Clinical trials: Bladder
Overactive Detrusor, Detrusor Hyperreflexia of Bladder
Onabotulinumtoxina Intradetrusorial Injections and NGF Expression
In the last years, botulinum toxin type A (onab/A) has been increasingly used as a treatment option for overactive bladder symptoms in patients affected by either neurogenic and idiopathic detrusor overactivity (DO).
- Trial name
- Onab/A-NGF (NCT01629433)
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University Of Perugia
Polyradiculopathy
Post-void Bladder Scanning in Acute Cauda Equina Syndrome
Expedient diagnosis and management of acute cauda equina syndrome (CES) is essential to prevent long-term neurological sequelae for these patients.
- Trial name
- NCT02806167
- Testing
- Clinical algorithm
- Where
- United Kingdom
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Urothelial Cancer, Bladder Cancer
Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma
This is a global, multicenter, randomized, open-label, Phase 2/3 study of Dato-DXd plus carboplatin or cisplatin versus gemcitabine plus carboplatin or cisplatin in participants with la/mUC who progressed during or after EV plus…
- Trial name
- NCT07129993
- Testing
- Dato-DXd, Carboplatin, Cisplatin
- Where
- 100 sites in United States, Austria and 5 more
- Volunteers
- 630 people
- Sponsor
- Daiichi Sankyo
Muscle Invasive Bladder Cancer, Urothelial Carcinoma
Neoadjuvant Dose Dense MVAC in MIBC and Locally Advanced Urothelial Carcinoma
The objective is to investigate the efficacy and safety of four cycles of ddMVAC with G-CSF support in patients with MIBC and locally advanced UC
- Conditions
- Muscle Invasive Bladder Cancer, Urothelial Carcinoma, Neoadjuvant Chemotherapy
- Trial name
- NCT04047693
- Testing
- dose dense MVAC with pegylated GCSF
- Where
- South Korea
- Volunteers
- 24 people
- Sponsor
- Pusan National University Yangsan Hospital
Overactive Bladder, Overactive Detrusor
Minimizing Pain During Office Intradetrussor Botox Injection
This will be a prospective double-blinded randomized controlled trial comparing two pre-treatment protocols for patients undergoing intradetrussor botox injections to determine if a buffered lidocaine solution offers superior…
- Conditions
- Overactive Bladder, Overactive Detrusor, Overactive Bladder Syndrome, Overactivity; Behavior
- Trial name
- NCT04270526
- Testing
- Bicarbonate protocol, Standard protocol
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Boston Urogynecology Associates
Overactive Bladder
Safety and Effectiveness of a Non-invasive Neuromodulation Device on Urgency Urinary Incontinence in Overactive Bladder
The purpose of this study is to evaluate the change from baseline between the active and sham treatment groups in the treatment of urgency (urinary) incontinence episodes (leaks).
- Trial name
- Beacon (NCT01369485)
- Testing
- (VERV™ System)
- Where
- 14 sites in United States
- Volunteers
- 163 people
- Sponsor
- Ethicon Endo-Surgery
Chronic Spinal Cord Injury, Neurogenic Bladder
Reducing Anticholinergic Bladder Medication Use in Spinal Cord Injury With Home Neuromodulation
The purpose of this study is to determine the efficacy of home transcutaneous tibial nerve stimulation (TTNS) in spinal cord injury(SCI) and to determine the impact on quality of life using TTNS at home
- Trial name
- TTNS-RCT (NCT04074616)
- Testing
- High Dose, Low dose
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas Health Science Center, Houston
Vesico-Ureteral Reflux
Endoscopic Injection of Dextranomer/Hyaluronic Acid Versus Ureteral Reimplantation In Treatment of Vesicoureteral Reflux
In this study, the investigators aim to compare the outcomes of Dextranomer/hyaluronic acid (Dexell®) and extravesical reimplantation (Lich- Gregoir) procedures for primary vesicoureteral reflux (VUR) grades III and IV in…
- Trial name
- NCT04798443
- Testing
- subureteral endoscopic Injection of Dextranomer/Hyaluronic acid (Dexell), open ureteral reimplantation (Lich-Gregoir)
- Volunteers
- 60 people
- Sponsor
- Elsayed Salih
Genitourinary Cancer, Adrenocortical Carcinoma
Nivolumab Combined With Ipilimumab for Patients With Advanced Rare Genitourinary Tumors
This research study is studying a combination of drugs as a possible treatment for rare genitourinary malignancies among four cohorts, bladder or upper tract carcinoma with variant histology, adrenocortical carcinoma, other rare…
- Conditions
- Genitourinary Cancer, Adrenocortical Carcinoma, Non-urothelial Bladder, Non-urothelial Upper Tract
- Trial name
- NCT03333616
- Testing
- Ipilimumab, Nivolumab
- Where
- 6 sites in United States
- Volunteers
- 100 people
- Sponsor
- Dana-Farber Cancer Institute
Solid Tumor
A Phase 1a/1b Study of ACTM-838 in Patients With Advanced Solid Tumors
This is a first in human (FIH) 2-part study using ACTM-838 in patients with advanced solid tumors resistant to standard of care treatment. Part 1a will evaluate dose escalation and Part 1b will evaluate dose expansion.
- Trial name
- NCT06336148
- Testing
- ACTM-838
- Where
- 5 sites in United States, Australia
- Volunteers
- 10 people
- Sponsor
- Actym Therapeutics, Inc.
Multiple Sclerosis, Lower Urinary Tract Symptoms
Central Nervous System Changes Following OnabotulinumtoxinA Injection in the Bladder
The purpose of this research study is to evaluate higher neural changes following intra-detrusor injection of Onabotulinumtoxin-A (BTX-A) in patients with Multiple Sclerosis (MS).
- Conditions
- Multiple Sclerosis, Lower Urinary Tract Symptoms, Neurogenic Bladder, Detrusor, Overactive
- Trial name
- NCT03033355
- Testing
- Intra-detrusor injection of Onabotulinumtoxin-A
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The Methodist Hospital Research Institute
Bladder Urothelial Carcinoma, Stage IV Bladder Cancer AJCC v8
Radiation Therapy and Durvalumab With or Without Tremelimumab in Treating Participants With Unresectable, Locally Advanced, or Metastatic Bladder Cancer
This phase II trial studies the side effects and how well radiation therapy and durvalumab with or without tremelimumab work in treating participants with bladder cancer that cannot be removed by surgery, has spread to nearby…
- Conditions
- Bladder Urothelial Carcinoma, Stage IV Bladder Cancer AJCC v8, Stage IVA Bladder Cancer AJCC v8, Stage IVB Bladder Cancer AJCC v8
- Trial name
- NCT03601455
- Testing
- Durvalumab, External Beam Radiation Therapy, Tremelimumab
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Underactive Bladder
Akyva First In Human
The goal of this study is to check if the study device, the Akyva System, is safe to use and to find out if it has any possible side effects.
- Trial name
- NCT06956209
- Testing
- Direct Bladder Wall Stimulation
- Where
- 2 sites in Australia
- Volunteers
- 15 people
- Sponsor
- Iota Biosciences, Inc
Bladder Cancer, Urinary Diversion
Comparison of Safety and Efficacy of Detaenial Sigmoid Neobladder and Ileal Neobladder
Bladder cancer is a common malignant tumor of the urinary system, radical resection plus urinary diversion is the first choice of treatment for muscle invasive bladder cancer.
- Trial name
- NCT03108196
- Testing
- sigmoid, ileal
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Zhujiang Hospital
Painful Bladder Syndrome, Interstitial Cystitis
Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome
Purpose: 1. To demonstrate better symptoms control (pain, urinary urgency and frequency) with sacral neuromodulation (SNM) in patients with interstitial cystitis /painful bladder syndrome (IC/PBS) using a stimulation frequency of…
- Conditions
- Painful Bladder Syndrome, Interstitial Cystitis, Pelvic Floor; Insufficiency, Bowel Dysfunction
- Trial name
- NCT01312259
- Testing
- Changing the Interstim parameter of '' Frequency" in patients with Interstitial Cystitis
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Pelvic and Sexual Health Institute
Urothelial Carcinoma Bladder, PD-1 Inhibitor
Bladder Sparing Treatment of Tislelizumab, Gemcitabine and Cisplatin for Patients With PD-L1 Positive Muscle Invasive Bladder Cancer
This is a phase II open label single-arm prospective study aiming to investigate the efficacy of PD-1 inhibitor Tislelizumab combined with conventional gemcitabine and cisplatin as bladder sparing treatment for patients with…
- Trial name
- NCT05401279
- Testing
- Tislelizumab, Gemcitabine, Cisplatin
- Where
- China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Urinary Tract Infections
A Trial of Different Methods for Bladder Drainage in Hip Surgery Patients
The aim of the project is to evaluate differences between intermittent and indwelling catheterisation in patients with hip surgery.
- Trial name
- NCT01333254
- Testing
- Intermittent urinary catheterisation
- Where
- Sweden
- Volunteers
- 170 people
- Sponsor
- Region Örebro County
Cesarean Section
The Bladder Flap at Cesarean Section: A Randomized Controlled Trial
Cesarean section is now the most common major surgical procedure performed on women world wide. In the United States, approximately 1 in 4 deliveries is by this method.
- Trial name
- NCT00918996
- Testing
- Omission of Bladder Flap Creation
- Where
- United States
- Volunteers
- 258 people
- Sponsor
- Washington University School of Medicine
Neurogenic Bladder
Comparison of Mobile Education and Face-to-Face Intermittent Catheterization Education
Today, Clean Intermittent Catheterization (CIC) is widely used to drain urine accumulated in the bladder in acute or chronic problems such as neurogenic bladder and prostate hypertrophy.The success of the technique depends…
- Trial name
- NCT06917027
- Testing
- education
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Neurogenic Bladder Dysfunction
Stimulation of Acupuncture Points in Female Patients With Multiple Sclerosis and Neurogenic Bladder Dysfunction
Electrical vs. manual stimulation: The study compares two types of acupuncture - one using mild electrical currents and one using just manual no-needle techniques in the treatment of urinary bladder disfunction.
- Trial name
- ACULUTS (NCT07183683)
- Testing
- group 1: electrical stimulation of acupuncture points plus routine care, group 2: acupressure plus routine care
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Charite University, Berlin, Germany
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