Clinical trials: Bladder, Overactive
Neurogenic Bladder, Multiple Sclerosis
Neuromodulating Cortical Regions Involved in Neurogenic Bladder in MS
Neurogenic overactive bladder (NOAB), characterized by urinary frequency, urgency or urgency incontinence symptoms occurring during the storage phase of the bladder, is the most common urinary complaint in multiple sclerosis…
- Conditions
- Neurogenic Bladder, Multiple Sclerosis, Overactive Bladder
- Trial name
- MSBLADDER (NCT06072703)
- Testing
- Magstim Rapid2 System
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- The Methodist Hospital Research Institute
Overactive Bladder (OAB), Urge Incontinence
Low-intensity Shockwave Therapy Versus Solifenacin for the Treatment of Overactive Bladder in Women
The goal of this clinical trial is to evaluate the effectiveness and safety of low-intensity shockwave therapy (Li-SWT) for the treatment of overactive bladder (OAB) in adult women.
- Trial name
- NCT07473310
- Testing
- Low intensity shockwave therapy, Oral Solifenacin succinate 5 mg
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mansoura University
Urinary Incontinence
A Practice-Based Intervention To Improve Care for a Diverse Population Of Women With Urinary Incontinence
The main goal of this clinical trial is to improve the care for urinary incontinence (UI) provided to adult women by primary care providers.
- Trial name
- OPTIMA (NCT05534412)
- Testing
- Academic Detailing, Electronic Clinical Decision Support, APP Co-management
- Where
- 4 sites in United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Lower Urinary Tract Symptoms
A Pilot Study to Assess Effects of Self-Administered Nitrous Oxide (SANO) on Urodynamic Study (UDS) Parameters
A urodynamic study (UDS) is a common procedure done to learn more about the cause of urinary symptoms. For some patients, UDS can be associated with anxiety or discomfort.
- Trial name
- NCT05883332
- Testing
- Self-Administered Nitrous Oxide, Oxygen
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Heart Failure, Overactive Bladder
Effect of Extended Release Torsemide in Patients With Congestive Heart Failure and Overactive Bladder
This research study is being done to compare the effectiveness two drugs: an Extended Release Torsemide (ERT) versus generic Immediate Release Torsemide (IRT) in reducing the worsening of symptoms of Overactive Bladder (OAB…
- Conditions
- Heart Failure, Overactive Bladder, Incontinence
- Trial name
- NCT06206512
- Testing
- Extended release torsemide, Immediate release torsemide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Sarfez Pharmaceuticals, Inc.
Radiation Exposure, Overactive Bladder
Fluoroscopy Radiation Reduction During Sacral Neuromodulation Lead Placement
Fluoroscopy is performed when placing a lead during a sacral neuromodulation procedure. During lead placement, subjects will receive either conventional or experimental fluoroscopic settings.
- Conditions
- Radiation Exposure, Overactive Bladder, Urge Incontinence, Urgency-frequency Syndrome
- Trial name
- NCT04527445
- Testing
- Reduced radiation fluoroscopy, Conventional fluoroscopy
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Loma Linda University
Urinary Incontinence, Urge, Urinary Incontinence
TReating Incontinence for Underlying Mental and Physical Health
The TRIUMPH study is a randomized, double-blinded, 3-arm, parallel-group trial designed to compare the effects of anticholinergic bladder therapy versus a) beta-3-adrenergic agonist bladder therapy and b) no bladder…
- Conditions
- Urinary Incontinence, Urge, Urinary Incontinence, Overactive Bladder, Incontinence, Urge
- Trial name
- TRIUMPH (NCT05362292)
- Testing
- Tolterodine Tartrate ER, Mirabegron
- Where
- 2 sites in United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Overactive Bladder
Clinical and Urodynamic Assessment of Bladder Sensation in Multiple Sclerosis
The aim of the study is to assess the association between bladder sensations progression during bladder filling and severity of Overactive bladder (OAB) in patients with multiple sclerosis.
- Trial name
- CUBS-MS (NCT05772637)
- Testing
- Repeated cystometries with bladder sensations assessment
- Where
- France
- Volunteers
- 113 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Overactive Bladder
Turkish USIQ: Validity & Reliability
The Urgency, Severity, and Impact Questionnaire (USIQ) assesses urinary urgency independently of incontinence, measuring both symptom severity and its impact on quality of life.
- Trial name
- NCT07452796
- Testing
- Observational Cohort
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Izmir Democracy University
Overactive Bladder, Urinary Urge Incontinence
Intradetrusor Botulinum Toxin A for OAB Via 1 Versus 10 Injections: A Randomized Clinical Trial
Patients with either overactive bladder (OAB) or urgency urinary incontinence (UUI) with be randomized (like a flip of a coin) to receive 100 units of bladder Botox® at either one injection site or ten injection sites.
- Conditions
- Overactive Bladder, Urinary Urge Incontinence, Overactive Bladder Syndrome, Urinary Incontinence, Urge
- Trial name
- NCT05308979
- Testing
- OnabotulinumtoxinA 100 UNT [Botox]
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Overactive Bladder
Efficacy of Gabapentin Combined With Solifenacin for Non-neurogenic Overactive Bladder in Women
The goal of the study is to compare the efficacy, safety and tolerability of solifenacin plus gabapentin versus solifenacin monotherapy for the treatment of women who are suffering from non-neurogenic ОАВ.
- Trial name
- NCT07429734
- Testing
- solifenacin combined with gabapentin, solifenacin monotherapy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Lower Urinary Tract Symptoms, Healthy
Electronic Urinary Flowmeter to Improve Accuracy of Bladder Diaries .
The goal of this clinical trial is to give an answer to the question of whether an automated calculation of voided volumes would produce a more accurate set of bladder diary data when compared to the traditional ''eye-balling''…
- Conditions
- Lower Urinary Tract Symptoms, Healthy, Overactive Bladder (OAB)
- Trial name
- e-BLaDR (NCT05702294)
- Testing
- Diary pod ( measuring vessel that automatically calculates voided volume)
- Where
- United Kingdom
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust
Overactive Bladder (OAB), Overactive Bladder Syndrome
Randomized Controlled Trial Comparing Low Dose Tadalafil Versus Solifenacin For Management of Overactive Bladder in Women: Multicenter Egyptian National Study
Researchers are studying two medicines to see which works better for women with overactive bladder (OAB). OAB causes sudden urges to urinate, frequent bathroom trips, and sometimes leakage.
- Trial name
- WoMEN'S (NCT07416968)
- Testing
- Tadalafil 5 mg, Solifenacin 5mg
- Where
- 14 sites in Egypt
- Volunteers
- 480 people
- Sponsor
- Mansoura University
Overactive Bladder and Urge Urinary Incontinence
The New Possibility of Treating Overactive Bladder With Radiofrequency
A prospective, randomized, single-blind, placebo-controlled study was conducted from June 2023 to May 2025. The study enrolled 95 women (N=48 in the study group; N=47 in the placebo group) who presented with confirmed symptoms of…
- Trial name
- RF and OAB (NCT07398014)
- Testing
- radiofrequency - TECAR
- Where
- Slovenia
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University Maribor
Overactive Bladder Syndrome
Role of Combination Therapy in Women With Refractory Overactive Bladder
Defined by the International Continence Society (ICS) as urinary "urgency, with or without urge incontinence, usually with frequency and nocturia", overactive bladder (OAB) presents as challenging syndrome to treat.
- Trial name
- NCT06438861
- Testing
- Vibegron 75mg
- Sponsor
- University of Alabama at Birmingham
Urge Incontinence, Urgency-frequency Syndrome
Percutaneous Nerve Evaluation Trial Time
Sacral neuromodulation (SNM) was approved by the Food and Drug Administration (FDA) for the treatment of urgency incontinence (UUI) in 1998.
- Conditions
- Urge Incontinence, Urgency-frequency Syndrome, Overactive Bladder
- Trial name
- NCT06226220
- Testing
- Sacral neuromodulation
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Overactive Bladder (OAB), Menopause
Effect of Vaginal Estrogen on Alterations in the Urine Microbiome of Menopausal Women With Overactive Bladder
The goal of this Pre-Post Quasi-experimental study is to investigates the effect of vaginal estrogen therapy on changes in the urinary microbiome and its association with improvement in overactive bladder (OAB) symptoms in…
- Conditions
- Overactive Bladder (OAB), Menopause, Microbiome
- Trial name
- NCT06780163
- Testing
- 17β-estradiol 10 mcg
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Mahidol University
Urinary Bladder, Overactive
FemPulse Therapy for Overactive Bladder in Women
The purpose of this clinical trial is to investigate a new medical device treatment for Overactive Bladder (OAB) in women.
- Trial name
- EVANESCE-OAB (NCT03784170)
- Testing
- FemPulse System
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- FemPulse Corporation
Overactive Bladder
Usability Study of the FemPulse System
The objective of the study is to demonstrate that the FemPulse System can be used as indicated in the Instructions for Use (IFU), as applicable.
- Trial name
- NCT06347380
- Testing
- FemPulse System
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- FemPulse Corporation
Overactive Bladder (OAB)
Ease of Use Study of the FemPulse System
The objective of the study is to demonstrate that the FemPulse System can be used as indicated
- Trial name
- NCT06885099
- Testing
- FemPulse System
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- FemPulse Corporation