Clinical trials: Biofilms
Oral Hygiene, Oral Health, Pediatric Pain and Anxiety
Efficacy of Guided Biofilm Therapy in Pediatric Patient
The present parallel randomized clinical trial aims to assess the efficacy of a plaque disclosing agent (PDA) and air-flowing with erythritol powder (Guided Biofilm Therapy) in the removal of biofilm and plaque in paediatric…
- Trial name
- BABYPLAK (NCT06765343)
- Testing
- Plaque disclosing agent, Guided Biofilm Therapy, Ultrasonic debridement and polishing
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Denture Stomatitis, Dentures
Oral Probiotics and Denture Care in Saudi Arabia: Evaluating Knowledge, Practices, and the Future of Innovative Hygiene Solutions
The goal of this observational study is to learn about denture wearers' knowledge, awareness, and self-reported practices regarding denture hygiene and oral probiotics, and to assess whether these are associated with clinical…
- Conditions
- Denture Stomatitis, Dentures, Halitosis, Biofilms
- Trial name
- NCT07475195
- Testing
- This is a cross-sectional observational study. Participants are not assigned to any treatment or preventive intervention.
- Where
- Saudi Arabia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- King Saud University
High Caries Risk Patients
Assessment of Inhibition of Biofilm Formation and Plaque Bacterial Count of Fluoride Varnish Containing Chlorhexidine and Cetylpyridinium Chloride Versus Conventional Fluoride Varnish
Two different Fluoride varnish systems(Fluoride varnish containing Chlorhexidine and Cetylpyridinium Chloride (CPC) and conventional fluoride) will be applied to high caries risk patients to assess their clinical effects on…
- Trial name
- NCT04254835
- Testing
- Cervitec F, Ivoclar Vivadent - Schaan Liechtenstein, Fluor Protector, Ivoclar Vivadent - Schaan Liechtenstein
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University
Intrabony Periodontal Defect
Comparison of MIST With PRF and GBT With PRF in the Treatment of Intrabony Periodontal Defect. A Prospective RCT
The aim is to evaluate in a prospective, randomized, controlled clinical study the healing of a MIST procedure combined with PRF, or GBT combined with PRF.
- Trial name
- NCT06768424
- Testing
- Guided biofilm therapy, Platelet Rich Fibrin, Minimally Invasive Surgical Technique
- Where
- Hungary
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Pit and Fissure Sealant Retention, Dental Caries
Clinical Evaluation of the Retention of Fissure Sealants Applied Following Guided Biofilm Therapy and Conventional Polishing
This randomized split-mouth clinical trial will compare two methods of occlusal surface cleaning before pit and fissure sealant placement in children aged 6-10 years.
- Trial name
- NCT07725133
- Testing
- Device: Guided Biofilm Therapy with erythritol, Device: Conventional Polishing
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Marmara University
Plaque Induced Gingivitis, Mouth Diseases
Anti-inflammatory and Anti-plaque Efficacies of Mouth Rinse Containing Hyaluronic Acid and Hydrogen Peroxide
The goal of this clinical trial is to test efficiency of using mouth rinse containing (H2O2 and HA) over a period of two weeks to control on gingival inflammation and plaque accumulation through measuring the clinical periodontal…
- Conditions
- Plaque Induced Gingivitis, Mouth Diseases, Bleeding Gum, Periodontal Diseases
- Trial name
- NCT05787600
- Testing
- Perhyal rinse, Chlorhexidine mouthwash
- Where
- Iraq
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Periodontal Disease, Periodontitis
Antibiotic Resistance Genes in Periodontitis
Antimicrobial resistance (AMR) is a major global public health concern, and the oral microbiome may serve as an important reservoir of antibiotic resistance genes (ARGs).
- Conditions
- Periodontal Disease, Periodontitis, Antibiotic Resistance Genes
- Trial name
- NCT07887204
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Periodontitis, Adult
Protozoans in Biofilm From Patients With Periodontitis
The buccal cavity is colonized by numerous microorganisms whose the number and composition could be modified with medical background (diseases and drugs) and the level of oral hygiene of the patients.
- Trial name
- Paro-Proto (NCT03240666)
- Testing
- non applicable
- Where
- France
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Typhoid Carrier, Typhoid Fever
Curcumin Extract Added to Ciprofloxacin for Typhoid Carriers Among Food Handlers of the Free Nutritious Meal Program
Some people keep carrying Salmonella Typhi after they recover from typhoid fever. These carriers have no symptoms. They can still pass the bacteria into food.
- Conditions
- Typhoid Carrier, Typhoid Fever, Salmonella Typhi Infection
- Trial name
- NCT07908030
- Testing
- Curcumin extract, Ciprofloxacin
- Where
- Indonesia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitas Sebelas Maret
Dental Plaque
Effect of Provisional-Crown Surface Coating on Biofilm Formation
Auto polymerizing poly methyl methacrylate (PMMA), and light initiated resin modified PMMAs, are commonly used for fabricating provisional restorations (PRs) during prosthetic treatment 1.
- Trial name
- NCT00254345
- Testing
- coating a dental restoration material ,polymethylmethacrylate, with liquid polish resin
- Where
- Israel
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Tobacco Use, Periodontitis
Snuff Use, Smoking, Periodontal Health and Premature Death: 30-year Study
Snuff use and smoking associated with poor periodontal health, especially if used together.
- Trial name
- NCT03614871
- Testing
- Epidemiological study
- Volunteers
- 1,676 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Biofilm Removal, Gingival Abrasion
Capacity of Biofilm Removal and Gingival Abrasion After Utilization Medium and Soft Toothbrushes
This study compared the removal of dental biofilm between soft and medium toothbrushes. The patients refrained from performing mechanical or chemical plaque control for 96 hours to allow dental biofilm accumulation on the tooth…
- Trial name
- NCT01125007
- Testing
- Two kind toothbrushes
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Franciscan University Center
Periodontitis
Novel Protocol for Supportive Periodontal Therapy
Supportive periodontal therapy (SPT) succeeds the active phase of periodontal therapy. SPT includes repeated supra- and subgingival scaling and root planing (SRP) at all sites with bleeding on probing and pocket depths ≥ 4-5 mm.
- Trial name
- GBM (NCT05799261)
- Testing
- Control (standard protocol), Test (Guided Biofilm management)
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bern
Dental Plaque
Efficacy of a Triclosan Formulation to Control the Initial Subgingival Biofilm Formation
The aim of the study is to compare the effect of a suspension containing Triclosan in dynamic of the subgingival biofilm formation versus a Placebo suspension.
- Trial name
- NCT02192060
- Testing
- Test - Using of a suspension containing Triclosan, Control - Using of a suspension without Triclosan
- Where
- Brazil
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Chronic Serous Otitis Media, Simple or Unspecified
Prevalence of Mucosal Biofilm Formations in Adenoidectomy Specimens
Rationale: Bacterial biofilms are defined as an assemblage of bacterial cells enclosed in a self-produced glycocalyx matrix. Adherence on surfaces, and resistance to both antibiotic treatments and host defenses are ones of the…
- Trial name
- BOLERO (NCT01022944)
- Testing
- With chronic middle ear effusion, Without chronic middle ear effusion
- Where
- France
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Periodontitis, Aggressive, Periodontal Diseases
Efficacy of GBT vs SRP+US, in the Treatment of Severe Generalized Periodontitis.
The first step in the management of periodontal disease involves the non-surgical removal of the soft and hard bacterial deposits at all supra- and sub-gingival sites, especially into deep pockets, which can be carried on with…
- Conditions
- Periodontitis, Aggressive, Periodontal Diseases, Periodontitis
- Trial name
- ERISRP (NCT05112471)
- Testing
- Airflow, Perioflow and Erythritol powder and ultrasonic debridement, Ultrasonic debridement and curettes
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Peri-implantitis
Effect of Metallic Particles on the Progression of Peri-Implantitis
This observational cross-sectional study aims to investigate the presence and characteristics of metallic micro- and nanoparticles in peri-implant tissues and their potential association with peri-implantitis progression, the…
- Trial name
- NCT07792499
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Biofilms, Substantivity
Immediate Effect and Substantivity of the Essential Oils Without Alcohol on the Oral Biofilm in Situ
This study aims to evaluate the in situ antibacterial activity of a mouthwash containing essential oils with and without alcohol on undisturbed de novo plaque-like biofilm (PL-biofilm) up to 7 h after its application.
- Conditions
- Biofilms, Substantivity, Oils, Essential
- Trial name
- NCT02946814
- Testing
- essential oils, essential oils without mouthwash, sterile water
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Dental Caries, Dental Plaque
Study of the Composition of Dental Plaque
This study will examine the composition of dental plaque-a naturally occurring substance that sticks to the teeth and can cause tooth decay and gum disease.
- Conditions
- Dental Caries, Dental Plaque, Periodontal Disease
- Trial name
- NCT00001726
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Dental Caries
Long-term Release of Fluoride Formed on Enamel by Fluoride Gel or Varnish to Biofilm Fluid
The anticaries effect of professional fluoride application has been associated with the formation of calcium fluoride-like products ("CaF2") on dental surface, which may function as a slow release fluoride reservoir.
- Trial name
- NCT02486458
- Testing
- 5% sodium fluoride varnish, 1.23% sodium fluoride acidic gel
- Where
- Brazil
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil