cannula or hıgh-flow nasal oxygen in geriatric patients for endoscopıc retrograde cholangıopancreatography procedures.
- Conditions
- Biliary Obstruction, Oddi's Sphincter Constriction, Biliary Stones
- Trial name
- HFNO (NCT05432661)
- Testing
- HİGH-FLOW NASAL OXYGEN USE (HFNO)
- Volunteers
- 120 people
- Sponsor
- Yunus Emre
Biliary Anastomotic Stricture, Biliary Tract Diseases
Magnetic Compression Anastomosis for Recanalization of Biliary Stricture
Biliary stricture is a common complication after end-to-end biliary anastomosis, especially after liver transplantation. This study is designed to investigate the safety and efficacy of magnetic recanalization technique, a newly…
- Conditions
- Biliary Anastomotic Stricture, Biliary Tract Diseases, Cholestasis, Extrahepatic, Endotoxicosis
- Trial name
- NCT04170933
- Testing
- Magnetic recanalization
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Cholangiocarcinoma, Cancer of the Head of the Pancreas
Pancreatico-biliary Tumor Mutation Profiling in Bile Samples
The differential diagnosis between benign and malignant bile duct strictures is a difficult and demanding task for clinicians. Clinical, biochemical, and radiological characteristics of malignant biliary strictures are…
- Trial name
- ONCOBIL (NCT02893085)
- Testing
- bile sample analysis, biochemical markers, VEGF and MMPs, in bile samples
- Where
- France
- Volunteers
- 100 people
- Sponsor
- CHU de Reims
Biliary Tract Cancer
X-MAS Biliary Study With Covered Biliary Stent
The purpose of this study is to provide safety and efficacy data for the X-Suit NIR® Covered Biliary Metallic Stent for subjects with malignant stricture(s) in the biliary tree.
- Trial name
- NCT01899976
- Testing
- X-Suit NIR Covered Biliary Stent
- Where
- 9 sites in Belgium, Israel and 1 more
- Volunteers
- 68 people
- Sponsor
- Medinol Ltd.
Biliary Stricture, Jaundice, Obstructive
Multicenter RCT for BIliary Brushing: RX Cytology, BOSTON vs. Infinity®, US Endoscopy
The aim of this prospective national multicenter randomized study is to compare, during an ERCP for VBP stenosis, the sensitivity of two biliary brushes: the INFINITY® vs the RX Cytology Brush® The main objective is the…
- Trial name
- BIB (NCT04251013)
- Testing
- Biliary brushing with the RX Cytology brush, Boston Scientific, Biliary brushing with the Infinity® brush, US Endoscopy
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Société Française d'Endoscopie Digestive
Cholangiocarcinoma, Biliary Stricture
EYEMAX® Versus SPYGLASS™ DS for Biliary Stricture Diagnosis
Cholangiocarcinoma remains difficult to diagnose because of the limited sensitivity of currently available endobiliary sampling techniques.
- Trial name
- EYE/SPY (NCT07620080)
- Testing
- EYEMAX® cholangioscopy system, SPYGLASS™ DS system
- Volunteers
- 120 people
- Sponsor
- David KARSENTI
Gastrointestinal Neoplasms, Biliary Tract Neoplasms
Endoscopic Stenting of Gastrointestinal Cancer
Obstruction of the digestive tract is a frequent cause of morbidity in patients with gastrointestinal cancer.Palliative endoscopic treatment with self- expanding metal stents(SEMS)is an alternative to palliative surgery and other…
- Trial name
- NCT00422409
- Testing
- Endoscopic stenting
- Where
- 7 sites in Norway
- Volunteers
- 270 people
- Sponsor
- Ullevaal University Hospital
Bile Duct Stricture, Choledocholithiasis
Direct Peroral Cholangioscopy by Using an Ultra-slim Upper Endoscope
This study was aimed to to evaluate the efficacy of the new multibending ultra-slim endoscope compared with a conventional ultra-slim endoscope for free-hand insertion of an endoscope into the bile duct for direct POC.
- Trial name
- NCT02276157
- Testing
- Direct peroral cholangioscopy
- Where
- South Korea
- Volunteers
- 92 people
- Sponsor
- Soonchunhyang University Hospital
Biliary Stricture
Real-Time Cholangioscopy Artificial Intelligence Evaluation of Biliary Strictures
The purpose of this study is to demonstrate the feasibility and validity of a previously developed peroral cholangioscopy (POC) convolutional neural network (CNN) to determine the etiology of biliary strictures when used in…
- Trial name
- NCT05779436
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Biliary Tract Neoplasms
Mid-Atlantic Research Group Single-Operator Cholangioscopic Assessment of Biliary Strictures
The purpose of this study is to determine if cholangioscopically-directed biopsies provide a higher diagnostic yield for malignancy in the setting of indeterminate biliary strictures when compared to standard means of sampling.
- Trial name
- SOCABS (NCT02615210)
- Testing
- SOC-directed biopsies using the SpyGlass System
- Volunteers
- 3 people
- Sponsor
- Temple University